AutismKB 2.0

Annotation Detail for KCNJ4


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Basic Information Top
Gene Symbol:KCNJ4 ( HIR,HIRK2,HRK1,IRK-3,IRK3,Kir2.3,MGC142066,MGC142068 )
Gene Full Name: potassium inwardly-rectifying channel, subfamily J, member 4
Band: 22q13.1
Quick LinksEntrez ID:3761; OMIM: 600504; Uniprot ID:IRK4_HUMAN; ENSEMBL ID: ENSG00000168135; HGNC ID: 6265
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of KCNJ4 mRNAincreases expression 16788091
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNJ4 mRNAaffects expression 16483693
D001464 Barium Barium inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 11283229
D001464 Barium Barium results in decreased activity of KCNJ4 proteindecreases activity 12598232
D001464 Barium Barium inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 17091215
D002259 Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 12118013
D002713 Chlorine Chlorine results in decreased expression of KCNJ4 mRNAdecreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of KCNJ4 mRNAaffects cotreatment|decreases expression 18636392
D005419 Flavonoids Flavonoids results in decreased expression of KCNJ4 mRNAdecreases expression 18035473
D019810 Sodium Azide Sodium Azide inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 12118013
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of KCNJ4 mRNAaffects cotreatment|decreases expression 18636392
D010126 Ozone Ozone results in decreased expression of KCNJ4 mRNAdecreases expression 16716893
D010622 Phencyclidine Phencyclidine results in increased expression of KCNJ4 mRNAincreases expression 17266109
D011188 Potassium Barium inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 11283229
D011188 Potassium KCNJ4 protein results in increased transport of Potassiumincreases transport 11283229
D011188 Potassium KCNJ4 protein results in increased transport of Potassiumincreases transport 12598232
D011188 Potassium Barium inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 17091215
D011188 Potassium Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 12118013
D011188 Potassium KCNJ4 protein results in increased transport of Potassiumincreases transport 12118013
17091215
D011188 Potassium Sodium Azide inhibits the reaction [KCNJ4 protein results in increased transport of Potassium]decreases reaction|increases transport 12118013
D012402 Rotenone KCNJ4 protein results in decreased susceptibility to Rotenonedecreases response to substance 18619942
D012402 Rotenone Tetradecanoylphorbol Acetate inhibits the reaction [KCNJ4 protein results in decreased susceptibility to Rotenone]decreases reaction|decreases response to substance 18619942
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate inhibits the reaction [KCNJ4 protein results in decreased susceptibility to Rotenone]decreases reaction|decreases response to substance 18619942
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury Chlorine 4.4420601635
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6617854713 16373670
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7615516495 19059883 18315731 14754758 18417511 16777450 17626835
MESH:D002100 Cachexia Ozone 4.8916183385
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 2.9918922899
MESH:D004417 Dyspnea Chlorine 4.8020016425
MESH:D004487 Edema Tetradecanoylphorbol Acetate 3.728273558 11698051 8113982 15177302 7812673 16716910 9599246
MESH:D005739 Gas Poisoning Chlorine 5.1820016425
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 6.0119822448
MESH:D007249 Inflammation Flavonoids 5.6317296493
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 5.638273558 11698051 7812673 7562506 15177302
MESH:D008171 Lung Diseases Ozone 3.458266340 19066396
MESH:D055370 Lung Injury Ozone 3.9920417186
MESH:D008175 Lung Neoplasms Ozone 2.868597069 7614698
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 2.8611807781
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.428985016
MESH:D008679 Metaplasia Ozone 5.2810496685
MESH:D009410 Nerve Degeneration therapeutic 18619942
MESH:D009410 Nerve Degeneration Rotenone 3.9617356569 18619942 15790535
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1715976015
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.438330346 18922899 18404319 12065085
MESH:D010300 Parkinson Disease therapeutic 18619942
MESH:D010300 Parkinson Disease Rotenone 3.0115451049 19114014 16140633 11535288 16412576 11445065 18191903 19232380 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.1818197244 15574749 15795934 15927086
MESH:D010538 Peritonitis Ozone 4.2716369182
MESH:D011014 Pneumonia Ozone 4.5518381685 18929643 18007984
MESH:D012120 Respiration Disorders Chlorine 5.3918579056
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 3.3212065085 8330346 8985016 18404319 11807781
Pathway ID Pathway Name
REACT:13685 Synaptic Transmission
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30048
    • No data
    No data
    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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