AutismKB 2.0

Annotation Detail for KIF5A


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Basic Information Top
Gene Symbol:KIF5A ( D12S1889,MY050,NKHC,SPG10 )
Gene Full Name: kinesin family member 5A
Band: 12q13.3
Quick LinksEntrez ID:3798; OMIM: 602821; Uniprot ID:KIF5A_HUMAN; ENSEMBL ID: ENSG00000155980; HGNC ID: 6323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1792Spastic paraplegia, Hereditary
No data
Desease Name
Rheumatoid arthritis
Desease Name
Spastic paraplegia 10
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D002330 Carmustine Carmustine results in decreased expression of KIF5A mRNAdecreases expression 15980968
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNAaffects cotreatment|decreases expression 18606552
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of KIF5A mRNAincreases expression 17854601
D004052 Diethylnitrosamine RB1 protein inhibits the reaction [Diethylnitrosamine results in increased expression of KIF5A mRNA]decreases reaction|increases expression 17854601
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in decreased expression of KIF5A mRNAaffects cotreatment|decreases expression 18606552
C025643 vinclozolin vinclozolin affects the expression of KIF5A mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 3.036695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.4416434500 17620307 17162532 19061943 18056438 19052882
MESH:D001008 Anxiety Disorders vinclozolin 3.9319015723
MESH:D001932 Brain Neoplasms Carmustine 4.7316187019
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1917474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8720727157 20084675 18393292 16698587 19539802 19822196 20514400 19107877 17978847 19383236 18506893 16540662 16878318 11831363 19919837 20935162 3084413 21159647 18788625 17162532 10672840 16830150 16569478 18785209 16681979 18494052 20214788 17138121 19701751 17428255 16328049 16779866 16288022 18978308 20432363 16807293 17173139 20512989 16935385 20007298 18691550 20101231 17055752 19519916 19208518 20524982 18056438 19335982 19052882 19394651 16502159 3581430 18210153 19171122 17761372 18665156 19418558 10737359 18971187
MESH:D009202 Cardiomyopathies Zalcitabine 4.9210591146
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0917174075 2727394 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 4.0119052882
MESH:D003456 Cryptorchidism vinclozolin 4.7814966744
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2520387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.1319107877
MESH:D004362 Drug Toxicity Zalcitabine 5.117515130
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.7316302075
MESH:D005234 Fatty Liver Diethylnitrosamine 9.6820387270 21071580
MESH:D005234 Fatty Liver Zalcitabine 9.6818299183
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.4716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.9116417039
MESH:D005909 Glioblastoma Carmustine 4.1416187019
MESH:D015658 HIV Infections Zalcitabine 4.4917457083
MESH:D007248 Infertility, Male vinclozolin 3.2616467254
MESH:D007249 Inflammation Diethylnitrosamine 2.5318785209
MESH:D007984 Leydig Cell Tumor vinclozolin 5.2716417039
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9918665156 18407596 18522880 19638242 20032147
MESH:D008107 Liver Diseases Diethylnitrosamine 2.1617034775
MESH:D008113 Liver Neoplasms Diethylnitrosamine 2.3419426721 19690152 18754104 20583210 19499222 19256749 20452335 16942905 19254457 19427195 19294768 19833225 20501860 9163691 20101389 20434301 19812893 19996281 19638242 19850985 20118626 21047994 15175105 21167192 12112319 15885732 18644402 19073162 21278145 20492335 18648771 10737359 20137499 19255062 18977376 20405173 18978307 2862719 12771043 19090486 19642983 21071580 2422723 19551842
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.8318544905 2563599 19539802 17174075 16267830 9362446 18079962 17942915 19009564 18093689 18775883 19126423 19004024 21159647 19519916 17854601 3124819 18308698 18164116 16842330 18282651 18253720
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 21163286 6695378
MESH:D008223 Lymphoma Zalcitabine 4.889488045 11980663 17941976 18798262 8764131 9205081 8840982
MESH:D008545 Melanoma Carmustine 2.9012393984
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.683581430 9029167
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.588764131 9488045 9205081
MESH:D009437 Neuralgia Zalcitabine 6.8617292584
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.6520387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.7320387270
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5216540662
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 12.4418606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 12.4418606552
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.882563599
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.4418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.4718220299
MESH:D011472 Prostatitis vinclozolin 5.4718629315
MESH:C537482 Spastic paraplegia 10, autosomal dominant marker/mechanism
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.257505956
Pathway ID Pathway Name
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30107
  • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    PA443434Arthritis, Rheumatoid
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018