AutismKB 2.0

Annotation Detail for TNPO1


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Basic Information Top
Gene Symbol:TNPO1 ( IPO2,KPNB2,MIP,MIP1,TRN )
Gene Full Name: transportin 1
Band: 5q13.2
Quick LinksEntrez ID:3842; OMIM: 602901; Uniprot ID:TNPO1_HUMAN; ENSEMBL ID: ENSG00000083312; HGNC ID: 6401
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of TNPO1 mRNAaffects expression 21346803
C016601 4-hydroxytamoxifen 4-hydroxytamoxifen results in decreased expression of TNPO1 mRNAdecreases expression 16514628
D000082 Acetaminophen Acetaminophen affects the expression of TNPO1 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of TNPO1 mRNAdecreases expression 19150397
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of TNPO1 mRNAincreases expression 15336504
D016572 Cyclosporine Cyclosporine results in increased expression of TNPO1 mRNAincreases expression 20106945
D002117 Calcitriol Calcitriol results in decreased expression of TNPO1 mRNAdecreases expression 16847355
D004958 Estradiol Estradiol results in increased expression of TNPO1 mRNAincreases expression 16514628
C070081 fulvestrant fulvestrant results in decreased expression of TNPO1 mRNAdecreases expression 16514628
C006253 pirinixic acid pirinixic acid results in decreased expression of TNPO1 mRNAdecreases expression 18445702
D020849 Raloxifene Raloxifene results in decreased expression of TNPO1 mRNAdecreases expression 16514628
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of TNPO1 mRNAincreases expression 19465110
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0014514962 15322242 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Estradiol 2.1211473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.4216434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.4216835633
MESH:D000419 Albuminuria Raloxifene 4.7217308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5615800139
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0511748828
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D001284 Atrophy fulvestrant 4.9711514358
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8315746008
MESH:D001930 Brain Injuries Raloxifene 4.6116580743
MESH:D001943 Breast Neoplasms Calcitriol 2.3811237771
MESH:D001943 Breast Neoplasms Estradiol 2.3817261762 14630087 17289903 19861407 17018787 16675129 18497071 12948864
MESH:D001943 Breast Neoplasms fulvestrant 2.3818984771
MESH:D001943 Breast Neoplasms Raloxifene 2.3817049068 17440819 15758505 16912660 17952589 17242785 17261762 17595753 17893378 16837676 15572757 15775269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3820435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.6216111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8916835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.6016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.603084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.6016924424
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 2.6511237771
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 4.1717572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4218670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5215775269
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 16.636135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 16.6320889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 16.6312371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 16.6318566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2616835633
MESH:D002779 Cholestasis Cyclosporine 8.0319486331
MESH:D002779 Cholestasis pirinixic acid 8.0319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1416354765 12621046 15668235 8697196 15340226
MESH:D003072 Cognition Disorders Raloxifene 4.7615800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 20055451 15322242
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003865 Depressive Disorder, Major Raloxifene 4.2617474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6917107852
MESH:D003928 Diabetic Nephropathies Estradiol 9.3419279558
MESH:D003928 Diabetic Nephropathies Raloxifene 9.3415920148 17451421 17308373
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.2918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2917562736 18713872 16485898 12540782 16177239 18071297 12594235 11739529 19923254 12153990 15968718 12705907 19085960 10663392 11834606 11529661 19370779 11743745 19164858 12392966 12958197 14550746 17906064 10915739 2444490 11287661 16109766 16393943 19739265 10774834 15619225 14725611 11461765 16227642 11421492 19416960 14986274 16081117 16781746 19420014 17522070
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8411462148
MESH:D004487 Edema pirinixic acid 12.0812083418
MESH:D004487 Edema Raloxifene 12.0815860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.0811000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0818230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 9.8215138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 9.8215845917
MESH:D016889 Endometrial Neoplasms 4-hydroxytamoxifen 8.0219148513
MESH:D016889 Endometrial Neoplasms Estradiol 8.0219148513 18566989 11473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1210568697 9294722
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1020426865
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0911564622
MESH:D005234 Fatty Liver Cyclosporine 13.7619224547
MESH:D005234 Fatty Liver pirinixic acid 13.7619236843 20131406
MESH:D005234 Fatty Liver Raloxifene 13.7617473493
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5911858732
MESH:D005355 Fibrosis Cyclosporine 8.9512639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9520067830
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3810048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.6111110106
MESH:D006333 Heart Failure pirinixic acid 2.6020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4411000095
MESH:D006529 Hepatomegaly pirinixic acid 8.7319772884 18467677 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.7316120746 15340226 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.2115709030
MESH:D019584 Hot Flashes Estradiol 3.9317088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.228697196 18606429 15340226 16959395 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006973 Hypertension Cyclosporine 8.8010903974
MESH:D006973 Hypertension Raloxifene 8.8015787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.8018670907 18850075
MESH:D007248 Infertility, Male fulvestrant 3.8211514358
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 7.4316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.4316306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.4416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.3312587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 10.3318776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 10.3315618244
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007889 Leiomyoma Raloxifene 4.6116973256
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4415474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6512587719 12969438 11587558 19460945 16610002 16611625 19014921 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.557678174
MESH:D008113 Liver Neoplasms pirinixic acid 7.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.5516984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 5.952876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9512151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6217203775 16891317 11408345 11807958
MESH:D020149 Manganese Poisoning Estradiol 4.6619453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.7315863610
MESH:D009101 Multiple Myeloma Raloxifene 3.5116497877
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1819151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.5316810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.5316411023
MESH:D009232 Myxoma Raloxifene 5.7316343187
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.017678174 18551238
MESH:D009369 Neoplasms pirinixic acid 1.9917405874
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8917289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.8911399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8914600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.5316049721
MESH:D010024 Osteoporosis Raloxifene 3.4615775268 17882678 19059307
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.3417893378 15758505 15579764 17823083
MESH:D010051 Ovarian Neoplasms Estradiol 2.2519401270
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.4212520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6918163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.3411118676 11399792 11222880 11896295
MESH:D011470 Prostatic Hyperplasia Calcitriol 4.9315572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9920887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.6216289102 18247401 12479363 16644109 15754350
MESH:D011471 Prostatic Neoplasms Estradiol 2.6216740699
MESH:D011471 Prostatic Neoplasms Raloxifene 2.6216536755 15731164 16220300
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011693 Purpura Raloxifene 5.7315770314
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9618990726
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 5.758532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.7516192470
MESH:D020521 Stroke Raloxifene 3.9116837676
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0812697716
MESH:D013978 Tibial Fractures Estradiol 14.3019048282
MESH:D013978 Tibial Fractures Raloxifene 14.3019048282
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.3416049721
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.3417572228
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7712125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.3816837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.7316343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.4215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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