AutismKB 2.0

Annotation Detail for KCNMB1


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Basic Information Top
Gene Symbol:KCNMB1 ( K(VCA)beta,SLO-BETA,hslo-beta )
Gene Full Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1
Band: 5q35.1
Quick LinksEntrez ID:3779; OMIM: 603951; Uniprot ID:KCMB1_HUMAN; ENSEMBL ID: ENSG00000145936; HGNC ID: 6285
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04270Vascular smooth muscle contraction
Pathway IDPathway Name
Hemostasis
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1860Brain tumor
2005Bronchial disease
Desease Name
baroreflex and blood pressure regulation
CARDIOVASCULAR
central pulse pressure
No data
Desease Name
Hypertension, diastolic, resistance to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNMB1 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of KCNMB1 proteindecreases expression 17229879
D004958 Estradiol Estradiol results in increased expression of KCNMB1 mRNAincreases expression 15849065
D005419 Flavonoids Flavonoids results in increased expression of KCNMB1 mRNAincreases expression 18035473
D009151 Mustard Gas Mustard Gas results in increased expression of KCNMB1 mRNAincreases expression 15674843
C025299 polyphenols polyphenols results in decreased expression of KCNMB1 mRNAdecreases expression 16293270
D014700 Verapamil KCNMB1 gene SNP affects the susceptibility to Verapamilaffects response to substance 17700361
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000230 Adenocarcinoma Estradiol 2.1511473722
MESH:D001249 Asthma Mustard Gas 2.7810378619
MESH:D001768 Blister Mustard Gas 5.5619167455
MESH:D001943 Breast Neoplasms Estradiol 2.1217018787 17289903 16675129 12948864 17261762 14630087 19861407 18497071
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.5615286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.4210378619 17687719
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416097048 15673190 3786805 15721981 16011737 16227642 10355542 15700767 16192424 16124888 16050911 18705752
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0918788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0916924424
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D003110 Colonic Neoplasms polyphenols 2.7116293270
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.397120509 16177239 6884620 4309450 3732212 7440962 19336974 17522070 15998439 9327722 7179309 21278145 15027814 16227642 6623471 2869522 10092053 3786805 11566570 10915739 15968718 19085960
MESH:D056486 Drug-Induced Liver Injury polyphenols 4.3919370779
MESH:D004487 Edema Mustard Gas 3.5911428647 9260866 11428631 11402378
MESH:D016889 Endometrial Neoplasms Estradiol 3.1511473722 19148513 18566989
MESH:D004890 Erythema Mustard Gas 5.569357497
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.4561145 12631006 16045604 12795759 19224547 15959796 16239168 17595544
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006973 Hypertension marker/mechanism 17700361
MESH:D006973 Hypertension Verapamil 4.2117700361
OMIM:608622 HYPERTENSION, DIASTOLIC, RESISTANCE TO marker/mechanism
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Flavonoids 9.2917296493
MESH:D007249 Inflammation Mustard Gas 9.2916001271 9260866 11428647 11428620 11402378 8975870 9357497 17524151 11428631
MESH:D007249 Inflammation polyphenols 9.2916366677
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9411408273 17174718 16943688 11903743 17334410 17157831 16221502 21278145 16239168
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.5117900296 12898905 16033810 12445418 11481614 18412020 15057751 14620537 14724832 18210741 16097048 18054572 20821823 12666154 18705752 18166357 18205269 17869086 15362042 18006644 13678700 18251166 12632512 15931870 12609069 18277467 18395095 12546737 18317297 17944888 17631135 17922224 15876570 17698563 17976157 17481882 15123356 15338365 17640975 18376398 12445421 16638106 17525996 14716496 12667390 16015684 16011737 17557913 16116963 12649538 18418968 18481824 16192424 16136751 18263696 14512876 18429990 17805973 12958196 18472332 15959796 15673190 14716833 17823541 16027843 18395914 12586293 14748882 17714472 15370692 15052691 16248980 12741479 17708605 18279442 15730626 18187930 18472094 18156304 12632514 10355542 15925388 17721639 15818738 17766677 12389079 15650968 17761835 15996030 17565644 15893842 18339082 18420326
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5114716833 14659978
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.5217285989 16964402 15720792 16246199 15830285
MESH:D008107 Liver Diseases polyphenols 4.5216698588
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.9516899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 2.3019294768
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 2.7712014681 15583823
MESH:D008171 Lung Diseases Mustard Gas 3.6218702808 18161513
MESH:D008175 Lung Neoplasms Mustard Gas 2.178781369 3148597
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7211807958 11408345 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4916810080
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Estradiol 3.9811399458 16427766
MESH:D009503 Neutropenia Mustard Gas 4.2716761898 7688884
MESH:D010051 Ovarian Neoplasms Estradiol 2.2919401270
MESH:D011041 Poisoning Mustard Gas 4.1015727166
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0416740699
MESH:D011537 Pruritus Mustard Gas 4.4918058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 3.0110334151 17894541 17720292 17266442 17620002
MESH:D012871 Skin Diseases Mustard Gas 2.7715451306 12880345 16961503
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.6917997062
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
Pathway ID Pathway Name
REACT:604 Hemostasis
KEGG:04270 Vascular smooth muscle contraction
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA221
    • No data
    Releated disease ID Related disease Name
    PA447288Essential hypertension
    PA445990Urinary Incontinence
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01110 antagonist Miconazole Antifungal Agents
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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