AutismKB 2.0

Annotation Detail for KPNA1


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Basic Information Top
Gene Symbol:KPNA1 ( IPOA5,NPI-1,RCH2,SRP1 )
Gene Full Name: karyopherin alpha 1 (importin alpha 5)
Band: 3q21.1
Quick LinksEntrez ID:3836; OMIM: 600686; Uniprot ID:IMA1_HUMAN; ENSEMBL ID: ENSG00000114030; HGNC ID: 6394
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Apoptosis
Influenza Infection
HIV Infection
Pathway IDPathway Name
200169Class I PI3K signaling events mediated by Akt
No data
Pathway IDPathway Name
500748Vpr-mediated nuclear import of PICs
500687Transport of Ribonucleoproteins into the Host Nucleus
500275Activation of DNA fragmentation factor
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001554 Benzene Benzene results in increased expression of KPNA1 mRNAincreases expression 15929907
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KPNA1 mRNAdecreases expression 19150397
D017373 Cyproterone Acetate Cyproterone Acetate results in increased expression of KPNA1 mRNAincreases expression 16906019
D003907 Dexamethasone Dexamethasone results in decreased expression of KPNA1 mRNAdecreases expression 16906019
D002117 Calcitriol Calcitriol results in decreased expression of KPNA1 mRNAdecreases expression 16847355
D002117 Calcitriol Calcitriol results in increased expression of KPNA1 mRNAincreases expression 18614847
D012643 Selenium [Selenium co-treated with Vitamin E] results in decreased expression of KPNA1 mRNAaffects cotreatment|decreases expression 19244175
D012643 Selenium Selenium results in decreased expression of KPNA1 mRNAdecreases expression 19244175
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KPNA1 mRNAincreases expression 19465110
D014212 Tretinoin Tretinoin results in increased expression of KPNA1 mRNAincreases expression 18614847
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in decreased expression of KPNA1 mRNAaffects cotreatment|decreases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of KPNA1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1315322242 11752688 14514962
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000505 Alopecia Tretinoin 3.7815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000741 Anemia, Aplastic Benzene 4.5317661222 14761424 11369114
MESH:D001169 Arthritis, Experimental Dexamethasone 7.9217659584
MESH:D001169 Arthritis, Experimental Tretinoin 7.9216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6416935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.6312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.6316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001855 Bone Marrow Diseases Benzene 5.5516183116
MESH:D001943 Breast Neoplasms Benzene 2.0117162533 11921183
MESH:D001943 Breast Neoplasms Calcitriol 2.0111237771
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Tretinoin 2.0116166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8816813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1916050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4816168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 4.9511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.9516051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002386 Cataract Tretinoin 3.2017460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.8620889678
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002822 Choriocarcinoma Tretinoin 5.4816461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0215668235 15340226 16354765 8697196 12621046
MESH:D002972 Cleft Palate Tretinoin 6.029407595
MESH:D003092 Colitis Selenium 10.3717936198
MESH:D003092 Colitis Tretinoin 10.3717035595
MESH:D003110 Colonic Neoplasms Dexamethasone 2.5215824018
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Benzene 7.5615643154
MESH:D019465 Craniofacial Abnormalities Dexamethasone 7.5617728286
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 7.5615322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 7.5616925845 9211117 10589399 9125849 9224671 9664655 17551590 8800419 9142499 14991402
MESH:D019465 Craniofacial Abnormalities Vitamin E 7.5619769572
MESH:D003872 Dermatitis Benzene 5.0215902427
MESH:D017449 Dermatitis, Allergic Contact Dexamethasone 3.6612438553
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D003967 Diarrhea Dexamethasone 3.937237001
MESH:D056486 Drug-Induced Liver Injury Selenium 3.9415131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.9420420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:C538011 Eales disease Vitamin E 5.029068938
MESH:D004485 Eczema Dexamethasone 4.7012438553
MESH:D004487 Edema Dexamethasone 7.5719703484
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.5712711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.0315322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 13.0318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1715138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2316569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1120426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.3411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.3416938888 9664655
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.5020067830
MESH:D005355 Fibrosis Tretinoin 9.5017994277
MESH:D005909 Glioblastoma Tretinoin 3.1317312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3216096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4816084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.7110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.719664655 14991402
MESH:D006330 Heart Defects, Congenital Vitamin E 11.7116080930
MESH:D006333 Heart Failure Selenium 3.1917162251
MESH:D006402 Hematologic Diseases Benzene 4.8716183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Dexamethasone 6.187520565
