AutismKB 2.0

Annotation Detail for ARG1


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Basic Information Top
Gene Symbol:ARG1 ( - )
Gene Full Name: arginase, liver
Band: 6q23.2
Quick LinksEntrez ID:383; OMIM: 608313; Uniprot ID:ARGI1_HUMAN; ENSEMBL ID: ENSG00000118520; HGNC ID: 663
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
CITRULBIO-PWYcitrulline biosynthesis
ARGASEDEG-PWYarginine degradation I (arginase pathway)
ARG-PRO-PWYarginine degradation VI (arginase 2 pathway)
PWY-4984urea cycle
PWY-5004superpathway of citrulline metabolism
Pathway IDPathway Name
hsa05146Amoebiasis
hsa00330Arginine and proline metabolism
hsa01100Metabolic pathways
Pathway IDPathway Name
Metabolism of amino acids and derivatives
Pathway IDPathway Name
200018IL4-mediated signaling events
200116ATF-2 transcription factor network
No data
Pathway IDPathway Name
500783Urea cycle
Related Diseases/Disorders Top
Desease IDDesease Name
Inherited disorders of amino acid metabolism
H00186Hyperargininemia
Genetic disorders
Desease IDDesease Name
1842Sickle cell disease
2019Hepatitis, Autoimmune
2091Hypertension
2074Asthma
2181Liver metastases
Desease Name
intima-media thickness myocardial infarct
CARDIOVASCULAR
IMMUNE
bronchodilator response
No data
Desease Name
Argininemia
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane affects the expression of ARG1 mRNAaffects expression 18648102
D000082 Acetaminophen Acetaminophen results in decreased expression of ARG1 mRNAdecreases expression 18246545
D000082 Acetaminophen Acetaminophen results in increased expression of ARG1 proteinincreases expression 16538043
16538041
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ARG1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone affects the expression of ARG1 mRNAaffects expression 19483382
D000643 Ammonium Chloride Ammonium Chloride affects the expression of ARG1 mRNAaffects expression 16483693
D001553 Benzbromarone Benzbromarone affects the expression of ARG1 mRNAaffects expression 19483382
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of ARG1 mRNAdecreases expression 20106945
C095105 bexarotene bexarotene results in decreased expression of ARG1 mRNAdecreases expression 16648578
C002791 bismuth tripotassium dicitrate bismuth tripotassium dicitrate results in increased expression of ARG1 mRNAincreases expression 15912405
C032036 bromobenzene bromobenzene metabolite binds to ARG1 proteinaffects binding 17305373
D002084 Butylated Hydroxytoluene Butylated Hydroxytoluene results in increased expression of ARG1 mRNAincreases expression 19925653
D002713 Chlorine [Ozone co-treated with Chlorine] affects the expression of ARG1 mRNAaffects cotreatment|affects expression 18636392
D002994 Clofibrate Clofibrate affects the expression of ARG1 mRNAaffects expression 19483382
C030123 coumarin coumarin affects the expression of ARG1 mRNAaffects expression 16963487
D003520 Cyclophosphamide Cyclophosphamide affects the expression of ARG1 mRNAaffects expression 18246545
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of ARG1 mRNAdecreases expression 18246545
D016572 Cyclosporine Cyclosporine results in decreased expression of ARG1 mRNAdecreases expression 20106945
C121718 dicyclanil dicyclanil results in increased expression of ARG1 mRNAincreases expression 15664270
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of ARG1 mRNAincreases expression 17942915
D004052 Diethylnitrosamine MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of ARG1 mRNA]decreases reaction|increases expression 17942915
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of ARG1 mRNAincreases expression 15289156
D004958 Estradiol Estradiol results in decreased expression of ARG1 mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of ARG1 mRNAincreases expression 15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of ARG1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of ARG1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARG1 mRNAaffects cotreatment|increases expression 17942748
D005001 Ethionine Ethionine affects the expression of ARG1 mRNAaffects expression 19483382
D005419 Flavonoids Flavonoids results in decreased expression of ARG1 mRNAdecreases expression 18035473
D005480 Flurbiprofen Flurbiprofen results in decreased expression of ARG1 mRNAdecreases expression 16949054
D019833 Genistein Genistein results in increased expression of ARG1 mRNAincreases expression 15289156
C008281 limonene limonene results in increased expression of ARG1 mRNAincreases expression 12815608
D008345 Manganese Manganese affects the activity of ARG1 proteinaffects activity 17252946
D008713 Methimazole Methimazole results in decreased expression of ARG1 mRNAdecreases expression 17403546
D008713 Methimazole Methimazole results in increased expression of ARG1 mRNAincreases expression 17403546
D009151 Mustard Gas Mustard Gas results in increased expression of ARG1 mRNAincreases expression 18988085
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of ARG1 mRNAincreases expression 17616710
D009853 Omeprazole Omeprazole affects the expression of ARG1 mRNAaffects expression 19483382
D010126 Ozone [Ozone co-treated with Chlorine] affects the expression of ARG1 mRNAaffects cotreatment|affects expression 18636392
C494474 perchlorate perchlorate results in decreased expression of ARG1 mRNAdecreases expression 17403546
C494474 perchlorate perchlorate results in increased expression of ARG1 mRNAincreases expression 17403546
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ARG1 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in decreased expression of ARG1 proteindecreases expression 15226431
C006253 pirinixic acid pirinixic acid affects the expression of ARG1 mRNAaffects expression 19483382
D011374 Progesterone Progesterone affects the expression of ARG1 mRNAaffects expression 17251523
