AutismKB 2.0

Annotation Detail for KCNMA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KCNMA1 ( BKTM,DKFZp686K1437,KCa1.1,MGC71881,MaxiK,SAKCA,SLO,SLO-ALPHA,SLO1,bA205K10.1,mSLO1 )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Band: 10q22.3
Quick LinksEntrez ID:3778; OMIM: 600150; Uniprot ID:KCMA1_HUMAN; ENSEMBL ID: ENSG00000156113; HGNC ID: 6284
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
hsa04970Salivary secretion
hsa04972Pancreatic secretion
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1789Movement disorder
1799Epilepsy
1831Prostate cancer
1878Ischemia
2062Neurodegenerative disorder
No data
Desease Name
Mortality among heart failure patients
Desease Name
Generalized epilepsy and paroxysmal dyskinesia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of KCNMA1 mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in increased expression of KCNMA1 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of KCNMA1 mRNAdecreases expression 20064835
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of KCNMA1 mRNAincreases expression 16644059
18339082
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of KCNMA1 proteinincreases expression 18339082
17229879
D003907 Dexamethasone Dexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 mRNA]decreases expression|decreases reaction 15088113
D003907 Dexamethasone Dexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 protein]decreases expression|decreases reaction 15088113
D004041 Dietary Fats Dietary Fats results in increased expression of KCNMA1 mRNAincreases expression 18042831
D004958 Estradiol Estradiol results in increased activity of KCNMA1 proteinincreases activity 18068743
D004958 Estradiol iberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D004958 Estradiol Progesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D004958 Estradiol Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D004958 Estradiol Estradiol results in decreased expression of KCNMA1 mRNAdecreases expression 16102753
D004958 Estradiol Estradiol results in decreased expression of KCNMA1 mRNA alternative formdecreases expression 16102753
D004958 Estradiol Estradiol results in decreased expression of KCNMA1 proteindecreases expression 16102753
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]decreases expression|decreases reaction 16102753
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]decreases expression|decreases reaction 16102753
D004958 Estradiol fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein]decreases expression|decreases reaction 16102753
C043090 estradiol-bovine serum albumin estradiol-bovine serum albumin results in increased activity of KCNMA1 proteinincreases activity 18068743
C043090 estradiol-bovine serum albumin iberiotoxin inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
C043090 estradiol-bovine serum albumin Tetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D000431 Ethanol Ethanol results in increased activity of KCNMA1 proteinincreases activity 16626657
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of KCNMA1 mRNAdecreases expression 17557909
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA]decreases expression|decreases reaction 16102753
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 mRNA alternative form]decreases expression|decreases reaction 16102753
C070081 fulvestrant fulvestrant inhibits the reaction [Estradiol results in decreased expression of KCNMA1 protein]decreases expression|decreases reaction 16102753
C064719 iberiotoxin iberiotoxin inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
C064719 iberiotoxin iberiotoxin inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
C064719 iberiotoxin iberiotoxin results in decreased activity of KCNMA1 proteindecreases activity 20050851
C007350 nitrofen Dexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 mRNA]decreases expression|decreases reaction 15088113
C007350 nitrofen Dexamethasone inhibits the reaction [nitrofen results in decreased expression of KCNMA1 protein]decreases expression|decreases reaction 15088113
C007350 nitrofen nitrofen results in decreased expression of KCNMA1 mRNAdecreases expression 15088113
C007350 nitrofen nitrofen results in decreased expression of KCNMA1 proteindecreases expression 15088113
D017239 Paclitaxel KCNMA1 protein affects the susceptibility to Paclitaxelaffects response to substance 16217747
C041786 palm oil palm oil results in increased expression of KCNMA1 mRNAincreases expression 18042831
D011188 Potassium KCNMA1 protein results in increased transport of Potassiumincreases transport 16020453
