AutismKB 2.0

Annotation Detail for KCNJ16


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Basic Information Top
Gene Symbol:KCNJ16 ( BIR9,KIR5.1,MGC33717 )
Gene Full Name: potassium inwardly-rectifying channel, subfamily J, member 16
Band: 17q24.3
Quick LinksEntrez ID:3773; OMIM: 605722; Uniprot ID:IRK16_HUMAN; ENSEMBL ID: ENSG00000153822; HGNC ID: 6262
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04971Gastric acid secretion
No data
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No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of KCNJ16 mRNAincreases expression 18648102
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of KCNJ16 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNJ16 mRNAaffects expression 16483693
C006780 bisphenol A bisphenol A affects the expression of KCNJ16 mRNAaffects expression 20170705
D016572 Cyclosporine Cyclosporine results in decreased expression of KCNJ16 mRNAdecreases expression 20106945
D004317 Doxorubicin Doxorubicin results in decreased expression of KCNJ16 mRNAdecreases expression 16404146
D004958 Estradiol Estradiol results in decreased expression of KCNJ16 mRNAdecreases expression 20106945
D005419 Flavonoids Flavonoids results in decreased expression of KCNJ16 mRNAdecreases expression 18035473
D011188 Potassium KCNJ16 protein affects the transport of Potassiumaffects transport 18023363
D011374 Progesterone Progesterone results in increased expression of KCNJ16 mRNAincreases expression 18070364
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KCNJ16 mRNAdecreases expression 20106945
D014415 Tunicamycin Tunicamycin results in decreased expression of KCNJ16 mRNAdecreases expression 17127020
C025643 vinclozolin vinclozolin affects the expression of KCNJ16 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6818287403
MESH:D000230 Adenocarcinoma Doxorubicin 4.5617418594
MESH:D000230 Adenocarcinoma Estradiol 4.5611473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000419 Albuminuria Doxorubicin 4.6421441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001008 Anxiety Disorders vinclozolin 3.7019015723
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8314601052
MESH:D001862 Bone Resorption bisphenol A 3.9411985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.8817150277
MESH:D001943 Breast Neoplasms bisphenol A 2.3617123778
MESH:D001943 Breast Neoplasms Doxorubicin 2.3611325840 18628466 15993339 19526202 17369602 18695136 16935488 16264153 15634643 16096432 15994142 15939500 17426702 15136595 15567936 15668708 15692762 16595493 16826403 16322301 16115903 17983394 18234424 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.3617261762 16675129 17289903 14630087 12948864 19861407 17018787 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.3617614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9416051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.697296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.6912619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 6.6917876044 16023760 16234567 18059187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.6916924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1117123778
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 6.677296757
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6716201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 2.656189445
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.5815811867 17351982 17924179 16651473 17382496 16364871 16242529 15476868 17974986 17519947 16612575 17131338 17928571 16731534 17007740 15505089 15792986 17308081 16455267 17329180 16278810 18627295 16952015 16269455 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9717334414 16243910
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.477505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.4712371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.4718566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.0819486331 9022650
MESH:D002779 Cholestasis Cyclosporine 8.0819486331
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1315340226 16354765 8697196 12621046 15668235
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418259882 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.4414966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9011906362 8156756 11298694 12868966 8970840 18759878 14531868 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.369653073 1440618 9022650 18289764 9328219 18692083 18648102 7440962 8291058 11289319 6482804 6679447 16192314
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 6.3617416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3620420201
MESH:D004362 Drug Toxicity Doxorubicin 8.3118602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3111462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0416714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8717692515
MESH:D016889 Endometrial Neoplasms Doxorubicin 7.7117359293
MESH:D016889 Endometrial Neoplasms Estradiol 7.7111473722 19148513 18566989
MESH:D004715 Endometriosis Progesterone 9.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.199294722 10568697
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.2918037988
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.123581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Cyclosporine 2.9419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7019069698
MESH:D005355 Fibrosis Cyclosporine 8.8312168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8320067830
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.0516973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.4316417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.348708960
MESH:D005909 Glioblastoma Doxorubicin 3.4017150277
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5815692506
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.5416244371 16495754 16330681 14766674 17888722 18006777 12587719 17875725 16707910 16244372 18674790 16879835 16144979
MESH:D006333 Heart Failure Doxorubicin 3.3917481944
MESH:D006394 Hemangiosarcoma Doxorubicin 3.9815692506
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease Doxorubicin 3.4815147373 18501091 17606976
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1815340226 16354765 8697196 18606429 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0415034207
MESH:D006973 Hypertension Cyclosporine 5.0410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.0418670907 18850075
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.9819822448
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007248 Infertility, Male vinclozolin 3.0916467254
MESH:D007249 Inflammation Flavonoids 8.5717296493
MESH:D007249 Inflammation Progesterone 8.5715869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.5712200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 7.6116393666
MESH:D007333 Insulin Resistance Estradiol 7.6116627594 16393666
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5815604871
MESH:D007674 Kidney Diseases Cyclosporine 10.358314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 10.3515699352 15369732 16775033
MESH:D007674 Kidney Diseases Estradiol 10.3515618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.2316707910
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.776582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.7712371664
MESH:D007680 Kidney Neoplasms Estradiol 12.7715610895
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.2916085563
MESH:D007984 Leydig Cell Tumor vinclozolin 4.8516417039
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5316595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5314659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5312878042
MESH:D008113 Liver Neoplasms Aflatoxin B1 4.5418177683 15890375 9163691 2125692
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.5416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.54598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 14.548603461
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.5416842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.5412151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.4814755239
MESH:D008175 Lung Neoplasms Doxorubicin 3.486189445 17418594
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D008223 Lymphoma Doxorubicin 3.5216098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.8617654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.6715621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.3315458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.3311807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 10.3317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008654 Mesothelioma Doxorubicin 3.0917638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9216801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.5815792986
MESH:D052016 Mucositis Doxorubicin 4.9117415656
MESH:D009203 Myocardial Infarction Doxorubicin 2.9819429709 15857846
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.943581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9418259882
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009401 Nephrosis Doxorubicin 4.8716636307 16899518
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 9.5419348381 18481113
MESH:D009404 Nephrotic Syndrome Doxorubicin 9.5416889571 15640375
MESH:D009421 Nervous System Malformations bisphenol A 16.9316427766 11399458
MESH:D009421 Nervous System Malformations Estradiol 16.9316427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D009447 Neuroblastoma Doxorubicin 3.3015555623
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D012516 Osteosarcoma Doxorubicin 4.1815930896
MESH:D010049 Ovarian Diseases bisphenol A 5.1111985600
MESH:D010051 Ovarian Neoplasms Estradiol 4.9519401270
MESH:D010051 Ovarian Neoplasms Progesterone 4.9517393432 16525653
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.2917983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.2917638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2912371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 16.9710548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.9711118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.9719015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.0518220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 10.8320887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 10.8320887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6016740699
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.6016888761 16729912 16868541 18437689 15749863 15897917
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011472 Prostatitis vinclozolin 5.0518629315
MESH:D011565 Psoriasis Cyclosporine 2.2516882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9010548101
MESH:D051437 Renal Insufficiency Doxorubicin 4.3317922066
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012509 Sarcoma Doxorubicin 4.0616767912 18313854 15625365 17203757 17710206 15675481
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3414601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9117846226
MESH:D012878 Skin Neoplasms Doxorubicin 5.8115692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.6715625365 17203757 16767912
MESH:D013119 Spinal Cord Injuries Progesterone 4.4016503802 15862959
MESH:D019966 Substance-Related Disorders bisphenol A 4.1016684133 16045194
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.473712494 6582329 1399818 6587162 7505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.4717909728 16010429
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2817653716
MESH:D014591 Uterine Diseases bisphenol A 5.1414652134
MESH:D014605 Uveitis Cyclosporine 4.121336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3317678736 17638931 17334414 16364871
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5817120751
Pathway ID Pathway Name
KEGG:04971 Gastric acid secretion
REACT:13685 Synaptic Transmission
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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