AutismKB 2.0

Annotation Detail for LAMA3


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Basic Information Top
Gene Symbol:LAMA3 ( BM600,E170,LAMNA,LOCS,lama3a )
Gene Full Name: laminin, alpha 3
Band: 18q11.2
Quick LinksEntrez ID:3909; OMIM: 600805; Uniprot ID:LAMA3_HUMAN; ENSEMBL ID: ENSG00000053747; HGNC ID: 6483
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Cell junction organization
Pathway IDPathway Name
200164Syndecan-2-mediated signaling events
200115Syndecan-4-mediated signaling events
200044Validated transcriptional targets of AP1 family members Fra1 and Fra2
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1990Skin disease, Genetic
1860Brain tumor
1944Breast cancer
2066Lung cancer
No data
No data
Desease Name
Laryngoonychocutaneous syndrome
Epidermolysis bullosa, junctional, Herlitz type
Epidermolysis bullosa, generalized atrophic benign
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of LAMA3 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of LAMA3 mRNAaffects expression 21346803
C002202 4-oxoretinoic acid 4-oxoretinoic acid results in decreased expression of LAMA3 mRNAdecreases expression 15982314
C103303 alitretinoin alitretinoin results in decreased expression of LAMA3 mRNAdecreases expression 15982314
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LAMA3 mRNAaffects expression 16483693
C006632 arsenic trioxide arsenic trioxide results in increased expression of LAMA3 mRNAincreases expression 20458559
D002251 Carbon Tetrachloride Carbon Tetrachloride results in increased expression of LAMA3 mRNAincreases expression 16644059
D016572 Cyclosporine Cyclosporine results in decreased expression of LAMA3 mRNAdecreases expression 20106945
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LAMA3 mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in increased expression of LAMA3 mRNAincreases expression 19619570
D004958 Estradiol [Progesterone co-treated with Estradiol] results in decreased expression of LAMA3 mRNAaffects cotreatment|decreases expression 17404688
C032881 lysophosphatidic acid lysophosphatidic acid results in increased expression of LAMA3 mRNAincreases expression 15541073
D008244 Lysophosphatidylcholines Lysophosphatidylcholines results in increased expression of LAMA3 mRNAincreases expression 15541073
D015735 Mifepristone Mifepristone results in decreased expression of LAMA3 mRNAdecreases expression 17584828
D009151 Mustard Gas Mustard Gas results in increased degradation of [LAMA3 protein binds to LAMB3 protein binds to LAMC2 protein]affects binding|increases degradation 18095945
C006253 pirinixic acid pirinixic acid results in decreased expression of LAMA3 mRNAdecreases expression 20059764
17426115
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in decreased expression of LAMA3 mRNA]decreases expression|increases reaction 20059764
D011374 Progesterone [Progesterone co-treated with Estradiol] results in decreased expression of LAMA3 mRNAaffects cotreatment|decreases expression 17404688
D015474 Isotretinoin Isotretinoin results in decreased expression of LAMA3 mRNAdecreases expression 15982314
C017947 sodium arsenite sodium arsenite results in increased expression of LAMA3 mRNAincreases expression 20308225
C060506 sphingosine 1-phosphate sphingosine 1-phosphate results in increased expression of LAMA3 mRNAincreases expression 15541073
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of LAMA3 mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of LAMA3 mRNAdecreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LAMA3 mRNAincreases expression 12377990
D014212 Tretinoin Tretinoin metabolite results in decreased expression of LAMA3 mRNAdecreases expression 15982314
D014212 Tretinoin Tretinoin results in decreased expression of LAMA3 mRNAdecreases expression 15982314
D014302 Trinitrobenzenesulfonic Acid Trinitrobenzenesulfonic Acid results in increased expression of LAMA3 mRNAincreases expression 17982090
D014303 Trinitrotoluene Trinitrotoluene affects the expression of LAMA3 mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 19.367525203
MESH:D000014 Abnormalities, Drug-Induced Isotretinoin 19.3618769834
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 19.3611752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 19.367525203
MESH:D000015 Abnormalities, Multiple Isotretinoin 4.8618769834
MESH:D000138 Acidosis Ammonium Chloride 3.4318287403
MESH:D017486 Acneiform Eruptions Isotretinoin 6.1616232082
MESH:D000152 Acne Vulgaris Isotretinoin 5.3516185265 18769834
MESH:D055371 Acute Lung Injury pirinixic acid 2.9918653653
MESH:D000230 Adenocarcinoma arsenic trioxide 4.2811798837 19825857
MESH:D000230 Adenocarcinoma Estradiol 4.2811473722
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.4616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.4616835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.5715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.7717306315 16712894
MESH:D000505 Alopecia Tretinoin 3.5115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8311748828
MESH:D001169 Arthritis, Experimental Tretinoin 3.0016412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2316292516