D011441 Propylthiouracil Propylthiouracil affects the expression of ARG1 mRNAaffects expression 19483382
D011441 Propylthiouracil Propylthiouracil results in decreased expression of ARG1 mRNAdecreases expression 17403546
D011441 Propylthiouracil Propylthiouracil results in increased expression of ARG1 mRNAincreases expression 17403546
D011794 Quercetin Quercetin results in increased expression of ARG1 mRNAincreases expression 16455785
C089730 rosiglitazone rosiglitazone results in increased expression of ARG1 mRNAincreases expression 18541527
D013629 Tamoxifen Tamoxifen affects the expression of ARG1 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of ARG1 mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ARG1 mRNAaffects cotreatment|increases expression 17942748
D013853 Thioacetamide Thioacetamide affects the expression of ARG1 mRNAaffects expression 19483382
D014028 Tobacco Smoke Pollution Tobacco Smoke Pollution results in decreased expression of ARG1 mRNAdecreases expression 18087596
D014212 Tretinoin Tretinoin results in increased expression of ARG1 mRNAincreases expression 16604517
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of ARG1 mRNAincreases expression 17982090
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0714745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.3915322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.1018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4717505938
MESH:D055371 Acute Lung Injury Chlorine 7.7320601635
MESH:D055371 Acute Lung Injury pirinixic acid 7.7318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.9920127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 8.9911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.9914692618
MESH:D000230 Adenocarcinoma Genistein 8.9911473722
MESH:D002282 Adenocarcinoma, Bronchiolo-Alveolar Tobacco Smoke Pollution 5.0515814487
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 9.493712494
MESH:D000236 Adenoma Benzo(a)pyrene 9.496695378
MESH:D000236 Adenoma Diethylnitrosamine 9.4910737359 6695378
MESH:D018248 Adenoma, Liver Cell dicyclanil 21.0917162532
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 21.0919061943 19052882 17620307 18056438 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 21.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 21.0916835633
MESH:D011125 Adenomatous Polyposis Coli Flurbiprofen 4.6610680582
MESH:D000505 Alopecia Tretinoin 3.2515955085
MESH:D000544 Alzheimer Disease Ozone 4.0715513908
MESH:D000544 Alzheimer Disease rosiglitazone 4.0719621015
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0415469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5511748828
MESH:D000743 Anemia, Hemolytic Quercetin 3.8217084956
MESH:D000756 Anemia, Sideroblastic Manganese 4.4516910769
MESH:D000799 Angioedema Acetaminophen 3.3710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.6219183758
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.4020041841 18218290 18057881
MESH:D001161 Arteriosclerosis Cyclophosphamide 8.6615014928
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.6611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.2215885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.2216412693
MESH:D001172 Arthritis, Rheumatoid Ozone 6.7515570426
MESH:D001172 Arthritis, Rheumatoid Tobacco Smoke Pollution 6.7519898480
MESH:D001172 Arthritis, Rheumatoid Tretinoin 6.7516292516
MESH:D001249 Asthma marker/mechanism 19281908
MESH:D001249 Asthma Mustard Gas 6.9910378619
MESH:D001249 Asthma Ozone 6.9917854713 16373670
MESH:D001249 Asthma Tretinoin 6.9916456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.5115336622
MESH:D001281 Atrial Fibrillation Amiodarone 3.5518651412 19698954
MESH:D001321 Autistic Disorder Acetaminophen 1.4718445737
MESH:D001327 Autoimmune Diseases Quercetin 3.9519761891
MESH:D001471 Barrett Esophagus Tretinoin 3.9616935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.5411289319 1440618
MESH:D001768 Blister Mustard Gas 4.6919167455
MESH:D001778 Blood Coagulation Disorders Amiodarone 56.9919483382
MESH:D001778 Blood Coagulation Disorders Benzbromarone 56.9919483382
MESH:D001778 Blood Coagulation Disorders Clofibrate 56.9919483382
MESH:D001778 Blood Coagulation Disorders Ethionine 56.9919483382
MESH:D001778 Blood Coagulation Disorders Omeprazole 56.9919483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 56.9919483382
MESH:D001778 Blood Coagulation Disorders Propylthiouracil 56.9919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 56.9912125929
MESH:D001778 Blood Coagulation Disorders Thioacetamide 56.9919483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 56.9916197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.3215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4615746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.8617868700
MESH:D001930 Brain Injuries Progesterone 3.8015665606 15380490 15845082
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.8917474063 20146248
MESH:D001943 Breast Neoplasms bexarotene 8.8916344269 16818667
MESH:D001943 Breast Neoplasms Cyclophosphamide 8.8915093573 17388661 16978400 11325840 17020986 18234424 15136595 18323546 12006526
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.8917474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.8915324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 8.8917261762 14630087 19861407 17018787 17289903 12948864 18497071 16675129
MESH:D001943 Breast Neoplasms Genistein 8.8916541309 17200150 16873071
MESH:D001943 Breast Neoplasms Progesterone 8.8916175315 15562024 17614352
MESH:D001943 Breast Neoplasms Quercetin 8.8918628248
