AutismKB 2.0

Annotation Detail for KCNH2


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Basic Information Top
Gene Symbol:KCNH2 ( ERG1,HERG,HERG1,Kv11.1,LQT2,SQT1 )
Gene Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 2
Band: 7q36.1
Quick LinksEntrez ID:3757; OMIM: 152427; Uniprot ID:KCNH2_HUMAN; ENSEMBL ID: ENSG00000055118; HGNC ID: 6251
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1866Sudden infant death syndrome
1870Drug abuse
1934Cancer
2075Heart failure
2092Long QT syndrome
Desease Name
CARDIOVASCULAR
CHEMDEPENDENCY
cardiac repolarization
Electrocardiographic traits
QT interval
atriventricular block long QT syndrome
cardiovascular
EKG, abnormal
unknown
Desease Name
Electrocardiographic traits
QT interval
Desease Name
Long QT syndrome-2
Short QT syndrome-1
Long QT syndrome, acquired, susceptibility to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C050232 1,3-ditolylguanidine 1,3-ditolylguanidine results in decreased activity of KCNH2 proteindecreases activity 17460149
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KCNH2 mRNAdecreases expression 18648102
D000143 Acids Acids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
D000143 Acids Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
D000143 Acids Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
D015761 4-Aminopyridine 4-Aminopyridine results in decreased activity of KCNH2 proteindecreases activity 19915712
D000638 Amiodarone Amiodarone binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D000638 Amiodarone Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
D000638 Amiodarone Amiodarone results in decreased activity of KCNH2 proteindecreases activity 16971508
11238279
10208308
18057881
15618689
15671647
18724381
15821840
16960444
D000638 Amiodarone naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
D000638 Amiodarone Potassium inhibits the reaction [Amiodarone results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15618689
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNH2 mRNAaffects expression 16483693
D000677 Amsacrine Amsacrine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15148258
D001151 Arsenic Arsenic affects the expression of KCNH2 mRNAaffects expression 18414638
C006632 arsenic trioxide arsenic trioxide results in decreased localization of KCNH2 proteindecreases localization 15213294
C006632 arsenic trioxide arsenic trioxide results in increased expression of KCNH2 mRNAincreases expression 15070760
D016589 Astemizole Astemizole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
D016589 Astemizole Astemizole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D016589 Astemizole Astemizole affects the localization of KCNH2 protein mutant formaffects localization 11741928
10531299
D016589 Astemizole Astemizole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 10376921
12388285
11705456
15272206
9658196
D016589 Astemizole Astemizole binds to KCNH2 gene polymorphismaffects binding 18701618
D016589 Astemizole Astemizole binds to KCNH2 proteinaffects binding 15272206
18701618
D016589 Astemizole Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 19139152
D016589 Astemizole Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]decreases metabolic processing|decreases reaction 19139152
D016589 Astemizole Astemizole results in decreased activity of KCNH2 proteindecreases activity 10828461
15671647
15740727
8641472
10422790
11741928
11082114
D016589 Astemizole Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
D016589 Astemizole Astemizole results in decreased activity of KCNH2 proteindecreases activity 16723379
D016589 Astemizole Astemizole results in decreased activity of KCNH2 proteindecreases activity 11040061
C086123 azimilide Acids inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
C086123 azimilide azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C086123 azimilide azimilide results in decreased activity of KCNH2 proteindecreases activity 15821840
18057881
16960444
C086123 azimilide naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C086123 azimilide Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D015764 Bepridil Bepridil results in decreased activity of KCNH2 proteindecreases activity 14975710
D015764 Bepridil Bepridil binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D015764 Bepridil Bepridil results in decreased activity of KCNH2 proteindecreases activity 15671647
D047392 beta-Cyclodextrins beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
D047392 beta-Cyclodextrins beta-Cyclodextrins analog inhibits the reaction [E 4031 results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
D047392 beta-Cyclodextrins beta-Cyclodextrins analog inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
D047392 beta-Cyclodextrins beta-Cyclodextrins analog results in decreased activity of KCNH2 proteindecreases activity 17513944
D001977 Brompheniramine Brompheniramine results in decreased activity of KCNH2 proteindecreases activity 17010640
D002118 Calcium Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium]affects abundance|decreases reaction 11040061
D002330 Carmustine Carmustine results in decreased expression of KCNH2 mRNAdecreases expression 15980968
C016300 chloramine-T chloramine-T results in increased oxidation of and results in decreased activity of KCNH2 proteindecreases activity|increases oxidation 17624316
D002724 Chlorobutanol Chlorobutanol binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 20071423
D002724 Chlorobutanol Chlorobutanol promotes the reaction [Terfenadine binds to and results in decreased activity of KCNH2 protein]affects binding|decreases activity|increases reaction 20071423
D002724 Chlorobutanol Terfenadine promotes the reaction [Chlorobutanol binds to and results in decreased activity of KCNH2 protein]affects binding|decreases activity|increases reaction 20071423
D020117 Cisapride Cisapride binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
D020117 Cisapride Cisapride results in decreased activity of KCNH2 proteindecreases activity 14975710
D020117 Cisapride Cisapride binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D020117 Cisapride beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
D020117 Cisapride Cisapride affects the localization of KCNH2 protein mutant formaffects localization 11741928
10531299
D020117 Cisapride Cisapride binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
11005845
12388285
D020117 Cisapride Cisapride binds to KCNH2 proteinaffects binding 18701618
19260734
D020117 Cisapride Cisapride results in decreased activity of KCNH2 proteindecreases activity 9395068
15740727
17513944
11741928
15306208
15671647
D003345 Corticosterone Corticosterone results in increased expression of KCNH2 mRNAincreases expression 18835572
C028457 cyamemazine cyamemazine metabolite results in decreased activity of KCNH2 proteindecreases activity 18957172
C028457 cyamemazine cyamemazine results in decreased activity of KCNH2 proteindecreases activity 16494862
C533908 cyamemazine sulfoxide cyamemazine sulfoxide results in decreased activity of KCNH2 proteindecreases activity 18957172
C040463 desmethylastemizole desmethylastemizole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 10376921
D004077 Digoxin Astemizole inhibits the reaction [Digoxin results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 19139152
D004077 Digoxin Astemizole inhibits the reaction [Digoxin results in decreased metabolism of KCNH2 protein modified form]decreases metabolic processing|decreases reaction 19139152
D004077 Digoxin Digoxin results in decreased activity of KCNH2 proteindecreases activity 19139152
D004077 Digoxin Digoxin results in decreased expression of KCNH2 protein modified formdecreases expression 19139152
D004077 Digoxin KCNH2 gene affects the susceptibility to Digoxinaffects response to substance 19139152
D004077 Digoxin Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]decreases expression|decreases reaction 19139152
D004155 Diphenhydramine Diphenhydramine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D004206 Disopyramide Disopyramide binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D004206 Disopyramide Disopyramide results in decreased activity of KCNH2 proteindecreases activity 18724381
