AutismKB 2.0

Annotation Detail for KIT


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Basic Information Top
Gene Symbol:KIT ( C-Kit,CD117,PBT,SCFR )
Gene Full Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Band: 4q12
Quick LinksEntrez ID:3815; OMIM: 164920; Uniprot ID:KIT_HUMAN; ENSEMBL ID: ENSG00000157404; HGNC ID: 6342
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04916Melanogenesis
hsa04640Hematopoietic cell lineage
hsa04144Endocytosis
hsa05221Acute myeloid leukemia
hsa04060Cytokine-cytokine receptor interaction
hsa05200Pathways in cancer
No data
Pathway IDPathway Name
200130C-MYB transcription factor network
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers of haematopoietic and lymphoid tissues
Cancers
Inherited disorders of amino acid metabolism
H00003Acute myeloid leukemia (AML)
H00170Piebaldism
Genetic disorders
Desease IDDesease Name
1728Gastrointestinal tumor
1918Atherosclerosis
1934Cancer
1946Thyroid gland disease
1979Testicular dysfunction
2072Neurofibromatosis
2108Nephritis
2138Osteoporosis
Desease Name
HEMATOLOGICAL
bipolar disorder
leukemia, myeloid
melanoma
CANCER
PSYCH
slow transit constipation
stomach cancer
bone density
mean corpuscular volume
METABOLIC
Infertility, Male
Translocation, Genetic
REPRODUCTION
Desease Name
Mean corpuscular volume
Bipolar disorder
Desease Name
Gastrointestinal stromal tumor, somatic
Leukemia, acute myeloid
Mast cell leukemia
Piebaldism
Germ cell tumors
Mastocytosis with associated hematologic disorder
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C112765 17-(allylamino)-17-demethoxygeldanamycin 17-(allylamino)-17-demethoxygeldanamycin results in decreased expression of KIT proteindecreases expression 16213582
C112765 17-(allylamino)-17-demethoxygeldanamycin 17-(allylamino)-17-demethoxygeldanamycin results in increased degradation of and results in decreased expression of KIT proteindecreases expression|increases degradation 16061882
C054919 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNAaffects cotreatment|increases expression 19422813
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]decreases reaction|increases expression 17420286
C011269 2,5-hexanedione 2,5-hexanedione results in decreased expression of KIT proteindecreases expression 17725299
C011269 2,5-hexanedione resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]decreases expression|decreases reaction 17725299
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of KIT mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen results in increased expression of KIT mRNAincreases expression 18467506
D000082 Acetaminophen Acetaminophen results in increased expression of KIT proteinincreases expression 18467506
D000452 Aldrin [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNAaffects cotreatment|increases expression 19422813
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of KIT mRNAincreases expression 16940010
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KIT mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of KIT mRNAdecreases expression 19654921
C006632 arsenic trioxide arsenic trioxide results in decreased expression of KIT protein modified formdecreases expression 19619438
C472777 bisperoxovanadium bisperoxovanadium results in increased expression of KIT proteinincreases expression 17601985
C461979 CT52923 CT52923 binds to and results in decreased activity of KIT proteinaffects binding|decreases activity 15994924
D003632 Dichlorodiphenyldichloroethane [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNAaffects cotreatment|increases expression 19422813
D003633 Dichlorodiphenyl Dichloroethylene [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNAaffects cotreatment|increases expression 19422813
D004026 Dieldrin [Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of KIT mRNAaffects cotreatment|increases expression 19422813
D004958 Estradiol Estradiol affects the expression of KIT mRNAaffects expression 15598610
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of KIT mRNAincreases expression 17942748
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of KIT exonincreases mutagenesis 15731517
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of KIT geneincreases mutagenesis 15820307
D015073 2-Acetylaminofluorene 2-Acetylaminofluorene results in increased expression of KIT proteinincreases expression 15133858
C097613 imatinib imatinib inhibits the reaction [KIT protein results in increased expression of HMOX1 protein]decreases reaction|increases expression 17420286
C097613 imatinib imatinib results in decreased activity of KIT proteindecreases activity 16940797
21471107
D007501 Iron Iron deficiency results in decreased expression of KIT mRNAdecreases expression 20368581
D008769 Methylnitronitrosoguanidine Methylnitronitrosoguanidine results in increased expression of KIT mRNAincreases expression 12634122
