AutismKB 2.0

Annotation Detail for KNG1


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Basic Information Top
Gene Symbol:KNG1 ( BDK,KNG )
Gene Full Name: kininogen 1
Band: 3q27.3
Quick LinksEntrez ID:3827; OMIM: 612358; Uniprot ID:KNG1_HUMAN; ENSEMBL ID: ENSG00000113889; HGNC ID: 6383
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04610Complement and coagulation cascades
Pathway IDPathway Name
Signaling by GPCR
Hemostasis
Pathway IDPathway Name
200164Syndecan-2-mediated signaling events
Pathway IDPathway Name
P00011Blood coagulation
Pathway IDPathway Name
500302Intrinsic Pathway
500405Peptide ligand-binding receptors
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1943Adenocarcinoma
2091Hypertension
2111Systemic infection
2237Neoplasm metastasis
No data
Desease Name
Adiponectin levels
Activated partial thromboplastin time
Desease Name
High molecular weight kininogen deficiency
Kininogen deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KNG1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KNG1 mRNAaffects expression 21346803
C031285 3-xylene 3-xylene results in increased expression of KNG1 mRNAincreases expression 12815608
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of KNG1 proteinaffects expression 20106945
D017962 alpha-Linolenic Acid alpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
D016718 Arachidonic Acid Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
C095105 bexarotene bexarotene results in increased expression of KNG1 mRNAincreases expression 17849452
C095105 bexarotene bexarotene results in decreased expression of KNG1 mRNAdecreases expression 16648578
C082229 bradykinin, Lys-Leu(8)-desArg(9)- bradykinin, Lys-Leu(8)-desArg(9)- affects the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|affects reaction|increases abundance|increases activity 17347322
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of KNG1 mRNAincreases expression 19925653
D002118 Calcium BDKRB2 protein affects the reaction [KNG1 protein affects the abundance of Calcium]affects abundance|affects reaction 18054572
D002118 Calcium KNG1 protein affects the abundance of Calciumaffects abundance 18054572
D002118 Calcium KNG1 protein results in increased abundance of Calciumincreases abundance 10535458
D002118 Calcium KNG1 protein results in increased transport of Calciumincreases transport 11812640
D002118 Calcium [KNG1 protein alternative form co-treated with Calcium] results in increased secretion of CALCA proteinaffects cotreatment|increases secretion 17666428
D002211 Capsaicin KNG1 protein alternative form affects the reaction [P2RY2 protein affects the susceptibility to Capsaicin]affects reaction|affects response to substance 18343036
D002211 Capsaicin Capsaicin inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|decreases reaction|increases abundance|increases activity 17347322
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of KNG1 mRNAincreases expression 16644059
D002251 Carbon Tetrachloride KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]decreases reaction|increases expression 18054572
D002251 Carbon Tetrachloride KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]decreases reaction|increases expression 18054572
D002251 Carbon Tetrachloride KNG1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]decreases reaction|increases expression 18054572
C511403 CGS 35601 CGS 35601 affects the expression of KNG1 proteinaffects expression 16364833
D016572 Cyclosporine Cyclosporine results in decreased expression of KNG1 mRNAdecreases expression 20106945
D004281 Docosahexaenoic Acids Docosahexaenoic Acids inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
D004958 Estradiol Estradiol results in decreased expression of KNG1 mRNAdecreases expression 20106945
D005472 Fluorouracil [Fluorouracil co-treated with irinotecan] results in decreased expression of KNG1 mRNAaffects cotreatment|decreases expression 16391804
C105311 FR 173657 FR 173657 inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 11104833
C105311 FR 173657 FR 173657 inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 15140628
C105311 FR 173657 FR 173657 inhibits the reaction [KNG1 protein alternative form results in increased activity of MAPK3 protein]decreases reaction|increases activity 11139431
C412815 GW 4064 alpha-Linolenic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
C412815 GW 4064 Arachidonic Acid inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
C412815 GW 4064 Docosahexaenoic Acids inhibits the reaction [GW 4064 results in increased expression of KNG1 mRNA]decreases reaction|increases expression 15307955
C412815 GW 4064 GW 4064 results in increased expression of KNG1 mRNAincreases expression 15307955
D019812 Heparan Sulfate Proteoglycans KNG1 protein results in increased abundance of Heparan Sulfate Proteoglycansincreases abundance 12639806
C065679 icatibant icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 11104833
C065679 icatibant icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 15140628
C065679 icatibant icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|decreases reaction|increases abundance|increases activity 17347322
D007295 Inositol Phosphates bradykinin, Lys-Leu(8)-desArg(9)- affects the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|affects reaction|increases abundance|increases activity 17347322
D007295 Inositol Phosphates Capsaicin inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|decreases reaction|increases abundance|increases activity 17347322
D007295 Inositol Phosphates icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]affects binding|decreases reaction|increases abundance|increases activity 17347322
D007295 Inositol Phosphates [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphatesaffects binding|increases abundance|increases activity 17347322
C051890 irinotecan [Fluorouracil co-treated with irinotecan] results in decreased expression of KNG1 mRNAaffects cotreatment|decreases expression 16391804
C403051 LF 16-0687 LF 16-0687 inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 15140628
C119318 MEN 11270 MEN 11270 inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 11104833
C119318 MEN 11270 MEN 11270 inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]affects binding|decreases reaction|increases activity 15140628
D008748 Methylcholanthrene AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 mRNA]decreases expression|increases reaction 11549291
D008748 Methylcholanthrene AHR protein promotes the reaction [Methylcholanthrene results in decreased expression of KNG1 protein]decreases expression|increases reaction 11549291
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of KNG1 mRNAdecreases expression 11549291
D008748 Methylcholanthrene Methylcholanthrene results in decreased expression of KNG1 proteindecreases expression 11549291
D009569 Nitric Oxide KNG1 protein results in increased abundance of Nitric Oxideincreases abundance 10535458
D009569 Nitric Oxide ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide]decreases reaction|increases abundance 12672649
D009569 Nitric Oxide KNG1 protein results in increased abundance of Nitric Oxideincreases abundance 12672649
C017947 sodium arsenite sodium arsenite affects the expression of KNG1 mRNAaffects expression 17450228
D012967 Sodium Dodecyl Sulfate Sodium Dodecyl Sulfate results in increased expression of KNG1 mRNAincreases expression 12815608
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of KNG1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KNG1 mRNAincreases expression 15644576
C017963 vinyl carbamate vinyl carbamate results in increased expression of KNG1 mRNAincreases expression 17849452
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 7.7118926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.7111752688 14514962 15322242
MESH:D058186 Acute Kidney Injury Capsaicin 4.2818460982
MESH:D055371 Acute Lung Injury 3-xylene 5.0515204773
MESH:D000230 Adenocarcinoma Estradiol 6.8711473722
MESH:D000230 Adenocarcinoma Fluorouracil 6.8717638652
MESH:D000230 Adenocarcinoma vinyl carbamate 6.8717363558 16247444
MESH:D000236 Adenoma Methylcholanthrene 3.3310545420 6695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.7016835633
MESH:D018248 Adenoma, Liver Cell vinyl carbamate 9.7012371669
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4015276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.6017306315 16712894
MESH:D000505 Alopecia Capsaicin 4.5017569567
MESH:D000544 Alzheimer Disease Nitric Oxide 3.2517556102
MESH:D000707 Anaphylaxis marker/mechanism 7623993
MESH:D000740 Anemia Fluorouracil 7.8316511603 17963324 15504547
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.8311748828
MESH:D001249 Asthma FR 173657 5.0112706475
MESH:D050197 Atherosclerosis Methylcholanthrene 3.2811922910
MESH:D001321 Autistic Disorder Arachidonic Acid 2.8818582451
MESH:D001321 Autistic Disorder Docosahexaenoic Acids 2.8818582451
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 2.7812125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001919 Bradycardia Capsaicin 4.7618207255
MESH:D002545 Brain Ischemia Capsaicin 4.6819211983
MESH:D001943 Breast Neoplasms bexarotene 2.8216818667 16344269
MESH:D001943 Breast Neoplasms Estradiol 2.8212948864 17261762 17289903 18497071 16675129 14630087 19861407 17018787
MESH:D001943 Breast Neoplasms Fluorouracil 2.8215136595 16595493 19217205 18608205 16110121 18357371 16557594
MESH:D001943 Breast Neoplasms Methylcholanthrene 2.8217474063
MESH:D001943 Breast Neoplasms Nitric Oxide 2.8215631943
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.8220435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.4916011737 15721981 16192424 16227642 10355542 15700767 16124888 15673190 3786805 18705752 16050911 16097048
MESH:D002276 Carcinoid Tumor Fluorouracil 4.3716051944
MESH:D002277 Carcinoma Fluorouracil 12.6517121937
MESH:D002277 Carcinoma Methylcholanthrene 12.6510545420
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 12.6516835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 16.0116705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 16.0116705839
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.0112619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 16.0118788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 16.0117088986 17045692 18930000 17971768 16799960 16332177
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 16.0115276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular vinyl carbamate 16.0112371669
