AutismKB 2.0

Annotation Detail for RESP18


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Basic Information Top
Gene Symbol:RESP18 ( - )
Gene Full Name: regulated endocrine-specific protein 18 homolog (rat)
Band: 2q35
Quick LinksEntrez ID:389075; OMIM: 612721; Uniprot ID:RES18_HUMAN; ENSEMBL ID: ENSG00000182698; HGNC ID: 33762
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of RESP18 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of RESP18 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of RESP18 mRNAincreases expression 17010207
D004958 Estradiol Estradiol results in increased expression of RESP18 mRNAincreases expression 17010207
D000431 Ethanol [Fish Oils co-treated with Ethanol] results in increased expression of RESP18 mRNAaffects cotreatment|increases expression 17347304
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RESP18 mRNAaffects cotreatment|increases expression 17942748
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of RESP18 mRNAaffects expression 15212814
D005395 Fish Oils [Fish Oils co-treated with Ethanol] results in increased expression of RESP18 mRNAaffects cotreatment|increases expression 17347304
D007657 Ketone Bodies Ketone Bodies results in increased expression of RESP18 mRNAincreases expression 16807920
C474055 octylphenol octylphenol results in increased expression of RESP18 mRNAincreases expression 17010207
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of RESP18 mRNAincreases expression 16221955
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of RESP18 mRNAincreases expression 16221955
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RESP18 mRNAaffects cotreatment|increases expression 17942748
D014241 Trichloroethylene Trichloroethylene results in decreased expression of RESP18 mRNAdecreases expression 17905399
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.8617676605 18926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.8611752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 10.8718287403
MESH:D000138 Acidosis Ethanol 10.8711192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0817505938
MESH:D000230 Adenocarcinoma Estradiol 4.2811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.2814692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.803712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.4515451040 15451039
MESH:D000686 Amyloidosis Diethylstilbestrol 4.5715469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D000853 Anophthalmos Ethanol 4.9215513904
MESH:D001008 Anxiety Disorders Ethanol 4.0711141031
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7115885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.1511289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0115324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 2.0117261762 12948864 19861407 14630087 16675129 18497071 17018787 17289903
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
MESH:D001943 Breast Neoplasms Trichloroethylene 2.0115986119
MESH:D002056 Burns Ethanol 4.7616374292
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.5816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.723581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 6.7215948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.7216924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.7218788625 15763234 15289165
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.717296757
MESH:D006332 Cardiomegaly Ethanol 6.9919332462
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.9918670907 18850075 16120746
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 6.847505956
MESH:D002471 Cell Transformation, Neoplastic Estradiol 6.8418566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.069022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.0616919318 17333356 17681005 17110522 16105132 15861022 11677210
MESH:D002971 Cleft Lip Ethanol 3.6215513904
MESH:D002972 Cleft Palate Ethanol 6.0615513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0615668235 8697196 12621046 15340226 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1314669216 17141729
MESH:D019465 Craniofacial Abnormalities Ethanol 2.6510194807 11198716 15451040 15451039 15513904 19302082 11873399
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.6520055451 10048152 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.6512952375 16002989
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9018759878 2524372 11298694 8970840 8156756 12868966 14531868 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.583621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4819279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.249653073 9022650 18289764 16192314 6482804 8291058 11289319 7440962 18648102 6679447 18692083 9328219 1440618
MESH:D056486 Drug-Induced Liver Injury Ethanol 9.2411566570
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.2420420201
MESH:D056486 Drug-Induced Liver Injury Trichloroethylene 9.247120509
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004487 Edema perfluorooctanoic acid 7.2112083418 17259670
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.2112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0415322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.8116402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.7215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 7.7211473722 19148513 18566989
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1010568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.703581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.7016704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0711564622
MESH:D005234 Fatty Liver Ethanol 13.8216409862 19236843 18620774
MESH:D005234 Fatty Liver Ethinyl Estradiol 13.8215345470
MESH:D005234 Fatty Liver Fish Oils 13.8218620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.8017920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7016534752 15751030 16513791 16611131 16002989
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.4216946407 15513904 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.156705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.0520067830
MESH:D005756 Gastritis Ethanol 4.8315046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.0616452187
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 4.3117162496
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.127505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3710048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.616705139
MESH:D006529 Hepatomegaly perfluorooctanoic acid 9.023609246
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 9.0215340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.1715709030
MESH:D019584 Hot Flashes Estradiol 3.8917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1818606429 16354765 15340226 8697196 16959395
MESH:D006930 Hyperalgesia Ethanol 8.4518783367
MESH:D006930 Hyperalgesia perfluorooctanoic acid 8.4512083418
MESH:D006949 Hyperlipidemias Fish Oils 4.8415752949
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.1915034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.1914722030 12960047
MESH:D006968 Hypersensitivity, Delayed Fish Oils 5.6411484837
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 11.6016002989
MESH:D007021 Hypospadias Ethinyl Estradiol 11.6016569931 16945680
MESH:D007246 Infertility Diethylstilbestrol 4.4515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5417937319
MESH:D007249 Inflammation perfluorooctanoic acid 5.2812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.0216393666 16627594
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.158074119 9022650
MESH:D007569 Jaw Abnormalities Ethanol 10.3915513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.3916580747
MESH:D007674 Kidney Diseases Estradiol 2.6315618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.876582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 12.8714681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 12.8715610895
MESH:D007859 Learning Disorders Diethylstilbestrol 10.1417184923
MESH:D007859 Learning Disorders Ethanol 10.1415451040
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.358812269
MESH:D017880 Limb Deformities, Congenital Ethanol 3.8717676605
MESH:D008103 Liver Cirrhosis Ethanol 3.4115289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.2118295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2415034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.5518166357
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5512878042
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.7617347304 17207112
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.7115890375 16712894
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 7.7114757943 18709148
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7116984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.23598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.2312151625
MESH:D008114 Liver Neoplasms, Experimental Trichloroethylene 10.237955063
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.2715166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5315700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.6516002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.6111408345 11807958 17203775 16891317
MESH:D020149 Manganese Poisoning Estradiol 4.6219453300
MESH:D008569 Memory Disorders Ethanol 4.2815451040 18411066
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.3416810080
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.503581430
MESH:D009369 Neoplasms Diethylstilbestrol 5.7615313581
MESH:D009369 Neoplasms Trichloroethylene 5.7611911487
MESH:D009389 Neovascularization, Pathologic Estradiol 3.8517289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 16.9511399458
MESH:D009421 Nervous System Malformations Estradiol 16.9516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.9514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.966679447
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 5.069802331
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.504026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.153988306
MESH:D010051 Ovarian Neoplasms Estradiol 2.2419401270
MESH:D010190 Pancreatic Neoplasms Ethanol 2.9912384795
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.597296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.606228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.3014722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.7716977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 17.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 17.0617132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.0611399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.9720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 3.3115846301 17136230 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 3.3116740699
MESH:D011537 Pruritus Ethinyl Estradiol 3.4315861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.433692021
MESH:D012640 Seizures Ethanol 3.229754883
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0816192470
MESH:D013088 Spermatocele Diethylstilbestrol 12.1716002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 12.1716709447
MESH:D013274 Stomach Neoplasms Ethanol 2.3018456281
MESH:D013276 Stomach Ulcer Ethanol 3.619211565 17918041 16755016 11906479 9562338 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.339754883
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.951399818 6587162 3712494 7505956 6582329
MESH:D013978 Tibial Fractures Estradiol 4.8219048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.288074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 5.2816712894 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.1116175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.3014652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 9.7915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 9.7914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.5416002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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