C121565 pifithrin pifithrin results in decreased expression of KIT mRNAdecreases expression 19098008
C411007 PKC412 PKC412 inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]decreases reaction|increases expression 17420286
C059514 resveratrol resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]decreases expression|decreases reaction 17725299
C017947 sodium arsenite sodium arsenite results in increased expression of KIT mRNAincreases expression 12016162
C116890 SU 5416 SU 5416 results in decreased activity of KIT proteindecreases activity 12673719
12649163
C412603 SU 6668 SU 6668 results in decreased phosphorylation of and results in decreased activity of KIT proteindecreases activity|decreases phosphorylation 16144927
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KIT mRNAincreases expression 16102516
D014212 Tretinoin Tretinoin results in increased expression of KIT mRNAincreases expression 16788091
D014212 Tretinoin Tretinoin results in increased expression of KIT mRNAincreases expression 17303670
D014635 Valproic Acid Valproic Acid results in increased expression of KIT mRNAincreases expression 19101580
C025643 vinclozolin vinclozolin affects the expression of KIT mRNAaffects expression 19015723
D014807 Vitamin D Vitamin D affects the expression of KIT mRNAaffects expression 20368581
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D015746 Abdominal Pain SU 5416 6.8612673719
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.1915322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 7.198875741
MESH:D000015 Abnormalities, Multiple imatinib 9.5118322153
MESH:D000015 Abnormalities, Multiple Valproic Acid 9.5119490988
MESH:D000022 Abortion, Spontaneous imatinib 5.8718322153
MESH:D000138 Acidosis Ammonium Chloride 3.2218287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6017505938
MESH:D058186 Acute Kidney Injury pifithrin 8.2217670903
MESH:D058186 Acute Kidney Injury resveratrol 8.2216538975
MESH:D000230 Adenocarcinoma arsenic trioxide 6.4911798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 6.4911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.4914692618
MESH:D000236 Adenoma 2-Acetylaminofluorene 10.3110737359
MESH:D000236 Adenoma Ethylnitrosourea 10.316695378
MESH:D000236 Adenoma resveratrol 10.3115688382
MESH:D002759 Adenoma, Bile Duct 2-Acetylaminofluorene 5.666705139
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.0416835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.3515276417
MESH:D018246 Adrenocortical Adenoma Arsenic 12.6417306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 12.6417306315 16712894
MESH:D000382 Agricultural Workers' Diseases Dichlorodiphenyl Dichloroethylene 4.4616487989
MESH:D000505 Alopecia Tretinoin 3.3515955085
MESH:D019896 alpha 1-Antitrypsin Deficiency Iron 5.3116640825
MESH:D000544 Alzheimer Disease Iron 4.3116640825 16563566
MESH:D000544 Alzheimer Disease resveratrol 4.3116183991 16162502
MESH:D000550 Amblyopia Valproic Acid 4.8917688650
MESH:D000740 Anemia Iron 7.9516566752 16434484
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.9511748828
MESH:D018798 Anemia, Iron-Deficiency Iron 4.3516569441 17163184 17162259 17375513 17147795
MESH:D000756 Anemia, Sideroblastic Iron 4.5116910769
MESH:D000799 Angioedema Acetaminophen 3.5010982225
MESH:D001008 Anxiety Disorders Valproic Acid 7.9717497229
MESH:D001008 Anxiety Disorders vinclozolin 7.9719015723
MESH:D001145 Arrhythmias, Cardiac Iron 4.0816604332
MESH:D020261 Arsenic Poisoning Arsenic 2.7716835338 16251483 12569548 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.1311256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 11.0515885639
MESH:D001169 Arthritis, Experimental resveratrol 11.0517115116
MESH:D001169 Arthritis, Experimental Tretinoin 11.0516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.1816292516
MESH:D053627 Asthenozoospermia 2,5-hexanedione 6.4110689203
MESH:D001249 Asthma Tretinoin 2.2416456186
MESH:D001260 Ataxia Telangiectasia Iron 5.1115336622
MESH:D050197 Atherosclerosis Arsenic 9.9719371607 12928151
MESH:D050197 Atherosclerosis Iron 9.9716632123 16640825
MESH:D050197 Atherosclerosis resveratrol 9.9717967414 16873680
MESH:D001321 Autistic Disorder Acetaminophen 2.1418445737
MESH:D001321 Autistic Disorder Iron 2.1417352947
MESH:D001321 Autistic Disorder Valproic Acid 2.1418558336 19232924 18985861 19460635 20603192 17688650 18316065 18940202 17507914 18177632 15238991 16609825 18775368 17157402 18396377
MESH:D001424 Bacterial Infections Iron 4.8516640825
MESH:D001471 Barrett Esophagus Tretinoin 4.0816935849
MESH:D001714 Bipolar Disorder Valproic Acid 2.9020046352 17594078
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 13.5816206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 13.5812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 13.5816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4415340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.3015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.308888407
