AutismKB 2.0

Annotation Detail for KLK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:KLK1 ( KLKR,Klk6,hK1 )
Gene Full Name: kallikrein 1
Band: 19q13.33
Quick LinksEntrez ID:3816; OMIM: 147910; Uniprot ID:KLK1_HUMAN; ENSEMBL ID: ENSG00000167748; HGNC ID: 6357
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
1902Kidney failure
1958Glomerulonephritis
2091Hypertension
2053Colon cancer
Desease Name
CARDIOVASCULAR
vesicoureteral reflux
hypertension
renal disease, end stage
No data
Desease Name
Kallikrein, decreased urinary activity of
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KLK1 mRNAdecreases expression 16788091
C006500 4-aminobenzamidine 4-aminobenzamidine binds to and results in decreased activity of KLK1 proteinaffects binding|decreases activity 11151026
C019498 4-nitroaniline 4-nitroaniline binds to and results in decreased activity of KLK1 proteinaffects binding|decreases activity 11151026
C019498 4-nitroaniline KLK1 protein affects the metabolism of 4-nitroaniline analogaffects metabolic processing 2330740
D000535 Aluminum Aluminum binds to and results in decreased activity of KLK1 proteinaffects binding|decreases activity 15558947
D000584 Amiloride KLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]affects response to substance|increases secretion 18086683
D000584 Amiloride KLK1 protein results in increased susceptibility to Amilorideincreases response to substance 18086683
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLK1 mRNAaffects expression 16483693
C023650 aniline aniline binds to and results in decreased activity of KLK1 proteinaffects binding|decreases activity 11151026
C032157 benzamidine benzamidine binds to and results in decreased activity of KLK1 proteinaffects binding|decreases activity 11151026
D002118 Calcium Calcium results in decreased activity of KLK1 proteindecreases activity 15558947
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of KLK1 mRNAincreases expression 16644059
D002945 Cisplatin KLK1 protein affects the susceptibility to Cisplatinaffects response to substance 16217747
D004280 Dobutamine KLK1 protein affects the susceptibility to Dobutamineaffects response to substance 12411458
D004958 Estradiol Estradiol affects the expression of KLK1 mRNAaffects expression 15598610
C025314 ferric citrate ferric citrate results in decreased activity of KLK1 proteindecreases activity 6421970
C020748 ferrous sulfate ferrous sulfate results in decreased activity of KLK1 proteindecreases activity 6421970
D005419 Flavonoids Flavonoids results in increased expression of KLK1 mRNAincreases expression 18035473
D005632 Fructose KLK1 protein inhibits the reaction [Fructose results in increased expression of AGTR1B mRNA]decreases reaction|increases expression 14568997
D005632 Fructose KLK1 protein inhibits the reaction [Fructose results in increased expression of EDN1 mRNA]decreases reaction|increases expression 14568997
D005632 Fructose KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA]decreases reaction|increases expression 14568997
D005839 Gentamicins icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]decreases reaction|increases expression 16401625
D005839 Gentamicins icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]decreases reaction|increases expression 16401625
D005839 Gentamicins icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]decreases reaction|increases phosphorylation 16401625
D005839 Gentamicins KLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]decreases abundance|decreases reaction 16401625
D005839 Gentamicins KLK1 protein inhibits the reaction [Gentamicins results in increased expression of CCL2 protein]decreases reaction|increases expression 16401625
D005839 Gentamicins KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]decreases reaction|increases expression 16401625
D005839 Gentamicins KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]decreases reaction|increases expression 16401625
D005839 Gentamicins KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]decreases reaction|increases phosphorylation 16401625
D005839 Gentamicins KLK1 protein results in decreased susceptibility to Gentamicinsdecreases response to substance 16401625
C065679 icatibant icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]decreases reaction|increases expression 16401625
C065679 icatibant icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]decreases reaction|increases expression 16401625
C065679 icatibant icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]decreases reaction|increases phosphorylation 16401625
C065679 icatibant icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]decreases reaction|increases abundance 16401625
