AutismKB 2.0

Annotation Detail for FAM89A


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Basic Information Top
Gene Symbol:FAM89A ( C1orf153,MGC15887,RP11-423F24.2 )
Gene Full Name: family with sequence similarity 89, member A
Band: 1q42.2
Quick LinksEntrez ID:375061; OMIM: NA; Uniprot ID:FA89A_HUMAN; ENSEMBL ID: ENSG00000182118; HGNC ID: 25057
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of FAM89A proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of FAM89A mRNAincreases expression 19774075
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FAM89A mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of FAM89A mRNAincreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of FAM89A mRNAdecreases expression 17490981
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of FAM89A mRNAaffects cotreatment|affects expression 17602206
D004958 Estradiol Estradiol results in increased expression of FAM89A mRNAincreases expression 20106945
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of FAM89A mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of FAM89A mRNAdecreases expression 19270015
D010634 Phenobarbital Phenobarbital results in increased expression of FAM89A mRNAincreases expression 19482888
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of FAM89A mRNAincreases expression 20106945
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 9.266195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.2611752688 15322242 14514962
MESH:D000230 Adenocarcinoma Estradiol 2.1411473722
MESH:D000236 Adenoma Diethylnitrosamine 2.966695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 19.0916434500 19061943 17162532 19052882 18056438 17620307
MESH:D018248 Adenoma, Liver Cell Phenobarbital 19.0917620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 19.0916835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.9918057881 20041841 18218290
MESH:D001281 Atrial Fibrillation Amiodarone 4.0519698954 18651412
MESH:D001778 Blood Coagulation Disorders Amiodarone 9.7419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.8117474063
MESH:D001943 Breast Neoplasms Estradiol 1.8118497071 12948864 16675129 14630087 17018787 17289903 19861407 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8120435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8112619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.8119394651 17173139 20007298 18210153 20512989 16935385 3581430 17761372 16807293 20214788 18665156 20935162 19822196 19701751 10737359 18788625 18785209 18506893 16779866 19171122 18971187 18393292 11831363 17428255 20084675 20514400 19335982 20727157 18056438 19919837 21159647 16288022 16681979 16878318 18691550 10672840 20432363 17055752 19519916 19539802 20524982 17138121 19418558 16569478 20101231 3084413 17162532 17978847 18494052 19052882 16830150 18978308 16328049 16698587 19107877 19208518 16540662 19383236 16502159
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 6.816705139 1701930 17173139 20007298 20935162
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9515710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3718974383
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.9612371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.9617174075 2727394 7505956 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.9618566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.514080065
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.9419052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.9416835633
MESH:D002779 Cholestasis Cyclosporine 3.0619486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1812621046 15340226 16354765 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.3620387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.3617107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.5919279558
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.5418218290 15265979
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5419107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.5420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D004421 Dystonia Phenobarbital 4.221851702
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 3.1111473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.373659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.193922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.9820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.726401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.517750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.303659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Amiodarone 14.3914986274
MESH:D005234 Fatty Liver Cyclosporine 14.3919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 14.3920387270 21071580
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Cyclosporine 9.3612168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4310048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Amiodarone 16.0615265979
MESH:D006529 Hepatomegaly Phenobarbital 16.0616109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.0616120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.3515709030
MESH:D019584 Hot Flashes Estradiol 4.0717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 18606429 16959395 15340226 8697196
MESH:D006937 Hypercholesterolemia Amiodarone 4.088137927 9751232
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007037 Hypothyroidism Amiodarone 4.7718020914 17991464
MESH:D007249 Inflammation Diethylnitrosamine 5.2218785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2212200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0916627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 6.308314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 6.3015618244
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D007680 Kidney Neoplasms Estradiol 7.8515610895
MESH:D008064 Lipidoses Amiodarone 3.6515342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.9918665156 18522880 20032147 18407596 19638242
MESH:D008103 Liver Cirrhosis Phenobarbital 6.9921047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3112878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.2517034775
MESH:D008107 Liver Diseases Phenobarbital 4.2519363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.9918177683 2125692 15890375 9163691
MESH:D008113 Liver Neoplasms Clofibric Acid 14.9917602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.9916942905 19499222 20434301 19638242 20492335 19426721 19642983 19256749 19850985 19833225 21047994 9163691 20405173 18644402 19090486 12112319 19073162 19812893 10737359 18977376 2862719 18754104 2422723 20137499 18978307 21278145 20118626 19690152 20501860 20101389 19427195 20452335 21071580 19294768 19551842 12771043 18648771 21167192 20583210 19254457 15885732 19996281 15175105 19255062
MESH:D008113 Liver Neoplasms Phenobarbital 14.9919812893 19482888 19073162 21047994 15975961 8742319
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.9916984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.148603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.1418544905 16842330 18775883 18282651 18079962 21159647 19009564 18308698 16267830 2563599 19539802 17854601 17942915 18093689 19519916 19004024 9362446 17174075 18253720 18164116 3124819 19126423
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 15.1418308698 17172636 6150874 1399818 2563599
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.1412151625
MESH:D008133 Long QT Syndrome Amiodarone 3.7317391786 15350150 11989578
MESH:D008171 Lung Diseases Amiodarone 3.5012587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.8018516814
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4914755239
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.4920512841 21163286 20970405 6695378
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4911884234 19555203
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6816891317 17203775 11807958 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.8019453300
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009181 Mycoses Amiodarone 5.2217974566 12754197
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4416810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.7617484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 10.2716427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2714600291
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D010018 Osteomalacia Phenobarbital 4.6517016548
MESH:D010051 Ovarian Neoplasms Estradiol 2.2719401270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.4716540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 16.3712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 16.372563599
MESH:D011230 Precancerous Conditions Phenobarbital 16.372563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11118676 11399792 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0920887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0516740699
MESH:D019310 Pseudolymphoma Phenobarbital 4.8112752131
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9212490602 11597910 12832656
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012640 Seizures Phenobarbital 2.8211442880 16876388 4039156 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 5.116407741
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3718724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013276 Stomach Ulcer Amiodarone 3.5218087811
MESH:D013610 Tachycardia Amiodarone 4.5311238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.4319225199
MESH:D013959 Thyroid Diseases Amiodarone 13.1419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 13.1412697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.707505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.701399818
MESH:D013971 Thyrotoxicosis Amiodarone 5.1218020914 19584973
MESH:D013978 Tibial Fractures Estradiol 5.0019048282
MESH:D016171 Torsades de Pointes Amiodarone 4.4711989578 17467628
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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