MESH:D001859 Bone Neoplasms imatinib 5.0115867366
MESH:D001927 Brain Diseases Ethylnitrosourea 4.5914991843
MESH:D002545 Brain Ischemia resveratrol 3.9417600658
MESH:D001932 Brain Neoplasms Ethylnitrosourea 8.9118412241 16436596 16357521 15144691 16651633
MESH:D001932 Brain Neoplasms SU 6668 8.9115739567
MESH:D001943 Breast Neoplasms Dichlorodiphenyl Dichloroethylene 3.5315061365
MESH:D001943 Breast Neoplasms Dieldrin 3.5315770527 11859874
MESH:D001943 Breast Neoplasms Estradiol 3.5318497071 17289903 17018787 12948864 14630087 19861407 16675129 17261762
MESH:D001943 Breast Neoplasms imatinib 3.5317614352
MESH:D001943 Breast Neoplasms resveratrol 3.5316393696 17651959 17534123
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.5320435547
MESH:D001943 Breast Neoplasms Tretinoin 3.5316166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2516813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5316835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4015504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8116168501
MESH:D006528 Carcinoma, Hepatocellular 2-Acetylaminofluorene 15.833581430 3084413 17761372 6705139 10737359
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 15.833084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 15.8317306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 15.8315073043 16217749 15553829 14691202 11135700
MESH:D006528 Carcinoma, Hepatocellular Estradiol 15.8316924424
MESH:D006528 Carcinoma, Hepatocellular resveratrol 15.8319321006 16227395
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 15.8315276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 15.831917145
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.2516675471
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5319014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8212490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 9.9417687452 18922899 15504454
MESH:D002294 Carcinoma, Squamous Cell resveratrol 9.9416227395
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 9.9418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 9.9416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 3.7818640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.1818670907 18850075 16120746
MESH:D009202 Cardiomyopathies Iron 3.8216640825
MESH:D002311 Cardiomyopathy, Dilated Iron 3.3416604332
MESH:D002318 Cardiovascular Diseases Arsenic 6.7915738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases resveratrol 6.7915458977
MESH:D002340 Carotid Artery Diseases Arsenic 4.0218022660 16973168
MESH:D002386 Cataract Acetaminophen 6.5610977129
MESH:D002386 Cataract Tretinoin 6.5617460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.2118566989
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 14.2116003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitronitrosoguanidine 14.212727394
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 14.2120056578 19524636
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.6417160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2516129372
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5820734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.8816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.6311677210 16105132 17110522 16919318 15861022 17681005 17333356
MESH:D002822 Choriocarcinoma Tretinoin 4.8116461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.2712621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.279407595
MESH:D003092 Colitis resveratrol 8.5216474422
MESH:D003092 Colitis Tretinoin 8.5217035595
MESH:D003110 Colonic Neoplasms 17-(allylamino)-17-demethoxygeldanamycin 5.7815993848
MESH:D003110 Colonic Neoplasms Iron 5.7816640825
MESH:D003110 Colonic Neoplasms resveratrol 5.7816338953
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5420501625
MESH:D015179 Colorectal Neoplasms resveratrol 2.5416550006
MESH:D000013 Congenital Abnormalities Dichlorodiphenyldichloroethane 8.8715095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.8717141729 14669216
MESH:D003327 Coronary Disease resveratrol 3.5316507316
MESH:D023903 Coronary Restenosis arsenic trioxide 3.8612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 6.8910525206
MESH:D019465 Craniofacial Abnormalities imatinib 6.8918322153
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.8915322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.899224671 16925845 14991402 9664655 9211117 17551590 8800419 10589399 9142499 9125849
MESH:D019465 Craniofacial Abnormalities Valproic Acid 6.8917688650 8888407 16575769
MESH:D003456 Cryptorchidism vinclozolin 4.0214966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.7815213294
MESH:D018500 Diabetes Insipidus, Nephrogenic 17-(allylamino)-17-demethoxygeldanamycin 5.9118854434
