AutismKB 2.0

Annotation Detail for ZKSCAN4


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Basic Information Top
Gene Symbol:ZKSCAN4 ( FLJ32136,P1P373C6,ZNF307,ZNF427,p373c6.1 )
Gene Full Name: zinc finger with KRAB and SCAN domains 4
Band: 6p22.1
Quick LinksEntrez ID:387032; OMIM: 611643; Uniprot ID:ZKSC4_HUMAN; ENSEMBL ID: ENSG00000187626; HGNC ID: 13854
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of ZKSCAN4 mRNAincreases expression 18061397
C075954 indolo(3,2-b)carbazole indolo(3,2-b)carbazole results in increased expression of ZKSCAN4 mRNAincreases expression 18061397
D010936 Plant Extracts Plant Extracts results in increased expression of ZKSCAN4 mRNAincreases expression 18061397
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ZKSCAN4 mRNAincreases expression 18061397
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 15322242 14514962
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0620464547 20127859
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000544 Alzheimer Disease Plant Extracts 3.0816962711
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001169 Arthritis, Experimental Plant Extracts 4.1714686799
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D002545 Brain Ischemia Plant Extracts 5.3616041641
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.8620146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8620435547
MESH:D002057 Burns, Chemical Plant Extracts 6.069625245
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 2.7918834353
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1320419170
MESH:D006332 Cardiomegaly Plant Extracts 7.6217645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 7.6218670907 16120746 18850075
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415340226 16354765 12621046 8697196 15668235
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2715322242 20055451 10048152
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Plant Extracts 4.7819706694
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Plant Extracts 8.4612787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 8.4612711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 6.4015268973
MESH:D004827 Epilepsy Plant Extracts 3.9019439326 19700373
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0816530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005234 Fatty Liver Plant Extracts 4.5215975614
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 7.0520471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 7.0511294989 10048152
MESH:D006333 Heart Failure Plant Extracts 4.0918097624
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4516120746 12621046 15340226
MESH:D006561 Herpes Simplex Plant Extracts 5.2510715843
MESH:D015658 HIV Infections Plant Extracts 3.8612878215
MESH:D019584 Hot Flashes Plant Extracts 5.4716566672 17454163 14716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.7716959395 15340226 16354765 18606429 8697196
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.8316484555
MESH:D006949 Hyperlipidemias Plant Extracts 4.9315268973 15975614
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218670907 18850075
MESH:D007249 Inflammation Plant Extracts 5.8315997105 16366677 19332304 12787963
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.8312200463 12878042
MESH:D007414 Intestinal Neoplasms Plant Extracts 5.0112351151 12628509 12584176
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D008103 Liver Cirrhosis Plant Extracts 3.9217157831
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 2.7215479170
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.7212878042
MESH:D008107 Liver Diseases Plant Extracts 3.0817034775
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 8.2120195826 21137059
MESH:D008113 Liver Neoplasms Plant Extracts 8.2119168119
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 8.2116984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 3.6617053015 20464547 20064080 20135361 18569708 18816296 20869020 18520028 6695378
MESH:D008175 Lung Neoplasms Plant Extracts 3.6620869020
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.6619555203 11884234
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.5016381670
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.3311141357
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.7214600291
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 5.7417168769
MESH:D009765 Obesity Plant Extracts 3.2120132043 19056576
MESH:D010212 Papilloma Plant Extracts 5.0515173996 16517061
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211896295 11222880 11399792 11118676
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3917292933
MESH:D011471 Prostatic Neoplasms Plant Extracts 3.3917804756 14666653
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 10.4319755658 10029692
MESH:D012878 Skin Neoplasms Plant Extracts 10.4315173996 16517061
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 10.4316192470
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013276 Stomach Ulcer Plant Extracts 4.3115255614 12787963 17135157 18237397 18193104
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 6.2017997062
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 5.3118097624
MESH:D020257 Ventricular Remodeling Plant Extracts 5.9518097624
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
MESH:D014947 Wounds and Injuries Plant Extracts 4.6020213670 19894650
Pathway ID Pathway Name
REACT:71 Gene Expression
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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