AutismKB 2.0

Annotation Detail for LAMA2


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Basic Information Top
Gene Symbol:LAMA2 ( LAMM )
Gene Full Name: laminin, alpha 2
Band: 6q22.33
Quick LinksEntrez ID:3908; OMIM: 156225; Uniprot ID:LAMA2_HUMAN; ENSEMBL ID: ENSG00000196569; HGNC ID: 6482
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC)
hsa05414Dilated cardiomyopathy
hsa05416Viral myocarditis
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Integrin cell surface interactions
No data
No data
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1832Congenital abnormality
2001Mental retardation
2115Muscular dystrophies
Desease Name
Leprosy
tuberculoid type of leprosy
INFECTION
Desease Name
Body mass index
Desease Name
Muscular dystrophy, congenital, due to partial LAMA2 deficiency
Muscular dystrophy, congenital merosin-deficient
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of LAMA2 mRNAdecreases expression 15982314
C103303 alitretinoin alitretinoin results in decreased expression of LAMA2 mRNAdecreases expression 15982314
D001149 Arsenates [Atrazine co-treated with Arsenates] results in increased expression of LAMA2 mRNAaffects cotreatment|increases expression 18585445
D001280 Atrazine [Atrazine co-treated with Arsenates] results in increased expression of LAMA2 mRNAaffects cotreatment|increases expression 18585445
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LAMA2 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of LAMA2 mRNAdecreases expression 17557909
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of LAMA2 geneincreases mutagenesis 16724327
D015735 Mifepristone Mifepristone results in decreased expression of LAMA2 mRNAdecreases expression 17584828
D008942 Mitoxantrone LAMA2 mRNA affects the susceptibility to Mitoxantroneaffects response to substance 16044152
D009151 Mustard Gas Mustard Gas results in decreased expression of LAMA2 mRNAdecreases expression 15674843
D015474 Isotretinoin Isotretinoin results in decreased expression of LAMA2 mRNAdecreases expression 15982314
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LAMA2 mRNAincreases expression 17586704
D014212 Tretinoin Tretinoin metabolite results in decreased expression of LAMA2 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of LAMA2 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of LAMA2 mRNAdecreases expression 16604517
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 9.0918769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.0914514962 15322242 11752688
MESH:D000015 Abnormalities, Multiple Isotretinoin 5.0618769834
MESH:D017486 Acneiform Eruptions Isotretinoin 6.4216232082
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 12.4517505938
MESH:D000152 Acne Vulgaris Isotretinoin 12.4516185265 18769834
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8314692618
MESH:D000236 Adenoma Ethylnitrosourea 3.766695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.4916835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.3411874814
MESH:D000505 Alopecia Tretinoin 3.6815955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.0211748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.3715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.3716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2816292516
MESH:D001249 Asthma Mustard Gas 5.0610378619
MESH:D001249 Asthma Tretinoin 5.0616456186
MESH:D001471 Barrett Esophagus Tretinoin 4.5016935849
MESH:D001768 Blister Mustard Gas 5.2819167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.2112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.2116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8115746008
MESH:D001927 Brain Diseases Ethylnitrosourea 4.9614991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.3718412241 16357521 16651633 15144691 16436596
MESH:D001943 Breast Neoplasms alitretinoin 1.9516344269
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9516873071 16166294 16443354
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2815286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.1117687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.7116813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.8815673190 18705752 16227642 16124888 15700767 16192424 15721981 10355542 16050911 16097048 3786805 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8616835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.2916168501
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.0718788625
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.071917145
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 5.1411237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.1416096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4118670907 18850075 16120746
MESH:D002386 Cataract Tretinoin 3.1417460283
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.7816003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.1217160924
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.7116129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9316919318 16105132 17110522 17681005 11677210 17333356 15861022
MESH:D002822 Choriocarcinoma Tretinoin 5.2916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.8715668235 8697196 16354765 15340226 12621046
MESH:D002972 Cleft Palate Tretinoin 5.879407595
MESH:D003092 Colitis Tretinoin 3.8117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1317141729 14669216
MESH:D019465 Craniofacial Abnormalities Isotretinoin 3.9518769834 9879862
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.9515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.959224671 10589399 9125849 17551590 8800419 16925845 9211117 9664655 9142499 14991402
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 3.7916227642 6884620 7440962 10092053 10915739 7120509 21278145 16177239 9327722 19336974 4309450 7179309 2869522 15998439 15968718 6623471 17522070 19085960 11566570 3732212 3786805 15027814
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.7920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8211462148
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.1218357618
MESH:D004487 Edema Mustard Gas 7.1111428647 11402378 9260866 11428631
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.1111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.4015322242 18230668 16714409
MESH:D004489 Edema, Cardiac Tretinoin 12.4018230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2812538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.1616569247
MESH:D004715 Endometriosis Mifepristone 9.4116134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 9.419294722 10568697
MESH:D004890 Erythema Mustard Gas 5.289357497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.0411564622
MESH:D005124 Eye Abnormalities Tretinoin 9.0416938888 9664655
MESH:D005234 Fatty Liver Carbon Tetrachloride 7.9619224547 15959796 16045604 12631006 61145 12795759 17595544 16239168
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9615345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5611858732
MESH:D005355 Fibrosis Carbon Tetrachloride 15.3918705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 15.3920067830
MESH:D005355 Fibrosis Tretinoin 15.3917994277
MESH:D005909 Glioblastoma Ethylnitrosourea 7.5916436596
MESH:D005909 Glioblastoma Tretinoin 7.5917312396
MESH:D005910 Glioma Ethylnitrosourea 3.5218412241 16357521 16651633
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.7310696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.2916084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.6711294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 6.679664655 14991402
MESH:D006331 Heart Diseases Mitoxantrone 4.2116019553
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.4211000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.6919900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.0012621046 15340226 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.188697196 16959395 15340226 18606429 16354765
