AutismKB 2.0

Annotation Detail for KIF5B


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Basic Information Top
Gene Symbol:KIF5B ( KINH,KNS,KNS1,UKHC )
Gene Full Name: kinesin family member 5B
Band: 10p11.22
Quick LinksEntrez ID:3799; OMIM: 602809; Uniprot ID:KINH_HUMAN; ENSEMBL ID: ENSG00000170759; HGNC ID: 6324
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Diabetes pathways
Pathway IDPathway Name
200180N-cadherin signaling events
No data
Pathway IDPathway Name
500128Insulin Synthesis and Processing
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2072Neurofibromatosis
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of KIF5B mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KIF5B mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in increased expression of KIF5B mRNAincreases expression 20406850
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KIF5B mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KIF5B mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KIF5B mRNAaffects expression 16483693
D016572 Cyclosporine Cyclosporine results in increased expression of KIF5B mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KIF5B mRNAincreases expression 17942748
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to KIF5B protein]affects binding|increases reaction 17220478
D010656 Phenylephrine Phenylephrine results in decreased expression of KIF5B mRNAdecreases expression 18158353
C045950 propiconazole propiconazole results in decreased expression of KIF5B mRNAdecreases expression 19363144
D013629 Tamoxifen Tamoxifen affects the expression of KIF5B mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KIF5B mRNAdecreases expression 19933214
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KIF5B mRNAincreases expression 19465110
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in increased expression of KIF5B mRNAincreases expression 18087596
C025643 vinclozolin vinclozolin affects the expression of KIF5B mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in decreased expression of KIF5B mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8214692618
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.5915814487
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4316835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D000799 Angioedema Acetaminophen 3.9110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.6619015723
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 4.1417460149
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 3.1919898480
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001919 Bradycardia Phenylephrine 4.5915306635
MESH:D001943 Breast Neoplasms Tamoxifen 1.9618855134 19221464 19289846 20544844 19066611 15565566 20005174 19189212 19244106 15668708 17261762 18815881 17440819 19084267 16873071 18351453 19410462 18629630 18425577 19155303 16273361 19011961 17242785 20135344 19059307 19189210 18984771 19115204 19142967 11161223 18997820 17893378 20390343 19487384 21138602 19103187 19200415 16202921 17049068 19288272 20065188 21152245 18821012 20859285 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9716050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.583084413
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5816924424
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 3.4311212258
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 3.2211212258
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Phenylephrine 6.9315728586 17287366 17124262 11179087 11754973 16170337
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9316120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 2.6010977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.646135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.6412371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1916835633
MESH:D002779 Cholestasis Cyclosporine 7.8419486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.8416919318 15861022 16105132 17333356 17681005 11677210 17110522
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.118697196 15668235 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4910048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.4919769572
MESH:D003456 Cryptorchidism vinclozolin 4.3814966744
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.0418551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.0418551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.0118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.0121346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.0119370779 14986274 10663392 11287661 11739529 16177239 12392966 17906064 17562736 11461765 12153990 19416960 12540782 14550746 19164858 11834606 11529661 16227642 15619225 18071297 10774834 16109766 2444490 19739265 18713872 12958197 16485898 14725611 11743745 16781746 12594235 16081117 19420014 19085960 16393943 12705907 19923254 10915739 11421492 17522070 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.0120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:C538011 Eales disease Vitamin E 4.779068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9615322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 3.0616202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 13.2319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.2315345470
MESH:D005234 Fatty Liver Tamoxifen 13.2319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005756 Gastritis Acetaminophen 3.7416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.9816973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.3616417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6210048152 11294989
MESH:D006330 Heart Defects, Congenital Vitamin E 6.6216080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006529 Hepatomegaly propiconazole 8.9717178689 17178688
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7116490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.0314716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1116959395 15340226 18606429 8697196 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7216870215
MESH:D006973 Hypertension Cyclosporine 8.6710903974
MESH:D006973 Hypertension Phenylephrine 8.678949925 12717712
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.6718670907 18850075
MESH:D006984 Hypertrophy Phenylephrine 4.5812791704 18502941
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.7217937319
MESH:D007248 Infertility, Male vinclozolin 6.7216467254
MESH:D007249 Inflammation Tamoxifen 8.4819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4812878042 12200463
MESH:D007249 Inflammation Tobacco Smoke Pollution 8.4818590791
MESH:D007251 Influenza, Human Vitamin E 4.2816624496
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3616580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Acetaminophen 10.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.1018776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 10.1012488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.9516705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 17.9516705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.9512371664
MESH:D007680 Kidney Neoplasms Tamoxifen 17.9518625569
MESH:D007984 Leydig Cell Tumor vinclozolin 4.7816417039
MESH:D008064 Lipidoses Tamoxifen 3.1717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4812878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.4816169303
MESH:D008107 Liver Diseases Acetaminophen 4.3419460945 16611625 19014921 16610002 12969438 12587719 19784758 11587558
MESH:D008107 Liver Diseases propiconazole 4.3419363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2616871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 10.837678174
MESH:D008113 Liver Neoplasms propiconazole 10.8319028983
MESH:D008113 Liver Neoplasms Tamoxifen 10.8316684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.8316984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 10.042876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental propiconazole 10.0417178689
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0412151625
MESH:D008171 Lung Diseases Vitamin E 3.1916863852
MESH:D008175 Lung Neoplasms Tamoxifen 4.9118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.9111884234 19555203
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 4.9116288123 12111688 11091918 3440675
MESH:D008175 Lung Neoplasms Vitamin E 4.9111062179
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.6411731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 4.3715006635
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.5218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.527678174 18551238
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.5519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3118481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2514600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8918514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.9816049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.9816049721
MESH:D010146 Pain Acetaminophen 2.4116870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.2512371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.6611222880 11896295 11118676 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 9.6618042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.9818220299
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.2515067354
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011472 Prostatitis vinclozolin 4.9818629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.6618410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.9318551238
MESH:D012852 Sinusitis Phenylephrine 4.757327846
MESH:D012871 Skin Diseases Vitamin E 2.4518709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9416192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 5.9418590791
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D020521 Stroke Vitamin E 3.5416517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.0516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.0516049721
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 12.0517572228 16712894 8653321
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 12.0512846360
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.1610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.1610091137
MESH:D014581 Urticaria Acetaminophen 3.0110982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:15380 Diabetes pathways
REACT:604 Hemostasis
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB03431 - Adenosine-5'-Diphosphate
DB04184 - Acetate Ion Indicators and Reagents
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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