AutismKB 2.0

Annotation Detail for ARF5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ARF5 ( - )
Gene Full Name: ADP-ribosylation factor 5
Band: 7q32.1
Quick LinksEntrez ID:381; OMIM: 103188; Uniprot ID:ARF5_HUMAN; ENSEMBL ID: ENSG00000004059; HGNC ID: 658
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
No data
Pathway IDPathway Name
200098Class I PI3K signaling events
Pathway IDPathway Name
P00029Huntington disease
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARF5 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARF5 mRNAdecreases expression 20106945
D002713 Chlorine Chlorine results in increased expression of ARF5 mRNAincreases expression 18636392
D002713 Chlorine [Ozone co-treated with Chlorine] results in decreased expression of ARF5 mRNAaffects cotreatment|decreases expression 18636392
D005419 Flavonoids Flavonoids results in decreased expression of ARF5 mRNAdecreases expression 18035473
D010126 Ozone [Ozone co-treated with Chlorine] results in decreased expression of ARF5 mRNAaffects cotreatment|decreases expression 18636392
D010269 Paraquat Paraquat results in increased expression of ARF5 mRNAincreases expression 17077588
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARF5 mRNAaffects binding|decreases expression|increases activity 19710929
D012643 Selenium Selenium results in increased expression of ARF5 mRNAincreases expression 19244175
D018038 Sodium Selenite Sodium Selenite results in increased expression of ARF5 mRNAincreases expression 18175754
D014635 Valproic Acid Valproic Acid results in increased expression of ARF5 mRNAincreases expression 19101580
D014810 Vitamin E Vitamin E results in increased expression of ARF5 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 3.688875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 4.0719490988
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury Chlorine 9.6520601635
MESH:D055371 Acute Lung Injury pirinixic acid 9.6518653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0120127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.736695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6716434500
MESH:D000382 Agricultural Workers' Diseases Paraquat 3.9611874814
MESH:D000544 Alzheimer Disease Ozone 2.4615513908
MESH:D000550 Amblyopia Valproic Acid 5.4517688650
MESH:D001008 Anxiety Disorders Valproic Acid 3.6817497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2519183758
MESH:D001172 Arthritis, Rheumatoid Ozone 2.5815570426
MESH:D001249 Asthma Ozone 2.6717854713 16373670
MESH:D001321 Autistic Disorder Valproic Acid 1.9919460635 18985861 19232924 18558336 15238991 17507914 20603192 17157402 18177632 17688650 18396377 18316065 18940202 16609825 18775368
MESH:D001714 Bipolar Disorder Valproic Acid 3.1420046352 17594078
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001848 Bone Diseases, Developmental Valproic Acid 3.498888407
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0217474063 20146248
MESH:D016535 Bronchial Hyperreactivity Ozone 3.7914754758 18417511 17626835 15516495 19059883 18315731 16777450
MESH:D002100 Cachexia Ozone 4.9316183385
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7520734317
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9315894690
MESH:D003092 Colitis Selenium 3.9517936198
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.7516575769 8888407 17688650
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7519769572
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9016285004
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5415131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 6.5415131321
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 6.541733752 19641884
MESH:D004417 Dyspnea Chlorine 4.8420016425
MESH:D004421 Dystonia Valproic Acid 4.201851702
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 4.3317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 4.133922381 16628512
MESH:D004827 Epilepsy Valproic Acid 3.0020417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.716254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.477750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 4.263659116
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0416530937
MESH:D005234 Fatty Liver pirinixic acid 8.1920131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 8.1919224547 14986274
MESH:D005315 Fetal Diseases Valproic Acid 5.1016575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.2918558336 8888407
MESH:D005739 Gas Poisoning Chlorine 5.2320016425
MESH:D005911 Gliosis Paraquat 5.3811124998
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.9220471113
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9216080930
MESH:D006333 Heart Failure pirinixic acid 7.2220558911
MESH:D006333 Heart Failure Selenium 7.2217162251
MESH:D006529 Hepatomegaly pirinixic acid 3.1719176532 19772884 18467677 16221962
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006849 Hydrocephalus Valproic Acid 5.0617688650
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D007248 Infertility, Male Paraquat 3.344850670
MESH:D007249 Inflammation Flavonoids 2.7117296493
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007333 Insulin Resistance pirinixic acid 7.6016306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6014714311
MESH:D007674 Kidney Diseases Vitamin E 2.8812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1717596541 16294345
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4116169303
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 4.5221137059 20195826
MESH:D008113 Liver Neoplasms pirinixic acid 4.5216377806 15890375 20007298
MESH:D008171 Lung Diseases Ozone 7.8219066396 8266340
MESH:D008171 Lung Diseases Vitamin E 7.8216863852
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.4817228818
MESH:D055370 Lung Injury Ozone 4.0220417186
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.5620464547 18569708 17053015 18816296 20135361 6695378 20064080 20869020 18520028
MESH:D008175 Lung Neoplasms Ozone 3.567614698 8597069
MESH:D008175 Lung Neoplasms Vitamin E 3.5611062179
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2114737004
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D008679 Metaplasia Ozone 5.3210496685
MESH:D008881 Migraine Disorders Valproic Acid 3.2918803445 18765137
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3016381670
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.178888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.2317596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009369 Neoplasms Benzo(a)pyrene 5.0311141357
MESH:D009369 Neoplasms pirinixic acid 5.0317405874
MESH:D009410 Nerve Degeneration Paraquat 3.8216893418
MESH:D009436 Neural Tube Defects Valproic Acid 3.2116359493 8888407
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D010300 Parkinson Disease Paraquat 2.8612911755 11445065 15451049 11124998 15824117 16510128 16140633 11181820
MESH:D010302 Parkinson Disease, Secondary Paraquat 4.6116190885
MESH:D010538 Peritonitis Ozone 4.3116369182
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011014 Pneumonia Ozone 11.7218929643 18007984 18381685
MESH:D011014 Pneumonia Paraquat 11.7212504350
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 4.0220603192
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5417292933
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5418760546
MESH:D011471 Prostatic Neoplasms Vitamin E 2.5415084515
MESH:D019310 Pseudolymphoma Valproic Acid 4.7611422049 12752131
MESH:D011658 Pulmonary Fibrosis Paraquat 2.9617997886 16324872
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012120 Respiration Disorders Chlorine 5.4318579056
MESH:D012128 Respiratory Distress Syndrome, Adult Paraquat 4.0511700416
MESH:D012135 Respiratory Sounds Paraquat 4.2311874814
MESH:D012162 Retinal Degeneration Paraquat 3.9716458197
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.3219155313
MESH:D012559 Schizophrenia Valproic Acid 2.0815737665 19110320
MESH:D012640 Seizures Valproic Acid 2.8314763951 15475178 16876388 11738929 17978042 11044598 3137016 1511512
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4319755658 10029692
MESH:D016135 Spinal Dysraphism Valproic Acid 3.8919490988
MESH:D013226 Status Epilepticus Valproic Acid 4.7612833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D014178 Translocation, Genetic Valproic Acid 5.4517262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.713119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.2217053015
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.828888407
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved