AutismKB 2.0

Annotation Detail for KRT1


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Basic Information Top
Gene Symbol:KRT1 ( CK1,EHK,EHK1,EPPK,K1,KRT1A,NEPPK )
Gene Full Name: keratin 1
Band: 12q13.13
Quick LinksEntrez ID:3848; OMIM: 139350; Uniprot ID:K2C1_HUMAN; ENSEMBL ID: ENSG00000167768; HGNC ID: 6412
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1832Congenital abnormality
No data
No data
Desease Name
Ichthyosis, cyclic, with epidermolytic hyperkeratosis
Epidermolytic hyperkeratosis
Keratosis palmoplantaris striata III
Plamoplantar keratoderma, epidermolytic
Ichthyosis histrix, Curth-Macklin Palmoplantar keratoderma, nonepidermolytic
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C403065 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to KRT1 proteinaffects binding 19539807
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid 15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of KRT1 mRNAdecreases expression 15982314
C047628 8-hydroxyeicosatetraenoic acid 8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]increases expression|increases reaction 12069687
C103303 alitretinoin alitretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
D001151 Arsenic Arsenic results in increased expression of KRT1 mRNAincreases expression 11134558
C015001 arsenite arsenite results in decreased expression of KRT1 mRNAdecreases expression 18633435
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KRT1 mRNAincreases expression 20064835
D002118 Calcium 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium 15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium 8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]increases expression|increases reaction 12069687
D002118 Calcium Calcium results in increased expression of KRT1 mRNAincreases expression 12069687
D002118 Calcium morin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium Nordihydroguaiaretic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium Quercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNAaffects binding|decreases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in decreased expression of KRT1 mRNAdecreases expression 20105288
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of KRT1 mRNAincreases expression 15171707
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KRT1 mRNAaffects expression 17555576
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D015741 Metribolone Metribolone results in decreased expression of KRT1 proteindecreases expression 17152098
C008548 morin morin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D009151 Mustard Gas Mustard Gas results in increased cleavage of KRT1 proteinincreases cleavage 12482751
D009151 Mustard Gas Mustard Gas results in increased expression of KRT1 proteinincreases expression 11428642
9665388
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of KRT1 mRNAincreases expression 17616710
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT1 mRNAdecreases expression 18633435
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D011794 Quercetin Quercetin results in increased expression of KRT1 proteinincreases expression 17292933
D011794 Quercetin Quercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D015474 Isotretinoin Isotretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of KRT1 mRNAincreases expression 19524636
C017947 sodium arsenite sodium arsenite results in increased expression of KRT1 proteinincreases expression 19524636
18572023
D013629 Tamoxifen Tamoxifen affects the expression of KRT1 mRNAaffects expression 17555576
D014212 Tretinoin Tretinoin metabolite results in increased expression of KRT1 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of KRT1 proteinincreases expression 16619266
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNAaffects binding|decreases expression 20105288
C002802 tungsten carbide tungsten carbide results in decreased expression of KRT1 mRNAdecreases expression 20105288
C101044 tyrphostin AG 1478 tyrphostin AG 1478 results in increased expression of KRT1 proteinincreases expression 18633435
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3214745880
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 4.3118769834
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.7718769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.0516232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 11.2317505938
MESH:D000152 Acne Vulgaris Isotretinoin 11.2318769834 16185265
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 3.9820127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 3.9814692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.526695378
