AutismKB 2.0

Annotation Detail for VGLL3


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Basic Information Top
Gene Symbol:VGLL3 ( DKFZp686O1845,FLJ38507,VGL-3,VGL3 )
Gene Full Name: vestigial like 3 (Drosophila)
Band: 3p12.1
Quick LinksEntrez ID:389136; OMIM: 609980; Uniprot ID:VGLL3_HUMAN; ENSEMBL ID: ENSG00000206538; HGNC ID: 24327
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of VGLL3 proteinaffects expression 20106945
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of VGLL3 mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in decreased expression of VGLL3 mRNAdecreases expression 20106945
D005492 Folic Acid Folic Acid affects the expression of VGLL3 mRNAaffects expression 17320366
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Folic Acid 4.7517003819 16316344 16595132
MESH:D000236 Adenoma Folic Acid 4.0016963246
MESH:D000544 Alzheimer Disease Folic Acid 3.1117116317
MESH:D001321 Autistic Disorder Folic Acid 2.8121388746
MESH:D001943 Breast Neoplasms Folic Acid 3.1316777985
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.3416124888 15673190 16011737 10355542 16227642 16097048 18705752 15721981 16192424 15700767 16050911 3786805
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 3.2021507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.2018788625
MESH:D002318 Cardiovascular Diseases Folic Acid 4.2116755160
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.7912371664
MESH:D002779 Cholestasis Cyclosporine 3.2119486331
MESH:D002971 Cleft Lip Folic Acid 4.1521254359
MESH:D002972 Cleft Palate Folic Acid 3.7021254359 8946559
MESH:D015179 Colorectal Neoplasms Folic Acid 2.7017116713 17245555 16985020 16963246 17087956
MESH:D003924 Diabetes Mellitus, Type 2 Folic Acid 3.2016886840
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 2.122869522 6623471 10092053 9327722 10915739 19085960 7179309 11566570 15027814 21278145 7120509 7440962 19336974 4309450 15968718 16227642 3732212 3786805 6884620 15998439 17522070 16177239
MESH:D016889 Endometrial Neoplasms Folic Acid 4.2517301261
MESH:D017889 Exfoliation Syndrome Folic Acid 6.1216504073
MESH:D005234 Fatty Liver Carbon Tetrachloride 9.1512631006 16239168 12795759 16045604 61145 17595544 19224547 15959796
MESH:D005234 Fatty Liver Cyclosporine 9.1519224547
MESH:D005355 Fibrosis Carbon Tetrachloride 10.6018705752
MESH:D005355 Fibrosis Cyclosporine 10.6012639820 12168785
MESH:D005756 Gastritis Folic Acid 5.8117171786
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.858708960
MESH:D005901 Glaucoma Folic Acid 5.5416504073
MESH:D006330 Heart Defects, Congenital Folic Acid 3.9716524890 17286298
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 5.0515720958
MESH:D006505 Hepatitis Carbon Tetrachloride 4.1019110552 19900420
MESH:D006679 HIV Seropositivity Folic Acid 6.1217209195
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.1616899240
MESH:D020138 Hyperhomocysteinemia Folic Acid 4.8616755160 16395265 16397167 16865747 16433478
MESH:D006973 Hypertension Cyclosporine 2.2110903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.6515338365
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 5.1615604871
MESH:D007674 Kidney Diseases Cyclosporine 2.548314463 10903974 18776723
MESH:D007680 Kidney Neoplasms Cyclosporine 3.0812371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 3.0017334410 16943688 11408273 17157831 16239168 11903743 21278145 16221502 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7517565644 14716833 15931870 18418968 12389079 18210741 18317297 17631135 18420326 12898905 16011737 18376398 16033810 16192424 14724832 12445421 14512876 15673190 18054572 18277467 12445418 13678700 18705752 12958196 11481614 17714472 17976157 17761835 17922224 15730626 15925388 12546737 16097048 18472094 16116963 17640975 18395095 18205269 15893842 15362042 15057751 18339082 18006644 18263696 17698563 17766677 15052691 17525996 17900296 18156304 20821823 12586293 15650968 16015684 16638106 18279442 18166357 14748882 14620537 16136751 17944888 15996030 12609069 18472332 15370692 17869086 18481824 17721639 17708605 17481882 17557913 16027843 18187930 18251166 17805973 18412020 15338365 15876570 12632512 15959796 18429990 15123356 17823541 14716496 18395914 10355542 12649538 12632514 12667390 12666154 15818738 16248980 12741479
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.6816964402 15720792 16246199 15830285 17285989
MESH:D008107 Liver Diseases Folic Acid 4.6816877991
MESH:D017093 Liver Failure Carbon Tetrachloride 4.7315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0814706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 5.0315890375 9163691 18177683 2125692
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 5.0319294768
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.768603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.7612014681 15583823
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8814755239
MESH:D008180 Lupus Erythematosus, Systemic Folic Acid 3.4217718048
MESH:D019767 Maxillofacial Abnormalities Folic Acid 6.3316832597
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.5116801185
MESH:D009402 Nephrosis, Lipoid Cyclosporine 5.1617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.6518481113 19348381
MESH:D009436 Neural Tube Defects Folic Acid 4.1917438019
MESH:D009503 Neutropenia Folic Acid 4.9716322990
MESH:D011230 Precancerous Conditions Cyclosporine 3.5912371664
MESH:D011565 Psoriasis Cyclosporine 2.3316882103
MESH:D051437 Renal Insufficiency Folic Acid 5.3415728788
MESH:D012559 Schizophrenia Folic Acid 2.9316641680
MESH:D012871 Skin Diseases Folic Acid 3.3218709164
MESH:D013118 Spinal Cord Diseases Folic Acid 6.1216361298
MESH:D013274 Stomach Neoplasms Folic Acid 2.7017171786
MESH:D020521 Stroke Folic Acid 4.6516517955
MESH:D014605 Uveitis Cyclosporine 4.711336536
MESH:D014985 Xerophthalmia Cyclosporine 5.1617120751
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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