C063533 dofetilide Acids inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
C063533 dofetilide dofetilide binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 20071423
C063533 dofetilide dofetilide binds to KCNH2 proteinaffects binding 15272206
18701618
C063533 dofetilide dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C063533 dofetilide dofetilide results in decreased activity of KCNH2 proteindecreases activity 10828461
16960444
18057881
9395068
15821840
17042915
C063533 dofetilide Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
C063533 dofetilide naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C063533 dofetilide Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
C063533 dofetilide [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D004317 Doxorubicin Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin]affects reaction|decreases response to substance 16086867
D004317 Doxorubicin KCNH2 protein results in decreased susceptibility to Doxorubicindecreases response to substance 16086867
C118667 dronedarone dronedarone results in decreased activity of KCNH2 proteindecreases activity 15618689
C118667 dronedarone Potassium inhibits the reaction [dronedarone results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15618689
D004329 Droperidol Droperidol binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
C063968 E 4031 E 4031 results in decreased activity of KCNH2 proteindecreases activity 14975710
C063968 E 4031 E 4031 binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
C063968 E 4031 beta-Cyclodextrins analog inhibits the reaction [E 4031 results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
C063968 E 4031 E 4031 affects the localization of KCNH2 protein mutant formaffects localization 11741928
C063968 E 4031 E 4031 binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
C063968 E 4031 E 4031 binds to KCNH2 proteinaffects binding 19260734
C063968 E 4031 E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]decreases reaction|increases activity 12070109
C063968 E 4031 E 4031 results in decreased activity of KCNH2 proteindecreases activity 20050851
18724381
11741928
17513944
14709917
16494862
C063968 E 4031 E 4031 results in increased activity of KCNH2 protein mutant formincreases activity 10531299
C063968 E 4031 E 4031 results in increased glycosylation of and affects the localization of KCNH2 protein mutant formaffects localization|increases glycosylation 10531299
C118951 ergotoxin, Centruroides noxius ergotoxin, Centruroides noxius binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 20071423
C118951 ergotoxin, Centruroides noxius [Terfenadine co-treated with ergotoxin, Centruroides noxius] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D004917 Erythromycin Erythromycin affects the reaction [KCNH2 protein results in decreased susceptibility to Doxorubicin]affects reaction|decreases response to substance 16086867
D004917 Erythromycin Erythromycin binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D004917 Erythromycin Erythromycin binds to KCNH2 proteinaffects binding 18701618
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KCNH2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KCNH2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNH2 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of KCNH2 mRNAdecreases expression 17557909
C093230 fexofenadine E 4031 inhibits the reaction [fexofenadine results in increased activity of KCNH2 protein mutant form]decreases reaction|increases activity 12070109
C093230 fexofenadine fexofenadine results in increased activity of KCNH2 protein mutant formincreases activity 12070109
D005419 Flavonoids Flavonoids results in increased expression of KCNH2 mRNAincreases expression 18035473
D005424 Flecainide Flecainide binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D005473 Fluoxetine Fluoxetine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D016666 Fluvoxamine Fluvoxamine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 20071423
D016666 Fluvoxamine [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D005576 Forskolin [[Forskolin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]affects binding|affects cotreatment|affects reaction|increases activity|increases transport 19419905
C040029 gabapentin gabapentin results in decreased activity of KCNH2 proteindecreases activity 15716081
C001277 geldanamycin geldanamycin affects the localization of KCNH2 proteinaffects localization 12775586
C001277 geldanamycin geldanamycin inhibits the reaction [KCNH2 protein binds to HSP90AA1 protein]affects binding|decreases reaction 12775586
C001277 geldanamycin geldanamycin results in decreased activity of KCNH2 proteindecreases activity 12775586
C001277 geldanamycin geldanamycin results in decreased expression of KCNH2 protein modified formdecreases expression 12775586
C001277 geldanamycin geldanamycin results in increased degradation of KCNH2 proteinincreases degradation 12775586
C442759 ginsenoside Rb1 ginsenoside Rb1 affects the activity of KCNH2 proteinaffects activity 15842772
C055328 ginsenoside Rf ginsenoside Rf affects the activity of KCNH2 proteinaffects activity 15842772
C035054 ginsenoside Rg1 ginsenoside Rg1 affects the activity of KCNH2 proteinaffects activity 15842772
D006096 Gramicidin Gramicidin results in decreased expression of KCNH2 protein modified formdecreases expression 19139152
D006096 Gramicidin Potassium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form]decreases expression|decreases reaction 19139152
D006096 Gramicidin Rubidium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form]decreases expression|decreases reaction 19139152
D006220 Haloperidol Haloperidol binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D006220 Haloperidol Haloperidol results in decreased activity of KCNH2 proteindecreases activity 16494862
15671647
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [Astemizole results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
D006861 Hydrogen Peroxide Hydrogen Peroxide inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
C026777 ICI 118551 ICI 118551 results in decreased activity of [KCNH2 protein binds to KCNH2 protein]affects binding|decreases activity 15679475
C010739 ifenprodil ifenprodil results in decreased activity of KCNH2 proteindecreases activity 17460149
C010739 ifenprodil SM 21 promotes the reaction [ifenprodil results in decreased activity of KCNH2 protein]decreases activity|increases reaction 17460149
D007099 Imipramine Imipramine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D015056 1-Methyl-3-isobutylxanthine [[Forskolin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]affects binding|affects cotreatment|affects reaction|increases activity|increases transport 19419905
D007654 Ketoconazole Ketoconazole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D007654 Ketoconazole Ketoconazole results in decreased activity of KCNH2 proteindecreases activity 9694927
D007654 Ketoconazole Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]decreases activity|increases reaction 9694927
C087257 L 706000 L 706000 binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
C087257 L 706000 L 706000 binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
11005845
C047781 lamotrigine lamotrigine results in decreased activity of KCNH2 proteindecreases activity 15716081
D017336 Loratadine Loratadine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 11705456
9658196
D017336 Loratadine Loratadine results in decreased activity of KCNH2 proteindecreases activity 10604956
D008628 Mercury Mercury results in increased expression of KCNH2 mRNAincreases expression 16823088
D008653 Mesoridazine Mesoridazine results in decreased activity of KCNH2 proteindecreases activity 17042915
C008493 methylselenic acid methylselenic acid results in increased expression of KCNH2 mRNAincreases expression 18548127
D008790 Metoprolol Metoprolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein]affects binding|decreases activity 15679475
