AutismKB 2.0

Annotation Detail for KLRC3


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Basic Information Top
Gene Symbol:KLRC3 ( NKG2-E,NKG2E )
Gene Full Name: killer cell lectin-like receptor subfamily C, member 3
Band: 12p13.2
Quick LinksEntrez ID:3823; OMIM: 602892; Uniprot ID:NKG2E_HUMAN; ENSEMBL ID: ENSG00000205810; HGNC ID: 6376
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04650Natural killer cell mediated cytotoxicity
hsa04612Antigen processing and presentation
No data
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLRC3 mRNAaffects expression 16483693
D004958 Estradiol CEBPB protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
D004958 Estradiol ESR1 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
D004958 Estradiol Estradiol promotes the reaction [ESR1 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D004958 Estradiol Estradiol promotes the reaction [NCOA2 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D004958 Estradiol Estradiol promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D004958 Estradiol Estradiol results in increased expression of KLRC3 mRNAincreases expression 17395694
D004958 Estradiol HSF2 protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
D004958 Estradiol JUN protein affects the reaction [Estradiol results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of KLRC3 mRNAaffects cotreatment|decreases expression 17404688
D004958 Estradiol Raloxifene inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]decreases reaction|increases expression 17395694
D004958 Estradiol Tamoxifen inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]decreases reaction|increases expression 17395694
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of KLRC3 mRNAaffects cotreatment|decreases expression 17404688
D020849 Raloxifene ESR1 protein affects the reaction [Raloxifene results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNAaffects cotreatment|decreases expression 19059307
D020849 Raloxifene Raloxifene inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]decreases reaction|increases expression 17395694
D020849 Raloxifene Raloxifene promotes the reaction [ESR1 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D020849 Raloxifene Raloxifene promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D020849 Raloxifene Raloxifene results in increased expression of KLRC3 mRNAincreases expression 17395694
D013629 Tamoxifen ESR1 protein affects the reaction [Tamoxifen results in increased expression of KLRC3 mRNA]affects reaction|increases expression 17395694
14699072
D013629 Tamoxifen ESR2 protein affects the reaction [Tamoxifen results in decreased expression of KLRC3 mRNA]affects reaction|decreases expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of KLRC3 mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]decreases reaction|increases expression 17395694
D013629 Tamoxifen Tamoxifen promotes the reaction [ESR1 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOA2 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D013629 Tamoxifen Tamoxifen promotes the reaction [NCOA3 protein binds to KLRC3 gene]affects binding|increases reaction 17395694
D013629 Tamoxifen Tamoxifen results in increased expression of KLRC3 mRNAincreases expression 17395694
D019287 Zinc Sulfate Zinc Sulfate results in decreased expression of KLRC3 mRNAdecreases expression 16330358
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.0714745880
MESH:D000138 Acidosis Ammonium Chloride 12.2118287403
MESH:D000138 Acidosis Zinc Sulfate 12.217265320
MESH:D000230 Adenocarcinoma Estradiol 2.1611473722
MESH:D000419 Albuminuria Raloxifene 4.9817451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5915800139
MESH:D000860 Anoxia Zinc Sulfate 5.487265320
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.8617868700
MESH:D001930 Brain Injuries Progesterone 12.4015665606 15845082 15380490
MESH:D001930 Brain Injuries Raloxifene 12.4016580743
MESH:D001943 Breast Neoplasms Estradiol 2.0212948864 16675129 17289903 17261762 17018787 14630087 19861407 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.0216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Raloxifene 2.0217595753 15758505 17440819 16912660 17952589 15572757 15775269 16837676 17893378 17242785 17049068 17261762
MESH:D001943 Breast Neoplasms Tamoxifen 2.0220390343 18815881 19487384 18629630 17261762 17893378 17049068 19221464 19289846 20135344 16273361 19189210 21138602 19115204 21152245 15565566 19059307 18351453 20859285 19011961 19200415 20544844 17242785 11161223 18425577 19142967 16873071 16202921 17440819 19288272 18984771 19189212 20005174 19084267 19066611 18855134 16818667 19155303 19244106 15668708 19103187 18821012 18997820 20065188 19410462
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.9316111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9219066611
MESH:D006528 Carcinoma, Hepatocellular Estradiol 3.1016924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 3.1016924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.5317572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.5317572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.6515775269
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9818566989
MESH:D003072 Cognition Disorders Raloxifene 5.0415800139
MESH:D003711 Demyelinating Diseases Tamoxifen 4.7819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4517474826
MESH:D003928 Diabetic Nephropathies Estradiol 16.7419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 16.7417308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 16.7419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.9117187935
MESH:D004487 Edema Raloxifene 3.6615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 17.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 17.7715845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 17.7719031437
MESH:D016889 Endometrial Neoplasms Estradiol 8.0419148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.0420544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Progesterone 4.0716134523
MESH:D005234 Fatty Liver Raloxifene 9.0917473493
MESH:D005234 Fatty Liver Tamoxifen 9.0914986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4116709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.9914745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.6419069698
MESH:D006331 Heart Diseases Raloxifene 3.7411110106
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 5.4117063115
MESH:D006558 Herpes Genitalis Estradiol 5.5515709030
MESH:D019584 Hot Flashes Estradiol 4.2717088409
MESH:D006973 Hypertension Raloxifene 2.9617577099 15787275
MESH:D007022 Hypotension Zinc Sulfate 4.827265320
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.8215869954
MESH:D007249 Inflammation Progesterone 5.6515869954
MESH:D007249 Inflammation Tamoxifen 5.6519457130
MESH:D007333 Insulin Resistance Estradiol 3.1616393666 16627594
MESH:D007674 Kidney Diseases Estradiol 2.7415618244
MESH:D007680 Kidney Neoplasms Estradiol 8.2915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.2918625569
MESH:D007889 Leiomyoma Raloxifene 4.8516973256
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.5315237267
MESH:D008064 Lipidoses Tamoxifen 3.3717567588 15342952
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.5214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.5218564211
MESH:D008113 Liver Neoplasms Tamoxifen 2.3116684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.2219428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 11.1017203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 11.1017203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 11.1019196722 14580682 16827153 11731420 19196723
MESH:D020149 Manganese Poisoning Estradiol 14.4519453300
MESH:D020149 Manganese Poisoning Tamoxifen 14.4519453300
MESH:D008545 Melanoma Tamoxifen 1.9119393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.6415990972
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.0815863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6516497877
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5216810080
MESH:D009232 Myxoma Raloxifene 6.0816343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6519393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.5219189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1917289903
MESH:D009421 Nervous System Malformations Estradiol 4.0311399458 16427766
MESH:D010024 Osteoporosis Raloxifene 3.5715775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.5817823083 17893378 15579764 15758505
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Progesterone 5.1416525653 17393432
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.2120887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.5316740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5316220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5315067354
MESH:D011693 Purpura Raloxifene 6.0815770314
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9418045962
MESH:D013088 Spermatocele Tamoxifen 4.8116709447
MESH:D013119 Spinal Cord Injuries Progesterone 12.4616503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 12.4619457130
MESH:D020521 Stroke Raloxifene 4.0816837676
MESH:D013978 Tibial Fractures Estradiol 15.5119048282
MESH:D013978 Tibial Fractures Raloxifene 15.5119048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.5717572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.5716712894 8653321 17572228
MESH:D054556 Venous Thromboembolism Raloxifene 5.7316837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.0816343187
Pathway ID Pathway Name
KEGG:04612 Antigen processing and presentation
KEGG:04650 Natural killer cell mediated cytotoxicity
Pharmacogenomics Knowledge Base Top
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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