MESH:D003920 Diabetes Mellitus Iron 4.1716640825 16604332
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.5016873680
MESH:D003922 Diabetes Mellitus, Type 1 Iron 3.2516506275
MESH:D003924 Diabetes Mellitus, Type 2 Iron 4.2516506275
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.0819279558
MESH:D003928 Diabetic Nephropathies resveratrol 8.0816286809
MESH:D003967 Diarrhea SU 5416 4.9712673719
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 5.5110663392 11421492 11739529 19923254 15619225 11461765 18713872 19739265 14550746 19085960 12540782 12958197 12153990 11287661 19420014 10915739 11743745 17522070 12392966 16109766 11529661 14725611 10774834 12705907 19370779 19416960 16485898 17906064 17562736 16081117 16393943 11834606 19164858 14986274 12594235 18071297 15968718 16227642 2444490 16781746 16177239
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.5120420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 5.511733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.7519426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5111462148
MESH:D004417 Dyspnea Dichlorodiphenyl Dichloroethylene 10.1716487989
MESH:D004417 Dyspnea SU 5416 10.1712649163 12673719
MESH:D004421 Dystonia Valproic Acid 3.741851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.6418357618
MESH:D004487 Edema imatinib 9.9519703484
MESH:D004487 Edema resveratrol 9.958985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 9.9512711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.7916714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.7918230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.0512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 8.0517872969
MESH:D016889 Endometrial Neoplasms Estradiol 6.6711473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.6716569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.739294722 10568697
MESH:D020345 Enterocolitis, Necrotizing resveratrol 4.5217923197
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.8217275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.573922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.7620417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.316426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.967750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.723659116
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2212903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.0011564622
MESH:D005124 Eye Abnormalities Tretinoin 8.009664655 16938888
MESH:D005221 Fatigue SU 5416 6.0412673719 12649163
MESH:D005234 Fatty Liver arsenic trioxide 16.3415073043
MESH:D005234 Fatty Liver Ethinyl Estradiol 16.3415345470
MESH:D005234 Fatty Liver Iron 16.3416640825
MESH:D005234 Fatty Liver Valproic Acid 16.3419224547 14986274
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.5416575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.8118558336 8888407
MESH:D018222 Fibromatosis, Aggressive imatinib 5.3117453242
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 7.5220067830
MESH:D005355 Fibrosis Tretinoin 7.5217994277
MESH:D005534 Foot Diseases Arsenic 5.216392382
MESH:D005621 Friedreich Ataxia Iron 5.0916604332 16640825
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9416904648
MESH:D005756 Gastritis Acetaminophen 3.3316983495
MESH:D046152 Gastrointestinal Stromal Tumors marker/mechanism
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.5916973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.9516417039
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3416452187
MESH:D005909 Glioblastoma Ethylnitrosourea 6.6816436596
MESH:D005909 Glioblastoma Tretinoin 6.6817312396
MESH:D005910 Glioma Ethylnitrosourea 6.7216651633 16357521 18412241
MESH:D005910 Glioma SU 6668 6.7215739567
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2510696789
MESH:D006261 Headache SU 5416 5.7112673719 12649163
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9616096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8116084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.9310048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 5.939664655 14991402
MESH:D006331 Heart Diseases pifithrin 4.3614766674
MESH:D006390 Hemangioendothelioma 2-Acetylaminofluorene 4.976705139
MESH:D006394 Hemangiosarcoma 2-Acetylaminofluorene 4.106705139
MESH:D006432 Hemochromatosis Iron 4.2416574947 16604332 16640825 17053826 17236123 17255318
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0311000095
MESH:D006486 Hemosiderosis Iron 4.8716604332
MESH:D006505 Hepatitis Dichlorodiphenyl Dichloroethylene 4.7216487989
MESH:D006525 Hepatitis, Viral, Human Iron 5.1216640825
MESH:D006527 Hepatolenticular Degeneration Iron 4.6117182432
MESH:D006529 Hepatomegaly Iron 7.6516890145
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.6516120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.6915709030
MESH:D006561 Herpes Simplex resveratrol 3.8416876885