MESH:D001943 Breast Neoplasms Tamoxifen 8.8918997820 19288272 20135344 16873071 17242785 19289846 20065188 18425577 18351453 20859285 19066611 17440819 18629630 21152245 19221464 20005174 19059307 18984771 18821012 19200415 19142967 19103187 18855134 15565566 19155303 19410462 16273361 19189210 17893378 20544844 19011961 17049068 19244106 19487384 18815881 20390343 11161223 19189212 16202921 21138602 16818667 17261762 19115204 19084267 15668708
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.8920435547
MESH:D001943 Breast Neoplasms Tretinoin 8.8916443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity Ozone 3.3115516495 17626835 16777450 18315731 18417511 19059883 14754758
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.6915286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.5017687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.1216813970
MESH:D002100 Cachexia Ozone 4.2716183385
MESH:D002105 Cadmium Poisoning Quercetin 5.0716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.0016111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0519066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6816168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 33.447296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 33.443084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 33.4412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Benzbromarone 33.441701930
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 33.4419701751
MESH:D006528 Carcinoma, Hepatocellular dicyclanil 33.4417162532
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 33.4416328049 17138121 20432363 16779866 20514400 11831363 10737359 17173139 18788625 19335982 20101231 20084675 19107877 16540662 19383236 17428255 18691550 17978847 16878318 3581430 20512989 16807293 18978308 19171122 16681979 16698587 17162532 16288022 18971187 21159647 18665156 16830150 19418558 18506893 18494052 20524982 16502159 20935162 18056438 18785209 17055752 19394651 20727157 19519916 18210153 19539802 19052882 20007298 16569478 19701751 3084413 19822196 19208518 19919837 16935385 10672840 20214788 17761372 18393292
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 33.4416924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 33.4416924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 33.4416924424
MESH:D006528 Carcinoma, Hepatocellular Quercetin 33.4412508355 19519916
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 33.4416924424
MESH:D006528 Carcinoma, Hepatocellular Thioacetamide 33.4417997003
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 33.441917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.4216152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 5.4116247446
MESH:D002289 Carcinoma, Non-Small-Cell Lung Tobacco Smoke Pollution 5.4111212258
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.5017234771
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 5.907296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 5.9016201981
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.7020419170
MESH:D002294 Carcinoma, Squamous Cell Tobacco Smoke Pollution 6.7011212258
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 6.7016051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.2117572228
MESH:D006332 Cardiomegaly Quercetin 5.9019794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9018670907 16120746 18850075
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.7215710769 19225199
MESH:D002318 Cardiovascular Diseases Genistein 2.9816332659
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.6218974383
MESH:D002386 Cataract Acetaminophen 6.2810977129
MESH:D002386 Cataract Tretinoin 6.2817460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 17.647505956
MESH:D002471 Cell Transformation, Neoplastic Clofibrate 17.641399818
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 17.6412371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 17.6421159647 2727394 17174075 7505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 17.6418566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.1216129372
MESH:D002637 Chest Pain Omeprazole 4.6315447763
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 13.8519052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 13.8516835633
MESH:D018281 Cholangiocarcinoma Thioacetamide 13.8518291259
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 16.369022650 19486331
MESH:D002779 Cholestasis Cyclosporine 16.3619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 16.3616105132 17110522 15861022 17333356 16919318 17681005 11677210
MESH:D002779 Cholestasis pirinixic acid 16.3619176532
MESH:D002822 Choriocarcinoma Tretinoin 4.6816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.068697196 15340226 16354765 15668235 12621046
MESH:D002972 Cleft Palate Tretinoin 5.069407595
MESH:D003092 Colitis Tretinoin 8.2717035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 8.2717936198 16474422 17991707 16804969 18023891 16782535 16867261 11698051 18200517
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.2717276891
MESH:D003110 Colonic Neoplasms Genistein 3.5717182828
MESH:D003110 Colonic Neoplasms Quercetin 3.5711134977 19056647 17148506 17191121 19440933 16640504 15741050
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6717141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.2815322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.289125849 16925845 8800419 9211117 9664655 9224671 14991402 9142499 17551590 10589399
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.1112952375 16002989
MESH:D003556 Cystitis Cyclophosphamide 4.5110498854 10700343 17010015 18295254 15643279 18483878 18433785 17979934 12913760 11948286 12161096 18372110 16651033 16413132 18710439 12388444 16614059 16989017 18093676 15276878
MESH:D003711 Demyelinating Diseases Tamoxifen 3.9119031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3818759878 11906362 2524372 11298694 14531868 8970840 8156756 12868966