MESH:D001249 Asthma Mustard Gas 4.8510378619
MESH:D001249 Asthma Tretinoin 4.8516456186
MESH:D001471 Barrett Esophagus Tretinoin 4.2716935849
MESH:D001768 Blister Mustard Gas 5.0319167455
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 20.9516206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 20.9519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 20.9512125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 20.9516206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.6615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6815746008
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2117868700
MESH:D001930 Brain Injuries Progesterone 4.1315665606 15845082 15380490
MESH:D001943 Breast Neoplasms alitretinoin 2.3016344269
MESH:D001943 Breast Neoplasms Estradiol 2.3017261762 17289903 19861407 12948864 14630087 16675129 17018787 18497071
MESH:D001943 Breast Neoplasms Progesterone 2.3017614352 15562024 16175315
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D001943 Breast Neoplasms Tretinoin 2.3016873071 16443354 16166294
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.0315286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.8517687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4616813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.2011589617
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.3316111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.6516011737 15721981 16124888 15673190 18705752 16227642 16097048 15700767 10355542 16050911 3786805 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6916835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0316168501
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 11.1216705839
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 11.1211135700 14691202 15553829 16217749 15073043
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 11.1218788625
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.1216924424
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.1215276417 17306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.121917145
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.7519014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.0012490120
MESH:D002294 Carcinoma, Squamous Cell Isotretinoin 7.4711237771
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 7.4718572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 7.4716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3018670907 18850075 16120746
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.1114694615
MESH:D002386 Cataract Tretinoin 12.1117460283
MESH:D002386 Cataract Trinitrotoluene 12.1114694615 15817613
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.6512371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.6518566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 10.6519524636 20056578
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4616129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.0516835633
MESH:D002779 Cholestasis Cyclosporine 7.4319486331
MESH:D002779 Cholestasis pirinixic acid 7.4319176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0316461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.5812621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 5.589407595
MESH:D003092 Colitis Tretinoin 9.3417035595
MESH:D003092 Colitis Trinitrobenzenesulfonic Acid 9.3416782535 17936198 16867261 16474422 18023891 18200517 17991707 16804969 11698051
MESH:D003093 Colitis, Ulcerative Trinitrobenzenesulfonic Acid 3.4017276891
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 14.9515095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 14.9514669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 14.9515095906
MESH:D023903 Coronary Restenosis arsenic trioxide 4.0612609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 5.3310525206
MESH:D019465 Craniofacial Abnormalities Isotretinoin 5.339879862 18769834
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 5.3310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 5.339224671 16925845 14991402 10589399 9125849 17551590 9664655 9211117 9142499 8800419
MESH:D003490 Cyanosis 2,4-dinitrotoluene 10.7918551238
MESH:D003490 Cyanosis Trinitrotoluene 10.7918551238
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.9715213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3718249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6417107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.3019279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3617187935
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 11.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.6221346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.626623471 15968718 15998439 10915739 6884620 16227642 7120509 17522070 3732212 11566570 10092053 16177239 3786805 9327722 15027814 19085960 7179309 2869522 19336974 21278145 7440962 4309450
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.6220420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 11.6218551238 21346803