D008274 Magnesium Magnesium results in decreased activity of KLK1 proteindecreases activity 15558947
D008770 Methylnitrosourea Methylnitrosourea results in increased expression of KLK1 mRNAincreases expression 15240709
D009569 Nitric Oxide icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide]decreases reaction|increases abundance 16401625
D009569 Nitric Oxide KLK1 protein inhibits the reaction [Gentamicins results in decreased abundance of Nitric Oxide]decreases abundance|decreases reaction 16401625
D009569 Nitric Oxide KLK1 protein results in increased abundance of Nitric Oxideincreases abundance 16401625
D011188 Potassium Potassium results in decreased activity of KLK1 proteindecreases activity 15558947
D012964 Sodium Sodium results in decreased activity of KLK1 proteindecreases activity 15558947
D012964 Sodium KLK1 protein affects the susceptibility to [Amiloride results in increased secretion of Sodium]affects response to substance|increases secretion 18086683
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KLK1 mRNAincreases expression 16267337
D014212 Tretinoin Tretinoin results in decreased expression of KLK1 mRNAdecreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6411752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D058186 Acute Kidney Injury Cisplatin 8.5115814532 12690470 17670903
MESH:D058186 Acute Kidney Injury Gentamicins 8.5111274264
MESH:D000230 Adenocarcinoma Cisplatin 6.9611798837 17638652
MESH:D000230 Adenocarcinoma Estradiol 6.9611473722
MESH:D000230 Adenocarcinoma Methylnitrosourea 6.9615113128 15688392
MESH:D000236 Adenoma Magnesium 4.4317823441
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.1716835633
MESH:D000505 Alopecia Tretinoin 3.4515955085
MESH:D000544 Alzheimer Disease Aluminum 4.9610721010 17662457
MESH:D000544 Alzheimer Disease Nitric Oxide 4.9617556102
MESH:D000740 Anemia 4-nitroaniline 8.853710033
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D001169 Arthritis, Experimental Tretinoin 2.9516412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001321 Autistic Disorder Magnesium 3.6016846101
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 14.466421970
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.4612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.4616206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D019046 Bone Marrow Neoplasms Cisplatin 4.6714601052
MESH:D001943 Breast Neoplasms Cisplatin 2.8719526202 18382427
MESH:D001943 Breast Neoplasms Estradiol 2.8717289903 16675129 12948864 17018787 18497071 17261762 19861407 14630087
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.8711306469 14633655 16253758
MESH:D001943 Breast Neoplasms Nitric Oxide 2.8715631943
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8720435547
MESH:D001943 Breast Neoplasms Tretinoin 2.8716873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.5718705752 15673190 16097048 15700767 16192424 16227642 16050911 15721981 10355542 16011737 3786805 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.3218788625
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 6.3217982673
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.3216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.321917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 2.9612023789 16685392
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 4.6417066447 6189445 18337622
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.6416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Amiloride 4.9014644129
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518670907 18850075 16120746
MESH:D002386 Cataract Methylnitrosourea 7.3412484553
MESH:D002386 Cataract Tretinoin 7.3417460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.5718566989
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 6.577505956 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Nitric Oxide 4.3016919318
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.478697196 16354765 15340226 12621046 15668235
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Amiloride 9.3012065299
MESH:D003092 Colitis Tretinoin 9.3017035595
MESH:D003111 Colonic Polyps Magnesium 5.8517823441
MESH:D015179 Colorectal Neoplasms Cisplatin 3.2015273666
MESH:D015179 Colorectal Neoplasms Magnesium 3.2017823441
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8817141729 14669216
MESH:D003327 Coronary Disease Fructose 4.3418504504
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.3815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.389125849 16925845 9211117 17551590 9664655 10589399 14991402 8800419 9142499 9224671
MESH:D015140 Dementia, Vascular Nitric Oxide 5.7517556102