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2018249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.062952479 3621924
MESH:D003920 Diabetes Mellitus rosiglitazone 3.9117446233
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 7.4110990075 11751995 15331540
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 7.4119496084
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.0618772604
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 12.1819647726
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 12.1820387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 12.1816647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 12.1812642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 12.1817107852
MESH:D003928 Diabetic Nephropathies Estradiol 7.5419279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 7.5419279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.0417187935
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 16.1918648102 18289764 6679447 9328219 9022650 7440962 18692083 16192314 8291058 1440618 11289319 6482804 9653073
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 16.1919416960 16081117 18071297 17522070 11739529 16177239 11529661 2444490 11743745 19420014 11461765 16227642 12705907 19739265 16781746 19164858 14725611 12594235 10915739 11287661 19370779 12958197 17562736 17906064 14550746 14986274 10774834 15619225 12540782 19923254 12153990 11834606 16393943 11421492 18713872 16109766 12392966 15968718 10663392 19085960 16485898
MESH:D056486 Drug-Induced Liver Injury Amiodarone 16.1915265979 18218290
MESH:D056486 Drug-Induced Liver Injury bromobenzene 16.1912628495 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 16.1919107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 16.1920420201
MESH:D056486 Drug-Induced Liver Injury Thioacetamide 16.1912963478
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.6219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.4111462148
MESH:D004381 Duodenal Ulcer Omeprazole 3.8915991576 16613094 17151854 21218061
MESH:D050171 Dyslipidemias Clofibrate 3.7316707586
MESH:D004417 Dyspnea Chlorine 4.1520016425
MESH:D004487 Edema Mustard Gas 13.0811428631 11428647 9260866 11402378
MESH:D004487 Edema pirinixic acid 13.0812083418
MESH:D004487 Edema rosiglitazone 13.0812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 13.0812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.3615322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 10.3618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 12.7712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 12.7717692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 12.7719031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.3416402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.3416402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 20.0416804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 20.0419148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 20.0411473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 20.0417893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 20.0416569247
MESH:D004715 Endometriosis Progesterone 7.5916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.5910568697 9294722
MESH:D004802 Eosinophilia Cyclophosphamide 3.7711006010
MESH:D004890 Erythema Mustard Gas 4.699357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6416302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 6.453581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.4516530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.4515623463 15264214 16805852 15878914 15547733 15547721 15150132 16510608 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 7.679664655 16938888
MESH:D005218 Fat Necrosis Thioacetamide 5.2516456712
MESH:D005234 Fatty Liver Amiodarone 36.0414986274
MESH:D005234 Fatty Liver Clofibrate 36.0419224547
MESH:D005234 Fatty Liver Cyclosporine 36.0419224547
MESH:D005234 Fatty Liver Diethylnitrosamine 36.0421071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 36.0415345470
MESH:D005234 Fatty Liver pirinixic acid 36.0420131406 19236843
MESH:D005234 Fatty Liver rosiglitazone 36.0419196556
MESH:D005234 Fatty Liver Tamoxifen 36.0414986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.2416534752 16611131 16002989 16513791 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.2416709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.0011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.546705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.7219069698
MESH:D005355 Fibrosis Cyclosporine 22.9412168785 12639820
MESH:D005355 Fibrosis Quercetin 22.9419474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 22.9420067830
MESH:D005355 Fibrosis Tretinoin 22.9417994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 22.9417994277
MESH:D005739 Gas Poisoning Chlorine 4.5420016425
MESH:D005756 Gastritis Acetaminophen 3.2016983495
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.4816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.758708960
MESH:D005909 Glioblastoma Genistein 14.4416598420
MESH:D005909 Glioblastoma Manganese 14.4417043766
MESH:D005909 Glioblastoma Quercetin 14.4419804834
MESH:D005909 Glioblastoma Tretinoin 14.4417312396
MESH:D005910 Glioma Quercetin 2.8617643826
MESH:D018316 Gliosarcoma Cyclophosphamide 5.0511389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 10.057505956
MESH:D006042 Goiter perchlorate 10.0518801409
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.1210696789
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.5811014644 16376943 15172196
