AutismKB 2.0

Annotation Detail for KRT6A


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Basic Information Top
Gene Symbol:KRT6A ( CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D )
Gene Full Name: keratin 6A
Band: 12q13.13
Quick LinksEntrez ID:3853; OMIM: 148041; Uniprot ID:K2C6A_HUMAN; ENSEMBL ID: ENSG00000205420; HGNC ID: 6443
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
No data
No data
Desease Name
Pachyonychia congenita, Jadassohn-Lewandowsky type
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of KRT6A mRNAdecreases expression 15982314
C103303 alitretinoin alitretinoin results in decreased expression of KRT6A mRNAdecreases expression 15982314
D001151 Arsenic Arsenic results in increased expression of KRT6A mRNAincreases expression 18414623
D001151 Arsenic Arsenic results in increased expression of KRT6A proteinincreases expression 18414623
C006632 arsenic trioxide arsenic trioxide results in increased expression of KRT6A mRNAincreases expression 15949261
D002104 Cadmium Cadmium results in increased expression of KRT6A mRNAincreases expression 18414623
D002104 Cadmium Cadmium results in increased expression of KRT6A proteinincreases expression 18414623
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of KRT6A mRNAincreases expression 16636312
15171707
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6A mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of KRT6A mRNAincreases expression 19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of KRT6A mRNAaffects cotreatment|increases expression 17404688
D005472 Fluorouracil Fluorouracil affects the expression of KRT6A mRNAaffects expression 16584549
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of KRT6A mRNAaffects cotreatment|increases expression 17404688
D011374 Progesterone Progesterone results in increased expression of KRT6A mRNAincreases expression 17404688
D015474 Isotretinoin Isotretinoin results in decreased expression of KRT6A mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of KRT6A mRNAincreases expression 12016162
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT6A mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KRT6A mRNAincreases expression 16704738
19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KRT6A mRNAincreases expression 17035482
D014212 Tretinoin Tretinoin metabolite results in decreased expression of KRT6A mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of KRT6A mRNAdecreases expression 15982314
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 9.0918769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0914514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.0618769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.4216232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.6116185265 18769834
MESH:D000230 Adenocarcinoma arsenic trioxide 7.2419825857 11798837
MESH:D000230 Adenocarcinoma Estradiol 7.2411473722
MESH:D000230 Adenocarcinoma Fluorouracil 7.2417638652
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.8315276417
MESH:D018246 Adrenocortical Adenoma Arsenic 14.2517306315
MESH:D018246 Adrenocortical Adenoma sodium arsenite 14.2516712894 17306315
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000740 Anemia Fluorouracil 8.9415504547 17963324 16511603
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.9411748828
MESH:D020261 Arsenic Poisoning Arsenic 2.8912569548 18414634 16251483 16835338
MESH:D001169 Arthritis, Experimental Tretinoin 3.1216412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Tretinoin 2.3616456186
MESH:D050197 Atherosclerosis Arsenic 7.1812928151 19371607
MESH:D050197 Atherosclerosis Cadmium 7.1815687053
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 15.8316206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.8312125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.8316206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.4717868700
MESH:D001930 Brain Injuries Progesterone 4.3615665606 15380490 15845082
MESH:D001943 Breast Neoplasms alitretinoin 3.8216344269
MESH:D001943 Breast Neoplasms Diethylstilbestrol 3.8217129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 3.8212948864 18497071 17289903 16675129 17261762 17018787 14630087 19861407
MESH:D001943 Breast Neoplasms Fluorouracil 3.8219217205 16595493 15136595 18608205 18357371 16110121 16557594
MESH:D001943 Breast Neoplasms Progesterone 3.8216175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.8220435547
MESH:D001943 Breast Neoplasms Tretinoin 3.8216873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.4211589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.8016051944
MESH:D002277 Carcinoma Fluorouracil 8.4017121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.4016835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6315504454 17687452
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 14.3017306315 16507464
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 14.3015553829 14691202 15073043 16217749 11135700
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 14.3015948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.3016924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 14.3017971768 17045692 16799960 16332177 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 14.3017306315 15276417 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 14.301917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.0119014326
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0518695887
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.1912490120
MESH:D002294 Carcinoma, Squamous Cell Arsenic 14.6118922899 15504454 17687452
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 14.6116280240 16757204 18986760 17066447
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 14.6111237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 14.6118572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 14.6116051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.1518640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Arsenic 3.5017938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.3818022660 16973168
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Cadmium 11.6617332340
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.6618566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 11.6619524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.878697196 15668235 15340226 16354765 12621046