C076170 mizolastine mizolastine results in decreased activity of KCNH2 proteindecreases activity 11082114
C035359 monorden monorden results in decreased activity of KCNH2 proteindecreases activity 12775586
C035359 monorden monorden results in decreased expression of KCNH2 protein modified formdecreases expression 12775586
D009151 Mustard Gas Mustard Gas affects the expression of KCNH2 mRNAaffects expression 15651846
C005273 naringenin Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
C005273 naringenin naringenin results in decreased activity of KCNH2 proteindecreases activity 18057881
C005273 naringenin Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
D009553 Nimodipine Nimodipine inhibits the reaction [KCNH2 protein affects the abundance of Calcium]affects abundance|decreases reaction 11040061
C041094 N,N-bis(3,4-dimethoxyphenethyl)-N-methylamine N,N-bis(3,4-dimethoxyphenethyl)-N-methylamine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
C106448 norastemizole norastemizole binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 10376921
C076029 olanzapine olanzapine results in decreased activity of KCNH2 proteindecreases activity 16494862
D009966 Orphenadrine Orphenadrine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
C004564 panaxadiol panaxadiol affects the activity of KCNH2 proteinaffects activity 15842772
C004563 panaxatriol panaxatriol affects the activity of KCNH2 proteinaffects activity 15842772
D010419 Pentamidine Pentamidine affects the localization of and affects the activity of KCNH2 proteinaffects activity|affects localization 15340016
D010424 Pentobarbital Pentobarbital results in decreased activity of KCNH2 proteindecreases activity 11862331
D010480 Perhexiline Perhexiline binds to KCNH2 proteinaffects binding 18701618
D010656 Phenylephrine Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]affects reaction|increases transport 19419905
D010868 Pimozide Pimozide binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D010868 Pimozide Pimozide results in decreased activity of KCNH2 proteindecreases activity 15671647
D011188 Potassium [[Forskolin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]affects binding|affects cotreatment|affects reaction|increases activity|increases transport 19419905
D011188 Potassium [KCNH2 protein binds to KCNE2 protein] which results in increased transport of Potassiumaffects binding|increases transport 15679475
D011188 Potassium [KCNH2 protein binds to KCNH2 protein] which results in increased transport of Potassiumaffects binding|increases transport 15679475
D011188 Potassium KCNH2 protein results in increased transport of Potassiumincreases transport 17624316
19419905
D011188 Potassium Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]affects reaction|increases transport 19419905
D011188 Potassium Potassium affects the stability of and affects the localization of KCNH2 protein modified formaffects localization|affects stability 19139152
D011188 Potassium Potassium deficiency affects the folding of KCNH2 proteinaffects folding 19139152
D011188 Potassium Potassium inhibits the reaction [Amiodarone results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15618689
D011188 Potassium Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D011188 Potassium Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D011188 Potassium Potassium inhibits the reaction [dronedarone results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15618689
D011188 Potassium Potassium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form]decreases expression|decreases reaction 19139152
D011188 Potassium Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D011188 Potassium Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D011342 Procainamide Procainamide binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D011405 Propafenone Propafenone binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D011405 Propafenone Propafenone results in decreased activity of KCNH2 proteindecreases activity 18724381
D011433 Propranolol Propranolol results in decreased activity of [KCNH2 protein binds to KCNE2 protein]affects binding|decreases activity 15679475
D011433 Propranolol Propranolol results in decreased activity of [KCNH2 protein binds to KCNH2 protein]affects binding|decreases activity 15679475
C023666 pyridine pyridine analog binds to KCNH2 proteinaffects binding 17768047
D011802 Quinidine Acids inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 15821840
D011802 Quinidine KCNH2 gene SNP affects the susceptibility to Quinidineaffects response to substance 12695533
D011802 Quinidine naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
D011802 Quinidine Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D011802 Quinidine Quinidine affects the localization of KCNH2 protein mutant formaffects localization 11741928
D011802 Quinidine Quinidine binds to KCNH2 proteinaffects binding 18701618
D011802 Quinidine Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]decreases activity|increases reaction 18057881
D011802 Quinidine Quinidine results in decreased activity of KCNH2 proteindecreases activity 11741928
15821840
16960444
18724381
15671647
12695533
17042915
18057881
D011803 Quinine KCNH2 gene SNP affects the susceptibility to Quinineaffects response to substance 12695533
D011803 Quinine Quinine results in decreased activity of KCNH2 proteindecreases activity 12695533
D018967 Risperidone Risperidone results in decreased activity of KCNH2 proteindecreases activity 14975710
D012413 Rubidium Rubidium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form]decreases expression|decreases reaction 19139152
D012503 Saponins Saponins affects the activity of KCNH2 proteinaffects activity 15842772
C107044 SM 21 SM 21 promotes the reaction [ifenprodil results in decreased activity of KCNH2 protein]decreases activity|increases reaction 17460149
D012964 Sodium Sodium deficiency inhibits the reaction [Digoxin results in decreased expression of KCNH2 protein]decreases expression|decreases reaction 19139152
D013015 Sotalol Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 16960444
D013015 Sotalol Sotalol analog binds to KCNH2 proteinaffects binding 18701618
D013015 Sotalol Sotalol results in decreased activity of KCNH2 proteindecreases activity 16960444
D010042 Ouabain Ouabain results in decreased expression of KCNH2 protein modified formdecreases expression 19139152
D013629 Tamoxifen Tamoxifen binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 15272206
D013629 Tamoxifen Tamoxifen affects the expression of KCNH2 mRNAaffects expression 17555576
D016593 Terfenadine Terfenadine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
D016593 Terfenadine Terfenadine results in decreased activity of KCNH2 proteindecreases activity 14975710
D016593 Terfenadine Terfenadine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D016593 Terfenadine beta-Cyclodextrins analog inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein]decreases activity|decreases reaction 17513944
D016593 Terfenadine Chlorobutanol promotes the reaction [Terfenadine binds to and results in decreased activity of KCNH2 protein]affects binding|decreases activity|increases reaction 20071423
D016593 Terfenadine Hydrogen Peroxide inhibits the reaction [Terfenadine results in decreased activity of KCNH2 protein mutant form]decreases activity|decreases reaction 10828461
D016593 Terfenadine Terfenadine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 12388285
11705456
15272206
20071423
9658196
11005845
D016593 Terfenadine Terfenadine binds to KCNH2 proteinaffects binding 18701618
19260734
D016593 Terfenadine [Terfenadine co-treated with dofetilide] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D016593 Terfenadine [Terfenadine co-treated with ergotoxin, Centruroides noxius] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D016593 Terfenadine [Terfenadine co-treated with Fluvoxamine] binds to and results in decreased activity of KCNH2 proteinaffects binding|affects cotreatment|decreases activity 20071423