MESH:D002658 Developmental Disabilities Magnesium 4.7716846101
MESH:D003921 Diabetes Mellitus, Experimental Fructose 4.3218603373
MESH:D003924 Diabetes Mellitus, Type 2 Fructose 4.4818603373
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.2419279558
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.5219336974 7440962 6884620 2869522 3732212 19085960 15998439 10915739 15027814 4309450 6623471 16177239 10092053 9327722 7120509 15968718 3786805 16227642 11566570 21278145 7179309 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5220420201
MESH:D004362 Drug Toxicity Cisplatin 12.9912649298 19839026 15033597 12231392
MESH:D004362 Drug Toxicity Gentamicins 12.9915033597 11033412
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.9911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.2011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D016889 Endometrial Neoplasms Estradiol 6.9618566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 6.9616569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.849294722 10568697
MESH:D004938 Esophageal Neoplasms Cisplatin 2.7315173087 16481741 15464296 16785472 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.329664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.6416239168 12631006 61145 15959796 17595544 12795759 19224547 16045604
MESH:D005234 Fatty Liver Fructose 7.6418395287 18641190 19196556
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.0211555667
MESH:D005355 Fibrosis Carbon Tetrachloride 19.5018705752
MESH:D005355 Fibrosis Fructose 19.5018504504
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.5020067830
MESH:D005355 Fibrosis Tretinoin 19.5017994277
MESH:D005909 Glioblastoma Tretinoin 2.8717312396
MESH:D005910 Glioma Methylnitrosourea 3.489825942
MESH:D018149 Glucose Intolerance Fructose 5.1319165636
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006130 Growth Disorders Amiloride 4.6219703807
MESH:D006261 Headache Nitric Oxide 4.9611284996 11554966
MESH:D006258 Head and Neck Neoplasms Cisplatin 7.4515464296 15102660
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.4516096774
MESH:D034381 Hearing Loss Cisplatin 9.7019898482
MESH:D034381 Hearing Loss Gentamicins 9.7018024279 17868369 15968427 19130971
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.2515464296
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.1711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.179664655 14991402
MESH:D006333 Heart Failure Dobutamine 4.3217440445
MESH:D006394 Hemangiosarcoma 4-nitroaniline 5.6815200160
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006486 Hemosiderosis 4-nitroaniline 6.463710033
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6912621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease Cisplatin 3.4216200630 16170182
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8316354765 18606429 15340226 16959395 8697196
MESH:D006930 Hyperalgesia icatibant 8.1612727271
MESH:D006930 Hyperalgesia Tretinoin 8.1616870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.3216899240
MESH:D053565 Hypercalciuria Gentamicins 5.5017652376
MESH:D006940 Hyperemia Nitric Oxide 5.4011156591
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006946 Hyperinsulinism Fructose 4.7215752949 18563319 18360027 14757778 19008412
MESH:D006949 Hyperlipidemias Fructose 4.5615752949
MESH:D006973 Hypertension therapeutic 14568997
MESH:D006973 Hypertension Amiloride 8.4515174897 18524855 19344079
MESH:D006973 Hypertension Fructose 8.4516843071 19008412 14633139 14568997 14573337
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4518850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8815338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.2715838368
MESH:D015228 Hypertriglyceridemia Fructose 4.8919799862 19342510
MESH:D020514 Hypokalemic Periodic Paralysis Amiloride 12.4219822448
MESH:D020514 Hypokalemic Periodic Paralysis Potassium 12.4219822448
MESH:D007248 Infertility, Male Methylnitrosourea 3.667193160
MESH:D007249 Inflammation Aluminum 11.2116052892
MESH:D007249 Inflammation Amiloride 11.2117237260
MESH:D007249 Inflammation Flavonoids 11.2117296493
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.2112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.3416627594 16393666
MESH:D007333 Insulin Resistance Fructose 7.3419342510 14633139 14757778 18057795 19799862 19586609 17133782 14573337 19008412 18563319 18981581
MESH:D007410 Intestinal Diseases Nitric Oxide 9.4211574821 11713966 10210152
MESH:D007410 Intestinal Diseases Tretinoin 9.4217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007673 Kidney Cortex Necrosis Cisplatin 12.6115464296
MESH:D007673 Kidney Cortex Necrosis Gentamicins 12.6118842672
