AutismKB 2.0

Annotation Detail for KCNA4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCNA4 ( HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, member 4
Band: 11p14.1
Quick LinksEntrez ID:3739; OMIM: 176266; Uniprot ID:KCNA4_HUMAN; ENSEMBL ID: ENSG00000182255; HGNC ID: 6222
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of KCNA4 mRNAincreases expression 15520326
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNA4 mRNAaffects expression 16483693
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of KCNA4 mRNAaffects cotreatment|affects expression 18636392
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased activity of KCNA4 proteindecreases activity 19279288
D006851 Hydrochloric Acid Hydrochloric Acid results in decreased expression of KCNA4 proteindecreases expression 19279288
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of KCNA4 mRNAaffects cotreatment|affects expression 18636392
C025299 polyphenols polyphenols results in decreased expression of KCNA4 mRNAdecreases expression 16293270
D011189 Potassium Chloride Potassium Chloride results in increased expression of KCNA4 mRNAincreases expression 16412482
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 12.0818287403
MESH:D000138 Acidosis Hydrochloric Acid 12.0815920416 20872349 11574821 19262391 12771618 16144966
MESH:D000141 Acidosis, Renal Tubular Hydrochloric Acid 6.1317183249
MESH:D000142 Acidosis, Respiratory Hydrochloric Acid 6.2620597076
MESH:D055371 Acute Lung Injury Chlorine 10.7920601635
MESH:D055371 Acute Lung Injury Hydrochloric Acid 10.7916759491 19760209 19060228 19094174 11953099 11850527 15970105
MESH:D000544 Alzheimer Disease Ozone 2.4815513908
MESH:D000860 Anoxia Hydrochloric Acid 5.7015090967
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.0718057881 18218290 20041841
MESH:D001172 Arthritis, Rheumatoid Ozone 2.6115570426
MESH:D001249 Asthma Ozone 2.7017854713 16373670
MESH:D001281 Atrial Fibrillation Amiodarone 4.1118651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.6519483382
MESH:D001778 Blood Coagulation Disorders Hydrochloric Acid 10.6515920416
MESH:D016535 Bronchial Hyperreactivity Hydrochloric Acid 9.6912378975
MESH:D016535 Bronchial Hyperreactivity Ozone 9.6917626835 18315731 16777450 18417511 14754758 15516495 19059883
MESH:D001986 Bronchial Spasm Hydrochloric Acid 5.9115578804
MESH:D002100 Cachexia Ozone 5.1416183385
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9719225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.4818974383
MESH:D003110 Colonic Neoplasms polyphenols 2.7116293270
MESH:D003556 Cystitis Hydrochloric Acid 5.9119279288 12599022 20719367 12853844
MESH:D018856 Cystitis, Interstitial Hydrochloric Acid 6.2617714534
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.5218218290 15265979
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.5219370779
MESH:D004417 Dyspnea Chlorine 5.0720016425
MESH:D004935 Esophageal Diseases Hydrochloric Acid 6.1919566590
MESH:D004941 Esophagitis Hydrochloric Acid 6.3912928072
MESH:D004942 Esophagitis, Peptic Hydrochloric Acid 6.4620516732 14621274 11346197
MESH:D005234 Fatty Liver Amiodarone 3.8014986274
MESH:D005355 Fibrosis Hydrochloric Acid 5.0718497604
MESH:D005739 Gas Poisoning Chlorine 13.6520016425
MESH:D005739 Gas Poisoning Hydrochloric Acid 13.6512378975
MESH:D005764 Gastroesophageal Reflux Hydrochloric Acid 5.6619957777 19951613 20616304 20516732 12212954 20545468
MESH:D006356 Heartburn Hydrochloric Acid 6.1919566590
MESH:D006529 Hepatomegaly Amiodarone 4.1115265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.159751232 8137927
MESH:D006940 Hyperemia Hydrochloric Acid 6.0512646421
MESH:D006975 Hypertension, Portal Hydrochloric Acid 5.7116984587
MESH:D006976 Hypertension, Pulmonary Hydrochloric Acid 4.6519262391
MESH:D007022 Hypotension Hydrochloric Acid 5.0611574821
MESH:D007037 Hypothyroidism Amiodarone 4.8718020914 17991464
MESH:D007249 Inflammation Hydrochloric Acid 6.2311574821
MESH:D007249 Inflammation polyphenols 6.2316366677
MESH:D007410 Intestinal Diseases Hydrochloric Acid 5.3311574821
MESH:D007818 Laryngeal Diseases Hydrochloric Acid 6.8116498863
MESH:D007826 Laryngismus Hydrochloric Acid 6.8111510729
MESH:D008064 Lipidoses Amiodarone 3.7017567588 15342952
MESH:D008103 Liver Cirrhosis Hydrochloric Acid 4.2016984587
MESH:D008107 Liver Diseases polyphenols 2.8316698588
MESH:D008133 Long QT Syndrome Amiodarone 3.7915350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 13.5912587719
MESH:D008171 Lung Diseases Hydrochloric Acid 13.5916784557
MESH:D008171 Lung Diseases Ozone 13.598266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.9218516814
MESH:D055370 Lung Injury Hydrochloric Acid 10.7417627322 16129981 20597076 18573544 11395602 18339021 15607125 15044056 21311175 15090967 21114838 19644408 19262391 18497604
MESH:D055370 Lung Injury Ozone 10.7420417186
MESH:D008175 Lung Neoplasms Ozone 2.107614698 8597069
MESH:D008679 Metaplasia Ozone 5.5510496685
MESH:D009181 Mycoses Amiodarone 5.3412754197 17974566
MESH:D009203 Myocardial Infarction Hydrochloric Acid 3.9018534312
MESH:D009784 Occupational Diseases Hydrochloric Acid 5.0312378975
MESH:D010538 Peritonitis Ozone 4.4916369182
MESH:D011014 Pneumonia Ozone 4.7918381685 18929643 18007984
MESH:D011015 Pneumonia, Aspiration Hydrochloric Acid 5.7715970105 15607125 18573544 18497604
MESH:D001261 Pulmonary Atelectasis Hydrochloric Acid 6.4620597076
MESH:D011654 Pulmonary Edema Hydrochloric Acid 5.6615090967
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9412832656 12490602 11597910
MESH:D012120 Respiration Disorders Chlorine 5.6518579056
MESH:D012128 Respiratory Distress Syndrome, Adult Hydrochloric Acid 5.0616784557 18549715 18339021 16129981 17627322
MESH:D012133 Respiratory Paralysis Hydrochloric Acid 6.8111510729
MESH:D012140 Respiratory Tract Diseases Hydrochloric Acid 5.6120516732
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.4818724381
MESH:D013276 Stomach Ulcer Amiodarone 8.6918087811
MESH:D013276 Stomach Ulcer Hydrochloric Acid 8.6915309881 17189318 16755016
MESH:D013610 Tachycardia Amiodarone 4.6211238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5219225199
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6917997062
MESH:D013959 Thyroid Diseases Amiodarone 5.2019731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.2218020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.5911989578 17467628
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA207
  • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02299 - Arginineamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018