AutismKB 2.0

Annotation Detail for AGRN


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Basic Information Top
Gene Symbol:AGRN ( FLJ45064 )
Gene Full Name: agrin
Band: 1p36.33
Quick LinksEntrez ID:375790; OMIM: 103320; Uniprot ID:AGRIN_HUMAN; ENSEMBL ID: ENSG00000188157; HGNC ID: 329
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04512ECM-receptor interaction
Pathway IDPathway Name
Axon guidance
No data
No data
Pathway IDPathway Name
500087NCAM1 interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
No data
No data
Desease Name
Myasthenia, limb-girdle, familial
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C068073 Am 580 Am 580 results in decreased expression of AGRN mRNAdecreases expression 16982809
D000499 Allylamine Allylamine results in increased expression of AGRN mRNAincreases expression 15910882
D000643 Ammonium Chloride Ammonium Chloride affects the expression of AGRN mRNAaffects expression 16483693
C004541 biochanin A biochanin A results in decreased expression of AGRN mRNAdecreases expression 12111696
D002166 Camptothecin Camptothecin results in increased expression of AGRN mRNAincreases expression 17374387
D003630 Daunorubicin Daunorubicin results in increased expression of AGRN mRNAincreases expression 17374387
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of AGRN mRNAaffects cotreatment|affects expression 17330099
D005047 Etoposide Etoposide results in increased expression of AGRN mRNAincreases expression 17374387
D007657 Ketone Bodies Ketone Bodies results in increased expression of AGRN mRNAincreases expression 16807920
C006253 pirinixic acid pirinixic acid results in decreased expression of AGRN mRNAdecreases expression 17426115
D011374 Progesterone Progesterone results in increased expression of AGRN proteinincreases expression 16777347
C089730 rosiglitazone rosiglitazone results in decreased expression of AGRN mRNAdecreases expression 16982809
D012643 Selenium Selenium results in increased expression of AGRN mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in increased expression of AGRN mRNAincreases expression 17879257
D014635 Valproic Acid Valproic Acid results in increased expression of AGRN mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in decreased expression of AGRN mRNAdecreases expression 19244175
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of AGRN mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.488875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.1018653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.4716434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.7015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.9016712894 17306315
MESH:D000544 Alzheimer Disease rosiglitazone 2.8519621015
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D001321 Autistic Disorder Valproic Acid 2.0118940202 17688650 19232924 18316065 19460635 17507914 17157402 18558336 18396377 18985861 15238991 18775368 18177632 16609825 20603192
MESH:D001714 Bipolar Disorder Valproic Acid 3.0617594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.1319483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.398888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.1614601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.3417868700
MESH:D001930 Brain Injuries Progesterone 4.2415665606 15845082 15380490
MESH:D001943 Breast Neoplasms decitabine 2.0919208741 18320071
MESH:D001943 Breast Neoplasms Etoposide 2.0916322251
MESH:D001943 Breast Neoplasms Progesterone 2.0917614352 16175315 15562024
MESH:D001943 Breast Neoplasms vorinostat 2.0916144943
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 1.9816507464 17306315 15276417
MESH:D002294 Carcinoma, Squamous Cell decitabine 4.7819215824
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7818572023
MESH:D002386 Cataract Am 580 4.3417460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.9720056578 19524636
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D002779 Cholestasis pirinixic acid 2.8119176532
MESH:D003092 Colitis Am 580 9.9117035595
MESH:D003092 Colitis Selenium 9.9117936198
MESH:D003110 Colonic Neoplasms decitabine 2.3317616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.718888407 17688650 16575769
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7119769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4118249437
MESH:D003920 Diabetes Mellitus rosiglitazone 4.2817446233
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 2.9312642470
MESH:D003929 Diabetic Neuropathies Progesterone 4.4817187935
MESH:D003967 Diarrhea vorinostat 4.4820479100
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9915131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 3.9919641884 1733752
MESH:D004421 Dystonia Valproic Acid 4.031851702
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004487 Edema pirinixic acid 6.9412083418
MESH:D004487 Edema rosiglitazone 6.9412083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.7617692515
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.1219294695
MESH:D004715 Endometriosis Progesterone 3.7516134523
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.143659116 17275665
MESH:D004828 Epilepsies, Partial Valproic Acid 3.9216628512 3922381
MESH:D004827 Epilepsy Valproic Acid 2.9220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.576254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.287750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.063659116
MESH:D005221 Fatigue vorinostat 5.5920479100
MESH:D005234 Fatty Liver pirinixic acid 13.1120131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 13.1119196556
MESH:D005234 Fatty Liver Valproic Acid 13.1114986274 19224547
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6716452187
MESH:D005909 Glioblastoma biochanin A 4.4516598420
MESH:D006258 Head and Neck Neoplasms decitabine 3.4719215824
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9816080930
MESH:D006333 Heart Failure pirinixic acid 6.9120558911
MESH:D006333 Heart Failure Selenium 6.9117162251
MESH:D006529 Hepatomegaly pirinixic acid 2.9818467677 16221962 19176532 19772884
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916863852 16490937