MESH:D007674 Kidney Diseases Cisplatin 9.6215190930 12649298 12231392 18289764 19839026
MESH:D007674 Kidney Diseases Estradiol 9.6215618244
MESH:D007674 Kidney Diseases Gentamicins 9.6219349640 18289764 17934191
MESH:D007680 Kidney Neoplasms Estradiol 2.8115610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 18.6016316344
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 18.6011231351
MESH:D007683 Kidney Tubular Necrosis, Acute Gentamicins 18.6011231351
MESH:D007896 Leishmaniasis Nitric Oxide 4.4817218153
MESH:D016773 Leishmaniasis, Cutaneous Gentamicins 4.2910219319
MESH:D007938 Leukemia Tretinoin 2.6717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.5119285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0417596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0216140955 19642359 17368321 19035177 12679006 19075265 16935935 17294898 17301526 16788101 19029980 17361223 17506722 16891316 19225113 17339181 16331271 17712046 15748426 17649720 16766008 17107899 16823087 17217047 9834237
MESH:D056929 Liddle Syndrome Amiloride 5.7619344079
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 7.9715526292
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.979224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6916943688 21278145 11408273 16239168 11903743 17174718 17334410 17157831 16221502
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 4.7212666154 12632514 14748882 12898905 17823541 16192424 18472332 12389079 18277467 17805973 14716496 17922224 17565644 15338365 20821823 18412020 18166357 18251166 18317297 18006644 15876570 14620537 17640975 16638106 12667390 15925388 15959796 12632512 18263696 16248980 12958196 18210741 15996030 17714472 15893842 17761835 15650968 18395914 16097048 18376398 17944888 18472094 16027843 12649538 18420326 15931870 18279442 12445418 17900296 15730626 16033810 17869086 17721639 17708605 17976157 12546737 13678700 17481882 14724832 14512876 18395095 15673190 12445421 15370692 16011737 16136751 18339082 17631135 17766677 17557913 17525996 15818738 10355542 17698563 18481824 18054572 18187930 11481614 15123356 12741479 12586293 15052691 16116963 18429990 18705752 15057751 18156304 14716833 18418968 18205269 15362042 12609069 16015684
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.7214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.7212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.7218397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0315720792 16964402 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 3.9615123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5114706259 16899240
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.1319294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.1316984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.3312014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.3312151625
MESH:D008133 Long QT Syndrome Dobutamine 4.5819353679
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.2616080182
MESH:D008171 Lung Diseases Aluminum 8.0216052892
MESH:D008171 Lung Diseases Dobutamine 8.0216638327
MESH:D055370 Lung Injury Nitric Oxide 4.5211395602
MESH:D008175 Lung Neoplasms Cisplatin 3.4411798837 17225452 6189445
MESH:D008175 Lung Neoplasms Methylnitrosourea 3.4418062963
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.4419555203 11884234
MESH:D008223 Lymphoma Methylnitrosourea 7.7511418001 16257854
MESH:D008223 Lymphoma Nitric Oxide 7.7516166326
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.5814633661
MESH:D008275 Magnesium Deficiency Magnesium 6.2317823441
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.8817203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 5.8815688392 15113128 10767621 16827153 16619500 17020996 15313902 14633655 11751437 12931682 14999141 19196723 10838139 16944150 11807958 16051031 17131329
MESH:D020149 Manganese Poisoning Estradiol 4.2719453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Cisplatin 3.3812393984 17023156 16809738 17761969 18176117 15577323 12883367 16432458 12374674 18505091 18332650 16248763 11135225
MESH:D008545 Melanoma Tretinoin 3.3816752155
MESH:D018328 Melanoma, Amelanotic Cisplatin 4.5615990972
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma Cisplatin 3.1617638057
MESH:D024821 Metabolic Syndrome X Fructose 4.6417098227 19165636 18497449 17261469 16815490
MESH:D008661 Metabolism, Inborn Errors marker/mechanism
MESH:D008708 Methemoglobinemia 4-nitroaniline 5.673710033
MESH:D008881 Migraine Disorders Magnesium 8.0318803445
MESH:D008881 Migraine Disorders Nitric Oxide 8.0311701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.9111304026 14659530
MESH:D020528 Multiple Sclerosis, Chronic Progressive Aluminum 6.1617086897
