AutismKB 2.0

Annotation Detail for KCNN2


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Basic Information Top
Gene Symbol:KCNN2 ( KCa2.2,SK2,SKCA2,hSK2 )
Gene Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Band: 5q22.3
Quick LinksEntrez ID:3781; OMIM: 605879; Uniprot ID:KCNN2_HUMAN; ENSEMBL ID: ENSG00000080709; HGNC ID: 6291
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KCNN2 mRNAaffects expression 17562736
D000639 Amitriptyline Amitriptyline results in decreased activity of KCNN2 proteindecreases activity 10915830
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNN2 mRNAaffects expression 16483693
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of KCNN2 mRNAaffects expression 20382639
C015712 bisdequalinium bisdequalinium results in decreased activity of KCNN2 proteindecreases activity 10915830
D002220 Carbamazepine Carbamazepine results in decreased activity of KCNN2 proteindecreases activity 10915830
D002746 Chlorpromazine Chlorpromazine results in decreased activity of KCNN2 proteindecreases activity 10915830
D003533 Cyproheptadine Cyproheptadine results in decreased activity of KCNN2 proteindecreases activity 10915830
D005419 Flavonoids Flavonoids results in decreased expression of KCNN2 mRNAdecreases expression 18035473
C106014 gedunin gedunin results in decreased expression of KCNN2 mRNAdecreases expression 17010675
D007099 Imipramine Imipramine results in decreased activity of KCNN2 proteindecreases activity 10915830
D007657 Ketone Bodies Ketone Bodies results in increased expression of KCNN2 mRNAincreases expression 16807920
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of KCNN2 mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of KCNN2 mRNAdecreases expression 19482888
D013619 Tacrine Tacrine results in decreased activity of KCNN2 proteindecreases activity 10915830
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of KCNN2 mRNAdecreases expression 18087596
D014268 Trifluoperazine Trifluoperazine results in decreased activity of KCNN2 proteindecreases activity 10915830
C050414 tripterine tripterine results in decreased expression of KCNN2 mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Carbamazepine 8.898986270
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.896195326
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.5315814487
MESH:D018248 Adenoma, Liver Cell Phenobarbital 3.9617620307
MESH:D000544 Alzheimer Disease Tacrine 3.9212725862
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1819898480
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001714 Bipolar Disorder Carbamazepine 4.1220046352 17594078
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.873084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.876705139 17173139 20935162 20007298 1701930
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4211212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2011212258
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7120889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D019465 Craniofacial Abnormalities Carbamazepine 2.959014606
MESH:D003866 Depressive Disorder Amitriptyline 8.8318083778 15014590
MESH:D003866 Depressive Disorder Imipramine 8.8320305041
OMIM:607208 DRAVET SYNDROME Carbamazepine 5.4311748493
MESH:D004342 Drug Hypersensitivity Carbamazepine 4.3916538176 16538175 15057820 20216337
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5311287661 16485898 14986274 11739529 16177239 10774834 16109766 14550746 18071297 10663392 11461765 18713872 11834606 16393943 17906064 2444490 11421492 19164858 17522070 12594235 15968718 17562736 12705907 12540782 12958197 19923254 19416960 19370779 16227642 11743745 19085960 11529661 16081117 12153990 10915739 12392966 16781746 15619225 14725611 19420014 19739265
MESH:D056486 Drug-Induced Liver Injury Carbamazepine 6.5317465707
MESH:D056486 Drug-Induced Liver Injury Chlorpromazine 6.5311461765
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Carbamazepine 4.4420216337
MESH:D004421 Dystonia Phenobarbital 3.991851702
MESH:D004487 Edema Amitriptyline 12.2312798668
MESH:D004487 Edema Cyproheptadine 12.237907874
MESH:D004487 Edema Imipramine 12.2312798668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Carbamazepine 4.7217654737
MESH:D004816 Epidermal Necrolysis, Toxic Carbamazepine 5.2420485159 19915237 18855540 16538176 16415921
MESH:D004831 Epilepsies, Myoclonic Carbamazepine 11.1417275665
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 11.143659116
MESH:D004828 Epilepsies, Partial Carbamazepine 10.3617116037 16628512 15008574
MESH:D004828 Epilepsies, Partial Phenobarbital 10.3611558140 3922381
