AutismKB 2.0

Annotation Detail for KCND3


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Basic Information Top
Gene Symbol:KCND3 ( KCND3L,KCND3S,KSHIVB,KV4.3,MGC142035,MGC142037 )
Gene Full Name: potassium voltage-gated channel, Shal-related subfamily, member 3
Band: 1p13.2
Quick LinksEntrez ID:3752; OMIM: 605411; Uniprot ID:KCND3_HUMAN; ENSEMBL ID: ENSG00000171385; HGNC ID: 6239
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1870Drug abuse
2075Heart failure
2092Long QT syndrome
Desease Name
CHEMDEPENDENCY
smoking cessation
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KCND3 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCND3 mRNAaffects expression 16483693
C016299 chelerythrine chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]decreases activity|decreases reaction 11709419
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of KCND3 mRNAdecreases expression 15834898
D010656 Phenylephrine chelerythrine inhibits the reaction [Phenylephrine results in decreased activity of KCND3 protein alternative form]decreases activity|decreases reaction 11709419
D010656 Phenylephrine [KCND3 protein co-treated with ADRA1A protein] affects the susceptibility to Phenylephrineaffects cotreatment|affects response to substance 11709419
D010656 Phenylephrine Phenylephrine results in decreased activity of [KCND3 protein alternative form co-treated with ADRA1A protein]affects cotreatment|decreases activity 11709419
D010656 Phenylephrine Phenylephrine results in decreased expression of KCND3 mRNAdecreases expression 17060317
11249870
16385079
D010656 Phenylephrine Phenylephrine results in decreased expression of KCND3 proteindecreases expression 16385079
17060317
11249870
D013739 Testosterone Testosterone results in increased expression of KCND3 proteinincreases expression 17054656
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in decreased activity of KCND3 protein alternative formdecreases activity 11709419
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D000987 Antisocial Personality Disorder Testosterone 6.307506515
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.3817460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001919 Bradycardia Phenylephrine 4.9415306635
MESH:D001943 Breast Neoplasms Testosterone 3.2817261762
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.403084413
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 3.0218922899
MESH:D006332 Cardiomegaly Phenylephrine 3.6716170337 11754973 17287366 15728586 17124262 11179087
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002659 Child Development Disorders, Pervasive Testosterone 3.7620678186
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0715861022 16919318 11677210 16105132 17333356 17681005 17110522
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6516227642 10663392 18071297 10774834 16109766 19370779 19085960 17562736 16781746 11529661 19416960 16485898 11287661 18713872 11461765 19923254 14986274 12392966 10915739 2444490 11421492 16393943 14725611 19164858 17522070 12153990 12705907 12594235 11743745 19420014 11834606 15619225 15968718 12958197 16081117 14550746 16177239 12540782 17906064 11739529 19739265
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.899599246 16716910 8113982 8273558 7812673 11698051 15177302
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D005391 Firesetting Behavior Testosterone 6.307506515
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Testosterone 4.2117162496
MESH:D006628 Hirsutism Testosterone 6.1017019078
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D017588 Hyperandrogenism Testosterone 5.7517019078
MESH:D006973 Hypertension Phenylephrine 3.168949925 12717712
MESH:D006984 Hypertrophy Phenylephrine 4.8412791704 18502941
MESH:D007006 Hypogonadism Testosterone 4.7712002444
MESH:D007018 Hypopituitarism Testosterone 6.6417426086
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1716945680 16569931
MESH:D007174 Impulse Control Disorders Testosterone 6.307506515
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 3.2115177302 8273558 7562506 11698051 7812673
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 16611625 19014921 11587558 19784758 16610002 12969438 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.4711807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.528985016
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.658330346 18922899 18404319 12065085
MESH:D019048 Prostatic Intraepithelial Neoplasia Testosterone 5.3420887781
MESH:D011537 Pruritus Ethinyl Estradiol 3.7116919318 15861022
MESH:D012735 Sexual Dysfunction, Physiological Testosterone 6.6416631401
MESH:D012852 Sinusitis Phenylephrine 5.107327846
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.398985016 8330346 11807781 18404319 12065085
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3816709447
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.6314692618
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8214671159 15869587
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA210
    • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00280 antagonist Disopyramide Antiarrhythmic Agents;Anti-Arrhythmia Agents
    DB00321 antagonist Triavil Tab Adrenergic Uptake Inhibitors;Analgesics, Non-Narcotic;Antidepressive Agents, Tricyclic
    DB00458 antagonist Imipramine Adrenergic Uptake Inhibitors;Antidepressive Agents, Tricyclic;Norepinephrine-Reuptake Inhibitors
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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