AutismKB 2.0

Annotation Detail for NHLRC2


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Basic Information Top
Gene Symbol:NHLRC2 ( DKFZp779F115,FLJ20147,FLJ25621,FLJ33312,MGC45492 )
Gene Full Name: NHL repeat containing 2
Band: 10q25.3
Quick LinksEntrez ID:374354; OMIM: NA; Uniprot ID:NHLC2_HUMAN; ENSEMBL ID: ENSG00000196865; HGNC ID: 24731
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NHLRC2 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NHLRC2 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NHLRC2 mRNAdecreases expression 20064835
D003474 Curcumin Curcumin results in decreased expression of NHLRC2 mRNAdecreases expression 17999991
D019833 Genistein Genistein results in decreased expression of NHLRC2 mRNAdecreases expression 18847459
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in decreased expression of NHLRC2 mRNAaffects cotreatment|decreases expression 17183730
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in decreased expression of NHLRC2 mRNAaffects cotreatment|decreases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.888875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.2119490988
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6120127859 20464547
MESH:D000230 Adenocarcinoma Genistein 4.6111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.806695378
MESH:D019973 Alcohol-Related Disorders Curcumin 5.5217887948
MESH:D000544 Alzheimer Disease Curcumin 2.6615590663
MESH:D000550 Amblyopia Valproic Acid 5.6817688650
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.7917497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.4319183758
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7916807698
MESH:D050197 Atherosclerosis Curcumin 3.4718704882
MESH:D001321 Autistic Disorder Acetaminophen 1.8618445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8620603192 18775368 18985861 18316065 15238991 17157402 18558336 17688650 19232924 16609825 19460635 18396377 17507914 18177632 18940202
MESH:D001327 Autoimmune Diseases Curcumin 4.8519761891
MESH:D001714 Bipolar Disorder Valproic Acid 3.2020046352 17594078
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.578888407
MESH:D002545 Brain Ischemia Curcumin 4.7316770732
MESH:D001932 Brain Neoplasms Curcumin 4.2017596214
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9820146248 17474063
MESH:D001943 Breast Neoplasms Curcumin 1.9818462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms Genistein 1.9816873071 16541309 17200150
MESH:D002277 Carcinoma Curcumin 4.0618593918
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.763084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.7616924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 3.0518414057
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9620419170
MESH:D002294 Carcinoma, Squamous Cell Curcumin 4.9618462866
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.956135515
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7920734317
MESH:D003092 Colitis Curcumin 4.5316804969 18200517 16782535
MESH:D003103 Coloboma Curcumin 4.8318809619
MESH:D003110 Colonic Neoplasms Curcumin 4.0919359593 16340194
MESH:D003110 Colonic Neoplasms Genistein 4.0917182828
MESH:D016510 Corneal Neovascularization Curcumin 5.2618497527
MESH:D019465 Craniofacial Abnormalities Valproic Acid 1.908888407 17688650 16575769
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 4.9018403477
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.9016647724
MESH:D003928 Diabetic Nephropathies Curcumin 4.2618204486
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6010663392 10915739 2444490 19416960 19420014 19085960 19370779 11739529 12594235 15968718 10774834 18071297 12392966 11461765 17562736 16781746 11529661 14986274 19923254 16109766 12153990 12958197 11421492 14725611 15619225 16081117 16393943 12705907 19164858 11834606 14550746 16227642 17522070 11743745 12540782 18713872 16485898 16177239 11287661 19739265 17906064
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.6019641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004381 Duodenal Ulcer Curcumin 4.3817351913
MESH:D004421 Dystonia Valproic Acid 4.351851702
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Genistein 3.5311473722
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.513659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 4.3616628512 3922381
MESH:D004827 Epilepsy Valproic Acid 3.0618234410 20417680
MESH:D004832 Epilepsy, Absence Valproic Acid 3.846426943 6254150 7562514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.667750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.463659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0616530937
MESH:D005234 Fatty Liver Curcumin 9.0219297423
MESH:D005234 Fatty Liver Valproic Acid 9.0219224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.3316575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.468888407 18558336
MESH:D005355 Fibrosis Curcumin 4.3418705752
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005770 Gastrointestinal Neoplasms Curcumin 5.0518462866
MESH:D005909 Glioblastoma Curcumin 7.9517596214
MESH:D005909 Glioblastoma Genistein 7.9516598420