MESH:D006561 Herpes Simplex Etoposide 4.5510809021
MESH:D006689 Hodgkin Disease Etoposide 7.5916135485 18180244 15147373 16200630 17606976
MESH:D006689 Hodgkin Disease sodium arsenite 7.5912676792
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006930 Hyperalgesia rosiglitazone 3.9012083418
MESH:D006943 Hyperglycemia pirinixic acid 3.1620558911
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.3915869954
MESH:D007248 Infertility, Male decitabine 6.8617581917
MESH:D007248 Infertility, Male sodium arsenite 6.8615346721 12646999
MESH:D007249 Inflammation Progesterone 5.4115869954
MESH:D007249 Inflammation rosiglitazone 5.4112083418
MESH:D007251 Influenza, Human Selenium 10.9616624496
MESH:D007251 Influenza, Human Vitamin E 10.9616624496
MESH:D007333 Insulin Resistance pirinixic acid 7.4616306350
MESH:D007333 Insulin Resistance rosiglitazone 7.4616306350
MESH:D007674 Kidney Diseases sodium arsenite 6.1520008137
MESH:D007674 Kidney Diseases Vitamin E 6.1512488133
MESH:D007676 Kidney Failure, Chronic Selenium 3.8716518626
MESH:D007938 Leukemia decitabine 3.0618980019 19235587
MESH:D007951 Leukemia, Myeloid decitabine 3.9817236224 18454857 19117987
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute decitabine 3.9819387464 18704418 19010910 18206229 17679729 18460780
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.9816294345 17596541
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.4618055864
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5615474484
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 3.5617347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5616169303
MESH:D008113 Liver Neoplasms pirinixic acid 4.4616377806 15890375 20007298
MESH:D008113 Liver Neoplasms sodium arsenite 4.4616712894 15276417
MESH:D008171 Lung Diseases sodium arsenite 7.3919095001
MESH:D008171 Lung Diseases Vitamin E 7.3916863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D008175 Lung Neoplasms sodium arsenite 2.5416712894 17306315 17077188 15276417 19931552
MESH:D008175 Lung Neoplasms Vitamin E 2.5411062179
MESH:D008223 Lymphoma decitabine 7.8419470736
MESH:D008223 Lymphoma Etoposide 7.8412854902 12556972
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.6720479100
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.0211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 10.0216827153
MESH:D008325 Mammary Neoplasms, Experimental Selenium 10.0215318939
MESH:D008545 Melanoma decitabine 3.4416505122 17785578
MESH:D008545 Melanoma sodium arsenite 3.4416487513 19082730
MESH:D008654 Mesothelioma Selenium 2.7815107826
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.3617261469
MESH:D008881 Migraine Disorders Valproic Acid 3.1718803445 18765137
MESH:D009101 Multiple Myeloma decitabine 3.3318172295
MESH:D009135 Muscular Diseases pirinixic acid 3.4916239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
OMIM:254300 MYASTHENIA, LIMB-GIRDLE, FAMILIAL marker/mechanism
MESH:D009190 Myelodysplastic Syndromes decitabine 7.4718608210 19010910 16882708 19157545
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 7.4717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1319151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9316411023
MESH:D009325 Nausea vorinostat 5.5220479100
MESH:D009369 Neoplasms decitabine 8.2219470736 17925555 19116145
MESH:D009369 Neoplasms pirinixic acid 8.2217405874
MESH:D009369 Neoplasms sodium arsenite 8.2211559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.6520056578
MESH:D009436 Neural Tube Defects sodium arsenite 7.2912854658
MESH:D009436 Neural Tube Defects Valproic Acid 7.298888407 16359493
MESH:D009765 Obesity pirinixic acid 1.8120558911
MESH:D010051 Ovarian Neoplasms decitabine 7.9219259094 19331143
MESH:D010051 Ovarian Neoplasms Progesterone 7.9216525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 7.9215276417 17306315
MESH:D010190 Pancreatic Neoplasms decitabine 5.6519294695
MESH:D010190 Pancreatic Neoplasms Etoposide 5.6519003803
MESH:D010954 Plasmacytoma Selenium 4.8915087411
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Daunorubicin 4.7621297632
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 3.8220603192
MESH:D055728 Primary Myelofibrosis decitabine 4.7117616702
MESH:D011471 Prostatic Neoplasms biochanin A 1.9312111696
MESH:D011471 Prostatic Neoplasms Etoposide 1.9317172428
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9316039940
MESH:D011471 Prostatic Neoplasms Vitamin E 1.9315084515
MESH:D011471 Prostatic Neoplasms vorinostat 1.9317218635
MESH:D019310 Pseudolymphoma Valproic Acid 4.5411422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.3819058328
MESH:D012208 Rhabdomyosarcoma decitabine 10.9219155313
MESH:D012208 Rhabdomyosarcoma Valproic Acid 10.9219155313
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8518045962
MESH:D012512 Sarcoma, Ewing's Etoposide 4.6914601052
MESH:D012559 Schizophrenia Valproic Acid 2.0715737665 19110320
MESH:D012640 Seizures Valproic Acid 2.7214763951 11044598 16876388 3137016 1511512 15475178 11738929 17978042
MESH:D012871 Skin Diseases Vitamin E 2.4418709164
MESH:D012878 Skin Neoplasms sodium arsenite 2.6918572023 19524636
MESH:D013119 Spinal Cord Injuries Progesterone 4.2715862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 9.4912854658
MESH:D016135 Spinal Dysraphism Valproic Acid 9.4919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D024801 Tauopathies Camptothecin 12.1916930453
MESH:D024801 Tauopathies Daunorubicin 12.1916930453
MESH:D013921 Thrombocytopenia vorinostat 4.9520479100
MESH:D013964 Thyroid Neoplasms decitabine 3.3117967635
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.2217616700 19087683
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2217306315 16712894 16452187 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7511813266
MESH:D014604 Uveal Neoplasms decitabine 4.9117785578
MESH:D014652 Vascular Diseases sodium arsenite 4.4217056641
Pathway ID Pathway Name
REACT:18266 Axon guidance
KEGG:04512 ECM-receptor interaction
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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