D016593 Terfenadine Terfenadine promotes the reaction [Chlorobutanol binds to and results in decreased activity of KCNH2 protein]affects binding|decreases activity|increases reaction 20071423
D016593 Terfenadine Terfenadine promotes the reaction [Ketoconazole results in decreased activity of KCNH2 protein]decreases activity|increases reaction 9694927
D016593 Terfenadine Terfenadine results in decreased activity of KCNH2 proteindecreases activity 12070109
19915712
15740727
10828461
10604956
10422790
8641472
15671647
17513944
8772706
17042915
16931984
14709917
9395068
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KCNH2 mRNAincreases expression 20055451
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KCNH2 mRNAaffects cotreatment|increases expression 17942748
D013881 Thioridazine Thioridazine binds to and results in decreased activity of KCNH2 proteinaffects binding|decreases activity 14678746
D013881 Thioridazine Thioridazine results in decreased activity of KCNH2 proteindecreases activity 15671647
C052342 topiramate topiramate results in decreased activity of KCNH2 proteindecreases activity 15716081
D014196 Trazodone Trazodone results in decreased activity of KCNH2 proteindecreases activity 15740727
D014700 Verapamil Verapamil results in decreased activity of KCNH2 proteindecreases activity 14975710
D014700 Verapamil Verapamil results in decreased activity of KCNH2 proteindecreases activity 15671647
C041667 vesnarinone KCNH2 gene SNP affects the susceptibility to vesnarinoneaffects response to substance 12695533
C041667 vesnarinone vesnarinone results in decreased activity of KCNH2 proteindecreases activity 12695533
D014810 Vitamin E Vitamin E results in increased expression of KCNH2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 3.6714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.0215322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 2.7018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0717505938
MESH:D000230 Adenocarcinoma arsenic trioxide 5.2111798837 19825857
MESH:D000230 Adenocarcinoma Doxorubicin 5.2117418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 5.2114692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.193712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 2.5216835633
MESH:D018246 Adrenocortical Adenoma Arsenic 4.3317306315
MESH:D017088 AIDS-Related Opportunistic Infections Pentamidine 5.4911806628
MESH:D000419 Albuminuria Doxorubicin 3.7221441931
MESH:D000437 Alcoholism topiramate 4.3319331489 17925516 18552399
OMIM:607154 ALLERGIC RHINITIS fexofenadine 13.1416037679
OMIM:607154 ALLERGIC RHINITIS Loratadine 13.1416527031
OMIM:607154 ALLERGIC RHINITIS Terfenadine 13.1416037679
MESH:D000544 Alzheimer Disease Trazodone 3.5717897735 16856516
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.1911748828
MESH:D000799 Angioedema Astemizole 4.782883202
MESH:D001008 Anxiety Disorders Fluoxetine 7.3818083778
MESH:D001008 Anxiety Disorders Pentobarbital 7.3811141031 18313124
MESH:D001145 Arrhythmias, Cardiac marker/mechanism 14678746 18250272
MESH:D001145 Arrhythmias, Cardiac Amiodarone 46.7618057881 20041841 18218290
MESH:D001145 Arrhythmias, Cardiac azimilide 46.7618057881 18651412
MESH:D001145 Arrhythmias, Cardiac dofetilide 46.7618651412 18057881
MESH:D001145 Arrhythmias, Cardiac dronedarone 46.7618651412
MESH:D001145 Arrhythmias, Cardiac E 4031 46.7618724381
MESH:D001145 Arrhythmias, Cardiac ifenprodil 46.7617460149
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 46.7617460149
MESH:D001145 Arrhythmias, Cardiac Propafenone 46.7616882315
MESH:D001145 Arrhythmias, Cardiac Quinidine 46.7618057881 18724381
MESH:D001145 Arrhythmias, Cardiac Sotalol 46.7618724381
MESH:D020261 Arsenic Poisoning Arsenic 2.5418414634 12569548 16251483 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.6311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.0715885639
MESH:D020817 Asperger Syndrome Risperidone 4.7316401163
MESH:D001249 Asthma Loratadine 4.469196086
MESH:D001249 Asthma Mustard Gas 4.4610378619
MESH:D050197 Atherosclerosis Arsenic 5.6212928151 19371607
MESH:D050197 Atherosclerosis Saponins 5.6218637019
MESH:D001281 Atrial Fibrillation Amiodarone 7.9219698954 18651412
MESH:D001281 Atrial Fibrillation dronedarone 7.9217804843
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.1518349709
MESH:D001321 Autistic Disorder Digoxin 5.7014585753
MESH:D001321 Autistic Disorder Fluoxetine 5.7018775368 19232924
MESH:D001321 Autistic Disorder Fluvoxamine 5.7018775368 19232924 12607287
MESH:D001321 Autistic Disorder Haloperidol 5.7018080171 19368416
MESH:D001321 Autistic Disorder Mercury 5.7017497416
MESH:D001321 Autistic Disorder olanzapine 5.7018685284 17069543
MESH:D001321 Autistic Disorder Propranolol 5.7018766980
MESH:D001321 Autistic Disorder Risperidone 5.7018080171 17069546 19232924 16239862 18775368 18026891 16601648 19368416 15994720 19013209 15492353 16379507 18278980 17019624 18349709 19154706 17929164 15930063 15543515 16730335 16948927
MESH:D001327 Autoimmune Diseases Mercury 4.0316634805
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.1411289319 1440618
MESH:D001714 Bipolar Disorder Risperidone 4.0019154706 18278980
MESH:D001768 Blister Mustard Gas 4.2919167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.8619483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.8616206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 10.8612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.1515746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 3.8214601052
MESH:D001919 Bradycardia Phenylephrine 8.2515306635
MESH:D001919 Bradycardia Propranolol 8.256740701
MESH:D001932 Brain Neoplasms Carmustine 6.6016187019
MESH:D001932 Brain Neoplasms Doxorubicin 6.6017150277
MESH:D001943 Breast Neoplasms Doxorubicin 2.0116096432 16115903 15939500 11325840 19526202 16322301 18628466 15668708 16264153 15634643 18695136 16595493 15136595 15692762 17983394 17426702 18382427 16826403 15567936 17369602 15993339 15994142 16935488 18234424
MESH:D001943 Breast Neoplasms Tamoxifen 2.0119103187 17893378 19059307 20135344 19487384 19155303 16818667 19084267 18425577 18815881 19244106 18855134 19289846 19189210 17049068 15565566 19066611 17261762 18821012 11161223 18997820 15668708 18984771 19221464 19200415 20544844 16873071 20390343 16273361 19011961 20065188 19115204 18351453 16202921 21152245 18629630 20859285 19142967 17242785 19189212 20005174 19288272 17440819 19410462 21138602
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.2915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.1017687719 10378619
MESH:D002051 Burkitt Lymphoma arsenic trioxide 3.5211589617
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.0916050911
MESH:D002276 Carcinoid Tumor Doxorubicin 3.9316051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.0916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.0315504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 3.6619066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 8.413581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Arsenic 8.4116507464 17306315
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.4114691202 15073043 16217749 15553829 11135700
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 8.4118059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular pyridine 8.4110696769
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.4116924424
MESH:D002291 Carcinoma, Papillary arsenic trioxide 3.9919014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 4.887296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 4.8816201981 1485588
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.3512490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 3.7717687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 3.776189445
MESH:D002295 Carcinoma, Transitional Cell Arsenic 6.9618640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 6.9617572228
MESH:D006332 Cardiomegaly Phenylephrine 5.0215728586 11179087 17124262 11754973 17287366 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.0218670907 18850075 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 2.9116952015 16731534 16242529 16109756 17974986 17131338 16278810 17308081 17007740 16651473 16455267 16269455 16612575 17329180 17928571 17351982 17924179 15505089 15792986 17519947 15811867 15476868 17382496 18627295 16364871