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.8716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6816084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 9.5820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 9.5810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 9.5814991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.2420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9515720958
MESH:D006467 Hemophilia A Cyclophosphamide 4.8311918545
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.9211000095
MESH:D006501 Hepatic Encephalopathy Thioacetamide 4.1615929193 18665440 17276928
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.0614986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 7.996705139
MESH:D006505 Hepatitis Thioacetamide 7.9916456712
MESH:D006529 Hepatomegaly Amiodarone 11.8015265979
MESH:D006529 Hepatomegaly pirinixic acid 11.8019176532 19772884 16221962 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.8015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.5615709030
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.4116135485 17606976
MESH:D019584 Hot Flashes Estradiol 3.2817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.578697196 16959395 16354765 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 10.9716870215
MESH:D006930 Hyperalgesia rosiglitazone 10.9712083418
MESH:D006930 Hyperalgesia Tretinoin 10.9716870215
MESH:D020162 Hyperargininemia marker/mechanism
MESH:D006937 Hypercholesterolemia Amiodarone 3.468137927 9751232
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.1116778211
MESH:D006943 Hyperglycemia pirinixic acid 7.9020558911
MESH:D006943 Hyperglycemia Quercetin 7.9011834736 18262572
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 9.3215034207
MESH:D006965 Hyperplasia Diethylstilbestrol 9.3214722030 12960047
MESH:D006967 Hypersensitivity Butylated Hydroxytoluene 4.1117604070
MESH:D006973 Hypertension Cyclosporine 7.4310903974
MESH:D006973 Hypertension Quercetin 7.4318356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.4318850075 18670907
MESH:D006980 Hyperthyroidism Methimazole 5.1714678291
MESH:D007021 Hypospadias Diethylstilbestrol 9.7316002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.7316945680 16569931
MESH:D007037 Hypothyroidism Amiodarone 16.9218020914 17991464
MESH:D007037 Hypothyroidism Methimazole 16.9218031379
MESH:D007037 Hypothyroidism Propylthiouracil 16.928137927 18031379
MESH:D007154 Immune System Diseases Cyclophosphamide 4.8616076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 3.9515869954
MESH:D007246 Infertility Diethylstilbestrol 3.9115036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0312013081
MESH:D007248 Infertility, Male Cyclophosphamide 5.8216517039 7193160
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.8217937319
MESH:D007249 Inflammation Diethylnitrosamine 28.0918785209
MESH:D007249 Inflammation Flavonoids 28.0917296493
MESH:D007249 Inflammation Flurbiprofen 28.0911099482
MESH:D007249 Inflammation Mustard Gas 28.0917524151 9357497 9260866 8975870 11402378 16001271 11428647 11428620 11428631
MESH:D007249 Inflammation Progesterone 28.0915869954
MESH:D007249 Inflammation rosiglitazone 28.0912083418
MESH:D007249 Inflammation Tamoxifen 28.0919457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 28.0912200463 12878042
MESH:D007249 Inflammation Tobacco Smoke Pollution 28.0918590791
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.3818200517
MESH:D007251 Influenza, Human Quercetin 4.0316624496
MESH:D007333 Insulin Resistance Estradiol 10.5716627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 10.5716306350
MESH:D007333 Insulin Resistance rosiglitazone 10.5716306350
MESH:D007410 Intestinal Diseases Tretinoin 8.4817994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 8.4817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.548074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.5516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.5517551590 15992940
MESH:D007627 Keloid Quercetin 4.5017086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9715604871
MESH:D007674 Kidney Diseases Acetaminophen 12.1215629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 12.1218776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 12.1215618244
MESH:D007674 Kidney Diseases Quercetin 12.1216962696
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 19.336582329
MESH:D007680 Kidney Neoplasms Cyclosporine 19.3312371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 19.3315003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 19.3315610895
MESH:D007680 Kidney Neoplasms Tamoxifen 19.3318625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.6117184923
MESH:D016773 Leishmaniasis, Cutaneous Omeprazole 3.7219248655
MESH:D007938 Leukemia Cyclophosphamide 12.9710602166
MESH:D007938 Leukemia Genistein 12.9717468513 18980019
MESH:D007938 Leukemia Quercetin 12.9717468513
MESH:D007938 Leukemia Tretinoin 12.9717143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.2917008537 17658394 17296974 17802794 18587576 18172266
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 3.7410373061
MESH:D007951 Leukemia, Myeloid Tretinoin 3.2816932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 1.9919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8417368321 16823087 19035177 17294898 16766008 16788101 15748426 19075265 17712046 17649720 17339181 19029980 17107899 17361223 19642359 16891316 9834237 19225113 16331271 17217047 17506722 16140955 12679006 16935935 17301526
MESH:D007970 Leukopenia Cyclophosphamide 4.5010052129 11830472
MESH:D017880 Limb Deformities, Congenital Tretinoin 2.979224671
MESH:D008064 Lipidoses Amiodarone 6.7915342952 17567588
MESH:D008064 Lipidoses Tamoxifen 6.7917567588 15342952
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.5618665156 19638242 18522880 20032147 18407596
