AutismKB 2.0

Annotation Detail for KCNN4


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Basic Information Top
Gene Symbol:KCNN4 ( IK1,IKCA1,KCA4,KCa3.1,SK4,hIKCa1,hKCa4,hSK4 )
Gene Full Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Band: 19q13.31
Quick LinksEntrez ID:3783; OMIM: 602754; Uniprot ID:KCNN4_HUMAN; ENSEMBL ID: ENSG00000104783; HGNC ID: 6293
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04970Salivary secretion
hsa04974Protein digestion and absorption
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1842Sickle cell disease
1961Endometrium cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C010914 2,4-diaminotoluene 2,4-diaminotoluene results in increased expression of KCNN4 mRNAincreases expression 20713471
C495450 4-chlorobenzo(f)isoquinoline 4-chlorobenzo(f)isoquinoline results in increased activity of KCNN4 proteinincreases activity 15148241
15921678
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of KCNN4 mRNAdecreases expression 19901195
C117298 7,8-benzoquinoline 7,8-benzoquinoline results in increased activity of KCNN4 proteinincreases activity 12967937
15921678
C014949 acetylhydrazine acetylhydrazine results in decreased expression of KCNN4 mRNAdecreases expression 15282401
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KCNN4 mRNAaffects expression 16483693
D000838 Anions KCNN4 protein affects the secretion of Anionsaffects secretion 12967937
C015001 arsenite arsenite results in decreased expression of KCNN4 mRNAdecreases expression 18191166
C039108 benzo(f)quinoline benzo(f)quinoline analog results in increased activity of KCNN4 proteinincreases activity 15921678
C039108 benzo(f)quinoline benzo(f)quinoline results in increased activity of KCNN4 proteinincreases activity 15921678
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of KCNN4 mRNAincreases expression 15003993
D000001 Calcimycin Calcimycin results in increased activity of KCNN4 proteinincreases activity 17699636
D002118 Calcium KCNN4 protein affects the abundance of Calciumaffects abundance 14985237
D002118 Calcium KCNN4 protein affects the reaction [Calcium results in increased transport of Potassium]affects reaction|increases transport 11826162
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of KCNN4 mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of KCNN4 proteinincreases expression 12629582
D018999 Charybdotoxin Charybdotoxin results in decreased activity of KCNN4 proteindecreases activity 15921678
D002753 Chlorzoxazone Chlorzoxazone results in increased activity of KCNN4 proteinincreases activity 14985237
D003022 Clotrimazole Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]affects cotreatment|decreases reaction|increases activity 14985237
D003022 Clotrimazole Clotrimazole results in decreased activity of KCNN4 proteindecreases activity 14985237
20050851
15921678
D003022 Clotrimazole Clotrimazole results in decreased activity of KCNN4 proteindecreases activity 17699636
C014347 decitabine decitabine results in increased expression of KCNN4 mRNAincreases expression 17785578
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of KCNN4 mRNAincreases expression 15289156
D004958 Estradiol Estradiol affects the expression of KCNN4 mRNAaffects expression 14699072
D004958 Estradiol Estradiol results in increased expression of KCNN4 mRNAincreases expression 15289156
D005419 Flavonoids Flavonoids results in increased expression of KCNN4 mRNAincreases expression 18035473
D005480 Flurbiprofen Flurbiprofen results in decreased expression of KCNN4 mRNAdecreases expression 16949054
D019833 Genistein Genistein results in increased expression of KCNN4 mRNAincreases expression 15289156
D015759 Ionomycin Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]affects cotreatment|decreases reaction|increases activity 14985237
D015759 Ionomycin [Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 proteinaffects cotreatment|increases activity 14985237
D008748 Methylcholanthrene Methylcholanthrene results in increased expression of KCNN4 mRNAincreases expression 20713471
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of KCNN4 mRNAincreases expression 17616710
C006253 pirinixic acid pirinixic acid results in decreased expression of KCNN4 mRNAdecreases expression 17426115
D011188 Potassium KCNN4 protein affects the reaction [Calcium results in increased transport of Potassium]affects reaction|increases transport 11826162
D011188 Potassium KCNN4 protein affects the transport of Potassiumaffects transport 15148241
D020849 Raloxifene Raloxifene affects the expression of KCNN4 mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNAaffects cotreatment|decreases expression 19059307
D018038 Sodium Selenite Sodium Selenite results in increased expression of KCNN4 mRNAincreases expression 18175754
D013629 Tamoxifen Tamoxifen affects the expression of KCNN4 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KCNN4 mRNAincreases expression 19901195
D019789 Tetraethylammonium Clotrimazole inhibits the reaction [[Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 protein]affects cotreatment|decreases reaction|increases activity 14985237
D019789 Tetraethylammonium [Ionomycin co-treated with Tetraethylammonium] results in increased activity of KCNN4 proteinaffects cotreatment|increases activity 14985237
C411671 TRAM 34 TRAM 34 results in decreased activity of KCNN4 proteindecreases activity 20050851
D002762 Cholecalciferol Cholecalciferol results in decreased expression of KCNN4 mRNAdecreases expression 16508948
D015049 Zoxazolamine Zoxazolamine results in increased activity of KCNN4 proteinincreases activity 14985237
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.1914745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2118287403
MESH:D055371 Acute Lung Injury pirinixic acid 2.7918653653
MESH:D000230 Adenocarcinoma Estradiol 4.1411473722
MESH:D000230 Adenocarcinoma Genistein 4.1411473722
MESH:D000236 Adenoma Methylcholanthrene 3.296695378 10545420