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 10.3615710769 19225199
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 10.3617334414 16243910
MESH:D002311 Cardiomyopathy, Dilated Mercury 10.3610334427
MESH:D002311 Cardiomyopathy, Dilated Metoprolol 10.3619477965
MESH:D002318 Cardiovascular Diseases Arsenic 5.4315738583 17938729 19152805
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 5.4316936243
MESH:D002340 Carotid Artery Diseases Arsenic 3.5616973168 18022660
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.2218974383
MESH:D002375 Catalepsy Haloperidol 9.211977408 15215559
MESH:D002375 Catalepsy Pimozide 9.211977408
MESH:D002389 Catatonia olanzapine 5.3718071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.147505956
MESH:D002637 Chest Pain Acids 10.1915447763
MESH:D002637 Chest Pain Trazodone 10.1915238202
MESH:D002659 Child Development Disorders, Pervasive topiramate 3.7015650499
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 5.6019486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 5.6015861022 16105132 17333356 17681005 17110522 16919318 11677210
MESH:D016770 Ciliophora Infections Quinine 4.9112113305
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.6715340226 15668235 8697196 12621046 16354765
MESH:D003110 Colonic Neoplasms marker/mechanism 16086867
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.3020501625
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.3018259882 18802399
MESH:D003128 Coma Trazodone 5.2510836866
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.3117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.3612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.9110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.9110048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.9119769572
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 19.5015213294
MESH:D016757 Death, Sudden, Cardiac Haloperidol 19.5020210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 19.5020210726
MESH:D016757 Death, Sudden, Cardiac Thioridazine 19.5020210726
MESH:D003704 Dementia Haloperidol 17.2911575062
MESH:D003704 Dementia Risperidone 17.2911575062
MESH:D003704 Dementia Thioridazine 17.2911575062
MESH:D003704 Dementia Trazodone 17.2911575062 12587811
MESH:D003711 Demyelinating Diseases Tamoxifen 3.5219031437
MESH:D003866 Depressive Disorder Fluoxetine 13.2015014590
MESH:D003866 Depressive Disorder Fluvoxamine 13.2019571598
MESH:D003866 Depressive Disorder Imipramine 13.2020305041
MESH:D003866 Depressive Disorder Trazodone 13.2019623435 18083778 20305041 3690436 4066620 15014590 3378227
MESH:D003865 Depressive Disorder, Major Fluvoxamine 8.6117474826
MESH:D003865 Depressive Disorder, Major Trazodone 8.6116968574
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 4.5112868966 11906362 18759878 2524372 8156756 14531868 8970840 11298694
MESH:D017449 Dermatitis, Allergic Contact Mercury 4.5116823706
MESH:D003876 Dermatitis, Atopic fexofenadine 4.2917133778
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 2.702952479 3621924
MESH:D002658 Developmental Disabilities olanzapine 4.0617069543
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7417107852
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 3.7416979414
MESH:D003928 Diabetic Nephropathies Tamoxifen 2.7319279558
MESH:D006970 Disorders of Excessive Somnolence Risperidone 5.4516379507
MESH:D053207 Diurnal Enuresis Risperidone 5.7917822346
MESH:D004244 Dizziness Astemizole 5.583105558
MESH:D004314 Down Syndrome Risperidone 4.4018349709
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 8.1818289764 18648102 18692083 7440962 9022650 6482804 8291058 9328219 9653073 6679447 11289319 1440618 16192314
MESH:D056486 Drug-Induced Liver Injury Amiodarone 8.1815265979 18218290
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 8.1817416283
MESH:D056486 Drug-Induced Liver Injury Ketoconazole 8.1818289764
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1820420201
MESH:D004362 Drug Toxicity Doxorubicin 5.8418602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 5.8411462148
MESH:D004409 Dyskinesia, Drug-Induced Trazodone 5.053690436
MESH:D004421 Dystonia Trazodone 4.833700695
MESH:C538011 Eales disease Vitamin E 3.829068938
MESH:D004487 Edema Fluoxetine 13.6112798668
MESH:D004487 Edema Imipramine 13.6112798668
MESH:D004487 Edema Mustard Gas 13.6111402378 9260866 11428647 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.6112711302 11000095
MESH:D004487 Edema Trazodone 13.6112798668
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.0218230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 6.2312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 6.2319031437
MESH:D016889 Endometrial Neoplasms Doxorubicin 5.4817359293
MESH:D016889 Endometrial Neoplasms Tamoxifen 5.4819155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.269294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.2818037988
MESH:D004802 Eosinophilia Astemizole 3.981355641
MESH:D004816 Epidermal Necrolysis, Toxic lamotrigine 5.3220235791
MESH:D004831 Epilepsies, Myoclonic gabapentin 9.553659116
MESH:D004831 Epilepsies, Myoclonic lamotrigine 9.5517275665
MESH:D004828 Epilepsies, Partial lamotrigine 5.0017116037
MESH:D004827 Epilepsy lamotrigine 6.1419668019
MESH:D004827 Epilepsy topiramate 6.1419148780
MESH:D004833 Epilepsy, Temporal Lobe lamotrigine 11.9816499746
MESH:D004833 Epilepsy, Temporal Lobe topiramate 11.9816499746
MESH:D004830 Epilepsy, Tonic-Clonic gabapentin 5.453659116
MESH:D007172 Erectile Dysfunction Trazodone 4.667604472
MESH:D004890 Erythema Mustard Gas 4.299357497
MESH:D004916 Erythromelalgia gabapentin 6.0419549232
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 3.413581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 3.4112903497
MESH:D020329 Essential Tremor Trazodone 5.253296121
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.3311564622
MESH:D005234 Fatty Liver Amiodarone 12.4414986274
MESH:D005234 Fatty Liver arsenic trioxide 12.4415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.4415345470
MESH:D005234 Fatty Liver Tamoxifen 12.4414986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 2.6416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6211858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.146705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 3.6614745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 8.5819069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 8.5819069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.1320067830
MESH:D005393 Fish Diseases Quinine 4.8812113305
MESH:D005499 Folliculitis Astemizole 5.041671328
MESH:D005534 Foot Diseases Arsenic 4.686392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.4416904648
MESH:D005909 Glioblastoma Carmustine 5.5116187019
MESH:D005909 Glioblastoma Doxorubicin 5.5117150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.237505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7110696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 2.9015692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 4.7710048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 4.7716080930
MESH:D006331 Heart Diseases Doxorubicin 2.8416495754 18674790 17875725 16707910 18006777 16144979 14766674 16330681 16244372 12587719 16879835 16244371 17888722
MESH:D006333 Heart Failure Doxorubicin 5.8217481944
MESH:D006333 Heart Failure Propranolol 5.8220082655
MESH:D006394 Hemangiosarcoma Doxorubicin 3.1215692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 2.706705139
MESH:D006529 Hepatomegaly Amiodarone 9.8815265979
MESH:D006529 Hepatomegaly Propranolol 9.8816371745
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.8812621046 15340226 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.3216490937 16863852
MESH:D006561 Herpes Simplex Amsacrine 4.7910809021
MESH:D006689 Hodgkin Disease Doxorubicin 2.7018501091 17606976 15147373
MESH:D019584 Hot Flashes Fluoxetine 17.4714716179
MESH:D019584 Hot Flashes gabapentin 17.4714716179
MESH:D019584 Hot Flashes Trazodone 17.4719711746