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.4715276417
MESH:D018246 Adrenocortical Adenoma Arsenic 13.0217306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 13.0217306315 16712894
MESH:D000505 Alopecia Tretinoin 3.4415955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2615469931
MESH:D000743 Anemia, Hemolytic Quercetin 4.0317084956
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8519183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8016251483 12569548 18414634 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2411256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7416412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2116292516
MESH:D001249 Asthma Mustard Gas 4.7410378619
MESH:D001249 Asthma Tretinoin 4.7416456186
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7515336622
MESH:D050197 Atherosclerosis Arsenic 3.1212928151 19371607
MESH:D001327 Autoimmune Diseases Quercetin 4.1819761891
MESH:D001471 Barrett Esophagus Tretinoin 4.1816935849
MESH:D001768 Blister Mustard Gas 4.9319167455
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.4016206674 16197459
MESH:D001943 Breast Neoplasms alitretinoin 4.5516344269
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 4.5520146248 17474063
MESH:D001943 Breast Neoplasms Cobalt 4.5515986119
MESH:D001943 Breast Neoplasms Diethylstilbestrol 4.5517129689 15324884
MESH:D001943 Breast Neoplasms Nordihydroguaiaretic Acid 4.5518418215
MESH:D001943 Breast Neoplasms Quercetin 4.5518628248
MESH:D001943 Breast Neoplasms Tamoxifen 4.5515565566 19066611 18351453 17261762 19189212 19487384 20135344 20390343 19244106 17049068 17893378 17242785 19189210 18997820 18629630 19200415 18855134 18821012 18815881 21152245 19155303 17440819 11161223 16818667 19011961 19115204 19142967 19410462 15668708 21138602 20544844 19289846 16202921 19103187 19221464 18425577 19084267 19288272 16273361 16873071 19059307 20859285 20005174 18984771 20065188
MESH:D001943 Breast Neoplasms Tretinoin 4.5516443354 16873071 16166294
MESH:D016535 Bronchial Hyperreactivity tyrphostin AG 1478 4.7112794006
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 4.9315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.7517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3616813970
MESH:D002105 Cadmium Poisoning Quercetin 5.3116962696
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.4615504454 17687452
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.2819066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9316168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 13.5017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.5016924424 15948411
MESH:D006528 Carcinoma, Hepatocellular morin 13.5019539802
MESH:D006528 Carcinoma, Hepatocellular Quercetin 13.5019519916 12508355
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 13.5015276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 13.501917145
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7317234771
MESH:D002294 Carcinoma, Squamous Cell marker/mechanism 18572023
MESH:D002294 Carcinoma, Squamous Cell Arsenic 13.6217687452 15504454 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 13.6220419170
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 13.6211237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 13.6218572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 13.6216096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 8.8418640142
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 8.8417572228
MESH:D006332 Cardiomegaly Quercetin 3.1919794523
MESH:D002318 Cardiovascular Diseases Arsenic 3.2915738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.1218022660 16973168
MESH:D002386 Cataract Tretinoin 2.9617460283
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 2.8420056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3616129372
MESH:D002779 Cholestasis Ethinyl Estradiol 2.7117333356 16919318 17110522 16105132 15861022 17681005 11677210
MESH:D002822 Choriocarcinoma Tretinoin 4.9316461808
MESH:D002972 Cleft Palate Tretinoin 2.579407595
MESH:D003092 Colitis Tretinoin 3.4817035595
MESH:D003110 Colonic Neoplasms arsenite 5.8615037631
MESH:D003110 Colonic Neoplasms Nordihydroguaiaretic Acid 5.8615936596
MESH:D003110 Colonic Neoplasms Quercetin 5.8619056647 17191121 15741050 11134977 19440933 17148506 16640504
MESH:D015179 Colorectal Neoplasms Quercetin 2.1818852136 18095365
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.009879862 18769834
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.0014991402 10589399 8800419 16925845 9125849 17551590 9224671 9211117 9142499 9664655