MESH:D015658 HIV Infections Iron 3.4916597321
MESH:D006689 Hodgkin Disease sodium arsenite 2.8812676792
MESH:D019584 Hot Flashes Estradiol 3.4117088409
MESH:D006849 Hydrocephalus Valproic Acid 4.5317688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.7015340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 6.7416870215
MESH:D006930 Hyperalgesia Tretinoin 6.7416870215
MESH:D006937 Hypercholesterolemia resveratrol 3.7017188708
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2416778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.1617050553
MESH:D006949 Hyperlipidemias resveratrol 3.7216873680
MESH:D006973 Hypertension Arsenic 4.7811953799 16076760 9931084
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.0117488730
MESH:D006987 Hypesthesia Arsenic 5.2116093927
MESH:D007006 Hypogonadism Iron 4.1616640825
MESH:D007021 Hypospadias Ethinyl Estradiol 3.4816569931 16945680
MESH:D007037 Hypothyroidism Iron 4.7516640825
MESH:D020244 Infarction, Middle Cerebral Artery pifithrin 10.8519475672
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 10.8517600658
MESH:D007247 Infertility, Female 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 15.5912515675
MESH:D007247 Infertility, Female Dieldrin 15.5910630421
MESH:D007247 Infertility, Female Ethinyl Estradiol 15.5912013081
MESH:D007248 Infertility, Male 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene 18.7612515675
MESH:D007248 Infertility, Male Dichlorodiphenyl Dichloroethylene 18.7617192596 12948891
MESH:D007248 Infertility, Male Ethinyl Estradiol 18.7617937319
MESH:D007248 Infertility, Male sodium arsenite 18.7612646999 15346721
MESH:D007248 Infertility, Male vinclozolin 18.7616467254
MESH:D007249 Inflammation resveratrol 4.4816366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.4812200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.2016624496
MESH:D007333 Insulin Resistance Estradiol 2.7516627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.4417994277
MESH:D019189 Iron Metabolism Disorders Iron 4.7217163184
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.9216580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.9215992940 17551590
MESH:D007642 Keratosis Arsenic 4.6516930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 8.8915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 8.8915618244
MESH:D007674 Kidney Diseases sodium arsenite 8.8920008137
MESH:D007680 Kidney Neoplasms Estradiol 6.8115610895
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 6.8117379185
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 9.6012970779
MESH:D007938 Leukemia arsenic trioxide 9.6015070760
MESH:D007938 Leukemia Tretinoin 9.6017143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.4912560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 3.9716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 8.0414633726
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive imatinib 8.0419208803 15748426 15107311 17301526
MESH:D007951 Leukemia, Myeloid arsenic trioxide 14.3919077051
MESH:D007951 Leukemia, Myeloid imatinib 14.3917236224
MESH:D007951 Leukemia, Myeloid Tretinoin 14.3916482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 10.9919850784 17050201 16467208 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute SU 5416 10.9912649163
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 10.9917596541 16294345 19850784
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 10.9916294345 17596541
MESH:D015470 Leukemia, Myeloid, Acute Vitamin D 10.9920368581
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 16.3717339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 16.3715213294 15622746 17712046 15748426 19075265 16331271 12018890 16966277 16823087 19225113 9834237 16330433 17107899 12679006 16891316 17869043 19642359 11161223 19035177 17217047 11468182 15336539 16112521 12712474 17649720
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 16.3716087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 16.3716891316 17506722 19642359 17217047 19075265 12679006 17649720 19225113 17339181 16140955 19035177 16935935 17294898 19029980 17361223 17301526 9834237 16766008 17368321 15748426 16823087 16331271 16788101 17107899 17712046
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0316882451
MESH:D020961 Lewy Body Disease Iron 5.0916563566
MESH:D007984 Leydig Cell Tumor vinclozolin 4.3916417039
MESH:D017880 Limb Deformities, Congenital Dichlorodiphenyl Dichloroethylene 7.8312745335
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.839224671
MESH:D008103 Liver Cirrhosis Iron 3.5416640825
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental imatinib 4.6316596278
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.6312878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.6316248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.7519460945 12587719 19014921 11587558 19784758 16610002 12969438 16611625
