AutismKB 2.0

Annotation Detail for RHOB


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Basic Information Top
Gene Symbol:RHOB ( ARH6,ARHB,MST081,MSTP081,RHOH6 )
Gene Full Name: ras homolog gene family, member B
Band: 2p24.1
Quick LinksEntrez ID:388; OMIM: 165370; Uniprot ID:RHOB_HUMAN; ENSEMBL ID: ENSG00000143878; HGNC ID: 668
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
No data
Pathway IDPathway Name
Signaling by GPCR
Axon guidance
Hemostasis
Signaling by Rho GTPases
No data
Pathway IDPathway Name
P00005Angiogenesis
P00008Axon guidance mediated by Slit/Robo
P00047PDGF signaling pathway
P00016Cytoskeletal regulation by Rho GTPase
P00034Integrin signalling pathway
P04393Ras Pathway
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
2025Polyarthritis
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of RHOB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of RHOB mRNAaffects expression 21346803
C534305 2-methyl-5-(1-methylethenyl)cyclohexanol 2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB proteinincreases expression 12671036
C534305 2-methyl-5-(1-methylethenyl)cyclohexanol Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of RHOB mRNAincreases expression 14600272
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of RHOB mRNAincreases expression 16788091
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RHOB mRNAincreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of RHOB mRNAincreases expression 14600272
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of RHOB mRNAdecreases expression 15982314
C534317 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RHOB proteinincreases expression 12671036
C534317 6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol Mevalonic Acid affects the reaction [6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D000082 Acetaminophen Acetaminophen affects the expression of RHOB mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of RHOB proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of RHOB mRNAincreases expression 14600272
C103303 alitretinoin alitretinoin results in decreased expression of RHOB mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RHOB mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine promotes the reaction [trichostatin A results in increased expression of RHOB mRNA]increases expression|increases reaction 18047684
D001374 Azacitidine [trichostatin A co-treated with Azacitidine] results in increased expression of RHOB proteinaffects cotreatment|increases expression 18047684
D001554 Benzene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of RHOB mRNAaffects cotreatment|decreases expression 17905399
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of RHOB mRNAdecreases expression 20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RHOB mRNAdecreases expression 20018196
C006780 bisphenol A bisphenol A results in increased expression of RHOB mRNAincreases expression 20678512
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in increased expression of RHOB mRNAincreases expression 17553608
C075856 carveol carveol results in increased expression of RHOB proteinincreases expression 12671036
C075856 carveol Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C006923 carvone carvone results in increased expression of RHOB proteinincreases expression 12671036
C006923 carvone Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C057862 cyanoginosin LR cyanoginosin LR results in increased expression of RHOB mRNAincreases expression 17654400
D016572 Cyclosporine Cyclosporine results in decreased expression of RHOB mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of RHOB mRNAincreases expression 19638242
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of RHOB mRNAincreases expression 14600272
D004997 Ethinyl Estradiol Ethinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of RHOB mRNA]decreases reaction|increases expression 12072388
C065180 fluvastatin [zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNAaffects cotreatment|increases expression 16996129
D007213 Indomethacin Indomethacin results in increased expression of RHOB mRNAincreases expression 16984733
D008610 Menthol Menthol analog results in increased expression of RHOB proteinincreases expression 12671036
D008610 Menthol Menthol results in increased expression of RHOB proteinincreases expression 12671036
D008610 Menthol Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008610 Menthol Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C030957 methylmercury II [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of RHOB mRNAaffects cotreatment|decreases expression 17905399
C008493 methylselenic acid methylselenic acid affects the expression of RHOB mRNAaffects expression 14617803
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [6,6-dimethylbicyclo(3.1.1)hept-2-ene-2-methanol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]affects reaction|increases expression 12671036
D008798 Mevalonic Acid Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C023036 perfluorooctanoic acid perfluorooctanoic acid results in decreased expression of RHOB mRNAdecreases expression 17560707
C032208 perilla alcohol Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C032208 perilla alcohol perilla alcohol results in increased expression of RHOB proteinincreases expression 12671036
C032208 perilla alcohol [perilla alcohol co-treated with Vitamin A] affects the expression of RHOB mRNAaffects cotreatment|affects expression 15959631
C032208 perilla alcohol [perilla alcohol co-treated with Vitamin A] affects the expression of RHOB proteinaffects cotreatment|affects expression 15959631
