AutismKB 2.0

Annotation Detail for KCNK3


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Basic Information Top
Gene Symbol:KCNK3 ( K2p3.1,OAT1,TASK,TASK-1,TBAK1 )
Gene Full Name: potassium channel, subfamily K, member 3
Band: 2p23.3
Quick LinksEntrez ID:3777; OMIM: 603220; Uniprot ID:KCNK3_HUMAN; ENSEMBL ID: ENSG00000171303; HGNC ID: 6278
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
P043745HT2 type receptor mediated signaling pathway
P043765HT4 type receptor mediated signaling pathway
P043755HT3 type receptor mediated signaling pathway
P043735HT1 type receptor mediated signaling pathway
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Related Diseases/Disorders Top
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Desease IDDesease Name
1807Autoimmune disease
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of KCNK3 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNK3 mRNAaffects expression 16483693
C024986 barium chloride barium chloride results in decreased activity of KCNK3 proteindecreases activity 16020457
D016572 Cyclosporine Cyclosporine results in increased expression of KCNK3 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KCNK3 mRNAincreases expression 15212814
D012701 Serotonin Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium]decreases reaction|increases transport 16020457
D011188 Potassium [KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassiumaffects binding|increases transport 18568022
D011188 Potassium KCNK3 protein results in increased transport of Potassiumincreases transport 18568022
D011188 Potassium sanshool inhibits the reaction [[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium]affects binding|decreases reaction|increases transport 18568022
D011188 Potassium sanshool inhibits the reaction [KCNK3 protein results in increased transport of Potassium]decreases reaction|increases transport 18568022
D011188 Potassium KCNK3 protein results in increased transport of Potassiumincreases transport 16020457
D011188 Potassium Serotonin inhibits the reaction [KCNK3 protein results in increased transport of Potassium]decreases reaction|increases transport 16020457
D011374 Progesterone Progesterone results in decreased expression of KCNK3 mRNAdecreases expression 18070364
C100574 sanshool KCNK3 protein affects the susceptibility to sanshoolaffects response to substance 18568022
C100574 sanshool sanshool inhibits the reaction [[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium]affects binding|decreases reaction|increases transport 18568022
C100574 sanshool sanshool inhibits the reaction [KCNK3 protein results in increased transport of Potassium]decreases reaction|increases transport 18568022
C100574 sanshool sanshool results in decreased activity of KCNK3 proteindecreases activity 18568022
C100574 sanshool sanshool results in decreased activity of [KCNK3 protein binds to KCNK9 protein]affects binding|decreases activity 18568022
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Serotonin 3.4518062943 19221690 18405062 18361446 15132762 8570775 17157402
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001919 Bradycardia Serotonin 5.768112388
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6617868700
MESH:D001930 Brain Injuries Progesterone 4.5215665606 15380490 15845082
MESH:D001943 Breast Neoplasms Progesterone 2.4317614352 15562024 16175315
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.763581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.307505956
MESH:D002471 Cell Transformation, Neoplastic barium chloride 12.308243401
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 12.3012371664
MESH:D002659 Child Development Disorders, Pervasive Serotonin 4.2321254450
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.2719486331 9022650
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2716919318 17333356 17681005 11677210 16105132 15861022 17110522
MESH:D021081 Chronobiology Disorders Serotonin 7.0117157402
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.062524372 11906362 18759878 11298694 8156756 8970840 12868966 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003929 Diabetic Neuropathies Progesterone 4.7517187935
MESH:D003967 Diarrhea Serotonin 5.0011488427 10446763 8112388
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.001440618 9328219 8291058 18289764 9022650 18692083 18648102 16192314 11289319 6679447 9653073 6482804 7440962
MESH:D004487 Edema Serotonin 4.6718841975
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.8412538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.8417692515
MESH:D004715 Endometriosis Progesterone 3.9616134523
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005234 Fatty Liver Cyclosporine 8.2719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 3.4012639820 12168785
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 2.1610903974
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 6.1419822448
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6615869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Progesterone 2.6915869954
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.448314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.651399818 598648 3712494 6587162
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9917203775 11408345
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4718481113 19348381
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010051 Ovarian Neoplasms Progesterone 2.5816525653 17393432
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5615862959 16503802
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.046582329 7505956 1399818 3712494 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7515869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
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Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30060
    • No data
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    Releated drug ID Related drug Name
    PA452249antiarrhythmics, class i and iii
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00561 antagonist Doxapram Central Nervous System Stimulants;Respiratory System Agents
    DB01159 binder Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
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    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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