Annotation Detail for KCNA4
Basic Information
TopGene Symbol: | KCNA4 ( HBK4,HK1,HPCN2,HUKII,KCNA4L,KCNA8,KV1.4,PCN2 ) |
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Gene Full Name: | potassium voltage-gated channel, shaker-related subfamily, member 4 |
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Band: | 11p14.1 |
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Quick Links | Entrez ID:3739; OMIM: 176266; Uniprot ID:KCNA4_HUMAN; ENSEMBL ID: ENSG00000182255; HGNC ID: 6222 |
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Relate to Another Database: |
SFARIGene;
denovo-db |
Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
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D000638 |
Amiodarone |
Amiodarone results in increased expression of KCNA4 mRNA | increases expression | 15520326
|
D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of KCNA4 mRNA | affects expression | 16483693
|
D002713 |
Chlorine |
[Ozone co-treated with Chlorine] affects the expression of KCNA4 mRNA | affects cotreatment|affects expression | 18636392
|
D006851 |
Hydrochloric Acid |
Hydrochloric Acid results in decreased activity of KCNA4 protein | decreases activity | 19279288
|
D006851 |
Hydrochloric Acid |
Hydrochloric Acid results in decreased expression of KCNA4 protein | decreases expression | 19279288
|
D010126 |
Ozone |
[Ozone co-treated with Chlorine] affects the expression of KCNA4 mRNA | affects cotreatment|affects expression | 18636392
|
C025299 |
polyphenols |
polyphenols results in decreased expression of KCNA4 mRNA | decreases expression | 16293270
|
D011189 |
Potassium Chloride |
Potassium Chloride results in increased expression of KCNA4 mRNA | increases expression | 16412482
|
Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
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MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
12.08 | 18287403 |
MESH:D000138 |
Acidosis |
|
Hydrochloric Acid |
12.08 | 15920416 20872349 11574821 19262391 12771618 16144966 |
MESH:D000141 |
Acidosis, Renal Tubular |
|
Hydrochloric Acid |
6.13 | 17183249 |
MESH:D000142 |
Acidosis, Respiratory |
|
Hydrochloric Acid |
6.26 | 20597076 |
MESH:D055371 |
Acute Lung Injury |
|
Chlorine |
10.79 | 20601635 |
MESH:D055371 |
Acute Lung Injury |
|
Hydrochloric Acid |
10.79 | 16759491 19760209 19060228 19094174 11953099 11850527 15970105 |
MESH:D000544 |
Alzheimer Disease |
|
Ozone |
2.48 | 15513908 |
MESH:D000860 |
Anoxia |
|
Hydrochloric Acid |
5.70 | 15090967 |
MESH:D001145 |
Arrhythmias, Cardiac |
|
Amiodarone |
4.07 | 18057881 18218290 20041841 |
MESH:D001172 |
Arthritis, Rheumatoid |
|
Ozone |
2.61 | 15570426 |
MESH:D001249 |
Asthma |
|
Ozone |
2.70 | 17854713 16373670 |
MESH:D001281 |
Atrial Fibrillation |
|
Amiodarone |
4.11 | 18651412 19698954 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Amiodarone |
10.65 | 19483382 |
MESH:D001778 |
Blood Coagulation Disorders |
|
Hydrochloric Acid |
10.65 | 15920416 |
MESH:D016535 |
Bronchial Hyperreactivity |
|
Hydrochloric Acid |
9.69 | 12378975 |
MESH:D016535 |
Bronchial Hyperreactivity |
|
Ozone |
9.69 | 17626835 18315731 16777450 18417511 14754758 15516495 19059883 |
MESH:D001986 |
Bronchial Spasm |
|
Hydrochloric Acid |
5.91 | 15578804 |
MESH:D002100 |
Cachexia |
|
Ozone |
5.14 | 16183385 |
MESH:D002311 |
Cardiomyopathy, Dilated |
|
Amiodarone |
2.97 | 19225199 15710769 |
MESH:D002341 |
Carotid Artery Thrombosis |
|
Amiodarone |
5.48 | 18974383 |
MESH:D003110 |
Colonic Neoplasms |
|
polyphenols |
2.71 | 16293270 |
MESH:D003556 |
Cystitis |
|
Hydrochloric Acid |
5.91 | 19279288 12599022 20719367 12853844 |
MESH:D018856 |
Cystitis, Interstitial |
|
Hydrochloric Acid |
6.26 | 17714534 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
Amiodarone |
4.52 | 18218290 15265979 |
MESH:D056486 |
Drug-Induced Liver Injury |
|
polyphenols |
4.52 | 19370779 |
MESH:D004417 |
Dyspnea |
|
Chlorine |
5.07 | 20016425 |
MESH:D004935 |
Esophageal Diseases |
|
Hydrochloric Acid |
6.19 | 19566590 |
MESH:D004941 |
Esophagitis |
|
Hydrochloric Acid |
6.39 | 12928072 |
MESH:D004942 |
Esophagitis, Peptic |
|
Hydrochloric Acid |
6.46 | 20516732 14621274 11346197 |
MESH:D005234 |
Fatty Liver |
|
Amiodarone |
3.80 | 14986274 |
MESH:D005355 |
Fibrosis |
|
Hydrochloric Acid |
5.07 | 18497604 |
MESH:D005739 |
Gas Poisoning |