C032208 perilla alcohol perilla alcohol results in increased expression of RHOB mRNAincreases expression 15959631
C032208 perilla alcohol perilla alcohol results in increased expression of RHOB proteinincreases expression 15959631
C033342 perillaldehyde Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C033342 perillaldehyde perillaldehyde results in increased expression of RHOB proteinincreases expression 12671036
C078706 perillic acid Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein]affects reaction|increases expression 12671036
C078706 perillic acid perillic acid results in increased expression of RHOB proteinincreases expression 12671036
C006253 pirinixic acid pirinixic acid results in increased expression of RHOB mRNAincreases expression 18301758
18445702
D015474 Isotretinoin Isotretinoin results in decreased expression of RHOB mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in decreased expression of RHOB mRNAdecreases expression 12760830
C041359 terbinafine terbinafine results in decreased expression of RHOB proteindecreases expression 17172416
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of RHOB mRNAincreases expression 15591033
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in increased expression of RHOB mRNAincreases expression 17951470
D014212 Tretinoin Tretinoin metabolite results in decreased expression of RHOB mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of RHOB mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in increased expression of RHOB mRNAincreases expression 16788091
D014241 Trichloroethylene [Benzene co-treated with methylmercury II co-treated with Trichloroethylene] results in decreased expression of RHOB mRNAaffects cotreatment|decreases expression 17905399
C012589 trichostatin A Azacitidine promotes the reaction [trichostatin A results in increased expression of RHOB mRNA]increases expression|increases reaction 18047684
C012589 trichostatin A [trichostatin A co-treated with Azacitidine] results in increased expression of RHOB proteinaffects cotreatment|increases expression 18047684
C012589 trichostatin A trichostatin A results in increased expression of RHOB mRNAincreases expression 18047684
C012589 trichostatin A trichostatin A results in increased expression of RHOB proteinincreases expression 18047684
D014801 Vitamin A [perilla alcohol co-treated with Vitamin A] affects the expression of RHOB mRNAaffects cotreatment|affects expression 15959631
D014801 Vitamin A [perilla alcohol co-treated with Vitamin A] affects the expression of RHOB proteinaffects cotreatment|affects expression 15959631
D014801 Vitamin A Vitamin A results in increased expression of RHOB mRNAincreases expression 15959631
D014801 Vitamin A Vitamin A results in increased expression of RHOB proteinincreases expression 15959631
C088658 zoledronic acid [zoledronic acid co-treated with fluvastatin] results in increased expression of RHOB mRNAaffects cotreatment|increases expression 16996129
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 7.0618769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.0614514962 11752688 15322242
MESH:D000015 Abnormalities, Multiple Isotretinoin 9.2818769834
MESH:D000015 Abnormalities, Multiple Vitamin A 9.2810992263
MESH:D000138 Acidosis Ammonium Chloride 3.0618287403
MESH:D017486 Acneiform Eruptions Isotretinoin 5.7816232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 10.3117505938
MESH:D000152 Acne Vulgaris Isotretinoin 10.3116185265 18769834
MESH:D058186 Acute Kidney Injury zoledronic acid 4.0219715164
MESH:D055371 Acute Lung Injury pirinixic acid 2.6618653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 4.9820200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 8.9420127859 20464547
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 8.9416033868
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 8.9414692618
MESH:D000230 Adenocarcinoma Indomethacin 8.9416537180
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 22.323712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 22.3216176798
MESH:D000236 Adenoma Benzo(a)pyrene 22.326695378
MESH:D000236 Adenoma Diethylnitrosamine 22.326695378 10737359
MESH:D000236 Adenoma Dimethylnitrosamine 22.3219555203
MESH:D000236 Adenoma Indomethacin 22.3211497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 14.4018056438 19052882 16434500 19061943 17620307 17162532
MESH:D018248 Adenoma, Liver Cell pirinixic acid 14.4016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 14.4016835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1915276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3917306315 16712894
MESH:D000505 Alopecia Tretinoin 3.2215955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8617225004
MESH:D000544 Alzheimer Disease Indomethacin 2.5817627676 15579461
MESH:D000740 Anemia Tetrachlorodibenzodioxin 7.5511748828
MESH:D000740 Anemia Vitamin A 7.5516960172
MESH:D000741 Anemia, Aplastic Benzene 3.9811369114 14761424 17661222
MESH:D018798 Anemia, Iron-Deficiency Vitamin A 4.3616960172
MESH:D000799 Angioedema Acetaminophen 3.3410982225
MESH:D001014 Aortic Aneurysm Indomethacin 4.3810231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.1019183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.1010388637
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 2.9811256880
MESH:D018771 Arthralgia Indomethacin 4.662160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.1415885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.1416412693
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.2911248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.2916292516
MESH:D001249 Asthma Tretinoin 4.6216456186