MESH:D020529 Multiple Sclerosis, Relapsing-Remitting Aluminum 6.1617086897
MESH:D009137 Muscular Dystrophy, Animal Gentamicins 6.0618694830
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9617596541
MESH:D009203 Myocardial Infarction therapeutic 12411458
MESH:D017202 Myocardial Ischemia Dobutamine 8.8412447174
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.1216810080
MESH:D009361 Neoplasm Invasiveness Amiloride 5.1014644129
MESH:D009364 Neoplasm Recurrence, Local 4-aminobenzamidine 5.2616430655
MESH:D009369 Neoplasms Cisplatin 7.8816773208
MESH:D009369 Neoplasms Methylnitrosourea 7.8815533788
MESH:D009369 Neoplasms Tretinoin 7.8816946489 16594593
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.2712696579
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009395 Nephritis, Interstitial Cisplatin 4.2815464296
MESH:D009421 Nervous System Malformations Estradiol 15.1616427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009436 Neural Tube Defects Tretinoin 2.929142499
MESH:D009442 Neurilemmoma Methylnitrosourea 5.2711555667
MESH:D009447 Neuroblastoma Cisplatin 3.348761367
MESH:D017599 Neuroectodermal Tumors Cisplatin 4.498761367
MESH:D009765 Obesity Fructose 3.3718585860 17707055
MESH:D010024 Osteoporosis Calcium 3.6517882678
MESH:D010051 Ovarian Neoplasms Cisplatin 7.5417225452 6897625 19769630 15464296
MESH:D010051 Ovarian Neoplasms Estradiol 7.5419401270
MESH:D010051 Ovarian Neoplasms Tretinoin 7.5416936753
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 8.3619003803
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 8.3616965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.3615976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.1115464296
MESH:D010997 Pleural Neoplasms Cisplatin 5.1317638057
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.1218573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms 4-aminobenzamidine 3.1016430655
MESH:D011471 Prostatic Neoplasms Estradiol 3.1016740699
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 3.1015682402 12376480
MESH:D011507 Proteinuria Gentamicins 8.8915033597
MESH:D011507 Proteinuria Tretinoin 8.8916636307
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D051437 Renal Insufficiency Cisplatin 9.9715464296
MESH:D051437 Renal Insufficiency Gentamicins 9.9715728788 17132701
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.2618172121 18155124
MESH:D012173 Retinitis Gentamicins 6.0618644591
MESH:D012175 Retinoblastoma Methylnitrosourea 5.2711555667
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9016283617 16116481
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.2314601052
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.249673227
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.2316192470
MESH:D012878 Skin Neoplasms Tretinoin 5.2316467112
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.1315464296
MESH:D013158 Splenic Diseases aniline 6.2015694462
MESH:D013274 Stomach Neoplasms Cisplatin 3.4415958060 17522103 18396642
MESH:D013274 Stomach Neoplasms Methylnitrosourea 3.4416257854 15930296 18593901
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D013276 Stomach Ulcer Nitric Oxide 4.0115138204
MESH:D013736 Testicular Neoplasms Cisplatin 4.4315464296 17225452
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.0211418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 6.997505956 3078959
MESH:D013964 Thyroid Neoplasms Tretinoin 6.9916026305 17045167
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D016171 Torsades de Pointes Dobutamine 5.1419353679
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 2.8715464296 12973940 17225452
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 8.9616803524
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.9616129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4016752155
MESH:D014625 Vaginal Neoplasms Cisplatin 4.4015577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D015837 Vestibular Diseases Gentamicins 5.3218776599
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D014839 Vomiting Cisplatin 4.5111897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
Pathway ID Pathway Name
KEGG:04961 Endocrine and other factor-regulated calcium reabsorption
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA224
    • No data
    Releated disease ID Related disease Name
    PA443796Coronary Artery Disease
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    PA450877perindopril
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB04184 - Acetate Ion Indicators and Reagents
    DB06692 - Tisseel Kit Vh 5.0 Antifibrinolytic Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved