Annotation Detail for IYD
Basic Information Top
| Gene Symbol: | IYD ( C6orf71,DEHAL1,TDH4,dJ422F24.1 ) |
|---|---|
| Gene Full Name: | iodotyrosine deiodinase |
| Band: | 6q25.1 |
| Quick Links | Entrez ID:389434; OMIM: 612025; Uniprot ID:IYD1_HUMAN; ENSEMBL ID: ENSG00000009765; HGNC ID: 21071 |
| Relate to Another Database: | SFARIGene; denovo-db |
| No data |
| No data |
| Pathway ID | Pathway Name |
|---|---|
| Hormone biosynthesis | |
| Metabolism of amino acids and derivatives |
| No data |
| No data |
| No data |
| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000082 | Acetaminophen | Acetaminophen affects the expression of IYD mRNA | affects expression | 17562736 |
| D016572 | Cyclosporine | Cyclosporine results in decreased expression of IYD mRNA | decreases expression | 20106945 |
| D014284 | Triiodothyronine | Triiodothyronine results in increased expression of IYD mRNA | increases expression | 19228888 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000799 | Angioedema | Acetaminophen | 4.71 | 10982225 | |
| MESH:D001321 | Autistic Disorder | Acetaminophen | 1.39 | 18445737 | |
| MESH:D006528 | Carcinoma, Hepatocellular | Acetaminophen | 1.41 | 3084413 | |
| MESH:D002386 | Cataract | Acetaminophen | 2.81 | 10977129 | |
| MESH:D002471 | Cell Transformation, Neoplastic | Cyclosporine | 2.82 | 12371664 | |
| MESH:D002779 | Cholestasis | Cyclosporine | 3.24 | 19486331 | |
| MESH:D056486 | Drug-Induced Liver Injury | Acetaminophen | 1.68 | 14550746 10774834 12540782 12153990 19739265 16393943 14986274 17562736 16109766 19164858 16781746 12594235 18071297 11739529 12705907 11743745 16227642 19085960 17906064 16485898 16177239 19420014 11834606 18713872 11287661 15968718 11461765 2444490 17522070 12392966 16081117 19923254 11529661 19370779 11421492 15619225 14725611 10663392 19416960 12958197 10915739 | |
| MESH:D056487 | Drug-Induced Liver Injury, Chronic | Acetaminophen | 4.96 | 19426721 | |
| MESH:D005234 | Fatty Liver | Cyclosporine | 3.34 | 19224547 | |
| MESH:D005355 | Fibrosis | Cyclosporine | 3.79 | 12639820 12168785 | |
| MESH:D005756 | Gastritis | Acetaminophen | 4.54 | 16983495 | |
| MESH:D005885 | Gingival Hyperplasia | Cyclosporine | 4.96 | 8708960 | |
| MESH:D006457 | Hemoglobinuria, Paroxysmal | Cyclosporine | 5.16 | 15720958 | |
| MESH:D006930 | Hyperalgesia | Acetaminophen | 3.06 | 16870215 | |
| MESH:D006973 | Hypertension | Cyclosporine | 2.23 | 10903974 | |
| MESH:D007638 | Keratoconjunctivitis Sicca | Cyclosporine | 5.31 | 15604871 | |
| MESH:D007674 | Kidney Diseases | Acetaminophen | 6.55 | 12587719 15629191 | |
| MESH:D007674 | Kidney Diseases | Cyclosporine | 6.55 | 18776723 10903974 8314463 | |
| MESH:D007680 | Kidney Neoplasms | Cyclosporine | 3.12 | 12371664 | |
| MESH:D008107 | Liver Diseases | Acetaminophen | 1.71 | 16611625 19014921 12587719 19460945 16610002 12969438 11587558 19784758 | |
| MESH:D017114 | Liver Failure, Acute | Acetaminophen | 3.68 | 16871587 17185352 | |
| MESH:D008546 | Melanoma, Experimental | Acetaminophen | 4.22 | 19513568 | |
| MESH:D008664 | Metal Metabolism, Inborn Errors | Cyclosporine | 5.65 | 16801185 | |
| MESH:D009402 | Nephrosis, Lipoid | Cyclosporine | 5.31 | 17954296 | |
| MESH:D009404 | Nephrotic Syndrome | Cyclosporine | 3.70 | 19348381 18481113 | |
| MESH:D019636 | Neurodegenerative Diseases | Acetaminophen | 3.26 | 18514411 | |
| MESH:D010146 | Pain | Acetaminophen | 2.77 | 16870215 | |
| MESH:D011230 | Precancerous Conditions | Cyclosporine | 3.64 | 12371664 | |
| MESH:D011565 | Psoriasis | Cyclosporine | 2.34 | 16882103 | |
| OMIM:274800 | THYROID DYSHORMONOGENESIS 4 | marker/mechanism | |||
| MESH:D014581 | Urticaria | Acetaminophen | 3.50 | 10982225 | |
| MESH:D014605 | Uveitis | Cyclosporine | 4.85 | 1336536 | |
| MESH:D014985 | Xerophthalmia | Cyclosporine | 5.31 | 17120751 |
| Pathway ID | Pathway Name |
|---|---|
| REACT:15314 | Hormone biosynthesis |
| REACT:13 | Metabolism of amino acids and derivatives |