MESH:D001249 Asthma Vitamin A 4.6216732791
MESH:D001321 Autistic Disorder Acetaminophen 1.4818445737
MESH:D001471 Barrett Esophagus Tretinoin 3.9316935849
MESH:D001477 Bartter Syndrome Indomethacin 4.5010684365
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.511440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 12.6919483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 12.6912125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 12.6916206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.4315746008
MESH:D001855 Bone Marrow Diseases Benzene 4.7216183116
MESH:D001859 Bone Neoplasms zoledronic acid 4.5015867366 16778634 17312309 19442620 16121404 11697798
MESH:D001862 Bone Resorption bisphenol A 8.3211985600
MESH:D001862 Bone Resorption zoledronic acid 8.328053405 18404659 11869084 18496637 15845617 16769263
MESH:D001929 Brain Edema Indomethacin 4.5211481608
MESH:D002545 Brain Ischemia Indomethacin 3.9212524144
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7.5020146248
MESH:D001943 Breast Neoplasms alitretinoin 7.5016344269
MESH:D001943 Breast Neoplasms Benzene 7.5011921183 17162533
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 7.5017474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 7.5017123778
MESH:D001943 Breast Neoplasms Diethylnitrosamine 7.5017474063
MESH:D001943 Breast Neoplasms Indomethacin 7.5017401462
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 7.5020435547
MESH:D001943 Breast Neoplasms Tretinoin 7.5016443354 16873071 16166294
MESH:D001943 Breast Neoplasms Trichloroethylene 7.5015986119
MESH:D001943 Breast Neoplasms zoledronic acid 7.5018695136 16096432
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 11.3616813970
MESH:D001997 Bronchopulmonary Dysplasia Vitamin A 11.3617426644 17377406
MESH:D002056 Burns Indomethacin 4.2210459503
MESH:D002100 Cachexia Indomethacin 4.5111239499 16537180 15141370 15625704
MESH:D002277 Carcinoma Dimethylnitrosamine 7.0419555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.0416835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.6516168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 17.8416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 17.8416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 17.847296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 17.843084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 17.8412907637 12619106 21507988
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 17.8419418558 19335982 19383236 16698587 16878318 16830150 16569478 3581430 18971187 19539802 10737359 21159647 10672840 18785209 20514400 16807293 16502159 16540662 16328049 18210153 18506893 19519916 18494052 20935162 19208518 19394651 18665156 17428255 18056438 19052882 17761372 11831363 19107877 20007298 19171122 18978308 17055752 18393292 19919837 16779866 18788625 19822196 20432363 3084413 20101231 19701751 16681979 20524982 17173139 20084675 16288022 17138121 20214788 16935385 17978847 18691550 17162532 20512989 20727157
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 17.8416391822
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 17.8417306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 17.841917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.4917123778
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2311053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8511352223 14736730 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.3519233551
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 9.447296757
MESH:D002292 Carcinoma, Renal Cell Indomethacin 9.4417341418
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 9.4418507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 15.8420419170
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 15.8416033868
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 15.8412636206 15482327
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 15.8411237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 15.8418572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 15.8416051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.0816120746 18670907 18850075
MESH:D002386 Cataract Acetaminophen 6.2010977129
MESH:D002386 Cataract Tretinoin 6.2017460283
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 21.806135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 21.807505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 21.8020889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 21.8012371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 21.802727394 7505956 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 21.8020056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.0916129372
MESH:D015362 Child Nutrition Disorders Vitamin A 4.9716153327
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9316835633
MESH:D002764 Cholecystitis Indomethacin 4.6611181007
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 21.329022650 19486331
MESH:D002779 Cholestasis Cyclosporine 21.3219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 21.3216919318 11677210 16105132 15861022 17681005 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 21.3219176532
MESH:D002779 Cholestasis Vitamin A 21.3216175620
MESH:D002822 Choriocarcinoma Tretinoin 4.6516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 8.5616354765 8697196 15668235 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 8.569407595
MESH:D002972 Cleft Palate Vitamin A 8.5616054864
MESH:D003092 Colitis Tretinoin 3.2217035595
MESH:D003110 Colonic Neoplasms Indomethacin 3.8811260862 15936596 15637740 15625704 15963497 15786552
MESH:D003110 Colonic Neoplasms Vitamin A 3.8816267017 17219422
MESH:D015179 Colorectal Neoplasms Azacitidine 2.8519934284