D011374 Progesterone Progesterone inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D011374 Progesterone Progesterone results in decreased activity of KCNMA1 proteindecreases activity 18068743
D011374 Progesterone Progesterone results in increased expression of KCNMA1 mRNAincreases expression 16102753
D011374 Progesterone Progesterone results in increased expression of KCNMA1 mRNA alternative formincreases expression 16102753
D019789 Tetraethylammonium Tetraethylammonium inhibits the reaction [estradiol-bovine serum albumin results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D019789 Tetraethylammonium Tetraethylammonium inhibits the reaction [Estradiol results in increased activity of KCNMA1 protein]decreases reaction|increases activity 18068743
D014050 Toluene Toluene results in decreased activity of KCNMA1 proteindecreases activity 16626657
D019772 Topotecan KCNMA1 protein affects the susceptibility to Topotecanaffects response to substance 16217747
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of KCNMA1 mRNAdecreases expression 17951470
C025643 vinclozolin vinclozolin affects the expression of KCNMA1 mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 3.7918926900 17676605
MESH:D000138 Acidosis Ethanol 4.3711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 9.8811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.8820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 9.8811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.8814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.586695378
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.1915451039 15451040
MESH:D000853 Anophthalmos Ethanol 4.6915513904
MESH:D001008 Anxiety Disorders Ethanol 8.6611141031
MESH:D001008 Anxiety Disorders vinclozolin 8.6619015723
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.9419183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6920041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 9.4715238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 9.4711256880
MESH:D001169 Arthritis, Experimental Dexamethasone 7.1117659584
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.1115885639
MESH:D001281 Atrial Fibrillation Amiodarone 3.8019698954 18651412
MESH:D001284 Atrophy fulvestrant 4.7211514358
MESH:D001321 Autistic Disorder marker/mechanism 16946189
MESH:D001778 Blood Coagulation Disorders Amiodarone 8.8719483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 8.8716206674
MESH:D001859 Bone Neoplasms Paclitaxel 4.4415867366
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2117868700
MESH:D001930 Brain Injuries Progesterone 4.1315665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9120146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.9120435547
MESH:D001943 Breast Neoplasms Estradiol 2.9116675129 17289903 17018787 19861407 14630087 18497071 17261762 12948864
MESH:D001943 Breast Neoplasms fulvestrant 2.9118984771
MESH:D001943 Breast Neoplasms Paclitaxel 2.9115136595 18223236 16244791 11325840 16273361 18234424 18323546 16115903
MESH:D001943 Breast Neoplasms Progesterone 2.9115562024 17614352 16175315
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002056 Burns Ethanol 4.5216374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6516124888 16227642 16192424 15721981 16097048 15700767 10355542 15673190 3786805 18705752 16050911 16011737
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 8.6715553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.6718788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.6716924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 8.6718788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 8.6716313753
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0120419170
MESH:D006332 Cardiomegaly Ethanol 3.3719332462
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8515710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.9518974383
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.6818566989
MESH:D002547 Cerebral Palsy Toluene 5.729294310
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7811677210 17681005 17333356 16919318 17110522 16105132 15861022
MESH:D002971 Cleft Lip Ethanol 3.5215513904
MESH:D002972 Cleft Palate Ethanol 3.1215513904
MESH:D003110 Colonic Neoplasms Dexamethasone 2.4715824018
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6820501625
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.6818802399
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 7.2410525206
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.2417728286
MESH:D019465 Craniofacial Abnormalities Ethanol 7.2415451040 15451039 11873399 19302082 11198716 10194807 15513904
