AutismKB 2.0

Annotation Detail for KLC1


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Basic Information Top
Gene Symbol:KLC1 ( KLC,KNS2,KNS2A,MGC15245 )
Gene Full Name: kinesin light chain 1
Band: 14q32.33
Quick LinksEntrez ID:3831; OMIM: 600025; Uniprot ID:KLC1_HUMAN; ENSEMBL ID: ENSG00000126214; HGNC ID: 6387
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200046Arf6 trafficking events
Pathway IDPathway Name
P00003Alzheimer disease-amyloid secretase pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1740Alzheimer's disease
1877Multiple sclerosis
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of KLC1 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of KLC1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of KLC1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of KLC1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of KLC1 mRNAaffects expression 16483693
D001151 Arsenic Arsenic results in decreased expression of KLC1 mRNAdecreases expression 19654921
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLC1 mRNAdecreases expression 19150397
C006780 bisphenol A bisphenol A affects the expression of KLC1 mRNAaffects expression 14967926
D016572 Cyclosporine Cyclosporine results in increased expression of KLC1 mRNAincreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of KLC1 mRNAdecreases expression 17490981
D005419 Flavonoids Flavonoids results in decreased expression of KLC1 mRNAdecreases expression 18035473
D006220 Haloperidol Haloperidol results in decreased expression of KLC1 mRNAdecreases expression 18797397
C475919 hydroxytamoxifen hydroxytamoxifen results in increased expression of KLC1 mRNAincreases expression 16849584
C076029 olanzapine olanzapine results in decreased expression of KLC1 mRNAdecreases expression 18797397
C025299 polyphenols polyphenols results in decreased expression of KLC1 mRNAdecreases expression 16293270
C009277 sodium arsenate sodium arsenate results in increased expression of KLC1 mRNAincreases expression 16882884
D014810 Vitamin E Vitamin E results in increased expression of KLC1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 3.947525203
MESH:D000138 Acidosis Ammonium Chloride 3.5518287403
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2117306315
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D020261 Arsenic Poisoning Arsenic 2.8616251483 16835338 12569548 18414634
MESH:D050197 Atherosclerosis Arsenic 3.2412928151 19371607
MESH:D001321 Autistic Disorder Acetaminophen 2.3818445737
MESH:D001321 Autistic Disorder Haloperidol 2.3818080171 19368416
MESH:D001321 Autistic Disorder olanzapine 2.3818685284 17069543
MESH:D001862 Bone Resorption bisphenol A 3.8411985600
MESH:D001943 Breast Neoplasms bisphenol A 2.4817123778
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.9216050911
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5815504454 17687452
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.5416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.5416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.543084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 6.5417306315 16507464
MESH:D002278 Carcinoma in Situ bisphenol A 4.9817123778
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.6817687452 15504454 18922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0618640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.4315738583 17938729 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.2916973168 18022660
MESH:D002375 Catalepsy Haloperidol 4.9015215559 1977408
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.3814694615
MESH:D002386 Cataract Acetaminophen 7.3810977129
MESH:D002389 Catatonia olanzapine 6.2518071103 16772815
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.056135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.0520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.0512371664
MESH:D002779 Cholestasis Cyclosporine 2.9019486331
MESH:D003110 Colonic Neoplasms polyphenols 2.6716293270
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.1415095906
MESH:D019465 Craniofacial Abnormalities sodium arsenate 3.0110525206
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.0119769572
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.8518551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.8518551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 4.8220210726
MESH:D003704 Dementia Haloperidol 4.5611575062
MESH:D002658 Developmental Disabilities olanzapine 4.6817069543
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 15.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 15.2121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2119370779 16177239 19164858 17522070 19420014 15968718 14550746 19085960 12153990 11421492 14725611 14986274 19923254 12958197 15619225 17906064 16781746 16109766 2444490 11287661 10663392 12705907 16393943 11834606 17562736 18071297 10774834 16227642 11739529 10915739 12540782 16081117 11529661 12594235 16485898 19739265 11743745 11461765 12392966 19416960 18713872
MESH:D056486 Drug-Induced Liver Injury polyphenols 15.2119370779
MESH:D056486 Drug-Induced Liver Injury sodium arsenate 15.2118186108
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:C538011 Eales disease Vitamin E 4.709068938
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0720426865
MESH:D005234 Fatty Liver Cyclosporine 2.8419224547
MESH:D005355 Fibrosis Cyclosporine 3.1312639820 12168785
MESH:D005534 Foot Diseases Arsenic 5.566392382
