AutismKB 2.0

Annotation Detail for KIF3C


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Basic Information Top
Gene Symbol:KIF3C ( - )
Gene Full Name: kinesin family member 3C
Band: 2p23.3
Quick LinksEntrez ID:3797; OMIM: 602845; Uniprot ID:KIF3C_HUMAN; ENSEMBL ID: ENSG00000084731; HGNC ID: 6321
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C403065 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to KIF3C proteinaffects binding 19539807
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KIF3C mRNAaffects expression 16483693
D002117 Calcitriol Calcitriol results in increased expression of KIF3C mRNAincreases expression 16002434
D004958 Estradiol Estradiol results in decreased expression of KIF3C mRNAdecreases expression 20068009
C030691 gluconic acid gluconic acid results in increased expression of KIF3C mRNAincreases expression 16556975
D009151 Mustard Gas Mustard Gas results in increased expression of KIF3C mRNAincreases expression 15674844
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KIF3C mRNAaffects binding|decreases expression|increases activity 19710929
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of KIF3C mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KIF3C mRNAaffects cotreatment|decreases expression 19059307
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KIF3C mRNAdecreases expression 19465110
D014501 Uranium Uranium affects the expression of KIF3C mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of KIF3C mRNAaffects expression 15672453
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.7214745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000419 Albuminuria Raloxifene 4.7217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D001249 Asthma Mustard Gas 2.7410378619
MESH:D001768 Blister Mustard Gas 5.3119167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Calcitriol 2.3711237771
MESH:D001943 Breast Neoplasms Estradiol 2.3718497071 12948864 14630087 17289903 19861407 17018787 16675129 17261762
MESH:D001943 Breast Neoplasms Raloxifene 2.3717893378 17261762 15758505 17595753 15572757 17952589 16912660 15775269 17242785 17440819 16837676 17049068
MESH:D001943 Breast Neoplasms Tamoxifen 2.3719066611 18629630 21138602 19189212 16818667 19189210 17049068 19115204 20065188 16202921 21152245 15668708 18821012 15565566 18997820 20544844 20390343 18855134 18425577 19011961 19200415 19084267 19059307 17893378 19289846 19142967 19103187 18815881 20005174 16873071 19288272 19221464 19244106 20135344 19487384 18351453 17261762 11161223 16273361 18984771 17242785 19410462 17440819 19155303 20859285
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3720435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.3115286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1517687719 10378619
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.6419066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.0316924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.0316924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6511237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 9.8517572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 9.8517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4216120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis pirinixic acid 2.9119176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1412621046 8697196 16354765 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5019031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 15.6119279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.6117308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.6119279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5620420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema Mustard Gas 17.3911428631 9260866 11402378 11428647
MESH:D004487 Edema pirinixic acid 17.3912083418
MESH:D004487 Edema Raloxifene 17.3915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 17.3912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 16.2215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.2215845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.2219031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.6219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.6219155303 20544844 17893378 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004890 Erythema Mustard Gas 5.319357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver pirinixic acid 13.8020131406 19236843
MESH:D005234 Fatty Liver Raloxifene 13.8017473493
MESH:D005234 Fatty Liver Tamoxifen 13.8014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3016709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.6814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.3419069698
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0920067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3811294989 10048152
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7316221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7315340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.2215340226 16354765 8697196 18606429 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Raloxifene 5.3515787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3518670907 18850075
MESH:D007249 Inflammation Mustard Gas 8.648975870 11402378 9260866 11428647 11428620 9357497 17524151 16001271 11428631
MESH:D007249 Inflammation Tamoxifen 8.6419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.6412878042 12200463
MESH:D007333 Insulin Resistance Estradiol 7.4316627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007674 Kidney Diseases Estradiol 2.6415618244
MESH:D007680 Kidney Neoplasms Estradiol 7.7015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 7.7018625569
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D008064 Lipidoses Tamoxifen 3.2317567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.0114659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 5.0115474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.0118564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.0112878042
MESH:D008113 Liver Neoplasms pirinixic acid 7.5616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 7.5616684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5616984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.1712151625
MESH:D008171 Lung Diseases Mustard Gas 3.5218161513 18702808
MESH:D008175 Lung Neoplasms Mustard Gas 3.483148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 3.4818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.9119428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2017203775 11807958 11408345 16891317
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2019196723 14580682 16827153 11731420 19196722
MESH:D020149 Manganese Poisoning Estradiol 13.2419453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.2419453300
MESH:D008545 Melanoma Tamoxifen 1.8919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.3415990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5819393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5519410462
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.1719189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D009503 Neutropenia Mustard Gas 4.097688884 16761898
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010024 Osteoporosis Raloxifene 3.4617882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3417823083 17893378 15758505 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D011041 Poisoning Mustard Gas 3.9115727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411896295 11118676 11222880 11399792
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.0816289102 12479363 16644109 15754350 18247401
MESH:D011471 Prostatic Neoplasms Estradiol 2.0816740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.0816220300 16536755 15731164
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0815067354
MESH:D011537 Pruritus Mustard Gas 4.2518058305
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9610334151 17266442 17720292 17620002 17894541
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012871 Skin Diseases Mustard Gas 2.7412880345 15451306 16961503
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0916192470
MESH:D013088 Spermatocele Tamoxifen 4.4716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.1919457130
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3617572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.3616712894 17572228 8653321
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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