AutismKB 2.0

Annotation Detail for KCNA5


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Basic Information Top
Gene Symbol:KCNA5 ( ATFB7,HCK1,HK2,HPCN1,KV1.5,MGC117058,MGC117059,PCN1 )
Gene Full Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Band: 12p13.32
Quick LinksEntrez ID:3741; OMIM: 176267; Uniprot ID:KCNA5_HUMAN; ENSEMBL ID: ENSG00000130037; HGNC ID: 6224
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1746Hypertension, Pulmonary
1832Congenital abnormality
1934Cancer
2091Hypertension
2158Pulmonary hypertension
No data
No data
Desease Name
Atrial fibrillation, familial, 7
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid 15-hydroxy-5,8,11,13-eicosatetraenoic acid affects the activity of KCNA5 proteinaffects activity 18984061
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid Nordihydroguaiaretic Acid inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNAdecreases expression|increases activity|increases chemical synthesis 18984061
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 proteindecreases expression|increases activity|increases chemical synthesis 18984061
D000638 Amiodarone Amiodarone results in decreased expression of KCNA5 mRNAdecreases expression 15520326
D000638 Amiodarone Amiodarone results in decreased expression of KCNA5 mRNAdecreases expression 8973384
9302343
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNA5 mRNAaffects expression 16483693
D015764 Bepridil Bepridil results in decreased activity of KCNA5 proteindecreases activity 11711026
C099255 cinnamyl-3,4-dihydroxycyanocinnamate cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
D003907 Dexamethasone Dexamethasone results in increased expression of KCNA5 mRNAincreases expression 15793248
15955845
D003907 Dexamethasone Somatostatin inhibits the reaction [Dexamethasone results in increased expression of KCNA5 mRNA]decreases reaction|increases expression 15955845
D002945 Cisplatin KCNA5 protein results in increased susceptibility to Cisplatinincreases response to substance 17428690
D004317 Doxorubicin KCNA5 protein results in increased susceptibility to Doxorubicinincreases response to substance 17428690
C058249 ebastine ebastine results in decreased activity of KCNA5 proteindecreases activity 9196279
D005419 Flavonoids Flavonoids results in increased expression of KCNA5 mRNAincreases expression 18035473
D005472 Fluorouracil KCNA5 protein results in increased susceptibility to Fluorouracilincreases response to substance 17428690
D007654 Ketoconazole Ketoconazole results in decreased activity of KCNA5 proteindecreases activity 9694927
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
D010100 Oxygen ALOX15 protein promotes the reaction [Oxygen deficiency results in decreased activity of KCNA5 protein]decreases activity|increases reaction 18984061
D010100 Oxygen cinnamyl-3,4-dihydroxycyanocinnamate inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
D010100 Oxygen Nordihydroguaiaretic Acid inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]decreases expression|decreases reaction|increases activity|increases chemical synthesis 18984061
D010100 Oxygen Oxygen deficiency results in decreased activity of KCNA5 proteindecreases activity 18984061
D010100 Oxygen Oxygen deficiency results in decreased expression of KCNA5 mRNAdecreases expression 18984061
D010100 Oxygen Oxygen deficiency results in decreased expression of KCNA5 proteindecreases expression 18984061
D010100 Oxygen [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNAdecreases expression|increases activity|increases chemical synthesis 18984061
D010100 Oxygen [[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 proteindecreases expression|increases activity|increases chemical synthesis 18984061
D011188 Potassium KCNA5 protein results in increased transport of Potassiumincreases transport 17428690
D011374 Progesterone Progesterone results in decreased activity of KCNA5 proteindecreases activity 18068743
D018038 Sodium Selenite Sodium Selenite results in decreased expression of KCNA5 mRNAdecreases expression 18175754
D013004 Somatostatin Somatostatin inhibits the reaction [Dexamethasone results in increased expression of KCNA5 mRNA]decreases reaction|increases expression 15955845
D013629 Tamoxifen Tamoxifen results in decreased expression of KCNA5 mRNAdecreases expression 15590111
D016593 Terfenadine Terfenadine results in decreased activity of KCNA5 proteindecreases activity 9196279
8772706
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KCNA5 mRNAdecreases expression 16120747
D014750 Vincristine KCNA5 protein results in increased susceptibility to Vincristineincreases response to substance 17428690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.7215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D058186 Acute Kidney Injury Cisplatin 3.8412690470 17670903 15814532