MESH:D008107 Liver Diseases Arsenic 3.7511134558
MESH:D008108 Liver Diseases, Alcoholic Iron 4.6716737972 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9417185352 16871587
MESH:D008113 Liver Neoplasms 2-Acetylaminofluorene 23.5716273603 11376686 18001218 14678523 10672840 10737359
MESH:D008113 Liver Neoplasms Arsenic 23.5716368122
MESH:D008113 Liver Neoplasms arsenic trioxide 23.5714682389
MESH:D008113 Liver Neoplasms Dieldrin 23.579539021 8742319
MESH:D008113 Liver Neoplasms Iron 23.5716640825 20302851
MESH:D008113 Liver Neoplasms resveratrol 23.5719812893 20405173 19073162 19321006
MESH:D008113 Liver Neoplasms sodium arsenite 23.5716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.5716984957
MESH:D008114 Liver Neoplasms, Experimental 2-Acetylaminofluorene 8.696150874 1399818 534488
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 8.6920377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 8.6912151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.0915213294
MESH:D008171 Lung Diseases marker/mechanism 21471107
MESH:D008171 Lung Diseases sodium arsenite 2.9519095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.9217228818
MESH:D008175 Lung Neoplasms 2-Acetylaminofluorene 9.9711376686
MESH:D008175 Lung Neoplasms Arsenic 9.9717306315 17976673 19168569
MESH:D008175 Lung Neoplasms arsenic trioxide 9.9719825857 11798837
MESH:D008175 Lung Neoplasms Ethylnitrosourea 9.9716271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Iron 9.9716640825
MESH:D008175 Lung Neoplasms sodium arsenite 9.9715276417 16712894 17077188 17306315 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 9.9711884234 19555203
MESH:D008223 Lymphoma Ethylnitrosourea 3.7015790496
MESH:D016393 Lymphoma, B-Cell resveratrol 3.9917088997
MESH:D017728 Lymphoma, Large-Cell, Anaplastic 17-(allylamino)-17-demethoxygeldanamycin 6.2717157164
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 3.6014749477
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 4.7215375218
MESH:D008268 Macular Degeneration Iron 3.7916640825
MESH:D015674 Mammary Neoplasms, Animal resveratrol 3.9115688416
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.8616891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 8.8610767621 10838139 18041768
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 8.8611606380 8985016
MESH:D020149 Manganese Poisoning Estradiol 4.1419453300
MESH:D034721 Mastocytosis, Systemic PKC412 6.7517420286
MESH:D008527 Medulloblastoma Tretinoin 2.6517453147
MESH:D008545 Melanoma resveratrol 4.7717992120
MESH:D008545 Melanoma sodium arsenite 4.7719082730 16487513
MESH:D008545 Melanoma Tretinoin 4.7716752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2419513568
MESH:D008579 Meningioma Ethylnitrosourea 5.6417943659
MESH:D008591 Meningomyelocele Tretinoin 4.0916940565
MESH:D008659 Metabolic Diseases resveratrol 4.0717112576
MESH:D053842 Microsatellite Instability Methylnitronitrosoguanidine 5.5517671175
MESH:D008881 Migraine Disorders Valproic Acid 2.9518765137 18803445
MESH:D009101 Multiple Myeloma arsenic trioxide 6.6219549372 19417148 15949261 14977855 11468182
MESH:D009101 Multiple Myeloma resveratrol 6.6217049120 16490592 17164350 17935668 14749477 16267019
MESH:D020528 Multiple Sclerosis, Chronic Progressive Iron 5.3317086897
MESH:D009134 Muscular Atrophy, Spinal resveratrol 4.5317962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.728888407
MESH:D009181 Mycoses Iron 5.1216640825
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3318349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 16.0416882451 16105982
MESH:D009190 Myelodysplastic Syndromes SU 5416 16.0412649163
MESH:D009190 Myelodysplastic Syndromes Tretinoin 16.0417596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 16.0417596541
MESH:D009203 Myocardial Infarction resveratrol 2.8917188708 17125593 16525036 16317513 17015251 16456233
MESH:D017202 Myocardial Ischemia Arsenic 19.6715371236
MESH:D017202 Myocardial Ischemia Iron 19.6716604332
MESH:D017202 Myocardial Ischemia resveratrol 19.6717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 19.6712213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.8816810080
MESH:D015428 Myocardial Reperfusion Injury Iron 7.8816604332
MESH:D009205 Myocarditis resveratrol 4.4217322642
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6416624393
MESH:D009362 Neoplasm Metastasis imatinib 3.8715867366
MESH:D009369 Neoplasms Dieldrin 10.608820588
MESH:D009369 Neoplasms sodium arsenite 10.6011559025
MESH:D009369 Neoplasms SU 5416 10.6017264769
MESH:D009369 Neoplasms Tretinoin 10.6016946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 13.4716707424
MESH:D009374 Neoplasms, Experimental resveratrol 13.478985016
MESH:D009374 Neoplasms, Experimental sodium arsenite 13.4720056578
MESH:D009376 Neoplasms, Hormone-Dependent imatinib 5.1217614352
