AutismKB 2.0

Annotation Detail for KCND2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCND2 ( KIAA1044,KV4.2,MGC119702,MGC119703,RK5 )
Gene Full Name: potassium voltage-gated channel, Shal-related subfamily, member 2
Band: 7q31.31
Quick LinksEntrez ID:3751; OMIM: 605410; Uniprot ID:KCND2_HUMAN; ENSEMBL ID: ENSG00000184408; HGNC ID: 6238
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2092Long QT syndrome
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the expression of KCND2 mRNAaffects expression 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of KCND2 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of KCND2 mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of KCND2 mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of KCND2 mRNA]affects expression|affects reaction 19414516
D000638 Amiodarone Amiodarone results in decreased expression of KCND2 mRNAdecreases expression 15520326
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of KCND2 mRNAaffects cotreatment|increases expression 18636392
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of KCND2 mRNAaffects cotreatment|increases expression 18636392
D010126 Ozone Ozone results in decreased expression of KCND2 mRNAdecreases expression 16330353
D010656 Phenylephrine CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 mRNA]decreases expression|increases reaction 17060317
D010656 Phenylephrine CABIN1 protein promotes the reaction [Phenylephrine results in decreased expression of KCND2 protein]decreases expression|increases reaction 17060317
D010656 Phenylephrine KCND2 protein inhibits the reaction [Phenylephrine results in increased activity of NFATC1 protein]decreases reaction|increases activity 12403671
D010656 Phenylephrine KCND2 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]decreases reaction|increases expression 12403671
D010656 Phenylephrine KCND2 protein results in decreased susceptibility to Phenylephrinedecreases response to substance 12403671
D010656 Phenylephrine Phenylephrine results in decreased expression of KCND2 mRNAdecreases expression 17060317
16385079
D010656 Phenylephrine Phenylephrine results in decreased expression of KCND2 proteindecreases expression 16385079
17060317
D011188 Potassium KCND2 protein results in increased transport of Potassiumincreases transport 17242957
D011189 Potassium Chloride Potassium Chloride results in increased expression of KCND2 mRNAincreases expression 16412482
D015032 Zinc Zinc results in increased expression of KCND2 mRNAincreases expression 15159208
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000169 Acrodermatitis Zinc 5.6416889938 17190629 17202136
MESH:D055371 Acute Lung Injury Chlorine 4.5120601635
MESH:D000544 Alzheimer Disease Ozone 4.5715513908
MESH:D000544 Alzheimer Disease Zinc 4.5716580781 16325427 16410023 17119284
MESH:D000755 Anemia, Sickle Cell Zinc 5.1016916123
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001145 Arrhythmias, Cardiac Amiodarone 9.6918218290 18057881 20041841
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 9.6917460149
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5915570426
MESH:D001249 Asthma Ozone 5.3317854713 16373670
MESH:D001249 Asthma Zinc 5.3317085522
MESH:D001281 Atrial Fibrillation Amiodarone 4.0318651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.0719483382
MESH:D001919 Bradycardia Phenylephrine 4.7815306635
MESH:D001930 Brain Injuries Zinc 4.9017109824
MESH:D016535 Bronchial Hyperreactivity Ozone 3.8118315731 19059883 15516495 17626835 18417511 16777450 14754758
MESH:D002100 Cachexia Ozone 4.9816183385
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.393084413
MESH:D002294 Carcinoma, Squamous Cell Zinc 2.9416543248
MESH:D006332 Cardiomegaly Phenylephrine 3.6217287366 17124262 16170337 15728586 11754973 11179087
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9415710769 19225199
MESH:D002318 Cardiovascular Diseases Zinc 3.7716936243
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.3218974383
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D019465 Craniofacial Abnormalities Zinc 2.4419302082
MESH:D003920 Diabetes Mellitus Zinc 4.3616479319
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0212392966 19416960 16393943 16177239 12153990 16227642 15619225 10915739 10663392 14550746 2444490 19739265 19923254 16781746 18713872 12540782 10774834 17906064 16485898 16109766 19420014 11461765 17562736 11421492 19370779 19085960 12594235 11287661 19164858 15968718 11739529 17522070 11529661 16081117 11743745 12705907 14725611 14986274 12958197 11834606 18071297
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.0215265979 18218290
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004417 Dyspnea Chlorine 4.8920016425
MESH:D004938 Esophageal Neoplasms Zinc 2.8916543248
MESH:D005234 Fatty Liver Amiodarone 3.6914986274
MESH:D005739 Gas Poisoning Chlorine 5.2720016425
MESH:D005756 Gastritis Acetaminophen 12.0716983495
MESH:D005756 Gastritis Zinc 12.0717241300
MESH:D006130 Growth Disorders Zinc 4.0717217573
MESH:D006333 Heart Failure Zinc 3.7117162251
MESH:D006335 Heart Injuries Zinc 6.0317074742
MESH:D016481 Helicobacter Infections Zinc 4.7217241300
MESH:D006527 Hepatolenticular Degeneration Zinc 4.9017276780
MESH:D006529 Hepatomegaly Amiodarone 3.9615265979
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia Amiodarone 4.048137927 9751232
MESH:D006973 Hypertension Phenylephrine 3.1312717712 8949925
MESH:D006984 Hypertrophy Phenylephrine 4.7312791704 18502941
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 6.1019822448
MESH:D007037 Hypothyroidism Amiodarone 4.7318020914 17991464
MESH:D007511 Ischemia Zinc 4.8516584753
MESH:D007674 Kidney Diseases Acetaminophen 6.4612587719 15629191
MESH:D007674 Kidney Diseases Zinc 6.4616960431
MESH:D007676 Kidney Failure, Chronic Zinc 4.5916518626
MESH:D008064 Lipidoses Amiodarone 3.6315342952 17567588
MESH:D008107 Liver Diseases Acetaminophen 1.6619784758 16611625 19014921 12587719 12969438 16610002 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008133 Long QT Syndrome Amiodarone 3.7115350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 7.9612587719
MESH:D008171 Lung Diseases Ozone 7.968266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.7418516814
MESH:D055370 Lung Injury Ozone 4.0620417186
MESH:D008175 Lung Neoplasms Ozone 2.108597069 7614698
MESH:D008325 Mammary Neoplasms, Experimental Zinc 3.4012773700
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008679 Metaplasia Ozone 5.3710496685
MESH:D020326 Migraine without Aura Cyclic AMP 5.3511304026
MESH:D009181 Mycoses Amiodarone 5.1712754197 17974566
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010538 Peritonitis Ozone 4.3516369182
MESH:D011014 Pneumonia Ozone 4.6318007984 18929643 18381685
MESH:D011225 Pre-Eclampsia Zinc 4.3117114810
MESH:D011471 Prostatic Neoplasms Zinc 3.7916606632 12429649 16700911 16517595
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9112832656 12490602 11597910
MESH:D012120 Respiration Disorders Chlorine 5.4818579056
MESH:D012162 Retinal Degeneration Zinc 4.2516584753
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.3218724381
MESH:D012852 Sinusitis Phenylephrine 4.947327846
MESH:D013276 Stomach Ulcer Amiodarone 3.4818087811
MESH:D013610 Tachycardia Amiodarone 4.4911238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.3919225199
MESH:D013959 Thyroid Diseases Amiodarone 5.0219731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.0818020914 19584973
MESH:D014062 Tongue Neoplasms Zinc 4.5616543248
MESH:D016171 Torsades de Pointes Amiodarone 4.4311989578 17467628
MESH:D014581 Urticaria Acetaminophen 3.1610982225
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00280 antagonist Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved