AutismKB 2.0

Annotation Detail for SLC16A12


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Basic Information Top
Gene Symbol:SLC16A12 ( CJMG,DKFZp686E188,MCT12 )
Gene Full Name: solute carrier family 16, member 12 (monocarboxylic acid transporter 12)
Band: 10q23.31
Quick LinksEntrez ID:387700; OMIM: 611910; Uniprot ID:MOT12_HUMAN; ENSEMBL ID: ENSG00000152779; HGNC ID: 23094
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
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Desease Name
Cataract, juvenile, with microcornea and glucosuria
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene results in decreased expression of SLC16A12 mRNAdecreases expression 20406850
D000082 Acetaminophen Acetaminophen affects the expression of SLC16A12 mRNAaffects expression 17562736
D006918 Hydroxyurea Hydroxyurea results in increased mutagenesis of SLC16A12 geneincreases mutagenesis 16868089
D008770 Methylnitrosourea Methylnitrosourea results in increased mutagenesis of SLC16A12 geneincreases mutagenesis 16868089
D010634 Phenobarbital Phenobarbital results in increased expression of SLC16A12 mRNAincreases expression 19270015
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D000230 Adenocarcinoma Methylnitrosourea 3.1915113128 15688392
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.5117620307
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Methylnitrosourea 3.1314633655 16253758 11306469
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.7816705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7820935162 17173139 6705139 1701930 20007298
MESH:D002386 Cataract Acetaminophen 8.1810977129
MESH:D002386 Cataract Methylnitrosourea 8.1812484553
OMIM:612018 CATARACT, JUVENILE, WITH MICROCORNEA AND GLUCOSURIA marker/mechanism
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.836135515
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 7.837505956 2727394
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 3.9918551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.9912594235 10915739 18713872 19923254 12540782 16109766 11461765 12958197 11529661 12705907 11739529 16177239 19164858 17562736 12153990 15619225 19420014 11287661 19739265 16081117 11743745 12392966 19416960 15968718 14550746 11421492 10663392 16781746 10774834 14725611 16227642 17522070 11834606 18071297 19370779 17906064 19085960 16393943 2444490 14986274 16485898
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.7711555667
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005910 Glioma Methylnitrosourea 3.679825942
MESH:D006529 Hepatomegaly Phenobarbital 3.9716109766
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D007248 Infertility, Male Methylnitrosourea 4.027193160
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D007951 Leukemia, Myeloid Hydroxyurea 5.3816532439
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.4515526292
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0721047994
MESH:D008107 Liver Diseases Acetaminophen 4.1716610002 12969438 11587558 19460945 16611625 19784758 19014921 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.967678174
MESH:D008113 Liver Neoplasms Phenobarbital 4.9619073162 8742319 19482888 19812893 15975961 21047994
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.646135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.642563599 18308698 1399818 6150874 17172636
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.9516080182
MESH:D008175 Lung Neoplasms Methylnitrosourea 2.7018062963
MESH:D008223 Lymphoma Methylnitrosourea 4.2611418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 5.1714633661
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 3.7912931682 16944150 11751437 16619500 16827153 15688392 17131329 16051031 10838139 11807958 19196723 15113128 17020996 14633655 14999141 15313902 10767621
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009369 Neoplasms Methylnitrosourea 3.4515533788
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 4.9512696579
MESH:D009442 Neurilemmoma Methylnitrosourea 6.0311555667
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.9516965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.9516965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 4.0515682402 12376480
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.6718172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 6.0311555667
MESH:D012640 Seizures 2,6-dinitrotoluene 6.7118551238
MESH:D012640 Seizures Phenobarbital 6.713137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.7016257854 15930296 18593901
MESH:D013953 Thymus Neoplasms Methylnitrosourea 5.7711418001
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 8.447505956 3078959
MESH:D013964 Thyroid Neoplasms Phenobarbital 8.441399818
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
MESH:D014581 Urticaria Acetaminophen 3.3810982225
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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