MESH:D006930 Hyperalgesia Tretinoin 3.2816870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6516899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.6716778211
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9318850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.1915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 3.9116569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5512013081
MESH:D007248 Infertility, Male Atrazine 7.0912948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.0917937319
MESH:D007249 Inflammation Mustard Gas 5.1811428620 11402378 8975870 9260866 17524151 9357497 16001271 11428631 11428647
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.1812200463 12878042
MESH:D007410 Intestinal Diseases Tretinoin 3.8717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.2116580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.2115992940 17551590
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.7516144296
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.0017379185
MESH:D007938 Leukemia Tretinoin 2.8117143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Mitoxantrone 3.8218172266
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7816482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0919850784 16294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2015748426 17294898 17217047 16823087 16935935 16788101 12679006 16891316 17368321 9834237 16331271 17712046 17649720 19035177 17301526 19642359 19225113 17361223 16140955 19075265 16766008 17107899 19029980 17339181 17506722
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.369224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8516943688 16221502 11903743 21278145 11408273 17157831 16239168 17334410 17174718
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5018339082 17805973 18429990 17761835 15123356 17823541 15362042 15925388 16027843 17698563 16116963 12632514 18705752 14620537 15057751 18006644 14724832 17714472 18156304 16638106 15996030 15818738 12958196 15730626 13678700 15370692 15650968 18205269 18263696 17922224 15893842 17721639 16097048 18210741 12741479 15673190 17481882 12898905 11481614 15338365 20821823 18279442 18395095 18472094 16033810 16015684 15876570 17708605 18187930 12445418 12586293 18412020 15052691 18251166 17766677 18277467 15959796 16248980 17640975 18395914 12445421 12389079 17525996 18472332 18481824 12649538 17900296 17869086 18166357 18054572 12667390 18376398 18420326 14716496 12609069 17557913 18418968 10355542 14716833 14512876 12632512 15931870 16192424 12546737 17631135 12666154 16011737 14748882 17565644 17976157 18317297 16136751 17944888
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.5018397230 16248980
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1017285989 16964402 15830285 15720792 16246199
MESH:D017093 Liver Failure Carbon Tetrachloride 4.2715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7716899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.4919294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.4916984957
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 5.9212014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 5.9212151625
MESH:D008171 Lung Diseases Mustard Gas 3.5018702808 18161513
MESH:D008175 Lung Neoplasms alitretinoin 6.7416413115
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.7416271038 6695378 16019985 17703301
MESH:D008175 Lung Neoplasms Isotretinoin 6.7415899809
MESH:D008175 Lung Neoplasms Mustard Gas 6.748781369 3148597
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.7419555203 11884234
MESH:D008223 Lymphoma Ethylnitrosourea 4.0015790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.1515375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.5610838139 10767621 18041768
MESH:D008527 Medulloblastoma Tretinoin 2.8117453147
MESH:D008545 Melanoma Isotretinoin 3.7617237267
MESH:D008545 Melanoma Tretinoin 3.7616752155
MESH:D008579 Meningioma Ethylnitrosourea 6.1217943659
MESH:D008591 Meningomyelocele Tretinoin 4.5316940565
MESH:D008654 Mesothelioma Atrazine 3.561916698
MESH:D009136 Muscular Dystrophies marker/mechanism 18074402
OMIM:607855 MUSCULAR DYSTROPHY, CONGENITAL MEROSIN-DEFICIENT, 1A marker/mechanism
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1217596541
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0812213967
MESH:D009369 Neoplasms alitretinoin 8.7616946489
MESH:D009369 Neoplasms Mitoxantrone 8.7616640825
MESH:D009369 Neoplasms Tretinoin 8.7616946489 16594593
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.5016707424
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.8314600291
MESH:D009421 Nervous System Malformations Tretinoin 9.839125849
MESH:D009436 Neural Tube Defects Tretinoin 3.109142499
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.5316003739 17160924 16651423
MESH:D009447 Neuroblastoma Isotretinoin 4.0817368321
MESH:D009503 Neutropenia Mustard Gas 4.067688884 16761898
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.1217160924
MESH:D010051 Ovarian Neoplasms Mifepristone 5.2216525653
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2216936753
MESH:D010146 Pain Tretinoin 2.9716870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.4915976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7711578682
MESH:D010300 Parkinson Disease Atrazine 3.3017218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3812520081
MESH:D011041 Poisoning Mustard Gas 3.8815727166
MESH:D017499 Porokeratosis alitretinoin 6.1416144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6518163543
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 10.2518769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.2511118676 11399792 11222880 11896295
MESH:D011507 Proteinuria Tretinoin 3.6916636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.9215861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.9218058305
MESH:D011596 Psychomotor Disorders Isotretinoin 6.0318769834
MESH:D011625 Pterygium Tretinoin 4.9116723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9510334151 17266442 17620002 17894541 17720292
MESH:D012135 Respiratory Sounds Atrazine 4.6211874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9318990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1916283617 16116481
MESH:D012871 Skin Diseases Mustard Gas 2.7316961503 12880345 15451306
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.6816192470
MESH:D012878 Skin Neoplasms Tretinoin 5.6816467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0816709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.7111994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2215669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.2815790496
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0412697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.0916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.8616051514
MESH:D014376 Tuberculosis Tretinoin 3.2716040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.7516129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3914692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.7416752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.7312125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.6214671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.1516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3815886252
MESH:D009396 Wilms Tumor Tretinoin 4.0416287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
KEGG:05414 Dilated cardiomyopathy
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05410 Hypertrophic cardiomyopathy (HCM)
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
KEGG:05416 Viral myocarditis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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