MESH:D019465 Craniofacial Abnormalities nitrofen 7.2411405365
MESH:D019465 Craniofacial Abnormalities Toluene 7.249294310
MESH:D003456 Cryptorchidism vinclozolin 4.2114966744
MESH:D003643 Death Toluene 5.546431079
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.2812438553
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3617187935
MESH:D003967 Diarrhea Dexamethasone 3.577237001
MESH:D056486 Drug-Induced Liver Injury Amiodarone 6.1515265979 18218290
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.154309450 10092053 9327722 19085960 7179309 19336974 2869522 15968718 7440962 3732212 21278145 11566570 17522070 7120509 16177239 6623471 10915739 15998439 16227642 3786805 6884620 15027814
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.1511566570
MESH:D050171 Dyslipidemias Dietary Fats 3.3618367378
MESH:D004485 Eczema Dexamethasone 4.3312438553
MESH:D004487 Edema Dexamethasone 3.2919703484
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.6112538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.6117692515
MESH:D016889 Endometrial Neoplasms Estradiol 2.9011473722 18566989 19148513
MESH:D004715 Endometriosis Progesterone 3.6516134523
MESH:D004938 Esophageal Neoplasms arsenic trioxide 10.1712903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.1716530937
MESH:D004938 Esophageal Neoplasms Ethanol 10.1716704527
MESH:D004938 Esophageal Neoplasms Paclitaxel 10.1716481741
MESH:D005234 Fatty Liver Amiodarone 29.1614986274
MESH:D005234 Fatty Liver arsenic trioxide 29.1615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.1615959796 16045604 12795759 61145 12631006 17595544 19224547 16239168
MESH:D005234 Fatty Liver Dietary Fats 29.1619004024 17967931 18296743 19551842
MESH:D005234 Fatty Liver Ethanol 29.1619236843 18620774 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.1615345470
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5417920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1716946407 10194807 15451040 15513904
MESH:D005355 Fibrosis Carbon Tetrachloride 8.3818705752
MESH:D005355 Fibrosis Dietary Fats 8.3818296743
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005756 Gastritis Ethanol 4.5615046732
OMIM:609446 GENERALIZED EPILEPSY AND PAROXYSMAL DYSKINESIA marker/mechanism
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.8016973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.1716417039
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital nitrofen 6.9216080930
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719110552 19900420
MESH:D006529 Hepatomegaly Amiodarone 3.6215265979
MESH:D006548 Hernia, Diaphragmatic marker/mechanism 15088113
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 6.287520565
MESH:D006548 Hernia, Diaphragmatic nitrofen 6.2815793718 15764645 12194112 17270546 16490937 10646786 8863223 7576705 12505043 16473863 15756563 9575882 7760232 9476886 15136996 11685700 10370016 9473106 12407540 18280291 11057544 16080930 11329586 10541330 15088113 17618886 18958481 11051153 11076806 10898222 17245593 12547725 18280292 10370017 9859898 10359170 16720372 12746050 12021965 16863852 15185205 11588001 9698600 15707848 10693666 16292651 12759764 15578192 11409163 11584395 12904592 7520565 10898224
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006930 Hyperalgesia Ethanol 3.6118783367
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D006937 Hypercholesterolemia Amiodarone 8.778137927 9751232
MESH:D006937 Hypercholesterolemia Dietary Fats 8.7721332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.4921332399
MESH:D006973 Hypertension Dexamethasone 2.8817042910
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.7319822448
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6816945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 4.3817991464 18020914
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2715869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.3412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 10.8117937319
MESH:D007248 Infertility, Male fulvestrant 10.8111514358
MESH:D007248 Infertility, Male vinclozolin 10.8116467254
MESH:D007249 Inflammation Dexamethasone 8.058960868 11099482
MESH:D007249 Inflammation Dietary Fats 8.0520412841
MESH:D007249 Inflammation Progesterone 8.0515869954
MESH:D007333 Insulin Resistance Dietary Fats 7.0911836018 18457598
MESH:D007333 Insulin Resistance Estradiol 7.0916393666 16627594
MESH:D007569 Jaw Abnormalities Ethanol 4.2915513904
MESH:D007674 Kidney Diseases Estradiol 2.5115618244
MESH:D007680 Kidney Neoplasms Estradiol 2.8715610895