MESH:D019584 Hot Flashes Vitamin E 17.4714716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.1716354765 15340226 16959395 8697196 18606429
MESH:D006930 Hyperalgesia Trazodone 4.1812790215
MESH:D006937 Hypercholesterolemia Amiodarone 3.108137927 9751232
MESH:D006943 Hyperglycemia Risperidone 4.4018278980
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 3.6817050553
MESH:D006963 Hyperphagia olanzapine 5.3617933447
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.1015034207
MESH:D006967 Hypersensitivity fexofenadine 7.4217910814
MESH:D006967 Hypersensitivity Terfenadine 7.422570798
MESH:D006973 Hypertension Arsenic 11.8516076760 11953799 9931084
MESH:D006973 Hypertension Ouabain 11.8518976649
MESH:D006973 Hypertension Phenylephrine 11.8512717712 8949925
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 11.8518670907 18850075
MESH:D006973 Hypertension Verapamil 11.8517700361
MESH:D006984 Hypertrophy Phenylephrine 3.7712791704 18502941
MESH:D006987 Hypesthesia Arsenic 4.6816093927
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.0019822448
MESH:D007021 Hypospadias Ethinyl Estradiol 9.0016945680 16569931
MESH:D007021 Hypospadias Loratadine 9.0016407038
MESH:D007022 Hypotension Propranolol 4.396740701
MESH:D007024 Hypotension, Orthostatic Trazodone 5.1415811171
MESH:D007037 Hypothyroidism Amiodarone 3.6717991464 18020914
MESH:D007077 Ileal Diseases 1-Methyl-3-isobutylxanthine 4.5618306037
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6612013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 1.8817937319
MESH:D007249 Inflammation Erythromycin 19.2319502290
MESH:D007249 Inflammation Flavonoids 19.2317296493
MESH:D007249 Inflammation Fluoxetine 19.2312798668
MESH:D007249 Inflammation Imipramine 19.2312798668
MESH:D007249 Inflammation Mustard Gas 19.238975870 11402378 17524151 11428647 9260866 11428631 11428620 16001271 9357497
MESH:D007249 Inflammation Tamoxifen 19.2319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 19.2312878042 12200463
MESH:D007249 Inflammation Trazodone 19.2312798668
MESH:D007251 Influenza, Human Vitamin E 3.3416624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.148074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.5516580747
MESH:D007579 Jejunal Diseases 1-Methyl-3-isobutylxanthine 4.5618306037
MESH:D007642 Keratosis Arsenic 4.1316930632 12749816
MESH:D007674 Kidney Diseases Doxorubicin 6.9715369732 15699352 16775033
MESH:D007674 Kidney Diseases Mercury 6.9717934191
MESH:D007674 Kidney Diseases Vitamin E 6.9712488133
MESH:D007676 Kidney Failure, Chronic Doxorubicin 7.5216707910
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 7.5216518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.526582329
MESH:D007680 Kidney Neoplasms pyridine 8.5210696769
MESH:D007680 Kidney Neoplasms Tamoxifen 8.5218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.1716316344
MESH:D007896 Leishmaniasis Pentamidine 4.6515340016
MESH:D016773 Leishmaniasis, Cutaneous Ketoconazole 7.041311351 2166429 8889330 19744259
MESH:D016773 Leishmaniasis, Cutaneous Pentamidine 7.0412453009 8889330 10617787 11806628
MESH:D007897 Leishmaniasis, Mucocutaneous Pentamidine 5.2110881086
MESH:D007898 Leishmaniasis, Visceral Ketoconazole 6.6411332679
MESH:D007898 Leishmaniasis, Visceral Pentamidine 6.641659303 7715298 10467834 12803856 7498017 16131481
MESH:D007938 Leukemia arsenic trioxide 2.3315070760
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.2816085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.0117077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.4516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 2.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 2.9819077051
MESH:D015470 Leukemia, Myeloid, Acute Amsacrine 3.7718043129 15148258
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.7716467208 16968895 20471514 17050201 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 5.6917339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 5.6919035177 12018890 16891316 15336539 16823087 17217047 17712046 12679006 15213294 16330433 9834237 15748426 11161223 15622746 19642359 16331271 17107899 19225113 11468182 16966277 12712474 17869043 16112521 17649720 19075265
MESH:D015458 Leukemia, T-Cell arsenic trioxide 3.5316882451
MESH:D017513 Lichen Nitidus Astemizole 5.582563723
MESH:D008064 Lipidoses Amiodarone 31.5517567588 15342952
MESH:D008064 Lipidoses Fluoxetine 31.5515342952 17567588
MESH:D008064 Lipidoses Imipramine 31.5517567588 15342952
MESH:D008064 Lipidoses Ketoconazole 31.5517567588
MESH:D008064 Lipidoses Loratadine 31.5517567588
MESH:D008064 Lipidoses Perhexiline 31.5515342952 17567588
MESH:D008064 Lipidoses Tamoxifen 31.5515342952 17567588
MESH:D008064 Lipidoses Thioridazine 31.5517567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.599327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 4.8916439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental naringenin 4.8914709902
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.8912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 4.8916169303
MESH:D008107 Liver Diseases Arsenic 3.8911134558
MESH:D008107 Liver Diseases naringenin 3.8916945181
MESH:D017114 Liver Failure, Acute Trazodone 4.6519857765
MESH:D008113 Liver Neoplasms Arsenic 7.1816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 7.1814682389
MESH:D008113 Liver Neoplasms Tamoxifen 7.1816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.1816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 9.18598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.1820377131
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.1817085340 16842330
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.1812151625
MESH:D008133 Long QT Syndrome marker/mechanism 11741928 17467628 15213294 12070109
MESH:D008133 Long QT Syndrome Amiodarone 53.8715350150 17391786 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 53.8715213294
MESH:D008133 Long QT Syndrome Astemizole 53.8718472280 11989578
MESH:D008133 Long QT Syndrome Cisapride 53.8718472280
MESH:D008133 Long QT Syndrome Droperidol 53.8720210726
MESH:D008133 Long QT Syndrome Metoprolol 53.8719353679
MESH:D008133 Long QT Syndrome olanzapine 53.8720210726
MESH:D008133 Long QT Syndrome Quinidine 53.8711989578 15350150
MESH:D008133 Long QT Syndrome Sotalol 53.8715350150 11989578
MESH:D008133 Long QT Syndrome Terfenadine 53.878772706
MESH:D008133 Long QT Syndrome Thioridazine 53.8720210726
MESH:D008133 Long QT Syndrome Trazodone 53.8718167038
MESH:D008171 Lung Diseases Amiodarone 8.7112587719
MESH:D008171 Lung Diseases Mustard Gas 8.7118702808 18161513
MESH:D008171 Lung Diseases Vitamin E 8.7116863852
MESH:D017563 Lung Diseases, Interstitial Amiodarone 3.6018516814
MESH:D008175 Lung Neoplasms Arsenic 7.8917306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 7.8919825857 11798837
MESH:D008175 Lung Neoplasms Doxorubicin 7.896189445 17418594
MESH:D008175 Lung Neoplasms Mustard Gas 7.893148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 7.8918625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 7.8911884234 19555203
MESH:D008175 Lung Neoplasms Vitamin E 7.8911062179
MESH:D008223 Lymphoma Doxorubicin 2.8116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.0717654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 3.7215621674
MESH:D008288 Malaria Astemizole 7.9616816845
MESH:D008288 Malaria desmethylastemizole 7.9616816845
MESH:D016778 Malaria, Falciparum Perhexiline 13.6116882315
MESH:D016778 Malaria, Falciparum Propafenone 13.6116882315
MESH:D016778 Malaria, Falciparum Thioridazine 13.6116882315
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 2.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Corticosterone 6.6012807724
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.6015458769
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.6016827153 11731420 19196722 14580682 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 3.6719453300
MESH:D008545 Melanoma Carmustine 3.8812393984
MESH:D008545 Melanoma Doxorubicin 3.8816827129
MESH:D008545 Melanoma Tamoxifen 3.8812393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.3215990972