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8511197048 17054584 18059344 12606626
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6414669216 17141729
MESH:D003327 Coronary Disease fluvastatin 4.4816142594
MESH:D018352 Coronavirus Infections Indomethacin 5.2117302372
MESH:D019465 Craniofacial Abnormalities Benzene 6.6015643154
MESH:D019465 Craniofacial Abnormalities Isotretinoin 6.609879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 6.6010048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 6.609142499 9664655 8800419 17551590 9211117 10589399 9224671 14991402 16925845 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin A 6.6010992263
MESH:D003490 Cyanosis 2,4-dinitrotoluene 9.2818551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 9.2818551238
MESH:D003872 Dermatitis Benzene 4.2815902427
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.3514531868 2524372 8156756 11906362 18759878 11298694 12868966 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1818249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.042952479 3621924
MESH:D003922 Diabetes Mellitus, Type 1 Vitamin A 3.3416506275
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 3.7320387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 3.7317107852
MESH:D003967 Diarrhea Indomethacin 3.347907874 7237001
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 22.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 22.4321346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 22.438291058 16192314 18289764 7440962 11289319 1440618 9653073 18692083 6482804 9022650 6679447 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 22.4311529661 11287661 12705907 2444490 16781746 16109766 19370779 19923254 11739529 17522070 17562736 14986274 18713872 12958197 15619225 10915739 10663392 11421492 19416960 17906064 16393943 16081117 11743745 11834606 12392966 19085960 11461765 19739265 12540782 16227642 19420014 12594235 10774834 15968718 18071297 16177239 12153990 19164858 14725611 14550746 16485898
MESH:D056486 Drug-Induced Liver Injury cyanoginosin LR 22.4317654400
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 22.4319107877
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 22.438172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 22.4320420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 22.437120509
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.5919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3911462148
MESH:D015352 Dry Eye Syndromes Vitamin A 5.3016146918
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.6518446180 17190690 18043480 16326151 16133044 12774134
MESH:D004381 Duodenal Ulcer Indomethacin 3.6717351913 17202747 17329845 11595431 17151854 16699067 11991626 11595415 17045617 10671773 11535926
MESH:C538011 Eales disease Vitamin A 5.119068938
MESH:D004480 Ectromelia Vitamin A 5.3116054864
MESH:D004487 Edema Indomethacin 12.8519703484 8273558 16100529 7990266 7907874 10653021 8985016
MESH:D004487 Edema perfluorooctanoic acid 12.8517259670 12083418
MESH:D004487 Edema pirinixic acid 12.8512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.8511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.2516714409 18230668 15322242
MESH:D004489 Edema, Cardiac Tretinoin 10.2518230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 2.7212538720
MESH:D004701 Endocrine Gland Neoplasms trichostatin A 5.1319294695
MESH:D016889 Endometrial Neoplasms Tretinoin 2.7716569247
MESH:D004715 Endometriosis Indomethacin 7.6315652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 7.6310568697 9294722
MESH:D019446 Endotoxemia Indomethacin 4.0118509659
MESH:D004751 Enteritis Indomethacin 4.2416328016 10567023 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.5017980183
MESH:D004802 Eosinophilia Indomethacin 3.5711298111
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6116302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 12.173581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 12.1720426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 12.1716530937
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 12.1717016578
MESH:D004938 Esophageal Neoplasms Indomethacin 12.1711005569
MESH:D005076 Exanthema terbinafine 6.0718833041
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 7.5911564622
MESH:D005124 Eye Abnormalities Tretinoin 7.5916938888 9664655
MESH:D005234 Fatty Liver Cyclosporine 15.0919224547
MESH:D005234 Fatty Liver Diethylnitrosamine 15.0921071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 15.0915345470
MESH:D005234 Fatty Liver pirinixic acid 15.0920131406 19236843
MESH:D005264 Femoral Fractures zoledronic acid 5.3316234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9711858732
MESH:D005327 Fetal Resorption Vitamin A 4.8616054864
MESH:D005334 Fever Indomethacin 3.6910431976 11852909 17627676
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.516705139
MESH:D005354 Fibrosarcoma Indomethacin 4.4010962813
MESH:D005355 Fibrosis Cyclosporine 17.1912168785 12639820
MESH:D005355 Fibrosis Indomethacin 17.1917994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.1920067830
MESH:D005355 Fibrosis Tretinoin 17.1917994277
MESH:D005499 Folliculitis Indomethacin 4.6611298111
MESH:D005756 Gastritis Acetaminophen 9.4616983495
MESH:D005756 Gastritis Indomethacin 9.4615046732
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.1816452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.728708960
MESH:D005909 Glioblastoma Indomethacin 10.0912870263
MESH:D005909 Glioblastoma Tretinoin 10.0917312396
MESH:D005909 Glioblastoma trichostatin A 10.0918801729
MESH:D005910 Glioma Indomethacin 3.0118371953 16487511