MESH:D007859 Learning Disorders Ethanol 4.0815451040
MESH:D007938 Leukemia arsenic trioxide 2.7715070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.6419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1216467208 20471514 19850784 16968895 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.1312018890 11161223 16331271 15336539 15748426 17869043 16823087 15622746 16112521 12679006 12712474 19225113 19075265 16330433 17217047 16966277 17649720 11468182 16891316 15213294 19642359 17712046 9834237 19035177 17107899
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2216882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.6016417039
MESH:D017880 Limb Deformities, Congenital Ethanol 3.7217676605
MESH:D008064 Lipidoses Amiodarone 3.4217567588 15342952
MESH:D008080 Liposarcoma Paclitaxel 4.7017353645
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 10.6811408273 21278145 16943688 16239168 11903743 17174718 17334410 17157831 16221502
MESH:D008103 Liver Cirrhosis Dietary Fats 10.6818296743
MESH:D008103 Liver Cirrhosis Ethanol 10.6815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9718295389
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.8818251166 15123356 15931870 16027843 15338365 12632512 17708605 12741479 18054572 15362042 17869086 17631135 18412020 18418968 14716496 14748882 18006644 14724832 18472094 18166357 14620537 12445421 15818738 15057751 15925388 17900296 16248980 10355542 17698563 18277467 12898905 12667390 18210741 17565644 17922224 16192424 12649538 18339082 12389079 18205269 16638106 17766677 12546737 18279442 17481882 15893842 17761835 18395095 15730626 18429990 17805973 18317297 18395914 11481614 12445418 17640975 17557913 16033810 16136751 14716833 15673190 15650968 15370692 18263696 14512876 18481824 17714472 17525996 17823541 17976157 12666154 18420326 12632514 16097048 18376398 17721639 18472332 18187930 16015684 15052691 16011737 13678700 15876570 18705752 16116963 12609069 18156304 17944888 12586293 12958196 15959796 20821823 15996030
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 4.8816718785
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.8814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 4.8818166357
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0517285989 16246199 15720792 15830285 16964402
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5217347304 17207112
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5714706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 7.1614682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.1621137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.1619294768
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.7220377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.7212014681 15583823
MESH:D008133 Long QT Syndrome Amiodarone 7.8617391786 11989578 15350150
MESH:D008133 Long QT Syndrome arsenic trioxide 7.8615213294
MESH:D008171 Lung Diseases Amiodarone 7.6812587719
MESH:D008171 Lung Diseases nitrofen 7.6816863852 9614859 9859898 17245593
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.3518516814
MESH:D008175 Lung Neoplasms arsenic trioxide 3.4111798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.4120869020 18569708 20064080 18816296 20135361 20464547 6695378 17053015 18520028
MESH:D008175 Lung Neoplasms Dexamethasone 3.4115824018 11195469
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 3.9814749477
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.7817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008545 Melanoma Paclitaxel 2.5712025231 12040289 16342250
MESH:D008569 Memory Disorders Ethanol 4.0615451040 18411066
MESH:D008607 Mental Retardation Toluene 3.619294310
MESH:D019957 Motor Skills Disorders Toluene 5.119294310
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0916381670
MESH:D009101 Multiple Myeloma arsenic trioxide 11.6919417148 19549372 11468182 14977855 15949261
MESH:D009101 Multiple Myeloma Dexamethasone 11.6915744524 15867202 16118317
MESH:D009101 Multiple Myeloma Paclitaxel 11.6914749477
MESH:D009181 Mycoses Amiodarone 4.7712754197 17974566
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.3116105982 16882451
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.319809623
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1816810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8316624393
MESH:D009362 Neoplasm Metastasis Paclitaxel 3.2015867366
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1111141357
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009421 Nervous System Malformations Estradiol 3.5216427766 11399458
MESH:D009436 Neural Tube Defects arsenic trioxide 3.0310525206