MESH:D009389 Neovascularization, Pathologic Estradiol 3.3917289903
MESH:D009404 Nephrotic Syndrome Iron 4.2317178036
MESH:D009422 Nervous System Diseases 2,5-hexanedione 5.7912164553
MESH:D009421 Nervous System Malformations Estradiol 14.4611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 14.4614600291
MESH:D009421 Nervous System Malformations Tretinoin 14.469125849
MESH:D009436 Neural Tube Defects Arsenic 20.4116620997
MESH:D009436 Neural Tube Defects arsenic trioxide 20.4110525206
MESH:D009436 Neural Tube Defects sodium arsenite 20.4112854658
MESH:D009436 Neural Tube Defects Tretinoin 20.419142499
MESH:D009436 Neural Tube Defects Valproic Acid 20.4116359493 8888407
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.0716651423 16003739 17160924
MESH:D019636 Neurodegenerative Diseases 2,5-hexanedione 17.9817492505
MESH:D019636 Neurodegenerative Diseases Acetaminophen 17.9818514411
MESH:D019636 Neurodegenerative Diseases Iron 17.9816604332 17296847
MESH:D019636 Neurodegenerative Diseases resveratrol 17.9817652729
MESH:D020078 Neurogenic Inflammation Arsenic 9.6617056641
MESH:D020078 Neurogenic Inflammation resveratrol 9.6617929310
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.6417160924
MESH:D010003 Osteoarthritis Iron 3.7616640825
MESH:D010014 Osteolysis imatinib 5.4015867366
MESH:D010024 Osteoporosis Iron 7.3416648989 16640825
MESH:D010024 Osteoporosis Vitamin D 7.3417882678
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 3.9417513867
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.3816211241
MESH:D010051 Ovarian Neoplasms Arsenic 17.3817306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 17.3816624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 17.3819401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 17.3817306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 17.3816936753
MESH:D010146 Pain Acetaminophen 5.6916870215
MESH:D010146 Pain Tretinoin 5.6916870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 4.8615580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 4.8615976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.3711578682
MESH:D010212 Papilloma Iron 4.1512065085
MESH:D010235 Paraganglioma arsenic trioxide 3.8519927285
MESH:D020447 Parasomnias Iron 5.6717352947
MESH:D010300 Parkinson Disease Dieldrin 5.5316112328 11181820 11445065 16809432 17291500
MESH:D010300 Parkinson Disease Iron 5.5316563566 16640825
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9012520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.8616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.6516905509 6392382 15371236
MESH:D016116 Piebaldism marker/mechanism
MESH:D010900 Pituitary Diseases Iron 5.3316604332
MESH:D011041 Poisoning Iron 3.9816604332
MESH:D017119 Porphyria Cutanea Tarda Iron 9.9516640825
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 9.9518163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma imatinib 4.2912476293
MESH:D011225 Pre-Eclampsia Iron 4.1616640825
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 20.4516679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 20.4511399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 20.4520603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 20.4518220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.5918220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.5820887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.9016140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.9019131511
MESH:D011471 Prostatic Neoplasms Estradiol 1.9016740699
MESH:D011471 Prostatic Neoplasms resveratrol 1.9017718901 16731767 15767336 17636462 17804756 17675339
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.9016039940
MESH:D011472 Prostatitis vinclozolin 4.5918629315
MESH:D011507 Proteinuria Arsenic 8.2421343184
MESH:D011507 Proteinuria Tretinoin 8.2416636307
MESH:D011528 Protozoan Infections Iron 5.6716640825
MESH:D011537 Pruritus Ethinyl Estradiol 2.9815861022 16919318
MESH:D019310 Pseudolymphoma Valproic Acid 4.1912752131 11422049
MESH:D011625 Pterygium Tretinoin 4.4516723453
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.2416325855
MESH:D015427 Reperfusion Injury resveratrol 3.1016314181 17058453 15827377 17520802 16317513
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5118990726
MESH:D012148 Restless Legs Syndrome Iron 4.3016930377
MESH:D012208 Rhabdomyosarcoma Tretinoin 9.8216116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 9.8219155313
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6416646077
MESH:D012559 Schizophrenia Valproic Acid 2.0219110320 15737665
MESH:D012640 Seizures Valproic Acid 2.521511512 11738929 11044598 16876388 3137016 15475178 14763951 17978042
MESH:D012871 Skin Diseases Arsenic 2.6618709164 17938729 19834688 17453740 16702368 17548696 17050553 16353154 6392382 16759981 15952646