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Chlorine |
13.65 | 20016425 |
MESH:D005739 |
Gas Poisoning |
|
Hydrochloric Acid |
13.65 | 12378975 |
MESH:D005764 |
Gastroesophageal Reflux |
|
Hydrochloric Acid |
5.66 | 19957777 19951613 20616304 20516732 12212954 20545468 |
MESH:D006356 |
Heartburn |
|
Hydrochloric Acid |
6.19 | 19566590 |
MESH:D006529 |
Hepatomegaly |
|
Amiodarone |
4.11 | 15265979 |
MESH:D006937 |
Hypercholesterolemia |
|
Amiodarone |
4.15 | 9751232 8137927 |
MESH:D006940 |
Hyperemia |
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Hydrochloric Acid |
6.05 | 12646421 |
MESH:D006975 |
Hypertension, Portal |
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Hydrochloric Acid |
5.71 | 16984587 |
MESH:D006976 |
Hypertension, Pulmonary |
|
Hydrochloric Acid |
4.65 | 19262391 |
MESH:D007022 |
Hypotension |
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Hydrochloric Acid |
5.06 | 11574821 |
MESH:D007037 |
Hypothyroidism |
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Amiodarone |
4.87 | 18020914 17991464 |
MESH:D007249 |
Inflammation |
|
Hydrochloric Acid |
6.23 | 11574821 |
MESH:D007249 |
Inflammation |
|
polyphenols |
6.23 | 16366677 |
MESH:D007410 |
Intestinal Diseases |
|
Hydrochloric Acid |
5.33 | 11574821 |
MESH:D007818 |
Laryngeal Diseases |
|
Hydrochloric Acid |
6.81 | 16498863 |
MESH:D007826 |
Laryngismus |
|
Hydrochloric Acid |
6.81 | 11510729 |
MESH:D008064 |
Lipidoses |
|
Amiodarone |
3.70 | 17567588 15342952 |
MESH:D008103 |
Liver Cirrhosis |
|
Hydrochloric Acid |
4.20 | 16984587 |
MESH:D008107 |
Liver Diseases |
|
polyphenols |
2.83 | 16698588 |
MESH:D008133 |
Long QT Syndrome |
|
Amiodarone |
3.79 | 15350150 11989578 17391786 |
MESH:D008171 |
Lung Diseases |
|
Amiodarone |
13.59 | 12587719 |
MESH:D008171 |
Lung Diseases |
|
Hydrochloric Acid |
13.59 | 16784557 |
MESH:D008171 |
Lung Diseases |
|
Ozone |
13.59 | 8266340 19066396 |
MESH:D017563 |
Lung Diseases, Interstitial |
|
Amiodarone |
4.92 | 18516814 |
MESH:D055370 |
Lung Injury |
|
Hydrochloric Acid |
10.74 | 17627322 16129981 20597076 18573544 11395602 18339021 15607125 15044056 21311175 15090967 21114838 19644408 19262391 18497604 |
MESH:D055370 |
Lung Injury |
|
Ozone |
10.74 | 20417186 |
MESH:D008175 |
Lung Neoplasms |
|
Ozone |
2.10 | 7614698 8597069 |
MESH:D008679 |
Metaplasia |
|
Ozone |
5.55 | 10496685 |
MESH:D009181 |
Mycoses |
|
Amiodarone |
5.34 | 12754197 17974566 |
MESH:D009203 |
Myocardial Infarction |
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Hydrochloric Acid |
3.90 | 18534312 |
MESH:D009784 |
Occupational Diseases |
|
Hydrochloric Acid |
5.03 | 12378975 |
MESH:D010538 |
Peritonitis |
|
Ozone |
4.49 | 16369182 |
MESH:D011014 |
Pneumonia |
|
Ozone |
4.79 | 18381685 18929643 18007984 |
MESH:D011015 |
Pneumonia, Aspiration |
|
Hydrochloric Acid |
5.77 | 15970105 15607125 18573544 18497604 |
MESH:D001261 |
Pulmonary Atelectasis |
|
Hydrochloric Acid |
6.46 | 20597076 |
MESH:D011654 |
Pulmonary Edema |
|
Hydrochloric Acid |
5.66 | 15090967 |
MESH:D011658 |
Pulmonary Fibrosis |
|
Amiodarone |
2.94 | 12832656 12490602 11597910 |
MESH:D012120 |
Respiration Disorders |
|
Chlorine |
5.65 | 18579056 |
MESH:D012128 |
Respiratory Distress Syndrome, Adult |
|
Hydrochloric Acid |
5.06 | 16784557 18549715 18339021 16129981 17627322 |
MESH:D012133 |
Respiratory Paralysis |
|
Hydrochloric Acid |
6.81 | 11510729 |
MESH:D012140 |
Respiratory Tract Diseases |
|
Hydrochloric Acid |
5.61 | 20516732 |
OMIM:609620 |
SHORT QT SYNDROME 1 |
|
Amiodarone |
5.48 | 18724381 |
MESH:D013276 |
Stomach Ulcer |
|
Amiodarone |
8.69 | 18087811 |
MESH:D013276 |
Stomach Ulcer |
|
Hydrochloric Acid |
8.69 | 15309881 17189318 16755016 |
MESH:D013610 |
Tachycardia |
|
Amiodarone |
4.62 | 11238279 |
MESH:D017180 |
Tachycardia, Ventricular |
|
Amiodarone |
4.52 | 19225199 |
MESH:D013705 |
Temporomandibular Joint Disorders |
|
polyphenols |
5.69 | 17997062 |
MESH:D013959 |
Thyroid Diseases |
|
Amiodarone |
5.20 | 19731979 |
MESH:D013971 |
Thyrotoxicosis |
|
Amiodarone |
5.22 | 18020914 19584973 |
MESH:D016171 |
Torsades de Pointes |
|
Amiodarone |
4.59 | 11989578 17467628 |
PharmGKB Accession:PA207
Releated drug ID |
Related drug Name |
PA452249 | antiarrhythmics, class i and iii |
Drugbank ID |
Action |
Drug Name |
Description |
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DB02299 |
- |
Arginineamide |
|