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D018149 Glucose Intolerance sodium arsenate 5.0619446573
MESH:D006330 Heart Defects, Congenital Vitamin E 2.9816080930
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.6916490937 16863852
MESH:D019584 Hot Flashes Vitamin E 3.9714716179
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4417050553
MESH:D006963 Hyperphagia olanzapine 6.2217933447
MESH:D006973 Hypertension Arsenic 5.2716076760 11953799 9931084
MESH:D006973 Hypertension Cyclosporine 5.2710903974
MESH:D006987 Hypesthesia Arsenic 5.5616093927
MESH:D007249 Inflammation Flavonoids 5.4017296493
MESH:D007249 Inflammation polyphenols 5.4016366677
MESH:D007251 Influenza, Human Vitamin E 4.2116624496
MESH:D007333 Insulin Resistance bisphenol A 3.2716393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007642 Keratosis Arsenic 4.9812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.9315629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.938314463 10903974 18776723
MESH:D007674 Kidney Diseases Vitamin E 9.9312488133
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.2616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.2612371664
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5417339181
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 6.6012969438 16611625 19784758 12587719 19014921 19460945 11587558 16610002
MESH:D008107 Liver Diseases Arsenic 6.6011134558
MESH:D008107 Liver Diseases polyphenols 6.6016698588
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2217185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.707678174
MESH:D008113 Liver Neoplasms Arsenic 4.7016368122
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.536135515 2876784 2876786
MESH:D008133 Long QT Syndrome olanzapine 4.7120210726
MESH:D008171 Lung Diseases Vitamin E 3.1616863852
MESH:D008175 Lung Neoplasms Arsenic 2.6519168569 17306315 17976673
MESH:D008175 Lung Neoplasms Vitamin E 2.6511062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D001523 Mental Disorders Haloperidol 8.5916856516
MESH:D001523 Mental Disorders olanzapine 8.5916856516
MESH:D008659 Metabolic Diseases olanzapine 5.3719142110
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D009139 Musculoskeletal Abnormalities sodium arsenate 4.8418186108
MESH:D017202 Myocardial Ischemia Arsenic 3.9615371236
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.327678174 18551238
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 3.9611399458 16427766
MESH:D009436 Neural Tube Defects Arsenic 7.7116620997
MESH:D009436 Neural Tube Defects sodium arsenate 7.7118186108 10525206 11749123 19446573
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8518514411
MESH:D020078 Neurogenic Inflammation Arsenic 4.3617056641
MESH:D009765 Obesity olanzapine 3.7118515891
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 15.0516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 15.0516049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 15.0514694615
MESH:D010049 Ovarian Diseases bisphenol A 4.9811985600
MESH:D010051 Ovarian Neoplasms Arsenic 2.7417306315
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9815371236 6392382 16905509
MESH:D011230 Precancerous Conditions Cyclosporine 3.2012371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 3.9410548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.1920887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.6616140617
MESH:D011471 Prostatic Neoplasms bisphenol A 2.6616740699
MESH:D011471 Prostatic Neoplasms Vitamin E 2.6615084515
MESH:D011507 Proteinuria Arsenic 3.9921343184
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011595 Psychomotor Agitation Haloperidol 11.7711575062
MESH:D011595 Psychomotor Agitation olanzapine 11.7718685284
MESH:D011618 Psychotic Disorders Haloperidol 4.2411575062
MESH:D011629 Puberty, Precocious bisphenol A 4.7810548101
MESH:D012559 Schizophrenia Haloperidol 4.3418513383 19369910 20107430 1830565
MESH:D012559 Schizophrenia olanzapine 4.3420521326 17726453 20107430
MESH:D012640 Seizures 2,4-dinitrotoluene 5.8218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 5.8218551238
MESH:D012871 Skin Diseases Arsenic 5.0219834688 17050553 18709164 17548696 16759981 17453740 15952646 16353154 16702368 6392382 17938729
MESH:D012871 Skin Diseases Vitamin E 5.0218709164
MESH:D012878 Skin Neoplasms Arsenic 3.0017976673 19538983 17029826 15504454 17050553 16251483
MESH:D020521 Stroke Vitamin E 3.5016517955
MESH:D019966 Substance-Related Disorders bisphenol A 3.9716684133 16045194
MESH:D017180 Tachycardia, Ventricular Haloperidol 10.9020210726
MESH:D017180 Tachycardia, Ventricular olanzapine 10.9020210726
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.2517997062
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3016049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 8.3017976673 17306315 11144890 18640142 19322015 19429237 15987713
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 11.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 11.9610091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014591 Uterine Diseases bisphenol A 5.0114652134
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014652 Vascular Diseases Arsenic 4.7317056641
MESH:D015430 Weight Gain olanzapine 5.1419434072 17933447 20107430
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
Pathway ID Pathway Name
REACT:604 Hemostasis
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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