MESH:D001523 Mental Disorders Fluoxetine 32.6216856516
MESH:D001523 Mental Disorders Fluvoxamine 32.6216856516
MESH:D001523 Mental Disorders Haloperidol 32.6216856516
MESH:D001523 Mental Disorders Imipramine 32.6216856516
MESH:D001523 Mental Disorders olanzapine 32.6216856516
MESH:D001523 Mental Disorders Pimozide 32.6216856516
MESH:D001523 Mental Disorders Risperidone 32.6216856516 16596465
MESH:D001523 Mental Disorders Thioridazine 32.6216856516
MESH:D001523 Mental Disorders Trazodone 32.6216856516
MESH:D008607 Mental Retardation Risperidone 3.7318349709
MESH:D008654 Mesothelioma Doxorubicin 2.6317638057
MESH:D008659 Metabolic Diseases olanzapine 4.6019142110
MESH:D024821 Metabolic Syndrome X Risperidone 4.4519142101
MESH:D008881 Migraine Disorders gabapentin 6.6718803445 18759728
MESH:D008881 Migraine Disorders topiramate 6.6718803445 16942474 18765137 18759728
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.7115792986
MESH:D019964 Mood Disorders Risperidone 4.9917019624
MESH:D009069 Movement Disorders Trazodone 4.964066620
MESH:D052016 Mucositis Doxorubicin 3.9317415656
MESH:D009101 Multiple Myeloma arsenic trioxide 2.4611468182 19417148 14977855 15949261 19549372
MESH:D009103 Multiple Sclerosis 4-Aminopyridine 5.0119915712
MESH:D009133 Muscular Atrophy marker/mechanism 16723379
MESH:D009181 Mycoses Amiodarone 4.0212754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 3.7918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 2.5816882451 16105982
MESH:D009203 Myocardial Infarction Doxorubicin 5.1415857846 19429709
MESH:D009203 Myocardial Infarction Metoprolol 5.1418072171
MESH:D017202 Myocardial Ischemia Arsenic 6.6215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 6.6212213967
MESH:D009207 Myoclonus Fluoxetine 5.018041377
MESH:D009224 Myotonia Congenita Quinine 5.381896199
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.1416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.903581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 6.9018259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 6.9019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.1519410462
MESH:D009369 Neoplasms naringenin 3.7815185748
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.1319189210 19196722 19200415
MESH:D009401 Nephrosis Doxorubicin 3.9216636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.2515640375 16889571
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 2.4014600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.556679447
MESH:D009436 Neural Tube Defects Arsenic 8.5516620997
MESH:D009436 Neural Tube Defects arsenic trioxide 8.5510525206
MESH:D009447 Neuroblastoma Doxorubicin 2.7415555623
MESH:D019636 Neurodegenerative Diseases Nimodipine 4.8916635102
MESH:D020078 Neurogenic Inflammation Arsenic 3.5717056641
MESH:D009503 Neutropenia Mustard Gas 3.1816761898 7688884
MESH:D053206 Nocturnal Enuresis Risperidone 5.4517822346
MESH:D009759 Nystagmus, Pathologic Astemizole 5.586135121
MESH:D009765 Obesity olanzapine 3.4418515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.6520418887
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 2.666482804 4026338
MESH:D053578 Opsoclonus-Myoclonus Syndrome Trazodone 5.591318289
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.143988306
MESH:D010024 Osteoporosis Calcium 3.1917882678
MESH:D012516 Osteosarcoma Doxorubicin 3.3915930896
MESH:D010051 Ovarian Neoplasms Arsenic 3.7917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 3.7912452020 19769630 16624393
MESH:D010146 Pain Fluoxetine 7.7712798668
MESH:D010146 Pain Imipramine 7.7712798668
MESH:D010146 Pain Trazodone 7.7712790215 12798668
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.1515580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8811578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 6.547296757
MESH:D010212 Papilloma Hydrogen Peroxide 6.5412065085
MESH:D010235 Paraganglioma arsenic trioxide 3.3619927285
MESH:D010302 Parkinson Disease, Secondary Trazodone 4.903378227
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3712520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.3616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.1315371236 6392382 16905509
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.596228378
MESH:D003557 Phyllodes Tumor Doxorubicin 4.2817983394
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.158041377
MESH:D010997 Pleural Neoplasms Doxorubicin 4.2817638057
MESH:D011020 Pneumonia, Pneumocystis Pentamidine 5.8315340016
MESH:D011041 Poisoning Diphenhydramine 6.9512460839
MESH:D011041 Poisoning Mustard Gas 6.9515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 2.7318163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.3411222880 11896295 11118676 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 1.9316140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9319131511
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.9316729912 15749863 16888761 16868541 15897917 18437689
MESH:D011471 Prostatic Neoplasms Ketoconazole 1.9317404083
MESH:D011471 Prostatic Neoplasms methylselenic acid 1.9316205645
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9315067354
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9315084515
MESH:D011507 Proteinuria Arsenic 3.2121343184
MESH:D011537 Pruritus Ethinyl Estradiol 11.4115861022 16919318
MESH:D011537 Pruritus fexofenadine 11.4117133778
MESH:D011537 Pruritus Mustard Gas 11.4118058305
MESH:D011595 Psychomotor Agitation Haloperidol 9.0211575062
MESH:D011595 Psychomotor Agitation olanzapine 9.0218685284
MESH:D011618 Psychotic Disorders Haloperidol 7.3211575062
MESH:D011618 Psychotic Disorders Thioridazine 7.3216882315
MESH:D011657 Pulmonary Eosinophilia Trazodone 5.258520792
MESH:D011658 Pulmonary Fibrosis Amiodarone 4.4111597910 12490602 12832656
MESH:D011658 Pulmonary Fibrosis Mustard Gas 4.4117620002 17894541 10334151 17266442 17720292
MESH:D012021 Reflex, Abnormal Pentobarbital 5.1610930210
MESH:D051437 Renal Insufficiency Doxorubicin 3.3817922066
MESH:D012131 Respiratory Insufficiency Trazodone 4.968520792
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0118990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 2.693692021
MESH:D012221 Rhinitis, Allergic, Perennial Astemizole 14.2610822083
MESH:D012221 Rhinitis, Allergic, Perennial mizolastine 14.2618020585
MESH:D012221 Rhinitis, Allergic, Perennial Terfenadine 14.268201490
MESH:D006255 Rhinitis, Allergic, Seasonal mizolastine 6.0318020585
MESH:D012509 Sarcoma Doxorubicin 3.2316767912 17203757 15625365 18313854 17710206 15675481
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 7.5516646077
MESH:D012512 Sarcoma, Ewing's Doxorubicin 7.5516326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 3.9317846226
MESH:D012559 Schizophrenia Haloperidol 6.2819369910 20107430 18513383 1830565
MESH:D012559 Schizophrenia olanzapine 6.2820107430 17726453 20521326
MESH:D012559 Schizophrenia Risperidone 6.2818278980 19154706 20107430
MESH:D012559 Schizophrenia Trazodone 6.287868106
MESH:D012640 Seizures gabapentin 9.2110454489
MESH:D012640 Seizures lamotrigine 9.219844417 16499746
MESH:D012640 Seizures Pentobarbital 9.2110087439 9754883
MESH:D012640 Seizures topiramate 9.2116499746
MESH:D020230 Serotonin Syndrome Fluoxetine 10.388704074
MESH:D020230 Serotonin Syndrome Trazodone 10.387854515 8704074 9050436
OMIM:608579 SEVERE CUTANEOUS ADVERSE REACTION, SUSCEPTIBILITY TO lamotrigine 5.7520485159 19668019
MESH:D012772 Shock, Septic Diphenhydramine 5.6118063050
OMIM:609620 SHORT QT SYNDROME 1 marker/mechanism 18724381
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.2218724381
MESH:D012852 Sinusitis Phenylephrine 3.847327846
MESH:D012871 Skin Diseases Arsenic 6.0617050553 19834688 16759981 17453740 16702368 17548696 17938729 16353154 18709164 15952646 6392382
MESH:D012871 Skin Diseases Mustard Gas 6.0616961503 12880345 15451306
MESH:D012871 Skin Diseases Vitamin E 6.0618709164
MESH:D012878 Skin Neoplasms Arsenic 9.4817976673 15504454 19538983 17050553 16251483 17029826
MESH:D012878 Skin Neoplasms Doxorubicin 9.4815692506
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 9.4812065085