MESH:D006548 Hernia, Diaphragmatic Vitamin E 6.1816863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2914716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3616354765 15340226 16959395 18606429 8697196
MESH:D006930 Hyperalgesia Tretinoin 3.3716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8316778211
MESH:D006973 Hypertension Benzene 9.1217940673
MESH:D006973 Hypertension Dexamethasone 9.1217042910
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 9.1218850075 18670907
MESH:D007249 Inflammation Dexamethasone 5.408960868 11099482
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.4012878042 12200463
MESH:D007251 Influenza, Human Selenium 12.0416624496
MESH:D007251 Influenza, Human Vitamin E 12.0416624496
MESH:D007410 Intestinal Diseases Tretinoin 4.0217994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.6316580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.6315992940 17551590
MESH:D007674 Kidney Diseases Vitamin E 2.9112488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0916518626
MESH:D007938 Leukemia Benzene 6.8518335105 17119257 14694614 15935818
MESH:D007938 Leukemia Tretinoin 6.8517143497
MESH:D007951 Leukemia, Myeloid Benzene 10.3817506065
MESH:D007951 Leukemia, Myeloid Tretinoin 10.3816932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute Benzene 4.1919478238
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1917596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2816935935 17339181 15748426 17649720 16766008 9834237 17217047 17361223 19035177 17294898 17301526 19075265 19029980 16891316 16140955 17712046 17368321 16788101 16331271 17107899 19642359 16823087 12679006 17506722 19225113
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.459224671
MESH:D008106 Liver Cirrhosis, Experimental Dexamethasone 5.1416718785
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 5.1412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1416248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 5.1416169303
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7816984957
MESH:D008114 Liver Neoplasms, Experimental Benzene 6.4112562636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.4112151625
MESH:D008171 Lung Diseases Vitamin E 3.3116863852
MESH:D017563 Lung Diseases, Interstitial Benzene 5.1314698565
MESH:D008175 Lung Neoplasms Benzene 5.0612562636
MESH:D008175 Lung Neoplasms Dexamethasone 5.0615824018 11195469
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 5.0619555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 5.0611062179
MESH:D008223 Lymphoma Benzene 3.8817119257 17584886
MESH:D015674 Mammary Neoplasms, Animal Benzene 4.7312562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 6.7111921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.7115318939
MESH:D008527 Medulloblastoma Tretinoin 2.8517453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6816940565
MESH:D008654 Mesothelioma Selenium 2.8615107826
MESH:D009101 Multiple Myeloma Benzene 8.1217119195
MESH:D009101 Multiple Myeloma Dexamethasone 8.1215867202 16118317 15744524
MESH:D009190 Myelodysplastic Syndromes Dexamethasone 7.909809623
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.9017596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009369 Neoplasms Tretinoin 2.4916946489 16594593
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.3214600291
MESH:D009421 Nervous System Malformations Tretinoin 10.329125849
MESH:D009436 Neural Tube Defects Benzene 7.9315643154
MESH:D009436 Neural Tube Defects Tretinoin 7.939142499
MESH:D009784 Occupational Diseases Benzene 4.3716737584 15576619 15935809 17178637 15727169 17479406 15612468 17119257 15913788
MESH:D010051 Ovarian Neoplasms Benzene 5.2612562636
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2616936753
MESH:D010146 Pain Tretinoin 3.0716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5215976015
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010954 Plasmacytoma Selenium 5.2115087411
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Dexamethasone 3.6521297632
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811118676 11399792 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0615572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3512479363 16289102 16644109 15754350 18247401
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3515084515
MESH:D011507 Proteinuria Tretinoin 3.8216636307
MESH:D011625 Pterygium Tretinoin 5.0816723453
MESH:D012128 Respiratory Distress Syndrome, Adult Dexamethasone 4.2411700416 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3216283617 16116481
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.8516192470
MESH:D012878 Skin Neoplasms Tretinoin 5.8516467112
MESH:D013272 Stomach Diseases Dexamethasone 4.6015472012
MESH:D013274 Stomach Neoplasms Benzene 2.7012562636
MESH:D013274 Stomach Neoplasms Tretinoin 2.7017261132
MESH:D013276 Stomach Ulcer Dexamethasone 3.6915138204
MESH:D020521 Stroke Vitamin E 3.6816517955
MESH:D013953 Thymus Neoplasms Benzene 5.2410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1816026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.9816051514
MESH:D014376 Tuberculosis Tretinoin 3.3416040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8716129372
MESH:D014594 Uterine Neoplasms Benzene 4.5712562636
MESH:D014604 Uveal Neoplasms Tretinoin 4.9316752155
MESH:D014605 Uveitis Dexamethasone 5.131336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D014820 Vitiligo Tretinoin 4.2916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D009396 Wilms Tumor Tretinoin 4.1516287080
Pathway ID Pathway Name
REACT:578 Apoptosis
REACT:6185 HIV Infection
REACT:6167 Influenza Infection
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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