AutismKB 2.0

Annotation Detail for SBK1


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Basic Information Top
Gene Symbol:SBK1 ( Sbk )
Gene Full Name: SH3-binding domain kinase 1
Band: 16p11.2
Quick LinksEntrez ID:388228; OMIM: NA; Uniprot ID:SBK1_HUMAN; ENSEMBL ID: ENSG00000188322; HGNC ID: 17699
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of SBK1 mRNAincreases expression 16788091
D000082 Acetaminophen Acetaminophen affects the expression of SBK1 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SBK1 mRNAaffects expression 16483693
D005419 Flavonoids Flavonoids results in increased expression of SBK1 mRNAincreases expression 18035473
D010634 Phenobarbital Phenobarbital results in increased expression of SBK1 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in increased expression of SBK1 mRNAincreases expression 18445702
C024746 tobacco tar tobacco tar results in decreased expression of SBK1 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.4218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.4817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.4816434500
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.4319483382
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.983084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 2.981701930 20007298 6705139 17173139 20935162
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.1319559774
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D002779 Cholestasis pirinixic acid 3.0319176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5318249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6512392966 14986274 16177239 18713872 11421492 11834606 17522070 14725611 14550746 11461765 16109766 19416960 16081117 10663392 15619225 16227642 19370779 12153990 19923254 16781746 16485898 12705907 19085960 12958197 15968718 10915739 16393943 18071297 11743745 17906064 12540782 11287661 11739529 19739265 19420014 11529661 12594235 10774834 2444490 19164858 17562736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004487 Edema pirinixic acid 2.7612083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005234 Fatty Liver pirinixic acid 3.0419236843 20131406
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006333 Heart Failure pirinixic acid 2.6920558911
MESH:D006529 Hepatomegaly Phenobarbital 9.7016109766
MESH:D006529 Hepatomegaly pirinixic acid 9.7019772884 19176532 18467677 16221962
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006943 Hyperglycemia pirinixic acid 3.4520558911
MESH:D007249 Inflammation Flavonoids 2.7717296493
MESH:D007333 Insulin Resistance pirinixic acid 2.8016306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3412587719 15629191
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1316610002 16611625 19014921 12587719 19460945 11587558 19784758 12969438
MESH:D008107 Liver Diseases Phenobarbital 4.1319363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.7619482888 21047994 8742319 15975961 19812893 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 4.7615890375 16377806 20007298
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.861399818 6150874 2563599 17172636 18308698
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009135 Muscular Diseases pirinixic acid 3.8616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2419151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009369 Neoplasms pirinixic acid 2.0617405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D009765 Obesity pirinixic acid 1.8620558911
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5019058328
MESH:D012640 Seizures Phenobarbital 2.8711442880 4039156 3137016 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014581 Urticaria Acetaminophen 3.2810982225
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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