AutismKB 2.0

Annotation Detail for KRT81


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Basic Information Top
Gene Symbol:KRT81 ( HB1,Hb-1,KRTHB1,MLN137,ghHkb1,hHAKB2-1 )
Gene Full Name: keratin 81
Band: 12q13.13
Quick LinksEntrez ID:3887; OMIM: 602153; Uniprot ID:KRT81_HUMAN; ENSEMBL ID: ENSG00000205426; HGNC ID: 6458
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1841Stomach cancer
No data
No data
Desease Name
Monilethrix
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT81 mRNAaffects cotreatment|decreases expression 19619570
D004958 Estradiol Estradiol results in increased expression of KRT81 mRNAincreases expression 19619570
C055122 orlistat orlistat results in increased expression of KRT81 mRNAincreases expression 18796435
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of KRT81 mRNAaffects cotreatment|decreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of KRT81 mRNAincreases expression 19619570
C024746 tobacco tar tobacco tar results in decreased expression of KRT81 mRNAdecreases expression 19559774
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.4711752688 15322242 14514962
MESH:D000230 Adenocarcinoma Estradiol 2.1711473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 4.0116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.3411748828
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.4712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.5115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 3.0015746008
MESH:D001943 Breast Neoplasms Estradiol 1.9012948864 16675129 17289903 18497071 19861407 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D019121 Burkholderia Infections orlistat 7.3617874328
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 5.0916111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D006528 Carcinoma, Hepatocellular Estradiol 1.7916924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5618670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic Estradiol 7.9818566989
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 7.9819559774
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.5316835633
MESH:D002916 Chylothorax orlistat 7.3617003701
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2415668235 15340226 12621046 8697196 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.4314669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2710048152 15322242 20055451
MESH:D048909 Diabetes Complications orlistat 6.5619207292
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.7819279558
MESH:D003967 Diarrhea orlistat 5.2220002075
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.6220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 3.0511462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.8011000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.6218230668 15322242 16714409
MESH:D016889 Endometrial Neoplasms Estradiol 3.2211473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.4210568697 9294722
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.3111564622
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 4.0211858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.5120067830
MESH:D005414 Flatulence orlistat 7.3620002075
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.3210696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.5110048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.7611000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.4515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.7615709030
MESH:D019584 Hot Flashes Estradiol 4.4717088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.778697196 16354765 15340226 16959395 18606429
MESH:D006949 Hyperlipidemias orlistat 5.5521332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 2.0218850075 18670907
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 2.0312878042 12200463
MESH:D007333 Insulin Resistance Estradiol 8.7216627594 16393666
MESH:D007333 Insulin Resistance orlistat 8.7217201808
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.7616580747
MESH:D007674 Kidney Diseases Estradiol 2.7815618244
MESH:C531755 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules orlistat 7.3617185156
MESH:D007680 Kidney Neoplasms Estradiol 3.3215610895
MESH:D008103 Liver Cirrhosis orlistat 4.5417404856
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.3514659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3512878042
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.8316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.3312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008207 Lymphatic Metastasis orlistat 6.3918770866 20805790
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.7911807958 16891317 17203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 5.2119453300
MESH:D008545 Melanoma orlistat 3.4620805790 18770866
MESH:D056734 Monilethrix marker/mechanism
MESH:D009135 Muscular Diseases orlistat 6.0118430571
MESH:D009164 Mycobacterium Infections orlistat 6.2121442799
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.3412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.5916810080
MESH:D009369 Neoplasms orlistat 4.0518710210
MESH:D009374 Neoplasms, Experimental orlistat 5.6219381703
MESH:D009389 Neovascularization, Pathologic Estradiol 12.6917289903
MESH:D009389 Neovascularization, Pathologic orlistat 12.6917012255
MESH:D009421 Nervous System Malformations Estradiol 11.2016427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 11.2014600291
MESH:C541083 Non-alcoholic Fatty Liver Disease orlistat 5.9917404856
MESH:D009765 Obesity orlistat 3.8320540997 20002075 19461584 18773755 20518802 19207292 20599501 16938137 21442799 19046740 21438711 20065556
MESH:D010051 Ovarian Neoplasms Estradiol 2.3119401270
MESH:D010195 Pancreatitis orlistat 5.3020065556 16938137
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.9712520081
MESH:D011085 Polycystic Ovary Syndrome orlistat 5.7217201808
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 4.0718163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.8211222880 11399792 11896295 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.3120887781
MESH:D011471 Prostatic Neoplasms Estradiol 3.0216740699
MESH:D012035 Refsum Disease orlistat 6.7020871815
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.3518990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.2016192470
MESH:D013274 Stomach Neoplasms orlistat 3.2819381703
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.6212697716
MESH:D013978 Tibial Fractures Estradiol 5.4119048282
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.3212125929
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.9715886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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