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3416002989 12952375
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1419031437
MESH:D017449 Dermatitis, Allergic Contact cobaltous chloride 3.8211298694 16823706 15059100
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5519496084
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.2919279558
MESH:D004487 Edema Mustard Gas 3.1111428631 9260866 11428647 11402378
MESH:D004489 Edema, Cardiac Tretinoin 4.2418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2212538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2219031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.4616402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 11.6416804899 15700306
MESH:D016889 Endometrial Neoplasms Tamoxifen 11.6417893378 20544844 16202921 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 11.6416569247
MESH:D004890 Erythema Mustard Gas 4.939357497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.4116530937
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.4116805852 16510608 15623463 15264214 15150132 15878914 15547721 16704527 15547733
MESH:D005124 Eye Abnormalities Tretinoin 3.419664655 16938888
MESH:D005234 Fatty Liver arsenite 11.9918296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 11.9915345470
MESH:D005234 Fatty Liver Tamoxifen 11.9919224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.7616534752 16513791 16611131 15751030 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.7616709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3014745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9519069698
MESH:D005355 Fibrosis arsenite 13.6718296743
MESH:D005355 Fibrosis Quercetin 13.6719474275
MESH:D005355 Fibrosis Tretinoin 13.6717994277
MESH:D005534 Foot Diseases Arsenic 5.336392382
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 12.0516452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 12.0516452187
MESH:D005909 Glioblastoma Quercetin 6.7719804834
MESH:D005909 Glioblastoma Tretinoin 6.7717312396
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.0316096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9316084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.2620471113
MESH:D006330 Heart Defects, Congenital Tretinoin 6.269664655 14991402
MESH:D006689 Hodgkin Disease sodium arsenite 2.9712676792
MESH:D006930 Hyperalgesia Tretinoin 3.0416870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3416778211
MESH:D006943 Hyperglycemia Quercetin 3.8318262572 11834736
MESH:D017488 Hyperkeratosis, Epidermolytic marker/mechanism
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.2617050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.2114722030 12960047
MESH:D006973 Hypertension Arsenic 8.449931084 16076760 11953799
MESH:D006973 Hypertension Cobalt 8.4417039479
MESH:D006973 Hypertension Quercetin 8.4418356687
MESH:D006987 Hypesthesia Arsenic 5.3316093927
MESH:D007021 Hypospadias Diethylstilbestrol 10.4916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.4916569931 16945680
OMIM:607602 ICHTHYOSIS, CYCLIC, WITH EPIDERMOLYTIC HYPERKERATOSIS marker/mechanism
OMIM:146590 ICHTHYOSIS HYSTRIX, CURTH-MACKLIN TYPE marker/mechanism
MESH:D007246 Infertility Diethylstilbestrol 4.1415036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.1417937319
MESH:D007248 Infertility, Male sodium arsenite 6.1412646999 15346721
MESH:D007249 Inflammation Mustard Gas 4.848975870 16001271 11428620 11428647 17524151 11428631 9260866 11402378 9357497
MESH:D007249 Inflammation Tamoxifen 4.8419457130
MESH:D007251 Influenza, Human Nordihydroguaiaretic Acid 10.8618473937
MESH:D007251 Influenza, Human Quercetin 10.8616624496
MESH:D007410 Intestinal Diseases Tretinoin 3.5417994277
MESH:D007511 Ischemia morin 5.7016806951
MESH:D007569 Jaw Abnormalities Tretinoin 3.6915992940 17551590
MESH:D007627 Keloid Quercetin 4.7317086741
MESH:D007642 Keratosis Arsenic 4.7616930632 12749816
OMIM:148700 KERATOSIS PALMOPLANTARIS STRIATA I marker/mechanism
OMIM:607654 KERATOSIS PALMOPLANTARIS STRIATA III marker/mechanism
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.4116144296
MESH:D007674 Kidney Diseases Quercetin 5.8616962696
MESH:D007674 Kidney Diseases sodium arsenite 5.8620008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 6.9615003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Tamoxifen 6.9618625569
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.8116316344
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8417184923
MESH:D007938 Leukemia Quercetin 6.0817468513