MESH:D018248 Adenoma, Liver Cell pirinixic acid 8.7216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 8.7216835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.7610680582
MESH:D000419 Albuminuria Raloxifene 4.2617308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.4615800139
MESH:D000686 Amyloidosis Diethylstilbestrol 4.1415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6411748828
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2411922910
MESH:D001327 Autoimmune Diseases Cholecalciferol 4.6816142846
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.7219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.7212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5415746008
MESH:D001930 Brain Injuries Raloxifene 4.1316580743
MESH:D001943 Breast Neoplasms 2,4-diaminotoluene 5.4411921183
MESH:D001943 Breast Neoplasms decitabine 5.4418320071 19208741
MESH:D001943 Breast Neoplasms Diethylstilbestrol 5.4415324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 5.4417261762 12948864 14630087 17289903 17018787 19861407 18497071 16675129
MESH:D001943 Breast Neoplasms Genistein 5.4416873071 16541309 17200150
MESH:D001943 Breast Neoplasms Methylcholanthrene 5.4417474063
MESH:D001943 Breast Neoplasms Raloxifene 5.4416837676 15758505 17049068 16912660 17261762 15572757 17952589 17893378 17440819 17595753 15775269 17242785
MESH:D001943 Breast Neoplasms Tamoxifen 5.4419410462 17893378 19288272 15668708 21138602 18629630 19066611 19155303 20135344 19011961 18425577 17049068 18821012 18855134 16873071 19084267 20390343 16202921 18984771 11161223 20005174 15565566 19103187 19189212 17242785 19189210 19059307 19221464 21152245 19115204 17261762 18815881 19200415 19487384 20065188 20544844 19289846 19142967 19244106 18351453 16818667 20859285 17440819 18997820 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 5.4420435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1116111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4318705752 16227642 16097048 15721981 16124888 15673190 16050911 15700767 10355542 16192424 3786805 16011737
MESH:D002277 Carcinoma Methylcholanthrene 7.4110545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.4116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.1619066611
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.1818788625
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 8.1815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 8.1816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 8.1816924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.1816924424
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.4919215824
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 8.4817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.4817572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1718850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 6.6916332659
MESH:D002318 Cardiovascular Diseases Raloxifene 6.6915775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.1318566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 6.1316192471
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8716835633
MESH:D002779 Cholestasis pirinixic acid 2.5719176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.4115894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9516354765 8697196 15668235 15340226 12621046
MESH:D003072 Cognition Disorders Raloxifene 4.2715800139
MESH:D003110 Colonic Neoplasms arsenite 5.4915037631
MESH:D003110 Colonic Neoplasms decitabine 5.4917616700
MESH:D003110 Colonic Neoplasms Genistein 5.4917182828
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.7617141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2420055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.2212952375 16002989
MESH:D003711 Demyelinating Diseases Tamoxifen 4.0219031437
MESH:D003865 Depressive Disorder, Major Raloxifene 3.8717474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2618249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.4816285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.0116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.0117107852
MESH:D003928 Diabetic Nephropathies Estradiol 13.3119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 13.3115920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 13.3119279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 5.567179309 15968718 10092053 4309450 6884620 16177239 3732212 16227642 15027814 7440962 6623471 10915739 15998439 17522070 11566570 2869522 3786805 19085960 19336974 9327722 7120509 21278145
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 5.5615131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5011462148
MESH:D004487 Edema pirinixic acid 9.6212083418
MESH:D004487 Edema Raloxifene 9.6215860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.6212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.5415322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 8.1315845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.1319031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.7519294695
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.7116402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.7116402032
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 20.9019148513
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 20.9015700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 20.9018566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 20.9011473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.9017893378 19155303 16202921 20544844
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7210568697 9294722
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.6815264214 16704527 15878914 15623463 16510608 16805852 15547733 15150132 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.7511564622
MESH:D005234 Fatty Liver arsenite 21.3218296743
MESH:D005234 Fatty Liver Carbon Tetrachloride 21.3215959796 16045604 12631006 19224547 12795759 61145 16239168 17595544
