AutismKB 2.0

Annotation Detail for IER5L


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Basic Information Top
Gene Symbol:IER5L ( MGC70833,bA247A12.2 )
Gene Full Name: immediate early response 5-like
Band: 9q34.11
Quick LinksEntrez ID:389792; OMIM: NA; Uniprot ID:IER5L_HUMAN; ENSEMBL ID: ENSG00000188483; HGNC ID: 23679
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of IER5L mRNAdecreases expression 19933214
D000082 Acetaminophen Acetaminophen affects the expression of IER5L mRNAaffects expression 17562736
C006632 arsenic trioxide arsenic trioxide results in decreased expression of IER5L mRNAdecreases expression 20458559
C006780 bisphenol A bisphenol A affects the expression of IER5L mRNAaffects expression 20170705
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of IER5L mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of IER5L mRNAaffects expression 20170705
D011374 Progesterone Progesterone results in increased expression of IER5L mRNAincreases expression 18037150
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of IER5L mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of IER5L mRNAdecreases expression 19933214
C024746 tobacco tar tobacco tar results in decreased expression of IER5L mRNAdecreases expression 19559774
C025643 vinclozolin vinclozolin results in decreased expression of IER5L mRNAdecreases expression 18042343
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D000230 Adenocarcinoma arsenic trioxide 4.4119825857 11798837
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.4114692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001008 Anxiety Disorders vinclozolin 3.7819015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 9.5416206674
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.5412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D001862 Bone Resorption bisphenol A 4.0311985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.6017868700
MESH:D001930 Brain Injuries Progesterone 4.4715665606 15845082 15380490
MESH:D001943 Breast Neoplasms bisphenol A 1.8917123778
MESH:D001943 Breast Neoplasms Progesterone 1.8915562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.8920435547
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.5111589617
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9915673190 18705752 15721981 16192424 15700767 16050911 16227642 10355542 3786805 16097048 16011737 16124888
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.683084413
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 4.6815553829 16217749 11135700 14691202 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6818788625
MESH:D002278 Carcinoma in Situ bisphenol A 5.2317123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.1419014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.2812490120
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518670907 16120746 18850075
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic tobacco tar 4.0619559774
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0011677210 17681005 17333356 16105132 17110522 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615340226 15668235 8697196 12621046 16354765
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 4.3812609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 2.5110525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5110048152 20055451 15322242
MESH:D003456 Cryptorchidism vinclozolin 4.5414966744
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.2815213294
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003929 Diabetic Neuropathies Progesterone 4.7117187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3911461765 19370779 19085960 17562736 14986274 16485898 12705907 12540782 16227642 2444490 14725611 10663392 16109766 19164858 19739265 14550746 16081117 11743745 18071297 19923254 11421492 11739529 17906064 16393943 16781746 12594235 10915739 18713872 19416960 11529661 11834606 12153990 15968718 15619225 12958197 12392966 11287661 19420014 17522070 10774834 16177239
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.3915027814 9327722 11566570 16177239 6623471 16227642 15998439 19085960 10092053 4309450 7120509 7440962 6884620 17522070 7179309 3732212 3786805 2869522 19336974 21278145 10915739 15968718
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.3920420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 9.7017692515
MESH:D004715 Endometriosis Progesterone 9.4716134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.4710568697 9294722
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.3412903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver arsenic trioxide 14.1415073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 14.1412631006 19224547 15959796 17595544 12795759 16239168 61145 16045604
MESH:D005234 Fatty Liver Ethinyl Estradiol 14.1415345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005355 Fibrosis Carbon Tetrachloride 9.3318705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3320067830
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.4616904648
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.1716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.5716417039
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1112621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.318697196 16959395 15340226 16354765 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.6215869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0317937319
MESH:D007248 Infertility, Male vinclozolin 7.0316467254
MESH:D007249 Inflammation Progesterone 5.2515869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.2512200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 3.3916393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2912587719 15629191
MESH:D007938 Leukemia arsenic trioxide 2.9115070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.9712560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.5416972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.5514633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 3.9319077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1616467208 16968895 20471514 19850784 17050201
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.3216330433 15336539 17649720 15622746 19035177 17869043 16823087 16331271 9834237 17217047 15213294 12018890 16112521 19225113 17107899 11161223 19642359 12679006 16891316 15748426 11468182 16966277 19075265 17712046 12712474
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.5516882451
MESH:D007984 Leydig Cell Tumor vinclozolin 4.9716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8911408273 16239168 16943688 16221502 17157831 17334410 17174718 11903743 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3318054572 17714472 16136751 17557913 12649538 17708605 17869086 15338365 17481882 18412020 18472094 17805973 12389079 18395914 12445418 15931870 14512876 18376398 18006644 16248980 17698563 17823541 14620537 12666154 15370692 18277467 15925388 15673190 17631135 18251166 17525996 14748882 18418968 14716496 18420326 12546737 12667390 15730626 17640975 18472332 15959796 12632514 18705752 12898905 17900296 18210741 18156304 16638106 18205269 17922224 12586293 16015684 17944888 15893842 15052691 15876570 18339082 16011737 20821823 17761835 18429990 12632512 10355542 16116963 12609069 15650968 15362042 17721639 18395095 12741479 15996030 14716833 16097048 18263696 14724832 17976157 15057751 18166357 18187930 15123356 12958196 15818738 18481824 17766677 12445421 18279442 16027843 16033810 18317297 16192424 13678700 17565644 11481614
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3312878042
MESH:D008107 Liver Diseases Acetaminophen 4.0319784758 16611625 12969438 11587558 19460945 12587719 19014921 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316246199 16964402 15830285 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9516899240 14706259
MESH:D008113 Liver Neoplasms arsenic trioxide 7.7414682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7419294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7416984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 10.4120377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.4112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.4112151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.4815213294
MESH:D008175 Lung Neoplasms arsenic trioxide 2.3419825857 11798837
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3419555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 2.9717203775 11408345
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D009101 Multiple Myeloma arsenic trioxide 3.2219417148 14977855 11468182 19549372 15949261
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.9418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.2316105982 16882451
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1612213967
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.1616624393
MESH:D009421 Nervous System Malformations bisphenol A 10.2516427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.2514600291
MESH:D009436 Neural Tube Defects arsenic trioxide 3.2210525206
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D010049 Ovarian Diseases bisphenol A 5.2311985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 5.1019769630 16624393 12452020
MESH:D010051 Ovarian Neoplasms Progesterone 5.1017393432 16525653
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.5815580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010235 Paraganglioma arsenic trioxide 4.3519927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 17.7010548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 17.7011222880 11118676 11896295 11399792
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 17.7019015723 18220299 18042343
MESH:D011469 Prostatic Diseases vinclozolin 5.1718220299
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3820887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.3019131511
MESH:D011471 Prostatic Neoplasms bisphenol A 3.3016740699
MESH:D011472 Prostatitis vinclozolin 5.1718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D011629 Puberty, Precocious bisphenol A 5.0210548101
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.9118045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.1616646077
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1116192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013119 Spinal Cord Injuries Progesterone 4.5215862959 16503802
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D019966 Substance-Related Disorders bisphenol A 4.2216045194 16684133
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 3.2219014326
MESH:D016171 Torsades de Pointes arsenic trioxide 4.2015213294
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 2.5312845720 20435036 12973940 11780464
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014591 Uterine Diseases bisphenol A 5.2714652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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