MESH:D055371 Acute Lung Injury Oxygen 4.4116759491
MESH:D000230 Adenocarcinoma Cisplatin 10.0411798837 17638652
MESH:D000230 Adenocarcinoma Doxorubicin 10.0417418594
MESH:D000230 Adenocarcinoma Fluorouracil 10.0417638652
MESH:D000230 Adenocarcinoma Vincristine 10.0419825857
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.2516835633
MESH:D000419 Albuminuria Doxorubicin 4.4221441931
OMIM:607154 ALLERGIC RHINITIS Terfenadine 5.5416037679
MESH:D000740 Anemia Fluorouracil 8.2917963324 16511603 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.2911748828
MESH:D000860 Anoxia Oxygen 4.9220872349
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6920041841 18218290 18057881
MESH:D001169 Arthritis, Experimental Dexamethasone 3.4617659584
MESH:D050197 Atherosclerosis Oxygen 3.7316391483
MESH:D001281 Atrial Fibrillation marker/mechanism 19698954
MESH:D001281 Atrial Fibrillation Amiodarone 3.8019698954 18651412
OMIM:612240 ATRIAL FIBRILLATION, FAMILIAL, 7 marker/mechanism
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.6419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 11.6314601052
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 11.6314601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2117868700
MESH:D001930 Brain Injuries Progesterone 4.1315380490 15665606 15845082
MESH:D001932 Brain Neoplasms Doxorubicin 3.6917150277
MESH:D001943 Breast Neoplasms Cisplatin 4.6419526202 18382427
MESH:D001943 Breast Neoplasms Doxorubicin 4.6415939500 16322301 15567936 16115903 16264153 11325840 17426702 15994142 18695136 17983394 19526202 18382427 15136595 15634643 16096432 15993339 18628466 15668708 16935488 17369602 16826403 18234424 15692762 16595493
MESH:D001943 Breast Neoplasms Fluorouracil 4.6415136595 16110121 19217205 16595493 16557594 18608205 18357371
MESH:D001943 Breast Neoplasms Nordihydroguaiaretic Acid 4.6418418215
MESH:D001943 Breast Neoplasms Oxygen 4.6417263869
MESH:D001943 Breast Neoplasms Progesterone 4.6417614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.6416202921 19059307 19189210 19410462 18855134 18984771 11161223 19103187 19115204 17049068 17893378 20859285 21152245 20005174 19084267 18425577 18815881 19487384 19142967 18821012 20135344 21138602 18629630 20065188 19189212 16818667 15668708 19200415 19221464 19066611 15565566 19288272 17261762 17242785 20544844 19244106 19011961 18997820 19155303 17440819 16273361 16873071 18351453 19289846 20390343
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 4.6420435547
MESH:D002276 Carcinoid Tumor Doxorubicin 11.9216051944
MESH:D002276 Carcinoid Tumor Fluorouracil 11.9216051944
MESH:D002277 Carcinoma Fluorouracil 7.8417121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3819066611
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.4617982673
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.4618059187 16023760 16234567 17876044
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 6.4617971768 16332177 16799960 17045692 18930000 17088986
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.4616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9916685392 12023789
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 10.661485588 16201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 10.6618695887
MESH:D002292 Carcinoma, Renal Cell Vincristine 10.6616201981
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 10.6117066447 18337622 6189445
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.616189445
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 10.6116757204 17066447 18986760 16280240
MESH:D002294 Carcinoma, Squamous Cell Vincristine 10.616189445
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5017572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.4416278810 17519947 16455267 16364871 17974986 17131338 16952015 16651473 17924179 16731534 16242529 18627295 17007740 16269455 15792986 17351982 15811867 15476868 17382496 16109756 16612575 15505089 17928571 17329180 17308081
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 5.8315710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 5.8317334414 16243910
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9518974383
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D019457 Chromosome Breakage Sodium Selenite 4.6215894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0515668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Dexamethasone 5.9415824018
MESH:D003110 Colonic Neoplasms Fluorouracil 5.9418772588 15001691 17016597 16510598 17169374 17172411 16340194 17725105 17018589 17287894
MESH:D003110 Colonic Neoplasms Nordihydroguaiaretic Acid 5.9415936596
MESH:D015179 Colorectal Neoplasms Cisplatin 3.4715273666
MESH:D015179 Colorectal Neoplasms Doxorubicin 3.4718802399 18259882