MESH:D009447 Neuroblastoma Topotecan 3.7815176712
MESH:D009765 Obesity Dietary Fats 2.2617217161 20518802 21332399 11836018 16723640 20132043 19632207 18674790 18457598
MESH:D010014 Osteolysis Paclitaxel 4.8515867366
MESH:D010051 Ovarian Neoplasms arsenic trioxide 10.9916624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 10.9919401270
MESH:D010051 Ovarian Neoplasms Paclitaxel 10.9911161223
MESH:D010051 Ovarian Neoplasms Progesterone 10.9916525653 17393432
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.3215580305
MESH:D010190 Pancreatic Neoplasms Ethanol 5.3212384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.5611578682
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.4721297632
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 3.7718220299 19015723 18042343
MESH:D011469 Prostatic Diseases vinclozolin 4.8018220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1119131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1117292933
MESH:D011471 Prostatic Neoplasms Estradiol 2.1116740699
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.1117172428 16356831 17136230 16729912
MESH:D011472 Prostatitis vinclozolin 4.8018629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.1816919318 15861022
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.8011597910 12490602 12832656
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 3.8911700416 18379247
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8118045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8316646077
MESH:D012640 Seizures Ethanol 6.249754883
MESH:D012640 Seizures Toluene 6.246431079 9294310
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.9518724381
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.3110029692 19755658
MESH:D013088 Spermatocele Ethinyl Estradiol 3.8116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.1515862959 16503802
MESH:D013272 Stomach Diseases Dexamethasone 4.1915472012
MESH:D013274 Stomach Neoplasms arsenic trioxide 4.6617007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.6620155912 2093021
MESH:D013274 Stomach Neoplasms Ethanol 4.6618456281
MESH:D013274 Stomach Neoplasms Paclitaxel 4.6618506536 18396642
MESH:D013276 Stomach Ulcer Amiodarone 11.4718087811
MESH:D013276 Stomach Ulcer Dexamethasone 11.4715138204
MESH:D013276 Stomach Ulcer Ethanol 11.479211565 17918041 9562338 16755016 17189318 11906479
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.149754883
MESH:D013610 Tachycardia Amiodarone 4.1611238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.0619225199
MESH:D024801 Tauopathies Paclitaxel 4.6816930453
MESH:D013733 Testicular Diseases Toluene 4.8310048760 10514026
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0415669648
MESH:D013959 Thyroid Diseases Amiodarone 4.6319731979
MESH:D013964 Thyroid Neoplasms arsenic trioxide 2.9919014326
MESH:D013971 Thyrotoxicosis Amiodarone 4.7319584973 18020914
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D016171 Torsades de Pointes Amiodarone 9.8217467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 9.8215213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.8712845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.8717053015
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.1714692618
MESH:D014605 Uveitis Dexamethasone 4.691336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4214671159 15869587
MESH:D015430 Weight Gain Dietary Fats 3.6216723640
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04972 Pancreatic secretion
KEGG:04970 Salivary secretion
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA220
    • No data
    Releated disease ID Related disease Name
    PA443319Alzheimer Disease
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00228 antagonist Enflurane Anesthetics, Inhalation;General Anesthetics
    DB00356 agonist Parafon Forte Tablets Muscle Relaxants, Central
    DB00436 agonist Corzide Tab W Nadolol 80mg Antihypertensive Agents;Diuretics;Diuretics, Thiazide;Sodium Chloride Symporter Inhibitors
    DB00774 other/unknown Hydroflumethiazide Antihypertensive Agents;Diuretics;Diuretics, Thiazide;Sodium Chloride Symporter Inhibitors
    DB00999 other/unknown Hydrochlorothiazide Antihypertensive Agents;Diuretics;Sodium Chloride Symporter Inhibitors
    DB01003 antagonist Cromoglicate Anti-Asthmatic Agents
    DB01110 antagonist Miconazole Antifungal Agents
    DB01119 other Diazoxide Antihypertensive Agents;Vasodilator Agents;Diuretics, Thiazide
    DB01159 inhibitor Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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