AutismKB 2.0

Annotation Detail for KRT1


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Basic Information Top
Gene Symbol:KRT1 ( CK1,EHK,EHK1,EPPK,K1,KRT1A,NEPPK )
Gene Full Name: keratin 1
Band: 12q13.13
Quick LinksEntrez ID:3848; OMIM: 139350; Uniprot ID:K2C1_HUMAN; ENSEMBL ID: ENSG00000167768; HGNC ID: 6412
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Related Diseases/Disorders Top
Desease IDDesease Name
1990Skin disease, Genetic
1832Congenital abnormality
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C403065 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide binds to KRT1 proteinaffects binding 19539807
C025984 15-hydroxy-5,8,11,13-eicosatetraenoic acid 15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of KRT1 mRNAdecreases expression 15982314
C047628 8-hydroxyeicosatetraenoic acid 8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]increases expression|increases reaction 12069687
C103303 alitretinoin alitretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
D001151 Arsenic Arsenic results in increased expression of KRT1 mRNAincreases expression 11134558
C015001 arsenite arsenite results in decreased expression of KRT1 mRNAdecreases expression 18633435
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of KRT1 mRNAincreases expression 20064835
D002118 Calcium 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium 15-hydroxy-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium 8-hydroxyeicosatetraenoic acid promotes the reaction [Calcium results in increased expression of KRT1 mRNA]increases expression|increases reaction 12069687
D002118 Calcium Calcium results in increased expression of KRT1 mRNAincreases expression 12069687
D002118 Calcium morin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium Nordihydroguaiaretic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D002118 Calcium Quercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D003035 Cobalt [tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNAaffects binding|decreases expression 20105288
C018021 cobaltous chloride cobaltous chloride results in decreased expression of KRT1 mRNAdecreases expression 20105288
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of KRT1 mRNAincreases expression 15171707
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of KRT1 mRNAaffects expression 17555576
D019377 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D015741 Metribolone Metribolone results in decreased expression of KRT1 proteindecreases expression 17152098
C008548 morin morin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D009151 Mustard Gas Mustard Gas results in increased cleavage of KRT1 proteinincreases cleavage 12482751
D009151 Mustard Gas Mustard Gas results in increased expression of KRT1 proteinincreases expression 11428642
9665388
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of KRT1 mRNAincreases expression 17616710
C419410 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester results in decreased expression of KRT1 mRNAdecreases expression 18633435
D009637 Nordihydroguaiaretic Acid Nordihydroguaiaretic Acid inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D011794 Quercetin Quercetin results in increased expression of KRT1 proteinincreases expression 17292933
D011794 Quercetin Quercetin inhibits the reaction [Calcium results in increased expression of KRT1 mRNA]decreases reaction|increases expression 12069687
D015474 Isotretinoin Isotretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of KRT1 mRNAincreases expression 19524636
C017947 sodium arsenite sodium arsenite results in increased expression of KRT1 proteinincreases expression 19524636
18572023
D013629 Tamoxifen Tamoxifen affects the expression of KRT1 mRNAaffects expression 17555576
D014212 Tretinoin Tretinoin metabolite results in increased expression of KRT1 mRNAincreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of KRT1 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of KRT1 proteinincreases expression 16619266
C002802 tungsten carbide [tungsten carbide binds to Cobalt] which results in decreased expression of KRT1 mRNAaffects binding|decreases expression 20105288
C002802 tungsten carbide tungsten carbide results in decreased expression of KRT1 mRNAdecreases expression 20105288
C101044 tyrphostin AG 1478 tyrphostin AG 1478 results in increased expression of KRT1 proteinincreases expression 18633435
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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