MESH:D015179 Colorectal Neoplasms Fluorouracil 3.4717695437 18949393 18509181 16391804 18383874 17016601 18802399 17594712 15148649 16524972 16282729 17255274 20501625 17094418 16331619 18448328 16303861 18288408 17401013 14970324 15289873 17454858
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.9514669216 17141729
MESH:D019465 Craniofacial Abnormalities Dexamethasone 2.5817728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5810048152 20055451 15322242
MESH:D007644 Darier Disease Fluorouracil 4.6616733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2319031437
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2812438553
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.6616285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3619279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3617187935
MESH:D003967 Diarrhea Dexamethasone 3.577237001
MESH:D056486 Drug-Induced Liver Injury Amiodarone 11.6415265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 11.6417416283
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 11.6418289764
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 11.6415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6420420201
MESH:D004362 Drug Toxicity Cisplatin 13.2112649298 12231392 19839026 15033597
MESH:D004362 Drug Toxicity Doxorubicin 13.2118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.2111462148
MESH:D004417 Dyspnea Oxygen 4.7020016425
MESH:D004485 Eczema Dexamethasone 4.3312438553
MESH:D004487 Edema Dexamethasone 6.4819703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.7715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.7417692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.7419031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.2817359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2819155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Progesterone 8.5416134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.549294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.0318037988
MESH:D004938 Esophageal Neoplasms Cisplatin 4.6616481741 16785472 17638652 15173087 15464296
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6615173087 16785472 16337965 16481741 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9111564622
MESH:D005234 Fatty Liver Amiodarone 7.5514986274
MESH:D005234 Fatty Liver Tamoxifen 7.5519224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1616709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4014745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 11.0019069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 11.0019069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.8220067830
MESH:D005739 Gas Poisoning Oxygen 5.0920016425
MESH:D005909 Glioblastoma Doxorubicin 3.2617150277
MESH:D005910 Glioma Fluorouracil 2.8216145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Cisplatin 12.5415464296 15102660
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.5415692506
MESH:D006258 Head and Neck Neoplasms Fluorouracil 12.5415162350 18337622 15102660
MESH:D034381 Hearing Loss Cisplatin 4.1819898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.3115464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2610048152 11294989
MESH:D006331 Heart Diseases Doxorubicin 3.3917888722 16244372 18674790 16495754 16244371 18006777 16144979 17875725 16707910 16879835 12587719 14766674 16330681
MESH:D006333 Heart Failure Doxorubicin 3.2617481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7815692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006529 Hepatomegaly Amiodarone 8.1115265979
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.1116120746 15340226 12621046
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 3.037520565
MESH:D006689 Hodgkin Disease Cisplatin 11.8916200630 16170182
MESH:D006689 Hodgkin Disease Doxorubicin 11.8917606976 15147373 18501091
MESH:D006689 Hodgkin Disease Vincristine 11.8916794504 16135485 15147373 17606976
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9215340226 16959395 16354765 8697196 18606429
MESH:D006937 Hypercholesterolemia Amiodarone 3.759751232 8137927
MESH:D006967 Hypersensitivity Terfenadine 5.122570798
MESH:D006973 Hypertension Dexamethasone 5.0917042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0918670907 18850075
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.7319822448
MESH:D007037 Hypothyroidism Amiodarone 4.3817991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2715869954
MESH:D007249 Inflammation Dexamethasone 15.158960868 11099482
MESH:D007249 Inflammation Flavonoids 15.1517296493
MESH:D007249 Inflammation Progesterone 15.1515869954
MESH:D007249 Inflammation Tamoxifen 15.1519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 15.1512878042 12200463
