Annotation Detail for PNPLA7
Basic Information
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| Gene Symbol: | PNPLA7 ( C9orf111,FLJ31318,FLJ43070,FLJ44279,NTE-R1,NTEL1 ) |
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| Gene Full Name: | patatin-like phospholipase domain containing 7 |
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| Band: | 9q34.3 |
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| Quick Links | Entrez ID:375775; OMIM: 612122; Uniprot ID:PLPL7_HUMAN; ENSEMBL ID: ENSG00000130653; HGNC ID: 24768 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| C023514 |
2,6-dinitrotoluene |
2,6-dinitrotoluene affects the expression of PNPLA7 mRNA | affects expression | 21346803
|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of PNPLA7 mRNA | affects expression | 16483693
|
| D004041 |
Dietary Fats |
Dietary Fats results in decreased expression of PNPLA7 mRNA | decreases expression | 18042831
|
| C041786 |
palm oil |
palm oil results in decreased expression of PNPLA7 mRNA | decreases expression | 18042831
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PNPLA7 mRNA | affects binding|decreases expression|increases activity | 19710929
|
| C009250 |
sevoflurane |
sevoflurane affects the expression of PNPLA7 mRNA | affects expression | 15967596
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.02 | 18287403 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
3.47 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.94 | 16434500 |
| MESH:D001161 |
Arteriosclerosis |
|
Dietary Fats |
4.31 | 15238619 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.47 | 19483382 |
| MESH:D001943 |
Breast Neoplasms |
|
Dietary Fats |
2.25 | 20435547 |
| MESH:D006528 |
Carcinoma, Hepatocellular |
|
2,6-dinitrotoluene |
1.78 | 16705839 |
| MESH:D002471 |
Cell Transformation, Neoplastic |
|
2,6-dinitrotoluene |
2.98 | 6135515 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.05 | 19176532 |
| MESH:D003490 |
Cyanosis |
|
2,6-dinitrotoluene |
4.44 | 18551238 |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.55 | 18249437 |
| MESH:D056486 |
Drug-Induced Liver Injury |
|
2,6-dinitrotoluene |
2.04 | 18551238 21346803 |
| MESH:D050171 |
Dyslipidemias |
|
Dietary Fats |
3.67 | 18367378 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.80 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
Dietary Fats |
8.80 | 17967931 19551842 19004024 18296743 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
8.80 | 19236843 20131406 |
| MESH:D005355 |
Fibrosis |
|
Dietary Fats |
3.94 | 18296743 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.71 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.41 | 18467677 19176532 16221962 19772884 |
| MESH:D006937 |
Hypercholesterolemia |
|
Dietary Fats |
3.92 | 21332399 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.49 | 20558911 |
| MESH:D006949 |
Hyperlipidemias |
|
Dietary Fats |
3.97 | 21332399 |
| MESH:D007249 |
Inflammation |
|
Dietary Fats |
2.57 | 20412841 |
| MESH:D007333 |
Insulin Resistance |
|
Dietary Fats |
7.89 | 18457598 11836018 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
7.89 | 16306350 |
| MESH:D007680 |
Kidney Neoplasms |
|
2,6-dinitrotoluene |
3.24 | 16705839 |
| MESH:D007859 |
Learning Disorders |
|
sevoflurane |
5.19 | 19212262 |
| MESH:D008103 |
Liver Cirrhosis |
|
Dietary Fats |
3.03 | 18296743 |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
2,6-dinitrotoluene |
4.74 | 7678174 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
4.74 | 15890375 16377806 20007298 |
| MESH:D008114 |
Liver Neoplasms, Experimental |
|
2,6-dinitrotoluene |
2.72 | 2876784 6135515 2876786 |
| MESH:D008569 |
Memory Disorders |
|
sevoflurane |
5.13 | 19212262 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.92 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.25 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.19 | 16411023 |
| MESH:D009336 |
Necrosis |
|
2,6-dinitrotoluene |
4.32 | 18551238 7678174 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.08 | 17405874 |
| MESH:D009765 |
Obesity |
|
Dietary Fats |
4.64 | 17217161 11836018 21332399 20132043 18674790 20518802 16723640 18457598 19632207 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
4.64 | 20558911 |
| MESH:D009784 |
Occupational Diseases |
|
2,6-dinitrotoluene |
3.74 | 16049721 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.52 | 19058328 |
| MESH:D012640 |
Seizures |
|
2,6-dinitrotoluene |
2.74 | 18551238 |
| MESH:D001749 |
Urinary Bladder Neoplasms |
|
2,6-dinitrotoluene |
2.39 | 16049721 |
| MESH:D014571 |
Urologic Neoplasms |
|
2,6-dinitrotoluene |
4.78 | 10091137 |
| MESH:D015430 |
Weight Gain |
|
Dietary Fats |
4.02 | 16723640 |
| Pathway ID |
Pathway Name |
|---|
| KEGG:00564 |
Glycerophospholipid metabolism |
Related Pathway Information