MESH:D007938 Leukemia Tretinoin 6.0817143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.4916932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0417596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 7.2717339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.2715748426 17506722 17294898 19225113 16766008 17301526 17339181 16935935 17712046 19029980 17107899 16140955 16331271 12679006 16788101 17368321 16891316 17217047 9834237 16823087 19642359 17649720 17361223 19075265 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.159224671
MESH:D008064 Lipidoses Tamoxifen 2.9917567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.3018296743
MESH:D008106 Liver Cirrhosis, Experimental morin 4.8518629640
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 4.8512741479
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 4.8518564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.8516248980 18397230
MESH:D008107 Liver Diseases Arsenic 2.4911134558
MESH:D008113 Liver Neoplasms Arsenic 16.8516368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 16.8520195826 21137059
MESH:D008113 Liver Neoplasms Diethylstilbestrol 16.8516712894 15890375
MESH:D008113 Liver Neoplasms Quercetin 16.8518980244
MESH:D008113 Liver Neoplasms sodium arsenite 16.8515276417 16712894
MESH:D008113 Liver Neoplasms Tamoxifen 16.8516684651
MESH:D008114 Liver Neoplasms, Experimental morin 6.3619539802
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.3619519916
MESH:D008171 Lung Diseases Mustard Gas 7.0418161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.0419095001
MESH:D008173 Lung Diseases, Obstructive Cobalt 5.646434250
MESH:D008175 Lung Neoplasms alitretinoin 14.8516413115
MESH:D008175 Lung Neoplasms Arsenic 14.8517976673 17306315 19168569
MESH:D008175 Lung Neoplasms arsenite 14.8516809336
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 14.8517053015 20869020 18569708 6695378 18816296 20135361 18520028 20064080 20464547
MESH:D008175 Lung Neoplasms Isotretinoin 14.8515899809
MESH:D008175 Lung Neoplasms Mustard Gas 14.853148597 8781369
MESH:D008175 Lung Neoplasms Quercetin 14.8516280456
MESH:D008175 Lung Neoplasms sodium arsenite 14.8517306315 15276417 16712894 17077188 19931552
MESH:D008175 Lung Neoplasms Tamoxifen 14.8518625569
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9215166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3115700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.2816002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5319428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 2.4811731420 16827153 14580682 19196722 19196723
MESH:D020149 Manganese Poisoning Tamoxifen 4.3219453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma Isotretinoin 6.9917237267
MESH:D008545 Melanoma sodium arsenite 6.9916487513 19082730
MESH:D008545 Melanoma Tamoxifen 6.9912393984 19393235
MESH:D008545 Melanoma Tretinoin 6.9916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9515990972
MESH:D008591 Meningomyelocele Tretinoin 4.2016940565
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0216381670
MESH:D009190 Myelodysplastic Syndromes Tretinoin 2.9517596541
MESH:D009203 Myocardial Infarction Quercetin 2.9019595682
MESH:D017202 Myocardial Ischemia Arsenic 3.8015371236
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.6219207477
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.4619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4419410462
MESH:D009369 Neoplasms alitretinoin 18.3416946489
MESH:D009369 Neoplasms Benzo(a)pyrene 18.3411141357
MESH:D009369 Neoplasms Diethylstilbestrol 18.3415313581
MESH:D009369 Neoplasms Quercetin 18.3415185748
MESH:D009369 Neoplasms sodium arsenite 18.3411559025
MESH:D009369 Neoplasms Tretinoin 18.3416946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.4420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7719200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 4.1815738583
MESH:D009421 Nervous System Malformations Diethylstilbestrol 9.1211399458
MESH:D009421 Nervous System Malformations Tretinoin 9.129125849
MESH:D009436 Neural Tube Defects Arsenic 11.3516620997
MESH:D009436 Neural Tube Defects sodium arsenite 11.3512854658
MESH:D009436 Neural Tube Defects Tretinoin 11.359142499
MESH:D009447 Neuroblastoma Isotretinoin 3.9317368321
MESH:D020078 Neurogenic Inflammation Arsenic 9.9817056641
MESH:D020078 Neurogenic Inflammation Quercetin 9.9817929310
MESH:D009503 Neutropenia Mustard Gas 3.767688884 16761898
MESH:D010024 Osteoporosis Calcium 3.6417882678
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0119495926
MESH:D010051 Ovarian Neoplasms Arsenic 10.7217306315
MESH:D010051 Ovarian Neoplasms Quercetin 10.7219005980