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6611462148
MESH:D004487 Edema Mustard Gas 10.7311428631 11428647 11402378 9260866
MESH:D004487 Edema pirinixic acid 10.7312083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.7311000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.5118230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.5118230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 3.6517692515
MESH:D016889 Endometrial Neoplasms Estradiol 7.1319148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Tretinoin 7.1316569247
MESH:D004715 Endometriosis Mifepristone 14.6616134523
MESH:D004715 Endometriosis Progesterone 14.6616134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 14.6610568697 9294722
OMIM:226700 EPIDERMOLYSIS BULLOSA, JUNCTIONAL, HERLITZ TYPE marker/mechanism
OMIM:226650 EPIDERMOLYSIS BULLOSA, JUNCTIONAL, NON-HERLITZ TYPE marker/mechanism
MESH:D004890 Erythema Mustard Gas 5.039357497
MESH:D004938 Esophageal Neoplasms arsenic trioxide 2.2812903497
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.5111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.519664655 16938888
MESH:D005234 Fatty Liver arsenic trioxide 17.7615073043
MESH:D005234 Fatty Liver Carbon Tetrachloride 17.7615959796 16239168 12795759 16045604 12631006 19224547 17595544 61145
MESH:D005234 Fatty Liver Cyclosporine 17.7619224547
MESH:D005234 Fatty Liver pirinixic acid 17.7619236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3311858732
MESH:D005355 Fibrosis Carbon Tetrachloride 26.3618705752
MESH:D005355 Fibrosis Cyclosporine 26.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 26.3620067830
MESH:D005355 Fibrosis Tretinoin 26.3617994277
MESH:D005355 Fibrosis Trinitrobenzenesulfonic Acid 26.3617994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.1316904648
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.5516452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.098708960
MESH:D005909 Glioblastoma Tretinoin 2.9217312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.4710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1016096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0316084493
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3110048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 6.319664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.4620558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2111000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.4719110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 13.7319772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 13.7316120746 12621046 15340226
MESH:D006529 Hepatomegaly Trinitrotoluene 13.7315817613
MESH:D006558 Herpes Genitalis Estradiol 4.9015709030
MESH:D006689 Hodgkin Disease sodium arsenite 3.0412676792
MESH:D019584 Hot Flashes Estradiol 3.6217088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.928697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.1116870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4016899240
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4416778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0720558911
MESH:D006973 Hypertension Cyclosporine 4.7810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.7818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.9615338365
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2715869954
MESH:D007248 Infertility, Male sodium arsenite 6.7912646999 15346721
MESH:D007248 Infertility, Male Trinitrotoluene 6.7912150543
MESH:D007249 Inflammation Mustard Gas 7.9611428620 11428631 9260866 16001271 8975870 11402378 11428647 9357497 17524151
MESH:D007249 Inflammation Progesterone 7.9615869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.9612200463 12878042
MESH:D015212 Inflammatory Bowel Diseases Trinitrobenzenesulfonic Acid 3.5318200517
MESH:D007333 Insulin Resistance Estradiol 6.9116627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.9116306350
MESH:D007410 Intestinal Diseases Tretinoin 9.5517994277
MESH:D007410 Intestinal Diseases Trinitrobenzenesulfonic Acid 9.5517994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.5316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.5315992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.3115604871
MESH:D017492 Keratosis, Seborrheic alitretinoin 5.5116144296
MESH:D007674 Kidney Diseases Cyclosporine 9.628314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.6215618244
MESH:D007674 Kidney Diseases sodium arsenite 9.6220008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 11.7416705839
MESH:D007680 Kidney Neoplasms Cyclosporine 11.7412371664
MESH:D007680 Kidney Neoplasms Estradiol 11.7415610895
OMIM:245660 LARYNGOONYCHOCUTANEOUS SYNDROME marker/mechanism
MESH:D007938 Leukemia arsenic trioxide 6.1315070760
MESH:D007938 Leukemia Tretinoin 6.1317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 3.6717077332 12560223
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.1816972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.3314633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 9.0719077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.0716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.8019850784 16467208 20471514 17050201 16968895