MESH:D012878 Skin Neoplasms Arsenic 20.3417976673 15504454 17029826 16251483 19538983 17050553
MESH:D012878 Skin Neoplasms Iron 20.3412065085
MESH:D012878 Skin Neoplasms resveratrol 20.3415837718 8985016
MESH:D012878 Skin Neoplasms sodium arsenite 20.3418572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 20.3416192470
MESH:D012878 Skin Neoplasms Tretinoin 20.3416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6016709447
MESH:D016135 Spinal Dysraphism sodium arsenite 8.6812854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.6819490988
MESH:D013226 Status Epilepticus Valproic Acid 4.1912833885
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.3617007042
MESH:D013274 Stomach Neoplasms imatinib 3.3615786421
MESH:D013274 Stomach Neoplasms Tretinoin 3.3617261132
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.1916321402
MESH:D013345 Subarachnoid Hemorrhage pifithrin 5.7118364113
MESH:D013398 Sudden Infant Death Iron 5.1116640825
MESH:D013733 Testicular Diseases 2,5-hexanedione 5.9817725299
MESH:D013736 Testicular Neoplasms marker/mechanism
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 8.6615669648
MESH:D013927 Thrombosis SU 5416 8.6612649163
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 4.8215790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.5612697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.6919014326
MESH:D013964 Thyroid Neoplasms imatinib 10.6916940797
MESH:D013964 Thyroid Neoplasms Tretinoin 10.6917045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3419048282
MESH:D014062 Tongue Neoplasms resveratrol 8.9316227395
MESH:D014062 Tongue Neoplasms Tretinoin 8.9316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6215213294
MESH:D014178 Translocation, Genetic Valproic Acid 4.8917262798
MESH:D014376 Tuberculosis Iron 7.4716597321
MESH:D014376 Tuberculosis Tretinoin 7.4716040207
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.183119515
MESH:D001749 Urinary Bladder Neoplasms 2-Acetylaminofluorene 10.841399818 15867355 15289314
MESH:D001749 Urinary Bladder Neoplasms Arsenic 10.8417976673 17306315 11144890 19429237 19322015 18640142 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 10.8412845720 20435036 12973940 11780464
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.8417306315 16452187 16712894 11723127
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.318888407
MESH:D014570 Urologic Diseases Dichlorodiphenyl Dichloroethylene 5.3916487989
MESH:D014581 Urticaria Acetaminophen 2.6710982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 14.1917473185
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.1911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.1916129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.4314692618
MESH:D014594 Uterine Neoplasms resveratrol 8.4317044934
MESH:D014604 Uveal Neoplasms Tretinoin 4.2616752155
MESH:D014652 Vascular Diseases Arsenic 10.7117056641
MESH:D014652 Vascular Diseases sodium arsenite 10.7117056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2512125929
MESH:D020301 Vasospasm, Intracranial pifithrin 5.2818364113
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2415869587 14671159
MESH:D018487 Ventricular Dysfunction, Left resveratrol 3.9717488730
MESH:D014820 Vitiligo Tretinoin 3.7316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9015886252
MESH:D009396 Wilms Tumor Tretinoin 3.6816287080
Pathway ID Pathway Name
KEGG:05221 Acute myeloid leukemia
KEGG:04060 Cytokine-cytokine receptor interaction
KEGG:04144 Endocytosis
KEGG:04640 Hematopoietic cell lineage
KEGG:04916 Melanogenesis
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30128
    • No data
    Releated disease ID Related disease Name
    PA443622Carcinoma, Non-Small-Cell Lung
    PA446661Carcinoma, Small Cell
    PA444818Lung Neoplasms
    PA151958383Gastrointestinal Stromal Tumors
    PA443448Asthenia
    PA443560Breast Neoplasms
    PA443624Carcinoma, Renal Cell
    PA443899Diarrhea
    PA443937Drug Toxicity
    PA444153Fatigue
    PA444552Hypertension
    PA445062Neoplasms
    PA445113Neutropenia
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA131301952gefitinib
    PA162372840sunitinib
    PA10804imatinib
    PA10804imatinib
    PA165291492pazopanib
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00398 antagonist Sorafenib Antineoplastic Agents;Protein Kinase Inhibitors;Anticancer Agents
    DB00619 inhibitor Imatinib Antineoplastic Agents;Protein Kinase Inhibitors
    DB01254 inhibitor Dasatinib Protein Kinase Inhibitors
    DB01268 antagonist Sunitinib Antineoplastic Agents;Angiogenesis Inhibitors
    DB01962 - Phosphonotyrosine
    DB03261 multitarget Sti-571 Antineoplastic Agents;Protein Kinase Inhibitors
    DB03431 - Adenosine-5'-Diphosphate
    DB04868 antagonist Nilotinib Anticancer Agents
    DB07417 - N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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