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.9416247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung vinyl carbamate 5.9416247446
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 2.8818695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.4618986760 16757204 16280240 17066447
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.4618572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2118670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 18.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 18.9612371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 18.9618566989
MESH:D002471 Cell Transformation, Neoplastic Methylcholanthrene 18.9616192471
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 18.9620056578 19524636
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9216835633
MESH:D002779 Cholestasis Cyclosporine 7.6419486331
MESH:D002779 Cholestasis Nitric Oxide 7.6416919318
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.9815668235 15340226 12621046 8697196 16354765
MESH:D003110 Colonic Neoplasms Fluorouracil 3.7717725105 16340194 15001691 18772588 16510598 17172411 17287894 17016597 17018589 17169374
MESH:D003110 Colonic Neoplasms irinotecan 3.7717725105 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.6517094418 17401013 16391804 16282729 15289873 17695437 17255274 17454858 18949393 18383874 18288408 18509181 14970324 16303861 17594712 16524972 17016601 20501625 18448328 15148649 16331619 18802399
MESH:D015179 Colorectal Neoplasms irinotecan 2.6517159606 16391804 15273666 18259882 17454858 16303861 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D003371 Cough Capsaicin 4.8810350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2415322242 10048152 20055451
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.9318551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.9318551238
MESH:D003550 Cystic Fibrosis Docosahexaenoic Acids 4.4219747007
MESH:D007644 Darier Disease Fluorouracil 4.5016733453
MESH:D015140 Dementia, Vascular Nitric Oxide 5.6617556102
MESH:D003872 Dermatitis 3-xylene 5.6015902427 12717741
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6017107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 8.1918551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 8.1921346803 18551238
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 8.193786805 17522070 15998439 15968718 11566570 4309450 7120509 16177239 15027814 2869522 6623471 21278145 10092053 16227642 7440962 19085960 3732212 10915739 19336974 9327722 7179309 6884620
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.1920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5511462148
MESH:D004381 Duodenal Ulcer Capsaicin 4.4111535926 10671773
MESH:D004487 Edema Arachidonic Acid 6.257990266 16716910 9831321 11698051 9599246 15177302
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.2511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6016714409 15322242 18230668
MESH:D016889 Endometrial Neoplasms Estradiol 2.7919148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.7710568697 9294722
MESH:D004935 Esophageal Diseases Capsaicin 5.4119566590
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.3816785472 16337965 16481741 15173087 17638652
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8011564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 6.8415959796 19224547 12795759 17595544 12631006 61145 16045604 16239168
MESH:D005234 Fatty Liver Cyclosporine 6.8419224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever Arachidonic Acid 4.4011852909
MESH:D005354 Fibrosarcoma Methylcholanthrene 4.6414633661 10962813
MESH:D005355 Fibrosis Carbon Tetrachloride 13.0418705752
MESH:D005355 Fibrosis Cyclosporine 13.0412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.0420067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.3816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Capsaicin 3.9318405923
MESH:D005910 Glioma Fluorouracil 2.7516145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006261 Headache Nitric Oxide 4.8811284996 11554966
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.1918337622 15162350 15102660
MESH:D006356 Heartburn Capsaicin 5.4119566590
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.1811294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.3219110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.6112621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
OMIM:228960 HIGH MOLECULAR WEIGHT KININOGEN DEFICIENCY marker/mechanism
MESH:D006689 Hodgkin Disease sodium arsenite 2.9112676792
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.758697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia marker/mechanism 16793879
MESH:D006930 Hyperalgesia Capsaicin 8.3517043245 17434803
MESH:D006930 Hyperalgesia icatibant 8.3512727271
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.2416899240
MESH:D006940 Hyperemia Nitric Oxide 5.3211156591
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.2517604070
MESH:D006973 Hypertension CGS 35601 8.1816364833
MESH:D006973 Hypertension Cyclosporine 8.1810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.8015338365
MESH:D006976 Hypertension, Pulmonary Nitric Oxide 4.2115838368