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.8017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.3517869043 17649720 16330433 15213294 15336539 19075265 16331271 19035177 12018890 12712474 19225113 17107899 15748426 9834237 11468182 19642359 17217047 16112521 12679006 16823087 16966277 17712046 11161223 16891316 15622746
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.3519035177 17712046 17649720 15748426 17301526 16766008 17339181 19225113 16891316 17368321 17361223 17217047 17294898 19029980 16935935 12679006 19642359 17506722 16823087 16140955 19075265 16331271 17107899 16788101 9834237
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.2216882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.219224671
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.7416943688 16239168 11408273 17174718 21278145 11903743 17334410 16221502 17157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.5515338365 12445418 17805973 16015684 18210741 16033810 17708605 17823541 16248980 12666154 12667390 15370692 18166357 14512876 18205269 18395914 17721639 18472094 12586293 17557913 15893842 18277467 17631135 17869086 15650968 14748882 18418968 14716496 12958196 17922224 17976157 14620537 16097048 18006644 16027843 15931870 18705752 17481882 10355542 17698563 15959796 15818738 11481614 12546737 15362042 17761835 17565644 17900296 15123356 18054572 12445421 18472332 16116963 16136751 18429990 12649538 15057751 17714472 15673190 12389079 18420326 18251166 12632512 18376398 13678700 12898905 14724832 16638106 17525996 15925388 18263696 18412020 12609069 12741479 18279442 14716833 15052691 17766677 18395095 18317297 16192424 18339082 15730626 18481824 12632514 20821823 15996030 17944888 16011737 18187930 15876570 17640975 18156304
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.5514716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.5515474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.5512878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.5516248980 18397230
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.0517285989 16246199 16964402 15830285 15720792
MESH:D017093 Liver Failure Carbon Tetrachloride 4.0315123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.5714706259 16899240
MESH:D008113 Liver Neoplasms arsenic trioxide 13.7114682389
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 13.7119294768
MESH:D008113 Liver Neoplasms pirinixic acid 13.7116377806 20007298 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 13.7115276417 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 13.7116984957
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 9.3420377131
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 9.3412014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.3412151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.2515213294
MESH:D008171 Lung Diseases Mustard Gas 7.2518161513 18702808
MESH:D008171 Lung Diseases sodium arsenite 7.2519095001
MESH:D008175 Lung Neoplasms alitretinoin 8.3616413115
MESH:D008175 Lung Neoplasms arsenic trioxide 8.3619825857 11798837
MESH:D008175 Lung Neoplasms Isotretinoin 8.3615899809
MESH:D008175 Lung Neoplasms Mustard Gas 8.363148597 8781369
MESH:D008175 Lung Neoplasms sodium arsenite 8.3619931552 17306315 17077188 15276417 16712894
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.3619555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.7811807958 11408345 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 5.7817203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.3519453300
MESH:D008527 Medulloblastoma Tretinoin 2.7317453147
MESH:D008545 Melanoma Isotretinoin 5.1217237267
MESH:D008545 Melanoma sodium arsenite 5.1216487513 19082730
MESH:D008545 Melanoma Tretinoin 5.1216752155
MESH:D008591 Meningomyelocele Tretinoin 4.2916940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.6616801185
MESH:D009101 Multiple Myeloma arsenic trioxide 3.0114977855 19417148 19549372 15949261 11468182
MESH:D009135 Muscular Diseases pirinixic acid 3.3816239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.5418349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 7.1416105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.1417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.0919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.9116810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.9116411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.2418551238
MESH:D009336 Necrosis Trinitrotoluene 10.2418551238
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.8316624393
MESH:D009369 Neoplasms alitretinoin 11.3616946489
MESH:D009369 Neoplasms pirinixic acid 11.3617405874
MESH:D009369 Neoplasms sodium arsenite 11.3611559025
MESH:D009369 Neoplasms Tretinoin 11.3616946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.5420056578
MESH:D009389 Neovascularization, Pathologic Estradiol 3.6017289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.3117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1718481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 15.5916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.5914600291
