AutismKB 2.0

Annotation Detail for KRT34


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Basic Information Top
Gene Symbol:KRT34 ( HA4,Ha-4,KRTHA4,hHa4 )
Gene Full Name: keratin 34
Band: 17q21.2
Quick LinksEntrez ID:3885; OMIM: 602763; Uniprot ID:KRT34_HUMAN; ENSEMBL ID: ENSG00000131737; HGNC ID: 6452
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2125Bladder cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of KRT34 mRNAaffects expression 17562736
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of KRT34 mRNAincreases expression 20382639
D019833 Genistein Genistein results in decreased expression of KRT34 mRNAdecreases expression 16705744
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in increased expression of KRT34 mRNAaffects cotreatment|increases expression 19059307
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in increased expression of KRT34 mRNAaffects cotreatment|increases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 5.1614745880
MESH:D000230 Adenocarcinoma Genistein 2.5411473722
MESH:D000419 Albuminuria Raloxifene 5.0417308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.6015800139
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001930 Brain Injuries Raloxifene 4.9616580743
MESH:D001943 Breast Neoplasms Genistein 1.9916541309 16873071 17200150
MESH:D001943 Breast Neoplasms Raloxifene 1.9917440819 17952589 17893378 17242785 15758505 17595753 15572757 17261762 16912660 17049068 15775269 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 1.9919011961 16202921 19244106 18629630 15668708 19084267 20065188 17893378 17261762 19115204 20005174 19142967 21138602 19189212 18425577 11161223 19200415 18815881 18997820 19155303 16818667 19189210 21152245 19221464 19410462 18351453 18984771 15565566 20859285 20544844 19059307 18855134 19066611 20135344 16273361 16873071 17049068 17440819 19103187 20390343 18821012 19288272 19487384 17242785 19289846
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.9919066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.823084413
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 4.8216924424
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.6817572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.6817572228
MESH:D002318 Cardiovascular Diseases Genistein 8.3016332659
MESH:D002318 Cardiovascular Diseases Raloxifene 8.3015775269
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.9620889678
MESH:D003072 Cognition Disorders Raloxifene 5.1015800139
MESH:D003110 Colonic Neoplasms Genistein 2.3317182828
MESH:D003711 Demyelinating Diseases Tamoxifen 4.8519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.4917474826
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5516647724
MESH:D003928 Diabetic Nephropathies Raloxifene 10.1317308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 10.1319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6619420014 10915739 18713872 14986274 17562736 12705907 10663392 11421492 16485898 19739265 19370779 16081117 12540782 12958197 19416960 11287661 11529661 17522070 19164858 16109766 12153990 17906064 14550746 16227642 16393943 15619225 11461765 11834606 11739529 19085960 2444490 15968718 10774834 18071297 11743745 16177239 19923254 16781746 12594235 14725611 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D004487 Edema Raloxifene 3.7015860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 10.7515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 10.7519031437
MESH:D004714 Endometrial Hyperplasia Genistein 5.1316402032
MESH:D016889 Endometrial Neoplasms Genistein 8.2611473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 8.2616202921 20544844 17893378 19155303
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Raloxifene 9.2517473493
MESH:D005234 Fatty Liver Tamoxifen 9.2514986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.4316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 5.0714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.7219069698
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D005909 Glioblastoma Genistein 3.4716598420
MESH:D006331 Heart Diseases Raloxifene 3.7711110106
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006973 Hypertension Raloxifene 2.9717577099 15787275
MESH:D007249 Inflammation Tamoxifen 2.5119457130
MESH:D007674 Kidney Diseases Acetaminophen 2.3812587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 3.3518625569
MESH:D007889 Leiomyoma Raloxifene 4.9016973256
MESH:D007938 Leukemia Genistein 3.1718980019 17468513
MESH:D008064 Lipidoses Tamoxifen 3.4015342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6717823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 2.6718564211
MESH:D008107 Liver Diseases Acetaminophen 1.6911587558 12969438 12587719 19784758 16611625 19460945 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5817185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 2.3216684651
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.3019428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.8312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.8314580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Tamoxifen 5.1619453300
MESH:D008545 Melanoma Tamoxifen 1.9219393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.7215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 6.1715863610
MESH:D009101 Multiple Myeloma Raloxifene 3.6816497877
MESH:D009203 Myocardial Infarction Genistein 2.9817141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.9317141266
MESH:D009232 Myxoma Raloxifene 6.1716343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6619393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.6019410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.6119189210 19200415 19196722
MESH:D009421 Nervous System Malformations Genistein 4.4716427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D010024 Osteoporosis Genistein 8.0019401787
MESH:D010024 Osteoporosis Raloxifene 8.0017882678 15775268 19059307
MESH:D015663 Osteoporosis, Postmenopausal Genistein 11.5216169203
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 11.5215579764 17823083 17893378 15758505
MESH:D010051 Ovarian Neoplasms Genistein 2.6819005980
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D011471 Prostatic Neoplasms Genistein 2.5816925846 15378649 15256057
MESH:D011471 Prostatic Neoplasms Raloxifene 2.5816220300 15731164 16536755
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.5815067354
MESH:D011693 Purpura Raloxifene 6.1715770314
MESH:D013088 Spermatocele Tamoxifen 4.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.5819457130
MESH:D020521 Stroke Raloxifene 4.1116837676
MESH:D013978 Tibial Fractures Raloxifene 5.8219048282
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 5.6117572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.6116712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D054556 Venous Thromboembolism Raloxifene 5.8216837676
MESH:D014846 Vulvar Neoplasms Raloxifene 6.1716343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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