MESH:D005234 Fatty Liver pirinixic acid 21.3219236843 20131406
MESH:D005234 Fatty Liver Raloxifene 21.3217473493
MESH:D005234 Fatty Liver Tamoxifen 21.3214986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.4915751030 16611131 16534752 16513791 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.4916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1111858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.1714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.8319069698
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.5814633661 10962813
MESH:D005355 Fibrosis arsenite 12.8318296743
MESH:D005355 Fibrosis Carbon Tetrachloride 12.8318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 12.8320067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.5916452187
MESH:D005909 Glioblastoma Genistein 3.0316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2310696789
MESH:D006258 Head and Neck Neoplasms decitabine 3.2519215824
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1411294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.2911110106
MESH:D006333 Heart Failure pirinixic acid 2.3220558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.2619900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 7.1219772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.1215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.6715709030
MESH:D019584 Hot Flashes Estradiol 3.3917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.6815340226 16959395 8697196 16354765 18606429
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.1816899240
MESH:D006943 Hyperglycemia pirinixic acid 2.8820558911
MESH:D006965 Hyperplasia Diethylstilbestrol 4.0914722030 12960047
MESH:D006973 Hypertension Raloxifene 4.7615787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.7415338365
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 5.5119822448
MESH:D007021 Hypospadias Diethylstilbestrol 4.2316002989
MESH:D007246 Infertility Diethylstilbestrol 4.0215036965
MESH:D007248 Infertility, Male decitabine 2.9717581917
MESH:D007249 Inflammation Flavonoids 10.4617296493
MESH:D007249 Inflammation Flurbiprofen 10.4611099482
MESH:D007249 Inflammation Tamoxifen 10.4619457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 10.4612878042 12200463
MESH:D007333 Insulin Resistance Estradiol 10.9716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.9716306350
MESH:D007333 Insulin Resistance Sodium Selenite 10.9714714311
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0216580747
MESH:D007674 Kidney Diseases Estradiol 2.3815618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 10.8216762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 10.8215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 10.8218625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.6916316344
MESH:D007859 Learning Disorders Diethylstilbestrol 3.7217184923
MESH:D007889 Leiomyoma Raloxifene 4.1716973256
MESH:D007938 Leukemia decitabine 5.9219235587 18980019
MESH:D007938 Leukemia Genistein 5.9218980019 17468513
MESH:D007951 Leukemia, Myeloid decitabine 3.6919117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.3218206229 19010910 19387464 18460780 18704418 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.1018055864
MESH:D008064 Lipidoses Tamoxifen 2.9017567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 6.1718296743
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.1711903743 11408273 16239168 17174718 17334410 16221502 21278145 17157831 16943688
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 8.0718395914 18277467 18412020 16248980 18376398 14716496 17714472 18472332 12898905 15931870 18251166 17761835 18418968 17698563 12958196 12632514 10355542 14512876 16033810 15370692 15650968 12666154 20821823 17708605 18187930 17823541 12445421 12389079 15362042 14748882 14716833 16638106 18263696 16136751 17565644 15673190 17976157 12649538 17631135 18006644 17525996 15338365 17900296 15818738 15057751 14620537 17944888 17922224 12546737 17869086 18166357 18472094 12632512 15730626 17766677 17805973 11481614 16097048 18429990 18054572 18420326 17481882 16192424 16015684 15959796 12445418 18705752 18210741 15052691 15925388 15876570 16027843 16011737 17721639 14724832 13678700 18339082 15123356 16116963 12609069 12667390 15996030 18481824 12741479 18317297 18156304 17640975 12586293 17557913 18205269 18395095 18279442 15893842
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.0714716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.0717823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.0715474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.0718564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.0712878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0016964402 15830285 17285989 16246199 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8215123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.3816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 12.7119294768
MESH:D008113 Liver Neoplasms Diethylstilbestrol 12.7116712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 12.7115890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 12.7116684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.7116984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 8.5912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 8.591399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.5912151625
MESH:D008175 Lung Neoplasms arsenite 4.5016809336
MESH:D008175 Lung Neoplasms Methylcholanthrene 4.501399818 17909032 20970405 21163286 15390079 20512841 16271038 6695378 7750092 11893704 10545420 9230183 16337739
MESH:D008175 Lung Neoplasms Tamoxifen 4.5018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.5019555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.7915166399
MESH:D008223 Lymphoma decitabine 6.8919470736
MESH:D008223 Lymphoma Diethylstilbestrol 6.8915700306
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 3.7314737004