MESH:D006258 Head and Neck Neoplasms Curcumin 3.8318829502 18462866
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7820471113
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.4017701891
MESH:D006849 Hydrocephalus Valproic Acid 5.2617688650
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006937 Hypercholesterolemia Curcumin 4.3318704882
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.9816612254
MESH:D007249 Inflammation Curcumin 3.0117151092 18403477 16956363
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.3018200517 18596194
MESH:D007414 Intestinal Neoplasms Curcumin 4.4810783313
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2116705839
MESH:D007889 Leiomyoma Curcumin 4.8818555241
MESH:D007938 Leukemia Curcumin 6.9918462866
MESH:D007938 Leukemia Genistein 6.9917468513 18980019
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.4916106398
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1916294345 17596541
MESH:D015458 Leukemia, T-Cell Curcumin 5.0916106398
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.8518705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.8517823541
MESH:D008107 Liver Diseases Acetaminophen 4.2912969438 16611625 19014921 12587719 19784758 11587558 16610002 19460945
MESH:D008107 Liver Diseases Curcumin 4.2916956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.787678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.7820195826 21137059
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.706135515 2876784 2876786
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.7017228818
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.6318569708 20869020 6695378 17053015 20464547 20064080 18816296 18520028 20135361
MESH:D008175 Lung Neoplasms Curcumin 2.6319359593 18462866 16243823
MESH:D008223 Lymphoma Curcumin 3.7818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 5.0516173963
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.1012929590 14578162
MESH:D008545 Melanoma Curcumin 2.4417885582 18462866
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008569 Memory Disorders Curcumin 4.4817263510
MESH:D008881 Migraine Disorders Valproic Acid 3.3818803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.4016381670
MESH:D009101 Multiple Myeloma Curcumin 3.7019372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.3117962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.318888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.3017596541
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.8717141266
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.267678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 4.7018495463
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2811141357
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.9812497104
MESH:D009421 Nervous System Malformations Genistein 4.3616427766
MESH:D009423 Nervous System Neoplasms Curcumin 6.0718462866
MESH:D009436 Neural Tube Defects Valproic Acid 3.308888407 16359493
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity Curcumin 2.8019297423
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010024 Osteoporosis Curcumin 7.8918719352
MESH:D010024 Osteoporosis Genistein 7.8919401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Curcumin 5.3619020741 18462866
MESH:D010051 Ovarian Neoplasms Genistein 5.3619005980
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Curcumin 3.0119196508 19401701 17440100
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.2320603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5817292933
MESH:D011471 Prostatic Neoplasms Curcumin 2.5812497104 15129424 11398177 18226269 18156803 18769126 10851300
MESH:D011471 Prostatic Neoplasms Genistein 2.5815378649 15256057 16925846
MESH:D019310 Pseudolymphoma Valproic Acid 4.9812752131 11422049
MESH:D011656 Pulmonary Emphysema Curcumin 4.7919168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.3318379247 10666014
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.4819155313
MESH:D012509 Sarcoma Curcumin 4.3818462866
MESH:D012559 Schizophrenia Valproic Acid 2.0915737665 19110320
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5518551238
MESH:D012640 Seizures Valproic Acid 6.5511044598 17978042 14763951 16876388 3137016 15475178 1511512 11738929
MESH:D018805 Sepsis Curcumin 4.3118389075
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4810029692 19755658
MESH:D016135 Spinal Dysraphism Valproic Acid 3.9919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.9812833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D013276 Stomach Ulcer Curcumin 3.7719188055 16631530
MESH:D014178 Translocation, Genetic Valproic Acid 5.6817262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.923119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.8916049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.8917053015
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.8918593936
MESH:D014564 Urogenital Abnormalities Valproic Acid 5.008888407
MESH:D014565 Urogenital Neoplasms Curcumin 5.6618462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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