MESH:D007251 Influenza, Human Nordihydroguaiaretic Acid 5.6118473937
MESH:D007333 Insulin Resistance Sodium Selenite 3.1914714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2116580747
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.0115464296
MESH:D007674 Kidney Diseases Cisplatin 6.1919839026 12649298 18289764 12231392 15190930
MESH:D007674 Kidney Diseases Doxorubicin 6.1915699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.0316707910
MESH:D007680 Kidney Neoplasms Fluorouracil 7.1516985049
MESH:D007680 Kidney Neoplasms Tamoxifen 7.1518625569
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 4.6711231351
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 4.598889330 2166429 1311351 19744259
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 4.4411332679
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.0316085563
MESH:D008064 Lipidoses Amiodarone 12.7715342952 17567588
MESH:D008064 Lipidoses Ketoconazole 12.7717567588
MESH:D008064 Lipidoses Tamoxifen 12.7715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.8516718785
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8516595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8518564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8512878042
MESH:D008113 Liver Neoplasms Fluorouracil 7.1418383874 15113037 16603448 17045692
MESH:D008113 Liver Neoplasms Tamoxifen 7.1416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.1416984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 5.6416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.6412151625
MESH:D008133 Long QT Syndrome Amiodarone 8.5011989578 15350150 17391786
MESH:D008133 Long QT Syndrome Terfenadine 8.508772706
MESH:D008171 Lung Diseases Amiodarone 3.2912587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3518516814
MESH:D055370 Lung Injury Oxygen 4.3818339021
MESH:D008175 Lung Neoplasms Cisplatin 10.476189445 17225452 11798837
MESH:D008175 Lung Neoplasms Dexamethasone 10.4711195469 15824018
MESH:D008175 Lung Neoplasms Doxorubicin 10.4717418594 6189445
MESH:D008175 Lung Neoplasms Fluorouracil 10.4715246190
MESH:D008175 Lung Neoplasms Tamoxifen 10.4718625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.4719555203 11884234
MESH:D008175 Lung Neoplasms Vincristine 10.4719825857 6189445
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.6615086387
MESH:D008223 Lymphoma Doxorubicin 3.3716098063
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.9314737004
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6817654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.4415621674
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6319428831
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 9.5515458769
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.5517203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.5516827153 14580682 19196722 11731420 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.4219453300
MESH:D008545 Melanoma Cisplatin 5.0612393984 15577323 11135225 16809738 12883367 16248763 18332650 16432458 12374674 17023156 18176117 18505091 17761969
MESH:D008545 Melanoma Doxorubicin 5.0616827129
MESH:D008545 Melanoma Tamoxifen 5.0612393984 19393235
MESH:D018328 Melanoma, Amelanotic Cisplatin 18.9015990972
MESH:D018328 Melanoma, Amelanotic Tamoxifen 18.9015990972
MESH:D018328 Melanoma, Amelanotic Vincristine 18.9015990972
MESH:D008654 Mesothelioma Cisplatin 6.2817638057
MESH:D008654 Mesothelioma Doxorubicin 6.2817638057
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3815792986
MESH:D009062 Mouth Neoplasms Fluorouracil 3.5316757204 18986760
MESH:D052016 Mucositis Doxorubicin 4.6617415656
MESH:D009101 Multiple Myeloma Dexamethasone 3.4115867202 15744524 16118317
MESH:D009181 Mycoses Amiodarone 4.7712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 3.479809623
MESH:D009203 Myocardial Infarction Doxorubicin 6.2719429709 15857846
MESH:D009203 Myocardial Infarction Vincristine 6.2717284715
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.7018259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4719410462
MESH:D009369 Neoplasms Cisplatin 5.1316773208
MESH:D009369 Neoplasms Fluorouracil 5.1316928823 18600527 18239605
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8719189210 19200415 19196722
MESH:D009395 Nephritis, Interstitial Cisplatin 4.3615464296
MESH:D009401 Nephrosis Doxorubicin 4.6416636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.8915640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0914600291
MESH:D009447 Neuroblastoma Cisplatin 6.928761367
MESH:D009447 Neuroblastoma Doxorubicin 6.9215555623
MESH:D017599 Neuroectodermal Tumors Cisplatin 11.398761367
MESH:D017599 Neuroectodermal Tumors Vincristine 11.3912837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.3516436463
MESH:D012516 Osteosarcoma Doxorubicin 4.0115930896