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8911849393
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.587505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0910696789
MESH:D006073 Gout Indomethacin 4.8511248219
MESH:D006258 Head and Neck Neoplasms Indomethacin 6.7815482327
MESH:D006258 Head and Neck Neoplasms Tretinoin 6.7816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.6516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 13.7020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 13.7010048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 13.7014991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin A 13.7010992263 16080930
MESH:D006333 Heart Failure pirinixic acid 2.2220558911
MESH:D006402 Hematologic Diseases Benzene 4.1916183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 3.9215720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8911000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1215633222
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.046705139
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2115135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 11.673609246
MESH:D006529 Hepatomegaly pirinixic acid 11.6716221962 19772884 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 11.6715340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin A 3.4316292552 16877224 17436238 16863852 16490937 15707848
MESH:D015658 HIV Infections Vitamin A 3.5516960176
MESH:D006679 HIV Seropositivity Vitamin A 5.1017209195
MESH:D006689 Hodgkin Disease sodium arsenite 2.7512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.5416354765 18606429 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 20.3316870215
MESH:D006930 Hyperalgesia Indomethacin 20.3312727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 20.3312083418
MESH:D006930 Hyperalgesia Tretinoin 20.3316870215
MESH:D006930 Hyperalgesia zoledronic acid 20.3316769263
MESH:D034321 Hyperamylasemia Indomethacin 5.2117883296
MESH:D006934 Hypercalcemia zoledronic acid 4.6018089816 19622757
MESH:D006940 Hyperemia Indomethacin 4.5112524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.0816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.7520558911
MESH:D006949 Hyperlipidemias Indomethacin 3.7117546600
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.4515034207
MESH:D006973 Hypertension Benzene 7.3617940673
MESH:D006973 Hypertension Cyclosporine 7.3610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 7.3618670907 18850075
MESH:D006986 Hypervitaminosis A Vitamin A 5.6616054864
MESH:D006996 Hypocalcemia zoledronic acid 5.6912669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.3216945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.5218306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8510651667 16133968 10647630
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.8616133044
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.0012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 5.5117937319
MESH:D007248 Infertility, Male sodium arsenite 5.5115346721 12646999
MESH:D007249 Inflammation Diethylnitrosamine 9.7218785209
MESH:D007249 Inflammation Indomethacin 9.727812673 12568917 3291741
MESH:D007249 Inflammation perfluorooctanoic acid 9.7212083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 9.7212200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 6.2016393666
MESH:D007333 Insulin Resistance pirinixic acid 6.2016306350
MESH:D007410 Intestinal Diseases Indomethacin 8.2717994277 15831440 10210152 11686837 11855677 15610444 11713966 18236018 17329856
MESH:D007410 Intestinal Diseases Tretinoin 8.2717994277
MESH:D019586 Intracranial Hypertension Indomethacin 12.5015241188
MESH:D019586 Intracranial Hypertension Vitamin A 12.5015955940
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.518074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 8.4516580747
MESH:D007569 Jaw Abnormalities Tretinoin 8.4515992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.5216133968 10574470 18306037
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 3.9315604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.1416144296
MESH:D007674 Kidney Diseases Acetaminophen 11.9615629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 11.968314463 18776723 10903974
MESH:D007674 Kidney Diseases Indomethacin 11.9617190690
MESH:D007674 Kidney Diseases sodium arsenite 11.9620008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.4216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.4216705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.426582329
MESH:D007680 Kidney Neoplasms Cyclosporine 14.4212371664
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.5011703811 10320625 12228301
MESH:D007938 Leukemia Azacitidine 9.1119148494
MESH:D007938 Leukemia Benzene 9.1114694614 17119257 15935818 18335105
MESH:D007938 Leukemia Tretinoin 9.1117143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.3218089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5515631656 16572323 10785260
MESH:D007951 Leukemia, Myeloid Azacitidine 13.5819077051
MESH:D007951 Leukemia, Myeloid Benzene 13.5817506065
MESH:D007951 Leukemia, Myeloid Tretinoin 13.5816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 10.4817596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Benzene 10.4819478238
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 10.4818360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 10.4816294345 17596541 19850784
MESH:D015470 Leukemia, Myeloid, Acute trichostatin A 10.4818206229