MESH:D007248 Infertility, Male sodium arsenite 2.8012646999 15346721
MESH:D007249 Inflammation Arachidonic Acid 7.6815177302 9831321 17371808
MESH:D007249 Inflammation Capsaicin 7.6816956363
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6812200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.7816627594 16393666
MESH:D007410 Intestinal Diseases Nitric Oxide 4.6410210152 11713966 11574821
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.0716580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Cyclosporine 9.078314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.0715618244
MESH:D007674 Kidney Diseases sodium arsenite 9.0720008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 20.8116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 20.8116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 20.8112371664
MESH:D007680 Kidney Neoplasms Estradiol 20.8115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 20.8116985049
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.7516316344
MESH:D007896 Leishmaniasis Nitric Oxide 4.4117218153
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Docosahexaenoic Acids 4.7417077332
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.6516221502 11903743 17157831 11408273 21278145 16943688 17174718 16239168 17334410
MESH:D008106 Liver Cirrhosis, Experimental therapeutic 18054572
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.2212741479 18412020 16011737 12632514 18705752 12546737 15057751 12649538 15893842 17714472 20821823 15730626 18317297 16015684 18263696 15931870 13678700 18472094 17944888 12445418 18429990 18376398 11481614 18251166 18187930 15338365 12958196 15925388 15650968 16136751 17631135 18210741 17900296 18395914 18418968 18054572 18395095 14620537 17766677 12898905 14724832 12389079 18166357 17557913 12609069 17698563 17976157 16638106 16027843 17805973 12586293 12445421 18156304 15876570 12667390 17481882 15123356 15370692 16116963 14512876 15052691 15673190 18420326 17761835 15959796 15818738 17565644 17640975 16097048 17869086 14716833 16248980 15362042 17922224 17721639 17708605 18339082 18006644 16192424 14716496 15996030 12666154 18481824 18472332 18205269 18277467 12632512 14748882 17525996 17823541 10355542 18279442 16033810
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.2214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2212878042
MESH:D008107 Liver Diseases Capsaicin 6.3916956363
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3915830285 16964402 17285989 16246199 15720792
MESH:D008107 Liver Diseases Docosahexaenoic Acids 6.3917056761
MESH:D017093 Liver Failure Carbon Tetrachloride 3.8715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.4316899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.127678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.129163691 2125692 15890375 18177683
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 20.1218177683
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 20.1219294768
MESH:D008113 Liver Neoplasms Fluorouracil 20.1215113037 16603448 18383874 17045692
MESH:D008113 Liver Neoplasms sodium arsenite 20.1215276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.1216984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 16.702876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.708603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 16.7015583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Methylcholanthrene 16.701399818 598648
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.7012151625
MESH:D008171 Lung Diseases sodium arsenite 2.9819095001
MESH:D055370 Lung Injury Nitric Oxide 4.4311395602
MESH:D008175 Lung Neoplasms Aflatoxin B1 12.2914755239
MESH:D008175 Lung Neoplasms bexarotene 12.2917849452
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 12.2911696405 16337739 19925653 11246140 19359593 15390079 18597497
MESH:D008175 Lung Neoplasms Fluorouracil 12.2915246190
MESH:D008175 Lung Neoplasms Methylcholanthrene 12.2915390079 21163286 16337739 17909032 20970405 10545420 9230183 6695378 1399818 20512841 7750092 11893704 16271038
MESH:D008175 Lung Neoplasms sodium arsenite 12.2917077188 17306315 15276417 16712894 19931552
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 12.2911884234 19555203
MESH:D008175 Lung Neoplasms vinyl carbamate 12.2915172992 11195469 17361011 16247444 15824018 17363558 11134547 14755239 17163412 12438228 16885199 12765245 12117777
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.5015086387
MESH:D008223 Lymphoma Nitric Oxide 4.0716166326
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.8611161223
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 9.1019196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 9.101500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 9.1016891317 11807958 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008545 Melanoma sodium arsenite 1.9919082730 16487513
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D008881 Migraine Disorders Nitric Oxide 4.0711701602
MESH:D020326 Migraine without Aura Nitric Oxide 4.8311304026 14659530
MESH:D009062 Mouth Neoplasms Fluorouracil 3.4116757204 18986760
MESH:D052016 Mucositis irinotecan 4.7117159606
MESH:D009101 Multiple Myeloma Capsaicin 3.9517505005