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.1516002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.4119428831
MESH:D008325 Mammary Neoplasms, Experimental 2,4-diaminotoluene 12.4311921183
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 12.4311408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 12.4314578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 12.4319196723 11731420 19196722 14580682 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.4419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.4419453300
MESH:D008545 Melanoma decitabine 3.1816505122 17785578
MESH:D008545 Melanoma Tamoxifen 3.1819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.8315990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.1915863610
MESH:D009101 Multiple Myeloma decitabine 6.6618172295
MESH:D009101 Multiple Myeloma Raloxifene 6.6616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.1616239165
MESH:D009190 Myelodysplastic Syndromes decitabine 3.1819157545 18608210 19010910 16882708
MESH:D009203 Myocardial Infarction Genistein 5.1617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.1619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.6116810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.6117141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.6116411023
MESH:D009232 Myxoma Raloxifene 5.1916343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4019410462
MESH:D009369 Neoplasms decitabine 7.2617925555 19116145 19470736
MESH:D009369 Neoplasms Diethylstilbestrol 7.2615313581
MESH:D009369 Neoplasms pirinixic acid 7.2617405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.6419189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 8.9715738583
MESH:D009389 Neovascularization, Pathologic Estradiol 8.9717289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 20.6911399458
MESH:D009421 Nervous System Malformations Estradiol 20.6916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 20.6916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 20.6914600291
MESH:D009765 Obesity pirinixic acid 1.7220558911
MESH:D010024 Osteoporosis Calcium 10.7317882678
MESH:D010024 Osteoporosis Genistein 10.7319401787
MESH:D010024 Osteoporosis Raloxifene 10.7317882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 9.0616169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 9.0617893378 17823083 15758505 15579764
MESH:D010051 Ovarian Neoplasms decitabine 7.2319259094 19331143
MESH:D010051 Ovarian Neoplasms Estradiol 7.2319401270
MESH:D010051 Ovarian Neoplasms Genistein 7.2319005980
MESH:D010190 Pancreatic Neoplasms decitabine 2.6419294695
MESH:D010243 Paralysis Zoxazolamine 6.5716109766
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.8912520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.8114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.3215687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2218163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.3917184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.3911222880 11118676 11399792 11896295
MESH:D055728 Primary Myelofibrosis decitabine 4.3817616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5720887781
MESH:D011471 Prostatic Neoplasms Cholecalciferol 2.3617024972
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3617136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.3616740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.3617409433
MESH:D011471 Prostatic Neoplasms Genistein 2.3616925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Raloxifene 2.3616536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.3618760546
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3615067354
MESH:D011693 Purpura Raloxifene 5.1915770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.2119058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5018990726
MESH:D012208 Rhabdomyosarcoma decitabine 4.0819155313
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.028532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.0216192470
MESH:D013088 Spermatocele Diethylstilbestrol 10.6416709447 16002989
MESH:D013088 Spermatocele Tamoxifen 10.6416709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.6819457130
MESH:D013274 Stomach Neoplasms decitabine 2.6419037991
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.6412958204 17575124
MESH:D020521 Stroke Raloxifene 3.5516837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5412697716
MESH:D013964 Thyroid Neoplasms decitabine 3.0717967635
MESH:D013978 Tibial Fractures Estradiol 12.5119048282
MESH:D013978 Tibial Fractures Raloxifene 12.5119048282
MESH:D001749 Urinary Bladder Neoplasms decitabine 10.7717616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.7716712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 10.7717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.7716712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 3.7316175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.8114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 3.7315809267 16690809
MESH:D014604 Uveal Neoplasms decitabine 4.5517785578
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.0916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2312125929
MESH:D054556 Venous Thromboembolism Raloxifene 4.8516837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.1916343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.8915886252
Pathway ID Pathway Name
KEGG:04974 Protein digestion and absorption
KEGG:04970 Salivary secretion
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00257 inhibitor Lotrisone Antifungal Agents;Anti-Infective Agents, Local;Growth Inhibitors
DB00468 blocker Triogene for Antimalarials;Analgesics, Non-Narcotic;Muscle Relaxants, Central
DB01110 antagonist Miconazole Antifungal Agents
DB01159 inhibitor Halothane Anesthetics, Inhalation;General Anesthetics;Anesthetics
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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