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 4.7319299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 2.8217301526 17217047 17294898 19642359 19225113 16766008 16935935 17368321 16140955 16331271 16788101 19075265 17506722 15748426 12679006 9834237 19029980 17339181 16823087 17107899 17361223 17712046 17649720 19035177 16891316
MESH:D007964 Leukocytosis Indomethacin 4.8616537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2117980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.738812269
MESH:D017880 Limb Deformities, Congenital Tretinoin 7.299224671
MESH:D017880 Limb Deformities, Congenital Vitamin A 7.2916054864
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2111479899
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.0319638242 20032147 18407596 18522880 18665156
MESH:D008103 Liver Cirrhosis Vitamin A 6.0316256175
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 2.8715034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 7.7115067225 15591649 17719030 15723089 15733078 17534399 16544323 16603200 16169303 15383259 15864749 18567088 15339415 15571005 15099470 15798949 16270385 18210741 14659978 15793283 17881167 15138612 17036385 18237412 17348192 15369754 18095165 17724770 17640959 18637143 18672772 18629640 17465448 14568256 15479170 17201889 17196135 17203207 16627068 15086199 17198567 16570917 18371158 15161499 14709902 16009107 15081153 15504291 15298665 14643895 15366600 15744066 18239293 18364076 14726149 16042886 15492853 15577212 15942678 12925901 12918455 17666798 15763062 17432682 15842777
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 7.7118194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 7.7115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 7.7112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 7.7116248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin A 7.7116248980
MESH:D008107 Liver Diseases Acetaminophen 5.7116611625 19014921 12969438 11587558 19784758 19460945 12587719 16610002
MESH:D008107 Liver Diseases Diethylnitrosamine 5.7117034775
MESH:D008107 Liver Diseases Vitamin A 5.7116175620
MESH:D008108 Liver Diseases, Alcoholic Vitamin A 4.6716762690
MESH:D017114 Liver Failure, Acute Acetaminophen 8.2416871587 17185352
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 8.2417457977
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 33.677678174
MESH:D008113 Liver Neoplasms 2-nitrofluorene 33.6715890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 33.6715890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 33.679163691 2125692 18177683 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 33.6720195826 21137059
MESH:D008113 Liver Neoplasms Diethylnitrosamine 33.6719996281 18648771 20492335 20434301 18644402 19850985 20583210 18978307 18754104 21167192 2862719 20118626 19426721 21278145 19690152 20101389 16942905 12112319 19255062 20501860 21047994 15175105 19073162 2422723 10737359 19642983 9163691 19812893 19256749 21071580 19833225 19499222 20405173 19638242 19427195 19254457 15885732 19090486 19294768 19551842 12771043 18977376 20452335 20137499
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 33.673113478 15890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 33.6718709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 33.6716377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 33.6716712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 33.6716984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 32.052876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 32.053712494 598648 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 32.058603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 32.0512562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 32.052563599 18282651 19009564 18253720 21159647 16842330 17854601 18164116 17174075 18093689 19539802 9362446 18544905 19126423 16267830 19519916 18775883 3124819 18308698 17942915 18079962 19004024
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 32.0515603536 1848544 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 32.0512151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 32.057955063
MESH:D008114 Liver Neoplasms, Experimental Vitamin A 32.0517113696
MESH:D008171 Lung Diseases sodium arsenite 6.6419095001
MESH:D008171 Lung Diseases Vitamin A 6.6416863852
MESH:D017563 Lung Diseases, Interstitial Benzene 4.3014698565
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 21.1719931552 16401635 14755239 9255578 15893417 18813816 18508827 15172992 12438228 16061637 17139156
MESH:D008175 Lung Neoplasms Aflatoxin B1 21.1714755239
MESH:D008175 Lung Neoplasms alitretinoin 21.1716413115
MESH:D008175 Lung Neoplasms Azacitidine 21.1721224363
MESH:D008175 Lung Neoplasms Benzene 21.1712562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 21.1720064080 20464547 18816296 17053015 18569708 18520028 20869020 20135361 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 21.1720970405 6695378 21163286 20512841
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 21.1716061637 19555203 11884234
MESH:D008175 Lung Neoplasms Indomethacin 21.1711053908 11497255 16537180
MESH:D008175 Lung Neoplasms Isotretinoin 21.1715899809
MESH:D008175 Lung Neoplasms sodium arsenite 21.1715276417 16712894 17077188 19931552 17306315
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 21.1719555203 11884234
MESH:D008223 Lymphoma Benzene 3.3817584886 17119257
MESH:D015674 Mammary Neoplasms, Animal Benzene 3.9512562636
MESH:D008325 Mammary Neoplasms, Experimental Benzene 5.5611921183
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 5.5617312309
MESH:D008527 Medulloblastoma Tretinoin 2.5717453147
MESH:D008545 Melanoma Isotretinoin 6.4617237267
MESH:D008545 Melanoma sodium arsenite 6.4616487513 19082730
MESH:D008545 Melanoma Tretinoin 6.4616752155