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2416340194 15001691 17172411 17725105 18772588 16510598 17018589 17016597 17169374 17287894
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.5620501625
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.5618509181 17094418 16331619 14970324 16282729 17255274 17401013 16391804 17695437 18288408 15148649 17016601 17454858 18949393 18448328 15289873 16303861 17594712 20501625 16524972 18383874 18802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D023903 Coronary Restenosis arsenic trioxide 4.2812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.5210525206
MESH:D019465 Craniofacial Abnormalities Isotretinoin 5.529879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.5210048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.529125849 16925845 9211117 17551590 14991402 10589399 9142499 9664655 8800419 9224671
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6516002989 12952375
MESH:D007644 Darier Disease Fluorouracil 4.9116733453
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.1815213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.6017187935
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5520420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4611000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4016714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.8717692515
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 12.7915700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 12.7911473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 12.7916569247
MESH:D004715 Endometriosis Progesterone 9.1916134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.1910568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6612903497
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.6616481741 15173087 17638652 16785472 16337965
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.049664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 3.3715073043
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016002989 16513791 16534752 16611131 15751030
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.9720067830
MESH:D005355 Fibrosis Tretinoin 8.9717994277
MESH:D005534 Foot Diseases Arsenic 5.696392382
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.3616904648
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.2116452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.2116452187
MESH:D005909 Glioblastoma Tretinoin 3.0517312396
MESH:D005910 Glioma Fluorouracil 2.9016145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 7.9715102660 18337622 15162350
MESH:D006258 Head and Neck Neoplasms Tretinoin 7.9716096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6710048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.6714991402 9664655
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.2212676792
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5317050553
MESH:D006965 Hyperplasia Diethylstilbestrol 4.5412960047 14722030
MESH:D006973 Hypertension Arsenic 5.3216076760 9931084 11953799
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.3218850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.6916093927
MESH:D007021 Hypospadias Diethylstilbestrol 4.6816002989
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.5115869954
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007248 Infertility, Male sodium arsenite 3.0415346721 12646999
MESH:D007249 Inflammation Progesterone 5.1115869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1112200463 12878042
MESH:D007333 Insulin Resistance Estradiol 3.0216627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D007642 Keratosis Arsenic 5.1116930632 12749816
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7516144296
MESH:D007674 Kidney Diseases Cadmium 10.4816962696 16322080 16226777
MESH:D007674 Kidney Diseases Estradiol 10.4815618244
MESH:D007674 Kidney Diseases sodium arsenite 10.4820008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.9116762066 15003126 14681315
MESH:D007680 Kidney Neoplasms Estradiol 12.9115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 12.9116985049
MESH:D007859 Learning Disorders Diethylstilbestrol 4.1617184923
MESH:D007938 Leukemia arsenic trioxide 6.4715070760
MESH:D007938 Leukemia Tretinoin 6.4717143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.8817077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.4216972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.4914633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.7519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.7516482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.9316467208 19850784 17050201 20471514 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.9319850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 13.0817339181
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 13.0811468182 17217047 16891316 16331271 19035177 19225113 19642359 15336539 12712474 12018890 17712046 17649720 9834237 17869043 17107899 16330433 19075265 15622746 16112521 15748426 15213294 12679006 16823087 16966277 11161223
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 13.0817649720 17301526 17712046 19029980 19075265 16140955 19642359 17506722 17361223 16788101 19035177 16331271 16823087 17368321 17294898 17217047 17339181 19225113 16891316 15748426 9834237 16935935 17107899 12679006 16766008
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.4516882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4912878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.4916248980 18397230
MESH:D008107 Liver Diseases Arsenic 2.5611134558
MESH:D008113 Liver Neoplasms Arsenic 18.3816368122
MESH:D008113 Liver Neoplasms arsenic trioxide 18.3814682389
MESH:D008113 Liver Neoplasms Diethylstilbestrol 18.3815890375 16712894
MESH:D008113 Liver Neoplasms Fluorouracil 18.3816603448 17045692 15113037 18383874
MESH:D008113 Liver Neoplasms sodium arsenite 18.3816712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 18.3816984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 5.9720377131
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9712151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4115213294
MESH:D008171 Lung Diseases sodium arsenite 3.2219095001
MESH:D008175 Lung Neoplasms alitretinoin 10.8716413115
MESH:D008175 Lung Neoplasms Arsenic 10.8719168569 17306315 17976673