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.0616810080
MESH:D009336 Necrosis 2,4-dinitrotoluene 9.3618551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.3618551238 7678174
MESH:D009362 Neoplasm Metastasis irinotecan 3.0518259882
MESH:D009369 Neoplasms Fluorouracil 4.7018600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 4.7011559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.3820056578
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 4.4819196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0418481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 8.5311399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 8.5314600291
MESH:D009436 Neural Tube Defects sodium arsenite 2.9512854658
MESH:D009447 Neuroblastoma irinotecan 3.338761367
MESH:D017599 Neuroectodermal Tumors irinotecan 4.438761367
MESH:D020078 Neurogenic Inflammation Capsaicin 4.8217961222
MESH:D020258 Neurotoxicity Syndromes 3-xylene 7.957820390 8907413
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 7.9516436463
MESH:D009765 Obesity Capsaicin 3.3219056576
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 8.0412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 8.0416049721
MESH:D010024 Osteoporosis Calcium 3.6017882678
MESH:D010051 Ovarian Neoplasms Estradiol 4.5219401270
MESH:D010051 Ovarian Neoplasms sodium arsenite 4.5215276417 17306315
MESH:D010146 Pain Capsaicin 3.7917043245 19081190 17084039 16996476 18987195 17434803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.5619003803 16929163 16500647 15113037
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D011014 Pneumonia Butylated Hydroxytoluene 4.8711893704
MESH:D011015 Pneumonia, Aspiration Nitric Oxide 5.0418573544
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 2.9812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9011399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6220887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6716740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.6719082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6716039940
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D012004 Rectal Neoplasms Fluorouracil 3.7618722050 16160472 15538739 18286688
MESH:D015427 Reperfusion Injury Capsaicin 3.8218460982 19211983
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012555 Schistosomiasis mansoni Nitric Oxide 5.169673227
MESH:D012640 Seizures 2,4-dinitrotoluene 8.8918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 8.8918551238
MESH:D012640 Seizures 3-xylene 8.898907413 6431079
MESH:D012878 Skin Neoplasms sodium arsenite 5.1318572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.1316192470
MESH:D016135 Spinal Dysraphism sodium arsenite 3.5712854658
MESH:D013274 Stomach Neoplasms Docosahexaenoic Acids 3.4719015929
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4718396642 17498489 17522103 16951190 16424979 19084572 18567086 19015929 15786421 17172411
MESH:D013274 Stomach Neoplasms irinotecan 3.4715723263
MESH:D013276 Stomach Ulcer Nitric Oxide 3.9415138204
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.4217997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Fluorouracil 3.7316280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 7.6116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 7.6116049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 7.6116452187 16712894 11723127 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.0010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.0010091137
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 8.6416803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.6411813266
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D014652 Vascular Diseases sodium arsenite 4.1317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
KEGG:04610 Complement and coagulation cascades
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA225
    • No data
    Releated disease ID Related disease Name
    PA443523Blood Coagulation Disorders
    PA445850Thrombosis
    PA443796Coronary Artery Disease
    PA443371Angioedema
    PA444552Hypertension
    Releated drug ID Related drug Name
    PA164712308Ace Inhibitors, Plain
    PA164712445Antihypertensives
    PA448765candesartan
    PA449899hydrochlorothiazide
    PA450877perindopril
    PA449456enalapril
    PA164768822chlorotrianisene
    PA164754789conjugated estrogens
    PA164745534dienestrol
    PA449307diethylstilbestrol
    PA449503estradiol
    PA449509estrogens
    PA449512estrone
    PA449527ethinyl estradiol
    PA448547beclomethasone
    PA164754818betamethasone
    PA448681budesonide
    PA164781399ciclesonide
    PA164776996desonide
    PA449247dexamethasone
    PA449661flunisolide
    PA449686fluticasone propionate
    PA452347glucocorticoids
    PA449905hydrocortisone
    PA450466methylprednisolone
    PA450541mometasone
    PA164777035paramethasone
    PA451096prednisolone
    PA451100prednisone
    PA164752251rimexolone
    PA451749triamcinolone
    PA164744376adenosine monophosphate
    PA448478l-arginine
    PA164747225l-citrulline
    PA450635nitric oxide
    PA164743471adenosine triphosphate
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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