AutismKB 2.0

Annotation Detail for CATSPER4


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Basic Information Top
Gene Symbol:CATSPER4 ( MGC149223 )
Gene Full Name: cation channel, sperm associated 4
Band: 1p36.11
Quick LinksEntrez ID:378807; OMIM: 609121; Uniprot ID:CTSR4_HUMAN; ENSEMBL ID: ENSG00000188782; HGNC ID: 23220
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
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DEVELOPMENTAL
Desease Name
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of CATSPER4 mRNAdecreases expression 18648102
C006632 arsenic trioxide arsenic trioxide results in increased expression of CATSPER4 mRNAincreases expression 20458559
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of CATSPER4 mRNAdecreases expression 20504355
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 4.6411798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6420464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.363712494
MESH:D000236 Adenoma Benzo(a)pyrene 7.366695378
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.7319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 4.1516206674
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9920146248 17474063
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.8611589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.183581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1814691202 11135700 16217749 15553829 15073043
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.7419014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.5712490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1420419170
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4719486331 9022650
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8720501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.7712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.6315213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4411298694 12868966 8970840 14531868 18759878 11906362 8156756 2524372
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.023621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.059022650 18289764 11289319 1440618 18692083 7440962 6482804 16192314 9653073 8291058 6679447 18648102 9328219
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.733581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 7.7312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.7316530937
MESH:D005234 Fatty Liver arsenic trioxide 3.7715073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.8516904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8520471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D007938 Leukemia arsenic trioxide 3.0115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.2812560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 5.0516972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.7514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.2419077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1916467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4816330433 12679006 17217047 15336539 12018890 19225113 16112521 15748426 19035177 16331271 9834237 16966277 11468182 19075265 16891316 11161223 17107899 15622746 16823087 17869043 12712474 17712046 17649720 19642359 15213294
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.9416882451
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4415034207 9327722
MESH:D008113 Liver Neoplasms arsenic trioxide 5.0014682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.0021137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.81598648 3712494 1399818 6587162
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.8120377131
MESH:D008133 Long QT Syndrome arsenic trioxide 3.6915213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.5119825857 11798837
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5117053015 20464547 18520028 18816296 20064080 6695378 20135361 20869020 18569708
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5316381670
MESH:D009101 Multiple Myeloma arsenic trioxide 3.4115949261 11468182 14977855 19549372 19417148
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3616882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.5416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3511141357
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.156679447
MESH:D009436 Neural Tube Defects arsenic trioxide 8.1510525206
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.876482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.5112452020 19769630 16624393
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6415580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010235 Paraganglioma arsenic trioxide 4.6919927285
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.0919131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.0917292933
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.5416646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5410029692 19755658
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4517007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.452093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 8.311399818 7505956 6587162 3712494 6582329
MESH:D013964 Thyroid Neoplasms arsenic trioxide 8.3119014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.7015213294
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 9.118074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 9.1111780464 20435036 12845720 12973940
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 9.1117053015
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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