AutismKB 2.0

Annotation Detail for KRT16


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Basic Information Top
Gene Symbol:KRT16 ( CK16,FNEPPK,K16,K1CP,KRT16A,NEPPK )
Gene Full Name: keratin 16
Band: 17q21.2
Quick LinksEntrez ID:3868; OMIM: 148067; Uniprot ID:K1C16_HUMAN; ENSEMBL ID: ENSG00000186832; HGNC ID: 6423
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Pachyonychia congenita, Jadassohn-Lewandowsky type
Palmoplantar verrucous nevus, unilateral
Palmoplantar keratoderma, nonepidermolytic
Palmoplantar keratoderma, nonepidermolytic, focal
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C006780 bisphenol A bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of KRT16 mRNA]decreases reaction|increases expression 19228888
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of KRT16 mRNAincreases expression 15171707
D002117 Calcitriol Calcitriol results in increased expression of KRT16 mRNAincreases expression 16002434
D017313 Fenretinide Fenretinide results in decreased expression of KRT16 mRNAdecreases expression 16467112
D009151 Mustard Gas Mustard Gas promotes the reaction [CASP6 protein results in increased cleavage of KRT16 protein]increases cleavage|increases reaction 18342354
D009151 Mustard Gas Mustard Gas results in increased alkylation of KRT16 proteinincreases alkylation 18342354
C058346 N-(4-methoxyphenyl)retinamide N-(4-methoxyphenyl)retinamide results in decreased expression of KRT16 mRNAdecreases expression 16467112
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of KRT16 mRNAdecreases expression 17616710
C017947 sodium arsenite NFE2L2 protein promotes the reaction [sodium arsenite results in increased expression of KRT16 mRNA]increases expression|increases reaction 18629308
C017947 sodium arsenite sodium arsenite results in increased expression of KRT16 mRNAincreases expression 19524636
18629308
C017947 sodium arsenite sodium arsenite results in increased expression of KRT16 proteinincreases expression 19524636
18629308
C025462 sulindac sulfide sulindac sulfide results in increased expression of KRT16 mRNAincreases expression 16184548
D014284 Triiodothyronine bisphenol A inhibits the reaction [Triiodothyronine results in increased expression of KRT16 mRNA]decreases reaction|increases expression 19228888
D014284 Triiodothyronine Triiodothyronine results in increased expression of KRT16 mRNAincreases expression 19228888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fenretinide 3.1410697514
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1717306315 16712894
MESH:D000544 Alzheimer Disease sulindac sulfide 3.1218759972
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D001249 Asthma Mustard Gas 2.7510378619
MESH:D001768 Blister Mustard Gas 5.4019167455
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D001932 Brain Neoplasms Fenretinide 4.5116187019
MESH:D001943 Breast Neoplasms bisphenol A 2.0717123778
MESH:D001943 Breast Neoplasms Calcitriol 2.0711237771
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0717129689 15324884
MESH:D001943 Breast Neoplasms Fenretinide 2.0716601279
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.4015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.2417687719 10378619
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.9216924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 4.9217159502 16270382
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.9217306315 16507464 15276417
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 3.5012391285
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 7.9711237771
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 7.9716274795
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.9718572023
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 3.1019524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.7116154183
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.6920423518
MESH:D015179 Colorectal Neoplasms Fenretinide 2.6817273769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7516002989 12952375
MESH:D004487 Edema Mustard Gas 3.4811428647 11428631 9260866 11402378
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.1315138306
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 3.5716804899 15700306
MESH:D004890 Erythema Mustard Gas 5.409357497
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7515751030 16513791 16002989 16611131 16534752
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.6216452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.6216452187
MESH:D005909 Glioblastoma Fenretinide 4.0016187019
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006965 Hyperplasia Diethylstilbestrol 4.6514722030 12960047
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male sodium arsenite 3.1015346721 12646999
MESH:D007249 Inflammation Mustard Gas 2.8611402378 9260866 11428631 17524151 16001271 11428620 11428647 8975870 9357497
MESH:D007333 Insulin Resistance bisphenol A 3.3916393666
MESH:D007674 Kidney Diseases sodium arsenite 2.8920008137
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 3.6015003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 4.2817184923
MESH:D007972 Leukoplakia, Oral Fenretinide 6.3116707609
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.9815890375 16712894
MESH:D008113 Liver Neoplasms sodium arsenite 4.9815276417 16712894
MESH:D008171 Lung Diseases Mustard Gas 7.9218161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.9219095001
MESH:D008175 Lung Neoplasms Mustard Gas 2.698781369 3148597
MESH:D008175 Lung Neoplasms sodium arsenite 2.6917077188 16712894 15276417 17306315 19931552
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 3.6710697514
MESH:D008545 Melanoma Fenretinide 3.7516270382
MESH:D008545 Melanoma sodium arsenite 3.7516487513 19082730
MESH:D009062 Mouth Neoplasms Fenretinide 4.4516274795
MESH:D009369 Neoplasms Diethylstilbestrol 8.9315313581
MESH:D009369 Neoplasms Fenretinide 8.9317353921 15958647
MESH:D009369 Neoplasms sodium arsenite 8.9311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009421 Nervous System Malformations bisphenol A 10.5916427766 11399458
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.5911399458
MESH:D009436 Neural Tube Defects sodium arsenite 3.2512854658
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.9216303764
MESH:D009503 Neutropenia Mustard Gas 4.1516761898 7688884
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms Fenretinide 5.3716133793
MESH:D010051 Ovarian Neoplasms sodium arsenite 5.3715276417 17306315
MESH:D053549 Pachyonychia Congenita marker/mechanism
OMIM:144200 PALMOPLANTAR KERATODERMA, EPIDERMOLYTIC marker/mechanism
OMIM:600962 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC marker/mechanism
OMIM:613000 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC, FOCAL marker/mechanism
MESH:D010190 Pancreatic Neoplasms Fenretinide 3.4015580305
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8915687265 16977796
MESH:D011041 Poisoning Mustard Gas 3.9815727166
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 10.6510548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.6517184923
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Calcitriol 1.8816289102 16644109 18247401 12479363 15754350
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 1.8817136230 15046698 15846301
MESH:D011471 Prostatic Neoplasms Fenretinide 1.8817024972
MESH:D011471 Prostatic Neoplasms sodium arsenite 1.8816039940
MESH:D011537 Pruritus Mustard Gas 4.3318058305
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9817620002 17894541 10334151 17266442 17720292
MESH:D012162 Retinal Degeneration Fenretinide 4.5316303925
MESH:D012871 Skin Diseases Mustard Gas 2.7512880345 15451306 16961503
MESH:D012878 Skin Neoplasms Fenretinide 10.2916467112
MESH:D012878 Skin Neoplasms N-(4-methoxyphenyl)retinamide 10.2916467112
MESH:D012878 Skin Neoplasms sodium arsenite 10.2918572023 19524636
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816709447 16002989
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216684133 16045194
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.1815864552
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.8616712894 16452187 17306315
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 8.8616720286
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.8617306315 16452187 16712894 11723127
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.9716175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 16.9716154183
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.9711813266
MESH:D014591 Uterine Diseases bisphenol A 14.7214652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 14.7214652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.6415809267 16690809
MESH:D014594 Uterine Neoplasms sulindac sulfide 10.6418645019
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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