MESH:D010051 Ovarian Neoplasms sodium arsenite 10.7215276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 10.7216936753
MESH:D010146 Pain Tretinoin 2.7216870215
OMIM:144200 PALMOPLANTAR KERATODERMA, EPIDERMOLYTIC marker/mechanism
OMIM:600962 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC marker/mechanism
MESH:D010190 Pancreatic Neoplasms Quercetin 5.1316965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4711578682
MESH:D010523 Peripheral Nervous System Diseases Arsenic 3.9616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.766392382 16905509 15371236
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9414722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4515687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.5915727166
MESH:D017499 Porokeratosis alitretinoin 5.7716144296
MESH:D011230 Precancerous Conditions Quercetin 3.7919056647
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 9.4317184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.4318769834
MESH:D011471 Prostatic Neoplasms Arsenic 2.0716140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0717292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0717136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Nordihydroguaiaretic Acid 2.0718491370
MESH:D011471 Prostatic Neoplasms Quercetin 2.0717292933 14715546
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0716039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011507 Proteinuria Arsenic 8.5721343184
MESH:D011507 Proteinuria Tretinoin 8.5716636307
MESH:D011537 Pruritus Ethinyl Estradiol 8.7615861022 16919318
MESH:D011537 Pruritus Mustard Gas 8.7618058305
MESH:D011596 Psychomotor Disorders Isotretinoin 5.6918769834
MESH:D011625 Pterygium Tretinoin 4.5616723453
MESH:D011658 Pulmonary Fibrosis Cobalt 5.976434250
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.9717266442 10334151 17894541 17620002 17720292
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8916116481 16283617
MESH:D012554 Schistosomiasis japonica Quercetin 5.3116862918
MESH:D012871 Skin Diseases Arsenic 4.9419834688 18709164 15952646 17050553 16759981 17548696 17453740 17938729 6392382 16702368 16353154
MESH:D012871 Skin Diseases Mustard Gas 4.9416961503 12880345 15451306
MESH:D012878 Skin Neoplasms marker/mechanism 18572023
MESH:D012878 Skin Neoplasms Arsenic 12.7117050553 17029826 16251483 17976673 15504454 19538983
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.7119755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 12.7119524636 18572023
MESH:D012878 Skin Neoplasms Tretinoin 12.7116467112
MESH:D013088 Spermatocele Diethylstilbestrol 18.7916709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 18.7916709447
MESH:D013088 Spermatocele Tamoxifen 18.7916709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8119457130
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6212854658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.282093021 20155912
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.2812958204 17575124
MESH:D013274 Stomach Neoplasms Tretinoin 3.2817261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9615669648
MESH:D013964 Thyroid Neoplasms Tretinoin 2.8617045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.5916051514
MESH:D014376 Tuberculosis Tretinoin 3.0916040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 18.7215987713 17976673 18640142 11144890 19429237 19322015 17306315
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 18.7217053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 18.7216712894 17306315 16452187
MESH:D001749 Urinary Bladder Neoplasms Quercetin 18.7216720314
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 18.7211723127 17306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 18.7217572228 8653321 16712894
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 14.7316175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 14.7311813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 14.7316129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.9414652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.7515809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.7514692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3816752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2116002989 16513791
MESH:D014652 Vascular Diseases Arsenic 11.0817056641
MESH:D014652 Vascular Diseases sodium arsenite 11.0817056641
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3314671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.8416761959
MESH:D009396 Wilms Tumor Tretinoin 3.7816287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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