AutismKB 2.0

Annotation Detail for TRIM23


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Basic Information Top
Gene Symbol:TRIM23 ( ARD1,ARFD1,RNF46 )
Gene Full Name: tripartite motif-containing 23
Band: 5q12.3
Quick LinksEntrez ID:373; OMIM: 601747; Uniprot ID:TRI23_HUMAN; ENSEMBL ID: ENSG00000113595; HGNC ID: 660
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of TRIM23 mRNAaffects expression 16483693
C014347 decitabine decitabine results in increased expression of TRIM23 mRNAincreases expression 17908484
D004317 Doxorubicin Doxorubicin results in increased expression of TRIM23 mRNAincreases expression 16404146
D006220 Haloperidol Haloperidol results in decreased expression of TRIM23 mRNAdecreases expression 15860345
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TRIM23 mRNAincreases expression 19465110
C025643 vinclozolin vinclozolin affects the expression of TRIM23 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.3114514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 4.0218287403
MESH:D000230 Adenocarcinoma Doxorubicin 2.6317418594
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.8416835633
MESH:D000419 Albuminuria Doxorubicin 4.9321441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2511748828
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001321 Autistic Disorder Haloperidol 2.7218080171 19368416
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.3115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 5.2214601052
MESH:D001932 Brain Neoplasms Doxorubicin 4.1117150277
MESH:D001943 Breast Neoplasms decitabine 1.9218320071 19208741
MESH:D001943 Breast Neoplasms Doxorubicin 1.9215668708 19526202 17369602 16935488 11325840 18695136 16115903 15993339 16096432 15634643 18234424 15136595 17983394 15994142 15939500 15692762 17426702 15567936 18628466 18382427 16595493 16322301 16264153 16826403
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9220435547
MESH:D002276 Carcinoid Tumor Doxorubicin 5.3316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 2.2617876044 16234567 18059187 16023760
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.2816201981 1485588
MESH:D002294 Carcinoma, Squamous Cell decitabine 5.1419215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 5.146189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5218850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.7217924179 16242529 16109756 15476868 16952015 17329180 17974986 16455267 16278810 16364871 17351982 15792986 15505089 17131338 16731534 17007740 16269455 17382496 16651473 15811867 18627295 17519947 16612575 17928571 17308081
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 3.0316243910 17334414
MESH:D002375 Catalepsy Haloperidol 5.371977408 15215559
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4516835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.218697196 15340226 16354765 15668235 12621046
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.7418981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.7418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.1920210726
MESH:D003704 Dementia Haloperidol 4.9011575062
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7217107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 4.1217416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.1220420201
MESH:D004362 Drug Toxicity Doxorubicin 8.8918602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.7012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.4215322242 18230668 16714409
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.6419294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.6417359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.339294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.6818037988
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2411564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8711858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 5.0519069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3620067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005909 Glioblastoma Doxorubicin 3.5417150277
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.1210696789
MESH:D006258 Head and Neck Neoplasms decitabine 8.6319215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 8.6315692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.6917888722 16495754 14766674 18006777 16244371 16244372 16330681 17875725 12587719 16879835 16707910 16144979 18674790
MESH:D006333 Heart Failure Doxorubicin 3.5217481944
MESH:D006394 Hemangiosarcoma Doxorubicin 4.2315692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.3115340226 16120746 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 3.6917606976 18501091 15147373
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.5715340226 16354765 8697196 18606429 16959395
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0018850075 18670907
MESH:D007248 Infertility, Male decitabine 7.6017581917
MESH:D007248 Infertility, Male vinclozolin 7.6016467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9912200463 12878042
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6616580747
MESH:D007674 Kidney Diseases Doxorubicin 3.2116775033 15699352 15369732
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.4816707910
MESH:D007938 Leukemia decitabine 3.2118980019 19235587
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.6816085563
MESH:D007951 Leukemia, Myeloid decitabine 4.3318454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4218206229 17679729 19010910 18460780 19387464 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.9818055864
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 2.5116439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.5112878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8116984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 6.5216842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.5212151625
MESH:D008175 Lung Neoplasms Doxorubicin 2.476189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4719555203 11884234
MESH:D008223 Lymphoma decitabine 8.4619470736
MESH:D008223 Lymphoma Doxorubicin 8.4616098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 4.0617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.9815621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 3.2115458769
MESH:D008545 Melanoma decitabine 3.6817785578 16505122
MESH:D008545 Melanoma Doxorubicin 3.6816827129
MESH:D001523 Mental Disorders Haloperidol 4.4716856516
MESH:D008654 Mesothelioma Doxorubicin 3.1617638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.8315792986
MESH:D052016 Mucositis Doxorubicin 5.2517415656
MESH:D009101 Multiple Myeloma decitabine 3.5618172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5418608210 16882708 19157545 19010910
MESH:D009203 Myocardial Infarction Doxorubicin 3.0515857846 19429709
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2712213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 3.0518259882
MESH:D009369 Neoplasms decitabine 2.8419470736 17925555 19116145
MESH:D009401 Nephrosis Doxorubicin 5.1916899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.2916889571 15640375
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.5914600291
MESH:D009447 Neuroblastoma Doxorubicin 3.4015555623
MESH:D012516 Osteosarcoma Doxorubicin 4.3715930896
MESH:D010051 Ovarian Neoplasms decitabine 2.7219331143 19259094
MESH:D010190 Pancreatic Neoplasms decitabine 2.8519294695
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.7712520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.6817983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.6817638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.9418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 11.0811399792 11896295 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 11.0818220299 19015723 18042343
MESH:D055728 Primary Myelofibrosis decitabine 5.1517616702
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.5018437689 16888761 15749863 15897917 16729912 16868541
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D011595 Psychomotor Agitation Haloperidol 5.3711575062
MESH:D011618 Psychotic Disorders Haloperidol 4.4711575062
MESH:D051437 Renal Insufficiency Doxorubicin 4.6417922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.2218990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.7519155313
MESH:D012509 Sarcoma Doxorubicin 4.2916767912 17203757 17710206 15625365 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.6214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 5.2517846226
MESH:D012559 Schizophrenia Haloperidol 2.8319369910 18513383 20107430 1830565
MESH:D012878 Skin Neoplasms Doxorubicin 6.1115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 6.1116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.9817203757 15625365 16767912
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D017180 Tachycardia, Ventricular Haloperidol 5.0920210726
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.4212697716
MESH:D013964 Thyroid Neoplasms decitabine 8.2317967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.2316010429 17909728
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.6919087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.6917653716
MESH:D014604 Uveal Neoplasms decitabine 5.4317785578
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.1212125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.6417334414 17638931 16364871 17678736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.7715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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