MESH:D010051 Ovarian Neoplasms Cisplatin 4.9817225452 19769630 15464296 6897625
MESH:D010051 Ovarian Neoplasms Progesterone 4.9816525653 17393432
MESH:D010190 Pancreatic Neoplasms Cisplatin 5.3819003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.3816929163 19003803 16500647 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1815464296
MESH:D003557 Phyllodes Tumor Doxorubicin 5.0317983394
MESH:D010997 Pleural Neoplasms Cisplatin 13.5017638057
MESH:D010997 Pleural Neoplasms Doxorubicin 13.5017638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 7.8721297632
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Vincristine 7.8721297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.0611896295 11118676 11222880 11399792
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9016868541 15897917 15749863 16729912 16888761 18437689
MESH:D011471 Prostatic Neoplasms Fluorouracil 1.9019082440 18626508
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.9017404083
MESH:D011471 Prostatic Neoplasms Nordihydroguaiaretic Acid 1.9018491370
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.9018760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9015067354
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8012490602 12832656 11597910
MESH:D012004 Rectal Neoplasms Fluorouracil 3.9018722050 18286688 16160472 15538739
MESH:D051437 Renal Insufficiency Cisplatin 9.9415464296
MESH:D051437 Renal Insufficiency Doxorubicin 9.9417922066
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 9.0718379247 11700416
MESH:D012128 Respiratory Distress Syndrome, Adult Oxygen 9.0717627322 18339021
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012221 Rhinitis, Allergic, Perennial Terfenadine 5.798201490
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8118045962
MESH:D012509 Sarcoma Doxorubicin 3.8715625365 17203757 16767912 17710206 15675481 18313854
MESH:D012512 Sarcoma, Ewing's Cisplatin 10.0214601052
MESH:D012512 Sarcoma, Ewing's Doxorubicin 10.0214601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.6617846226
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9518724381
MESH:D012878 Skin Neoplasms Doxorubicin 5.4815692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.4816192470
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.2115464296
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.4417203757 16767912 15625365
MESH:D013088 Spermatocele Tamoxifen 4.1616709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.4315862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.4319457130
MESH:D013272 Stomach Diseases Dexamethasone 4.1915472012
MESH:D013274 Stomach Neoplasms Cisplatin 2.6715958060 18396642 17522103
MESH:D013274 Stomach Neoplasms Fluorouracil 2.6717522103 15786421 16424979 18567086 18396642 19084572 17172411 16951190 17498489 19015929
MESH:D013276 Stomach Ulcer Amiodarone 7.0718087811
MESH:D013276 Stomach Ulcer Dexamethasone 7.0715138204
MESH:D013398 Sudden Infant Death Oxygen 5.4112563064
MESH:D015173 Supratentorial Neoplasms Vincristine 5.7412837982
MESH:D013610 Tachycardia Amiodarone 4.1611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0619225199
MESH:D013736 Testicular Neoplasms Cisplatin 4.5117225452 15464296
MESH:D013959 Thyroid Diseases Amiodarone 11.6219731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.6212697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 3.2717909728 16010429
MESH:D013971 Thyrotoxicosis Amiodarone 4.7319584973 18020914
MESH:D014062 Tongue Neoplasms Fluorouracil 3.8716280240
MESH:D016171 Torsades de Pointes Amiodarone 10.4617467628 11989578
MESH:D016171 Torsades de Pointes Terfenadine 10.468256756
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 8.1415464296 12973940 17225452
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.1417653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.1416712894 8653321 17572228
MESH:D014581 Urticaria Terfenadine 5.162565098 2885854 2569995 2568013 2859714
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 9.2616803524
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 9.2616803524
MESH:D014605 Uveitis Dexamethasone 4.691336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4815577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0917638931 17334414 16364871 17678736
MESH:D014839 Vomiting Cisplatin 4.5911897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA208
    • No data
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA443459Atrial Fibrillation
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA444807Long QT Syndrome
    PA445019Myocardial Infarction
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446294Torsades de Pointes
    PA446028Ventricular Fibrillation
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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