MESH:D008545 Melanoma trichostatin A 6.4616505122
MESH:D008546 Melanoma, Experimental Acetaminophen 3.0819513568
MESH:D008591 Meningomyelocele Tretinoin 3.9416940565
MESH:D008654 Mesothelioma zoledronic acid 3.5316675582
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.2816801185
MESH:D008881 Migraine Disorders Indomethacin 3.3211903285
MESH:D009006 Monosomy Azacitidine 5.5719299654
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3816381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.3812636206
MESH:D009101 Multiple Myeloma Azacitidine 23.6019549372 18443271
MESH:D009101 Multiple Myeloma Benzene 23.6017119195
MESH:D009101 Multiple Myeloma fluvastatin 23.6016996129
MESH:D009101 Multiple Myeloma trichostatin A 23.6018172295
MESH:D009101 Multiple Myeloma Vitamin A 23.6016374440
MESH:D009101 Multiple Myeloma zoledronic acid 23.6018089719 19621390 16996129
MESH:D009135 Muscular Diseases pirinixic acid 3.0216239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 6.7119805378 17596541 18720364 17611569
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.7117596541
MESH:D009203 Myocardial Infarction pirinixic acid 1.9219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6212213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.5616411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 8.6918551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 8.6918551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 11.813581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 11.819029167 3581430
MESH:D009362 Neoplasm Metastasis Indomethacin 11.8111053908 11239499 16537180
MESH:D009362 Neoplasm Metastasis zoledronic acid 11.8119139120 15867366 17312309
MESH:D009369 Neoplasms alitretinoin 16.3316946489
MESH:D009369 Neoplasms Benzo(a)pyrene 16.3311141357
MESH:D009369 Neoplasms pirinixic acid 16.3317405874
MESH:D009369 Neoplasms sodium arsenite 16.3311559025
MESH:D009369 Neoplasms Tretinoin 16.3316594593 16946489
MESH:D009369 Neoplasms Trichloroethylene 16.3311911487
MESH:D009374 Neoplasms, Experimental Indomethacin 7.6710663608 15625704
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.6720056578
MESH:D009402 Nephrosis, Lipoid Cyclosporine 3.9317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 2.8719348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 13.6416427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 13.6414600291
MESH:D009421 Nervous System Malformations Tretinoin 13.649125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 19.236679447
MESH:D009436 Neural Tube Defects Benzene 19.2315643154
MESH:D009436 Neural Tube Defects sodium arsenite 19.2312854658
MESH:D009436 Neural Tube Defects Tretinoin 19.239142499
MESH:D009436 Neural Tube Defects Vitamin A 19.2317400914
MESH:D009447 Neuroblastoma Isotretinoin 3.7717368321
MESH:D019636 Neurodegenerative Diseases Acetaminophen 11.7218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 11.7220387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 11.7212349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6120387270
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.479802331
MESH:D009765 Obesity pirinixic acid 1.6820558911
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.666374098
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 18.0516049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 18.0516049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 18.056482804 4026338
MESH:D009784 Occupational Diseases Benzene 18.0517119257 15935809 15913788 15612468 15576619 15727169 17178637 17479406 16737584
MESH:D014009 Onychomycosis terbinafine 6.3318360572 9382559
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.513988306
MESH:D010003 Osteoarthritis Indomethacin 3.357009135
MESH:D010014 Osteolysis zoledronic acid 4.8715867366
MESH:D010024 Osteoporosis zoledronic acid 3.7217882678
MESH:D010049 Ovarian Diseases bisphenol A 4.4911985600
MESH:D010051 Ovarian Neoplasms Benzene 9.8512562636
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.8517306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 9.8516936753
MESH:D010051 Ovarian Neoplasms trichostatin A 9.8519331143
MESH:D010146 Pain Acetaminophen 12.8516870215
MESH:D010146 Pain Indomethacin 12.8517627676 3291741 13679232 17440234
MESH:D010146 Pain Tretinoin 12.8516870215
MESH:D010146 Pain zoledronic acid 12.8516475674
MESH:D010149 Pain, Postoperative Indomethacin 4.1718702446 12538197
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.7212384795
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.7216540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 10.7215976015
MESH:D010190 Pancreatic Neoplasms trichostatin A 10.7219294695
MESH:D010195 Pancreatitis Indomethacin 3.4715028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2311578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.007296757
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2116537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6912349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2111903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7412520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6511148446
MESH:D010518 Periodontitis Indomethacin 4.4117225004
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 3.966228378
MESH:D011020 Pneumonia, Pneumocystis terbinafine 6.5411796365
MESH:D017499 Porokeratosis alitretinoin 5.5016144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0918163543
MESH:D011230 Precancerous Conditions Cyclosporine 7.5512371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.552563599
MESH:D047928 Premature Birth Indomethacin 4.6417000239
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 19.2410548101