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.9015034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.2314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.2317823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.2315474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 14.2312741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 14.2315980055 17347453
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.2318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.2312878042
MESH:D008106 Liver Cirrhosis, Experimental Thioacetamide 14.2318031379 18295389 16126171 11481614 17355460 15075984 16248980 18416461 15316131 18263696 18032466 12175628 17292413 16098781 11172339 12531686 15078482 15095483 15716488 18395095 18458672 17629604 18380797 15474484 12085344 14739098 15158331 15465738 16097051 17050028 12891558 15334695 15288472 17127702 15362042 12679928 10677585 15288473 16489207 11682029 18606216 18615449 16511523 12557150 16343077
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 14.2316248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 8.2919460945 12587719 19014921 16610002 12969438 11587558 16611625 19784758
MESH:D008107 Liver Diseases Diethylnitrosamine 8.2917034775
MESH:D008107 Liver Diseases limonene 8.291715830
MESH:D008107 Liver Diseases Thioacetamide 8.2915158337 16337175 18374380
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2916871587 17185352
MESH:D017114 Liver Failure, Acute Thioacetamide 8.2912479984 15313186 17276928 15633222
MESH:D008113 Liver Neoplasms Aflatoxin B1 30.1015890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 30.1021137059 20195826
MESH:D008113 Liver Neoplasms Butylated Hydroxytoluene 30.1018177683
MESH:D008113 Liver Neoplasms dicyclanil 30.1020118626
MESH:D008113 Liver Neoplasms Diethylnitrosamine 30.1020501860 19833225 2422723 19499222 19551842 10737359 15885732 19073162 19090486 19255062 21167192 21047994 20118626 19426721 19642983 19427195 19850985 12112319 20434301 20137499 21071580 9163691 18978307 21278145 2862719 19690152 18977376 19256749 18754104 16942905 18644402 20492335 19254457 12771043 15175105 19638242 19294768 19996281 18648771 20583210 19812893 20405173 20101389 20452335
MESH:D008113 Liver Neoplasms Diethylstilbestrol 30.1016712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 30.1016377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 30.1018980244
MESH:D008113 Liver Neoplasms Tamoxifen 30.1016684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 30.1016984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 15.463712494 1399818 598648 6587162
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 15.468603461
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 15.4618775883 16267830 18544905 9362446 18079962 19539802 19126423 18308698 18253720 17854601 17942915 21159647 18282651 17174075 3124819 19009564 18164116 19004024 18093689 16842330 19519916 2563599
MESH:D008114 Liver Neoplasms, Experimental Quercetin 15.4619519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 15.4612151625
MESH:D008133 Long QT Syndrome Amiodarone 3.2215350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 10.5812587719
MESH:D008171 Lung Diseases Mustard Gas 10.5818161513 18702808
MESH:D008171 Lung Diseases Ozone 10.588266340 19066396
MESH:D017563 Lung Diseases, Interstitial Amiodarone 4.0118516814
MESH:D055370 Lung Injury Ozone 3.4020417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 18.8014755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 18.8020064080 17053015 20135361 20464547 20869020 18520028 6695378 18816296 18569708
MESH:D008175 Lung Neoplasms bexarotene 18.8017849452
MESH:D008175 Lung Neoplasms Butylated Hydroxytoluene 18.8016337739 11246140 15390079 18597497 19925653 19359593 11696405
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.8021163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Mustard Gas 18.808781369 3148597
MESH:D008175 Lung Neoplasms Ozone 18.807614698 8597069
MESH:D008175 Lung Neoplasms Quercetin 18.8016280456
MESH:D008175 Lung Neoplasms Tamoxifen 18.8018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.8019555203 11884234
MESH:D008175 Lung Neoplasms Tobacco Smoke Pollution 18.8011091918 12111688 3440675 16288123
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6815166399
MESH:D008223 Lymphoma Cyclophosphamide 6.7712854902
MESH:D008223 Lymphoma Diethylstilbestrol 6.7715700306
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.1716675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 3.7911911406
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.6911161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0416002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.3019428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 23.7919196723 15591091 19196722
MESH:D008325 Mammary Neoplasms, Experimental Butylated Hydroxytoluene 23.791500032
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 23.7917203775 16891317 11408345 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 23.7914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 23.7917203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 23.7916827153
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 23.7914580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 19.6419453300
MESH:D020149 Manganese Poisoning Manganese 19.6416568477 16551646 19453300
MESH:D020149 Manganese Poisoning Tamoxifen 19.6419453300
MESH:D008527 Medulloblastoma Tretinoin 2.5917453147
MESH:D008545 Melanoma Tamoxifen 2.9812393984 19393235
MESH:D008545 Melanoma Tretinoin 2.9816752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 9.3219513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 9.3216388313
MESH:D008591 Meningomyelocele Tretinoin 3.9716940565
MESH:D024821 Metabolic Syndrome X rosiglitazone 4.0017261469
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.3116801185
