AutismKB 2.0

Annotation Detail for MAST4


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Basic Information Top
Gene Symbol:MAST4 ( DKFZp686E18148,DKFZp686N1467,FLJ16540,FLJ33039,KIAA0303 )
Gene Full Name: microtubule associated serine/threonine kinase family member 4
Band: 5q12.3
Quick LinksEntrez ID:375449; OMIM: NA; Uniprot ID:MAST4_HUMAN; ENSEMBL ID: ENSG00000069020; HGNC ID: 19037
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
Carotid atherosclerosis in HIV infection
Desease Name
Carotid atherosclerosis in HIV infection
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MAST4 mRNAaffects expression 17562736
D005472 Fluorouracil Fluorouracil results in increased expression of MAST4 mRNAincreases expression 16510598
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MAST4 mRNAaffects binding|increases activity|increases expression 19710929
D014415 Tunicamycin Tunicamycin results in increased expression of MAST4 mRNAincreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of MAST4 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of MAST4 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.4718653653
MESH:D000230 Adenocarcinoma Fluorouracil 2.4817638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.9416434500
MESH:D000740 Anemia Fluorouracil 4.0215504547 17963324 16511603
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8919015723
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4719483382
MESH:D001943 Breast Neoplasms Fluorouracil 2.4419217205 15136595 18608205 16110121 16557594 18357371 16595493
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.3516050911
MESH:D002276 Carcinoid Tumor Fluorouracil 5.1916051944
MESH:D002277 Carcinoma Fluorouracil 3.8217121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.063084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.0617045692 17971768 16332177 16799960 17088986 18930000
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1418695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 2.5616280240 16757204 18986760 17066447
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002779 Cholestasis pirinixic acid 3.0519176532
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2717169374 17725105 17172411 16510598 17018589 15001691 18772588 17287894 17016597 16340194
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 16524972 17016601 18509181 17255274 16331619 18288408 16282729 18448328 16303861 16391804 20501625 18949393 17695437 15289873 17454858 17401013 18802399 14970324 18383874 17094418 15148649
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003456 Cryptorchidism vinclozolin 4.7214966744
MESH:D007644 Darier Disease Fluorouracil 5.2516733453
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5518249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6517562736 16109766 12594235 18071297 10663392 19739265 11529661 19420014 16485898 17522070 11743745 15619225 12705907 16177239 16393943 12958197 12392966 16081117 12153990 19416960 2444490 19085960 18713872 11421492 19923254 17906064 12540782 14725611 14550746 11461765 19370779 11287661 19164858 15968718 11739529 10915739 10774834 16227642 14986274 11834606 16781746
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:C538011 Eales disease Vitamin E 5.229068938
MESH:D004487 Edema pirinixic acid 2.8012083418
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.5116481741 16337965 16785472 17638652 15173087
MESH:D005234 Fatty Liver pirinixic acid 3.0919236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.8216417039
MESH:D005910 Glioma Fluorouracil 2.9716145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5915102660 18337622 15162350
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1316080930
MESH:D006333 Heart Failure pirinixic acid 2.7120558911
MESH:D006529 Hepatomegaly pirinixic acid 3.4119772884 16221962 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.4914716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4920558911
MESH:D007248 Infertility, Male vinclozolin 3.2416467254
MESH:D007251 Influenza, Human Vitamin E 4.7316624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8216306350
MESH:D007674 Kidney Diseases Acetaminophen 6.5115629191 12587719
MESH:D007674 Kidney Diseases Vitamin E 6.5112488133
MESH:D007680 Kidney Neoplasms Fluorouracil 3.5716985049
MESH:D007984 Leydig Cell Tumor vinclozolin 5.1916417039
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4515474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4516169303
MESH:D008107 Liver Diseases Acetaminophen 1.6919784758 11587558 12969438 12587719 19014921 16611625 19460945 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5417185352 16871587
MESH:D008113 Liver Neoplasms Fluorouracil 4.8615113037 17045692 18383874 16603448
MESH:D008113 Liver Neoplasms pirinixic acid 4.8620007298 16377806 15890375
MESH:D008171 Lung Diseases Vitamin E 3.3716863852
MESH:D008175 Lung Neoplasms Fluorouracil 2.6615246190
MESH:D008175 Lung Neoplasms Vitamin E 2.6611062179
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.2515086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009062 Mouth Neoplasms Fluorouracil 3.8716757204 18986760
MESH:D009135 Muscular Diseases pirinixic acid 3.9216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2519151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1916411023
MESH:D009369 Neoplasms Fluorouracil 5.4416928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 5.4417405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6416436463
MESH:D009765 Obesity pirinixic acid 1.8720558911
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7515113037 16929163 16500647 19003803
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.3618220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4018220299
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2818626508 19082440
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011472 Prostatitis vinclozolin 5.4018629315
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3015538739 18286688 18722050 16160472
MESH:D015427 Reperfusion Injury pirinixic acid 2.5219058328
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 15786421 18396642 16424979 18567086 16951190 17498489 19084572 19015929 17172411
MESH:D020521 Stroke Vitamin E 3.7716517955
MESH:D014062 Tongue Neoplasms Fluorouracil 4.2916280240
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.1816803524
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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