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.4816192470
MESH:D012892 Sleep Deprivation Imipramine 10.9919798453
MESH:D012892 Sleep Deprivation Trazodone 10.9919798453
MESH:D012893 Sleep Disorders Risperidone 8.7618278980
MESH:D012893 Sleep Disorders Trazodone 8.7619395429
MESH:D007319 Sleep Initiation and Maintenance Disorders Trazodone 4.5717225163 15062207 15341891
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.7217203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 8.6516709447
MESH:D013088 Spermatocele Tamoxifen 8.6516709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.1819457130
MESH:D013262 Stevens-Johnson Syndrome lamotrigine 5.2620235791
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8817007042
MESH:D013276 Stomach Ulcer Amiodarone 2.5818087811
MESH:D020521 Stroke Trazodone 6.80810300
MESH:D020521 Stroke Vitamin E 6.8016517955
MESH:D013375 Substance Withdrawal Syndrome Pentobarbital 8.1311529278 9754883
MESH:D013375 Substance Withdrawal Syndrome Trazodone 8.1312749364 393279
MESH:D013610 Tachycardia Amiodarone 3.4711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 29.6419225199
MESH:D017180 Tachycardia, Ventricular Haloperidol 29.6420210726
MESH:D017180 Tachycardia, Ventricular olanzapine 29.6420210726
MESH:D017180 Tachycardia, Ventricular Risperidone 29.6420210726
MESH:D017180 Tachycardia, Ventricular Thioridazine 29.6420210726
MESH:D017180 Tachycardia, Ventricular Trazodone 29.642424891
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.4115669648
MESH:D013959 Thyroid Diseases Amiodarone 9.1419731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 9.1412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.021399818 6582329 7505956 6587162 3712494
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.0219014326
MESH:D013964 Thyroid Neoplasms Doxorubicin 8.0217909728 16010429
MESH:D013971 Thyrotoxicosis Amiodarone 4.0119584973 18020914
MESH:D016171 Torsades de Pointes marker/mechanism 15213294
MESH:D016171 Torsades de Pointes Amiodarone 41.7411989578 17467628
MESH:D016171 Torsades de Pointes arsenic trioxide 41.7415213294
MESH:D016171 Torsades de Pointes Astemizole 41.748256756 9583453
MESH:D016171 Torsades de Pointes Flecainide 41.7417467628
MESH:D016171 Torsades de Pointes Metoprolol 41.7419353679
MESH:D016171 Torsades de Pointes Propafenone 41.7417467628
MESH:D016171 Torsades de Pointes Sotalol 41.7411989578 17467628
MESH:D016171 Torsades de Pointes Terfenadine 41.748256756
MESH:D005879 Tourette Syndrome Risperidone 5.1019154706
MESH:D014202 Tremor Pimozide 5.6917594079 19467297
MESH:D014352 Trypanosomiasis Pentamidine 5.6315340016
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.108074119
MESH:D001749 Urinary Bladder Neoplasms Arsenic 11.1011144890 15987713 17976673 17306315 19322015 19429237 18640142
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 11.1012973940 20435036 12845720 11780464
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.1017653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.1016712894 17572228 8653321
MESH:D014581 Urticaria Astemizole 14.812885854 3080510 2859714 2565098 2568189 1976298 3134034 2883202 1683191 2568013 2147912 3097109
MESH:D014581 Urticaria Loratadine 14.812568013
MESH:D014581 Urticaria mizolastine 14.8118020585
MESH:D014581 Urticaria Terfenadine 14.812569995 2565098 2859714 2568013 2885854
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 2.4814692618
MESH:D014652 Vascular Diseases Arsenic 3.8717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 3.3817334414 17638931 17678736 16364871
MESH:D018879 Ventricular Premature Complexes Trazodone 5.942424891
MESH:D014717 Vertigo Astemizole 5.583105558
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3715886252
MESH:D015430 Weight Gain olanzapine 8.1420107430 17933447 19434072
MESH:D015430 Weight Gain Risperidone 8.1420564506 16379507
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA212
    • Releated gene ID Related gene Name
    PA134936082ALG10B
    PA212KCNH2
    Releated disease ID Related disease Name
    PA443421Arrhythmias, Cardiac
    PA443459Atrial Fibrillation
    PA159018367Brugada syndrome
    PA443633Cardiomyopathy, Hypertrophic
    PA443796Coronary Artery Disease
    PA443797Coronary Disease
    PA446379Death, Sudden, Cardiac
    PA444368Heart Diseases
    PA445019Myocardial Infarction
    PA445769Sudden Infant Death
    PA445848Thromboembolism
    PA446028Ventricular Fibrillation
    PA443224Abnormalities, Drug-Induced
    PA447300Acquired Long QT Syndrome (aLQTS)
    PA444807Long QT Syndrome
    PA446294Torsades de Pointes
    PA447228congenital long QT syndrome
    PA446450Tachycardia, Ventricular
    Releated drug ID Related drug Name
    PA164712547Beta blocking agents, selective
    PA451906warfarin
    PA448498astemizole
    PA449011cisapride
    PA449812grepafloxacin
    PA164784002sertindole
    PA451619terfenadine
    PA449493erythromycin
    PA450555moxifloxacin
    PA10202telithromycin
    PA130150436perhexiline
    PA449422droperidol
    PA450215levomethadyl acetate
    PA450492mibefradil
    PA449373disopyramide
    PA449958ibutilide
    PA450688olanzapine
    PA450965pimozide
    PA451201quetiapine
    PA451257risperidone
    PA451472sparfloxacin
    PA451666thioridazine
    PA451974ziprasidone
    PA451108procainamide
    PA448486arsenic trioxide
    PA448960chlorpheniramine
    PA449001cimetidine
    PA449841haloperidol
    PA450266loratadine
    PA450272lovastatin
    PA449409doxepin
    PA451107probucol
    PA449389dofetilide
    PA449673fluoxetine
    PA449690fluvoxamine
    PA449943hydroxyzine
    PA451744trazodone
    PA452233antipsychotics
    PA164754755bepridil
    PA448948chloroquine
    PA448964chlorpromazine
    PA134711056domperidone
    PA449839halofantrine
    PA450386mesoridazine
    PA448383amiodarone
    PA451457sotalol
    PA450850pentamidine
    PA450401methadone
    PA451209quinidine
    PA450488mexiletine
    PA452249antiarrhythmics, class i and iii
    PA449028clarithromycin
    PA165291889silodosin
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00204 antagonist Dofetilide Antiarrhythmic Agents;Potassium Channel Blockers;Anti-Arrhythmia Agents
    DB00276 antagonist Amsacrine Antineoplastic Agents;Intercalating Agents
    DB00308 inhibitor Ibutilide Anti-Arrhythmia Agents
    DB00342 antagonist Terfenadine Antiarrhythmic Agents;Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00457 antagonist Minizide Antihypertensive Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents
    DB00489 inhibitor Sotalol Adrenergic beta-Antagonists;Sympatholytics;Anti-Arrhythmia Agents
    DB00590 antagonist Doxazosin Antineoplastic Agents;Antihypertensive Agents;Vasodilator Agents;Adrenergic alpha-Antagonists;Alpha-adrenergic Blocking Agents;Antihyperplasia Agents
    DB00604 antagonist Cisapride Anti-Ulcer Agents;Gastrointestinal Agents;Serotonin Agonists;Prokinetic Agents
    DB00637 antagonist Astemizole Anti-Allergic Agents;Antihistamines;Histamine H1 Antagonists, Non-Sedating
    DB00661 blocker Tarka Vasodilator Agents;Antiarrhythmic Agents;Calcium Channel Blockers;Anti-Arrhythmia Agents
    DB00679 antagonist Thioridazine Antipsychotics;Dopamine Antagonists;Phenothiazines;Antipsychotic Agents
    DB00908 antagonist Quinidine Enzyme Inhibitors;Antiarrhythmic Agents;Antimalarials;Muscarinic Antagonists;Adrenergic alpha-Antagonists;Anti-Arrhythmia Agents
    DB01100 antagonist Pimozide Dopamine Antagonists;Antipsychotic Agents;Anti-Dyskinesia Agents
    DB01110 antagonist Miconazole Antifungal Agents
    DB01118 antagonist Amiodarone Vasodilator Agents;Enzyme Inhibitors;Anti-Arrhythmia Agents
    DB01136 inhibitor Carvedilol Antihypertensive Agents;Adrenergic Agents;Adrenergic beta-Antagonists;Vasodilator Agents;Adrenergic alpha-Antagonists
    DB01162 inhibitor Terazosin Antineoplastic Agents;Adrenergic alpha-Antagonists
    DB01182 antagonist Propafenone Anti-Arrhythmia Agents
    DB01218 antagonist Halofantrine Antiprotozoals;Antimalarials
    DB06144 antagonist Sertindole Neuroleptics;Antipsychotic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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