MESH:D008679 Metaplasia Ozone 4.6310496685
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.6016381670
MESH:D009062 Mouth Neoplasms Tobacco Smoke Pollution 7.6015006635
MESH:D009069 Movement Disorders Manganese 4.5816551646
MESH:D009135 Muscular Diseases pirinixic acid 3.0516239165
MESH:D009181 Mycoses Amiodarone 4.4317974566 12754197
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.8017596541
MESH:D009203 Myocardial Infarction Genistein 8.2517141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.2519151258
MESH:D009203 Myocardial Infarction Quercetin 8.2519595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 17.3516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 17.3517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 17.3516411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 17.3519207477
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 8.263581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.263581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.2619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 16.5911141357
MESH:D009369 Neoplasms Cyclophosphamide 16.5918854779
MESH:D009369 Neoplasms Diethylstilbestrol 16.5915313581
MESH:D009369 Neoplasms pirinixic acid 16.5917405874
MESH:D009369 Neoplasms Quercetin 16.5915185748
MESH:D009369 Neoplasms Tretinoin 16.5916946489 16594593
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 9.3619196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 9.3619200415 19196722 19189210
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2717289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8919348381 18481113
MESH:D009410 Nerve Degeneration Manganese 3.9216551646
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.0611399458
MESH:D009421 Nervous System Malformations Estradiol 26.0616427766 11399458
MESH:D009421 Nervous System Malformations Genistein 26.0616427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.0614600291
MESH:D009421 Nervous System Malformations Tretinoin 26.069125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 6.196679447
MESH:D009436 Neural Tube Defects Tretinoin 6.199142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.3915176712 16115947 8761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 6.9218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 6.9220387270
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.4212837982 8761367
MESH:D020078 Neurogenic Inflammation Quercetin 3.9317929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6420387270
MESH:D009503 Neutropenia Cyclophosphamide 8.118291058
MESH:D009503 Neutropenia Mustard Gas 8.117688884 16761898
MESH:D052556 Niemann-Pick Disease, Type C Clofibrate 4.489802331
MESH:D009765 Obesity pirinixic acid 1.6920558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.026482804 4026338
MESH:D009845 Oligospermia Cyclophosphamide 4.2516517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.543988306
MESH:D010024 Osteoporosis Genistein 2.9619401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 8.7116169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 8.7119495926
MESH:D010051 Ovarian Neoplasms Estradiol 13.1919401270
MESH:D010051 Ovarian Neoplasms Genistein 13.1919005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.1917393432 16525653
MESH:D010051 Ovarian Neoplasms Quercetin 13.1919005980
MESH:D010051 Ovarian Neoplasms Tretinoin 13.1916936753
MESH:D010146 Pain Acetaminophen 9.1216870215
MESH:D010146 Pain Cyclophosphamide 9.1212161096 18093676
MESH:D010146 Pain Tretinoin 9.1216870215
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 10.8211332152
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.8216540662
MESH:D010190 Pancreatic Neoplasms Quercetin 10.8216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.8215976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 3.7817698068
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2611578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.037296757
MESH:D010300 Parkinson Disease Manganese 3.1911181820
MESH:D020734 Parkinsonian Disorders Manganese 4.0716140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7712520081
MESH:D010538 Peritonitis Ozone 3.6816369182
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.996228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6914722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.2216977796 15687265
MESH:D011014 Pneumonia Butylated Hydroxytoluene 9.7811893704
MESH:D011014 Pneumonia Ozone 9.7818381685 18007984 18929643
MESH:D011041 Poisoning Mustard Gas 3.3715727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.1218163543
MESH:D011230 Precancerous Conditions Cyclosporine 13.0512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 13.052563599
MESH:D011230 Precancerous Conditions Quercetin 13.0519056647
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.5321297632
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 8.0217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.0211399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4720887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.3217292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.3217136230
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.3215046698 15846301 17136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.3216740699
MESH:D011471 Prostatic Neoplasms Flurbiprofen 2.3217409433
MESH:D011471 Prostatic Neoplasms Genistein 2.3215256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Quercetin 2.3214715546 17292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.3215067354
MESH:D011507 Proteinuria Tretinoin 3.1816636307
MESH:D011537 Pruritus Ethinyl Estradiol 7.9815861022 16919318
MESH:D011537 Pruritus Mustard Gas 7.9818058305
MESH:D011565 Psoriasis Cyclosporine 2.0516882103