MESH:D004827 Epilepsy Carbamazepine 7.0219620853 821787 7988514 17465707 17178248 9014606 18234410 20417680 19700373 19439326
MESH:D004827 Epilepsy Phenobarbital 7.0220417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.526401628
MESH:D017029 Epilepsy, Complex Partial Carbamazepine 11.657750514
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.657750514
MESH:D004830 Epilepsy, Tonic-Clonic Carbamazepine 10.843659116 15276670
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.843659116
MESH:D004916 Erythromelalgia Carbamazepine 5.7119549232
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005076 Exanthema Carbamazepine 5.4620485159
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D006529 Hepatomegaly Phenobarbital 3.4716109766
MESH:D006561 Herpes Simplex Chlorpromazine 5.281682908
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D020138 Hyperhomocysteinemia Carbamazepine 4.7110459572
MESH:D006965 Hyperplasia Carbamazepine 5.2018773962
MESH:D007249 Inflammation Amitriptyline 12.1112798668
MESH:D007249 Inflammation Flavonoids 12.1117296493
MESH:D007249 Inflammation Imipramine 12.1112798668
MESH:D007249 Inflammation Tobacco Smoke Pollution 12.1118590791
MESH:D007674 Kidney Diseases Acetaminophen 2.1915629191 12587719
MESH:D008064 Lipidoses Amitriptyline 13.6717567588 15342952
MESH:D008064 Lipidoses Chlorpromazine 13.6715342952 17567588
MESH:D008064 Lipidoses Imipramine 13.6715342952 17567588
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8821047994
MESH:D008107 Liver Diseases Acetaminophen 6.6716610002 12969438 11587558 19784758 12587719 19014921 16611625 19460945
MESH:D008107 Liver Diseases Chlorpromazine 6.6714986274
MESH:D008107 Liver Diseases Phenobarbital 6.6719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 2.3019812893 19073162 8742319 15975961 21047994 19482888
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.6918308698 17172636 6150874 1399818 2563599
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 2.7212111688 11091918 3440675 16288123
MESH:D008180 Lupus Erythematosus, Systemic Carbamazepine 3.5616628512
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D001523 Mental Disorders Amitriptyline 13.6516856516
MESH:D001523 Mental Disorders Chlorpromazine 13.6516856516
MESH:D001523 Mental Disorders Imipramine 13.6516856516
MESH:D008607 Mental Retardation Carbamazepine 3.729014606
MESH:D008881 Migraine Disorders Amitriptyline 4.7718803445
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3315006635
MESH:D009175 Mycoplasma Infections Chlorpromazine 6.0010773494
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009224 Myotonia Congenita Carbamazepine 5.4620399394
MESH:D009421 Nervous System Malformations Carbamazepine 4.8916990009
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D010018 Osteomalacia Carbamazepine 12.0717016548
MESH:D010018 Osteomalacia Phenobarbital 12.0717016548
MESH:D010146 Pain Acetaminophen 16.1516870215
MESH:D010146 Pain Amitriptyline 16.1512798668
MESH:D010146 Pain Carbamazepine 16.1515215642
MESH:D010146 Pain Imipramine 16.1512798668
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.4816965848
MESH:D010267 Parapsoriasis Carbamazepine 5.6916538176
OMIM:167400 PAROXYSMAL EXTREME PAIN DISORDER Carbamazepine 5.9217145499 17679678
MESH:D011230 Precancerous Conditions Phenobarbital 3.602563599
MESH:D011248 Pregnancy Complications Carbamazepine 5.149014606
MESH:D011297 Prenatal Exposure Delayed Effects Carbamazepine 4.889014606
MESH:D019310 Pseudolymphoma Carbamazepine 12.589591791 12752131
MESH:D019310 Pseudolymphoma Phenobarbital 12.5812752131
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.6118410779
MESH:D012640 Seizures Carbamazepine 6.349046859 15946322 16876388 19414003 9844417 16180713 16938433
MESH:D012640 Seizures Phenobarbital 6.3411442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 3.5218590791
MESH:D012892 Sleep Deprivation Imipramine 6.1919798453
MESH:D012893 Sleep Disorders Carbamazepine 5.1119414003
MESH:D007319 Sleep Initiation and Maintenance Disorders Amitriptyline 5.4515341891
MESH:D013262 Stevens-Johnson Syndrome Carbamazepine 5.2019915237 18855540 16538176 16415921 19694795 20485159 15057820
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.041399818
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 3.3312846360
MESH:D014581 Urticaria Acetaminophen 2.9610982225
Pathway ID Pathway Name
KEGG:04976 Bile secretion
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB01110 antagonist Miconazole Antifungal Agents
No data
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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