MESH:D009421 Nervous System Malformations Tretinoin 15.599125849
MESH:D009436 Neural Tube Defects arsenic trioxide 11.6610525206
MESH:D009436 Neural Tube Defects sodium arsenite 11.6612854658
MESH:D009436 Neural Tube Defects Tretinoin 11.669142499
MESH:D009447 Neuroblastoma Isotretinoin 3.9817368321
MESH:D009503 Neutropenia Mustard Gas 3.857688884 16761898
MESH:D009765 Obesity pirinixic acid 1.7820558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 14.6116049721 12819281
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.6114694615
MESH:D009784 Occupational Diseases Trinitrotoluene 14.6114694615 17852074 12819281
MESH:D010051 Ovarian Neoplasms arsenic trioxide 18.3419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 18.3419401270
MESH:D010051 Ovarian Neoplasms Mifepristone 18.3416525653
MESH:D010051 Ovarian Neoplasms Progesterone 18.3416525653 17393432
MESH:D010051 Ovarian Neoplasms sodium arsenite 18.3417306315 15276417
MESH:D010051 Ovarian Neoplasms Tretinoin 18.3416936753
MESH:D010146 Pain Tretinoin 2.8016870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 5.1315580305
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1315976015
MESH:D010195 Pancreatitis Trinitrobenzenesulfonic Acid 4.0817698068
MESH:D010235 Paraganglioma arsenic trioxide 4.0419927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1212520081
MESH:D011041 Poisoning Mustard Gas 3.6715727166
MESH:D017499 Porokeratosis alitretinoin 5.8716144296
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4318163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1112371664
MESH:D011297 Prenatal Exposure Delayed Effects Isotretinoin 9.4118769834
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4111118676 11399792 11896295 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.7620887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 2.6019131511
MESH:D011471 Prostatic Neoplasms Estradiol 2.6016740699
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6016039940
MESH:D011507 Proteinuria Tretinoin 3.4816636307
MESH:D011537 Pruritus Mustard Gas 3.9618058305
MESH:D011565 Psoriasis Cyclosporine 2.1816882103
MESH:D011596 Psychomotor Disorders Isotretinoin 5.7918769834
MESH:D011625 Pterygium Tretinoin 4.6616723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.8817720292 17894541 10334151 17266442 17620002
MESH:D015427 Reperfusion Injury pirinixic acid 2.3219058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7118990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9816116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8118045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.8316646077
MESH:D012640 Seizures 2,4-dinitrotoluene 5.9018551238
MESH:D012640 Seizures Trinitrotoluene 5.9018551238
MESH:D012871 Skin Diseases Mustard Gas 2.6815451306 12880345 16961503
MESH:D012878 Skin Neoplasms sodium arsenite 9.0719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.0716192470
MESH:D012878 Skin Neoplasms Tretinoin 9.0716467112
MESH:D013119 Spinal Cord Injuries Progesterone 4.1516503802 15862959
MESH:D016135 Spinal Dysraphism sodium arsenite 3.6912854658
MESH:D013163 Splenomegaly Trinitrotoluene 5.0715817613
MESH:D013274 Stomach Neoplasms arsenic trioxide 2.4217007042
MESH:D013274 Stomach Neoplasms Tretinoin 2.4217261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.7712697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 6.8819014326
MESH:D013964 Thyroid Neoplasms Tretinoin 6.8817045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.5619048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6716051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.8315213294
MESH:D014376 Tuberculosis Tretinoin 3.1516040207
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.0416049721
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 8.0412973940 12845720 11780464 20435036
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.0416452187 17306315 11723127 16712894
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.1810091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 9.0211813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 9.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.4816752155
MESH:D014605 Uveitis Cyclosporine 3.851336536
MESH:D014652 Vascular Diseases sodium arsenite 4.2917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.4712125929
MESH:D014820 Vitiligo Tretinoin 3.9316761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1215886252
MESH:D009396 Wilms Tumor Tretinoin 3.8516287080
MESH:D014947 Wounds and Injuries therapeutic 15541073
MESH:D014947 Wounds and Injuries lysophosphatidic acid 14.3415541073
MESH:D014947 Wounds and Injuries Lysophosphatidylcholines 14.3415541073
MESH:D014947 Wounds and Injuries sphingosine 1-phosphate 14.3415541073
MESH:D014985 Xerophthalmia Cyclosporine 4.3117120751
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
REACT:20676 Cell junction organization
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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