MESH:D011625 Pterygium Tretinoin 4.3316723453
MESH:D011658 Pulmonary Fibrosis Amiodarone 8.2312832656 11597910 12490602
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 8.2316636934
MESH:D011658 Pulmonary Fibrosis Mustard Gas 8.2317894541 17266442 10334151 17720292 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.1519058328
MESH:D012120 Respiration Disorders Chlorine 4.7418579056
MESH:D012135 Respiratory Sounds Tobacco Smoke Pollution 4.1718410779
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3918990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.033692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6716116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.6818045962
MESH:D012554 Schistosomiasis japonica Quercetin 5.0716862918
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.3916636934
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.6218724381
MESH:D012871 Skin Diseases Mustard Gas 2.5816961503 12880345 15451306
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.6410029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.6416192470
MESH:D012878 Skin Neoplasms Tobacco Smoke Pollution 11.6418590791
MESH:D012878 Skin Neoplasms Tretinoin 11.6416467112
MESH:D013088 Spermatocele Diethylstilbestrol 17.3816709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 17.3816709447
MESH:D013088 Spermatocele Tamoxifen 17.3816709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.0516517039
MESH:D013119 Spinal Cord Injuries Progesterone 9.3215862959 16503802
MESH:D013119 Spinal Cord Injuries Tamoxifen 9.3219457130
MESH:D013272 Stomach Diseases Omeprazole 4.1518545984
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.262093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2618456281
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.2612958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 4.2617261132
MESH:D013276 Stomach Ulcer Amiodarone 6.2218087811
MESH:D013276 Stomach Ulcer Omeprazole 6.2210750652 17977527 16755016 11906479 15991576 18237397
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.5912837982
MESH:D013610 Tachycardia Amiodarone 3.8511238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.7519225199
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1911994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7615669648
MESH:D013959 Thyroid Diseases Amiodarone 10.4719731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 10.4712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 14.207505956 1399818 6587162 6582329 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 14.207505956
MESH:D013964 Thyroid Neoplasms Propylthiouracil 14.2015710170
MESH:D013964 Thyroid Neoplasms Tretinoin 14.2016026305 17045167
MESH:D013971 Thyrotoxicosis Amiodarone 4.4018020914 19584973
MESH:D013978 Tibial Fractures Estradiol 4.2119048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.3816051514
MESH:D016171 Torsades de Pointes Amiodarone 3.7311989578 17467628
MESH:D014376 Tuberculosis Tretinoin 2.9316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 21.038074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 21.0317053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 21.0314692829
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 21.0316452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms Quercetin 21.0316720314
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 21.0317572228 8653321 16712894
MESH:D001749 Urinary Bladder Neoplasms Tobacco Smoke Pollution 21.0312846360
MESH:D014581 Urticaria Acetaminophen 2.5510982225
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.1716175088
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 8.1716129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6914652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.0116690809 15809267
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.0114692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1416752155
MESH:D014605 Uveitis Cyclosporine 3.511336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9816513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.1212125929
MESH:D014689 Venous Insufficiency coumarin 5.3012708602
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.1215869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.6116761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7715886252
MESH:D009396 Wilms Tumor Tretinoin 3.5716287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9717120751
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:00330 Arginine and proline metabolism
KEGG:01100 Metabolic pathways
REACT:13 Metabolism of amino acids and derivatives
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24947
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA445019Myocardial Infarction
    Releated drug ID Related drug Name
    PA134687887selective beta-2-adrenoreceptor agonists
    PA448681budesonide
    PA449686fluticasone propionate
    PA450601nedocromil
    PA448068salbutamol
    PA448478l-arginine
    PA451831urea
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00129 - L-Ornithine Dietary supplement;Micronutrient;Non-Essential Amino Acids
    DB01983 - 2(S)-Amino-6-Boronohexanoic Acid
    DB02381 - Nor-N-Omega-Hydroxy-L-Arginine
    DB02499 - Dinor-N(Omega)-Hydroxy-L-Arginine
    DB02689 - S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine
    DB03144 - N-Omega-Hydroxy-L-Arginine
    DB03731 - S-2-(Boronoethyl)-L-Cysteine
    DB03904 - Urea
    DB04197 - Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine
    DB04530 - S,S-(2-Hydroxyethyl)Thiocysteine
    DB04585 - DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID
    DB04648 - S-propylamine-L-cysteine
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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