MESH:D008175 Lung Neoplasms arsenic trioxide 10.8711798837 19825857
MESH:D008175 Lung Neoplasms Fluorouracil 10.8715246190
MESH:D008175 Lung Neoplasms Isotretinoin 10.8715899809
MESH:D008175 Lung Neoplasms sodium arsenite 10.8719931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.8719555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.9115086387
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.2311408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 6.2317203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Isotretinoin 5.3317237267
MESH:D008545 Melanoma sodium arsenite 5.3316487513 19082730
MESH:D008545 Melanoma Tretinoin 5.3316752155
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D009062 Mouth Neoplasms Fluorouracil 3.6918986760 16757204
MESH:D009101 Multiple Myeloma arsenic trioxide 3.1619549372 14977855 19417148 11468182 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.8118349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.5416882451 16105982
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5417596541
MESH:D017202 Myocardial Ischemia Arsenic 9.2215371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.2212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.0516624393
MESH:D009369 Neoplasms alitretinoin 16.1816946489
MESH:D009369 Neoplasms Diethylstilbestrol 16.1815313581
MESH:D009369 Neoplasms Fluorouracil 16.1818239605 18600527 16928823
MESH:D009369 Neoplasms sodium arsenite 16.1811559025
MESH:D009369 Neoplasms Tretinoin 16.1816946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.7720056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 24.2811399458
MESH:D009421 Nervous System Malformations Estradiol 24.2811399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 24.2814600291
MESH:D009421 Nervous System Malformations Tretinoin 24.289125849
MESH:D009436 Neural Tube Defects Arsenic 17.7916620997
MESH:D009436 Neural Tube Defects arsenic trioxide 17.7910525206
MESH:D009436 Neural Tube Defects sodium arsenite 17.7912854658
MESH:D009436 Neural Tube Defects Tretinoin 17.799142499
MESH:D009447 Neuroblastoma Isotretinoin 4.0817368321
MESH:D020078 Neurogenic Inflammation Arsenic 4.4617056641
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4916436463
MESH:D010051 Ovarian Neoplasms Arsenic 19.1917306315
MESH:D010051 Ovarian Neoplasms arsenic trioxide 19.1916624393 19769630 12452020
MESH:D010051 Ovarian Neoplasms Estradiol 19.1919401270
MESH:D010051 Ovarian Neoplasms Progesterone 19.1917393432 16525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 19.1917306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 19.1916936753
MESH:D053549 Pachyonychia Congenita marker/mechanism
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 8.8015580305
MESH:D010190 Pancreatic Neoplasms Fluorouracil 8.8016929163 19003803 16500647 15113037
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.8015976015
MESH:D010235 Paraganglioma arsenic trioxide 4.2519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.2716093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 13.486392382 15371236 16905509
MESH:D016491 Peripheral Vascular Diseases Cadmium 13.4815687053
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7715687265 16977796
MESH:D017499 Porokeratosis alitretinoin 6.1416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.1217184923
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 17.1218769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.1211399792 11118676 11222880 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Arsenic 2.1216140617
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.1219131511
MESH:D011471 Prostatic Neoplasms Cadmium 2.1217075824
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.1217136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Estradiol 2.1216740699
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1219082440 18626508
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.1216039940
MESH:D011507 Proteinuria Arsenic 9.5721343184
MESH:D011507 Proteinuria Tretinoin 9.5716636307
MESH:D011596 Psychomotor Disorders Isotretinoin 6.0318769834
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0818722050 16160472 15538739 18286688
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8818045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.0516646077
MESH:D012871 Skin Diseases Arsenic 2.7616353154 16759981 19834688 15952646 17050553 17453740 6392382 17938729 18709164 17548696 16702368
MESH:D012878 Skin Neoplasms Arsenic 13.8817029826 15504454 17976673 19538983 16251483 17050553
MESH:D012878 Skin Neoplasms sodium arsenite 13.8818572023 19524636
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.8816192470
MESH:D012878 Skin Neoplasms Tretinoin 13.8816467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.8516002989 16709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.4015862959 16503802
MESH:D016135 Spinal Dysraphism sodium arsenite 3.8612854658
MESH:D013274 Stomach Neoplasms arsenic trioxide 3.4417007042
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4416951190 19015929 19084572 18396642 17172411 17522103 15786421 16424979 18567086 17498489
MESH:D013274 Stomach Neoplasms Tretinoin 3.4417261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.4219014326
MESH:D013964 Thyroid Neoplasms Tretinoin 7.4217045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 10.0916280240
MESH:D014062 Tongue Neoplasms Tretinoin 10.0916051514
MESH:D016171 Torsades de Pointes arsenic trioxide 4.0815213294
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 12.2317306315 11144890 19429237 17976673 18640142 19322015 15987713
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 12.2311780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 12.2316452187 16712894 17306315
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.2317306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 23.2916175088
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 23.2916803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 23.2911813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 23.2916129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.1615809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416002989 16513791
MESH:D014652 Vascular Diseases Arsenic 12.2417056641
MESH:D014652 Vascular Diseases sodium arsenite 12.2417056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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