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 19.2418769834
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 19.2417132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.2411118676 11222880 11399792 11896295
MESH:D055728 Primary Myelofibrosis trichostatin A 4.7617616702
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 3.7620887781
MESH:D011471 Prostatic Neoplasms Azacitidine 2.0118324645
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.0117292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0116740699
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.0116205645
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.0116039940
MESH:D011471 Prostatic Neoplasms trichostatin A 2.0118798265 19789329
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.0119103299 12438248
MESH:D011507 Proteinuria Indomethacin 7.8211849393
MESH:D011507 Proteinuria Tretinoin 7.8216636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.8216919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.0416882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.4218769834
MESH:D011625 Pterygium Tretinoin 4.2916723453
MESH:D011629 Puberty, Precocious bisphenol A 4.2910548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.1319058328
MESH:D012127 Respiratory Distress Syndrome, Newborn Vitamin A 5.3016877224
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3618990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.003692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.6416283617 16116481
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.4616121404
MESH:D012640 Seizures 2,4-dinitrotoluene 4.7318551238
MESH:D012640 Seizures 2,6-dinitrotoluene 4.7318551238
MESH:D012871 Skin Diseases Vitamin A 3.2118709164
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 11.4419755658 10029692
MESH:D012878 Skin Neoplasms sodium arsenite 11.4419524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 11.4416192470
MESH:D012878 Skin Neoplasms Tretinoin 11.4416467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.4316709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.4112854658
MESH:D013158 Splenic Diseases Dimethylnitrosamine 4.7612587719
MESH:D013272 Stomach Diseases Indomethacin 3.9215472012 18209964 17207306 16280098 16184426 10215738 15038085 17638125 18545984 17160473 10486359 16113693 10192188
MESH:D013274 Stomach Neoplasms Benzene 7.4412562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.442093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.4418456281
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 7.4416033868
MESH:D013274 Stomach Neoplasms Indomethacin 7.4415609394
MESH:D013274 Stomach Neoplasms Tretinoin 7.4417261132
MESH:D013276 Stomach Ulcer Indomethacin 3.1612498302 10878458 16169175 16631530 18193104 17977527 11523592 17627676 18087811 1323529 15138204 10750652 11595415 18431645 16397915 11906479 11145282 18543354 18237397 15104355 12467913 10423059 12787963 17135157 16252198 17657623 15255614 16934674 12500499 11595431 11729361 18209962 18726076 16755016 14567935 17918041 18299717 18181030 12077510 17895592 16150113 17654042
MESH:D019966 Substance-Related Disorders bisphenol A 3.4916684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.7315669648
MESH:D013953 Thymus Neoplasms Benzene 4.4610850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 13.991399818 3712494 6582329 7505956 6587162
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.997505956
MESH:D013964 Thyroid Neoplasms Indomethacin 13.9918791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 13.9916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.3616051514
MESH:D014376 Tuberculosis Tretinoin 2.9116040207
MESH:D014456 Ulcer Indomethacin 4.4017380554 10574470
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 13.4516049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 13.4516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 13.458074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 13.4517053015
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 13.4517306315 11723127 16712894 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 10.3310091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 10.3310091137
MESH:D014581 Urticaria Acetaminophen 2.5210982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 7.9711813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.9716129372
MESH:D014591 Uterine Diseases bisphenol A 4.5014652134
MESH:D014594 Uterine Neoplasms Benzene 8.0012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.0014692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.1016752155
MESH:D014605 Uveitis Cyclosporine 3.481336536
MESH:D014652 Vascular Diseases sodium arsenite 3.9317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0914671159 15869587
MESH:D014802 Vitamin A Deficiency Vitamin A 4.8216175781 16960172 16146918
MESH:D014820 Vitiligo Tretinoin 3.5816761959
MESH:D014839 Vomiting Indomethacin 4.2411897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7415886252
MESH:D009396 Wilms Tumor Tretinoin 3.5516287080
MESH:D014985 Xerophthalmia Cyclosporine 3.9317120751
Pathway ID Pathway Name
REACT:18266 Axon guidance
REACT:604 Hemostasis
REACT:14797 Signaling by GPCR
REACT:11044 Signaling by Rho GTPases
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24950
    • No data
    Releated disease ID Related disease Name
    PA445174Osteoarthritis
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00083 - Botulinum Toxin Type A Anti-Wrinkle Agents;Antidystonic Agents;Neuromuscular Blocking Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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