AutismKB 2.0

Annotation Detail for FRRS1


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Basic Information Top
Gene Symbol:FRRS1 ( SDFR2,SDR2 )
Gene Full Name: ferric-chelate reductase 1
Band: 1p21.2
Quick LinksEntrez ID:391059; OMIM: 611578; Uniprot ID:FRRS1_HUMAN; ENSEMBL ID: ENSG00000156869; HGNC ID: 27622
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of FRRS1 mRNAaffects expression 17562736
D004041 Dietary Fats Dietary Fats results in decreased expression of FRRS1 mRNAdecreases expression 18042831
C041786 palm oil palm oil results in decreased expression of FRRS1 mRNAdecreases expression 18042831
D010634 Phenobarbital Phenobarbital affects the expression of FRRS1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid affects the expression of FRRS1 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of FRRS1 mRNAdecreases expression 17426115
C006253 pirinixic acid pirinixic acid results in increased expression of FRRS1 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.986195326
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell Phenobarbital 11.9817620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 11.9816434500
MESH:D000799 Angioedema Acetaminophen 4.4510982225
MESH:D001161 Arteriosclerosis Dietary Fats 4.3715238619
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.2520435547
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.013084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 3.0117173139 6705139 1701930 20935162 20007298
MESH:D002386 Cataract Acetaminophen 2.7710977129
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.744080065
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6616485898 18071297 10774834 17906064 19923254 12958197 15619225 14986274 12153990 19164858 12540782 11421492 12392966 15968718 10663392 11287661 16393943 19085960 18713872 19739265 2444490 16227642 19370779 16177239 17562736 10915739 14550746 19416960 11529661 19420014 16781746 12594235 14725611 11834606 11739529 16081117 12705907 17522070 11743745 11461765 16109766
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.7119426721
MESH:D050171 Dyslipidemias Dietary Fats 3.7018367378
MESH:D004421 Dystonia Phenobarbital 4.411851702
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.593659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.4811558140 3922381
MESH:D004827 Epilepsy Phenobarbital 3.0420417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.876401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.747750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.563659116
MESH:D005234 Fatty Liver Dietary Fats 8.9619004024 17967931 19551842 18296743
MESH:D005234 Fatty Liver pirinixic acid 8.9620131406 19236843
MESH:D005355 Fibrosis Dietary Fats 4.0118296743
MESH:D005756 Gastritis Acetaminophen 4.2916983495
MESH:D006333 Heart Failure pirinixic acid 2.7320558911
MESH:D006529 Hepatomegaly Phenobarbital 10.1416109766
MESH:D006529 Hepatomegaly pirinixic acid 10.1419176532 16221962 19772884 18467677
MESH:D006930 Hyperalgesia Acetaminophen 2.9916870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.9721332399
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D006949 Hyperlipidemias Dietary Fats 4.0221332399
MESH:D007249 Inflammation Dietary Fats 2.5920412841
MESH:D007333 Insulin Resistance Dietary Fats 7.9711836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 7.9716306350
MESH:D007674 Kidney Diseases Acetaminophen 2.3815629191 12587719
MESH:D008103 Liver Cirrhosis Dietary Fats 7.2418296743
MESH:D008103 Liver Cirrhosis Phenobarbital 7.2421047994
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3515474484
MESH:D008107 Liver Diseases Acetaminophen 4.1711587558 19014921 16610002 12969438 12587719 19784758 16611625 19460945
MESH:D008107 Liver Diseases Phenobarbital 4.1719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5816871587 17185352
MESH:D008113 Liver Neoplasms Phenobarbital 4.8319812893 21047994 15975961 19482888 19073162 8742319
MESH:D008113 Liver Neoplasms pirinixic acid 4.8320007298 16377806 15890375
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.906150874 18308698 2563599 17172636 1399818
MESH:D008546 Melanoma, Experimental Acetaminophen 4.0519513568
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 5.0217484760
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1818514411
MESH:D009765 Obesity Dietary Fats 4.6718674790 17217161 16723640 21332399 20518802 20132043 11836018 19632207 18457598
MESH:D009765 Obesity pirinixic acid 4.6720558911
MESH:D010018 Osteomalacia Phenobarbital 4.9017016548
MESH:D010146 Pain Acetaminophen 2.6916870215
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5916965848
MESH:D011230 Precancerous Conditions Phenobarbital 3.952563599
MESH:D019310 Pseudolymphoma Phenobarbital 5.1112752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures Phenobarbital 2.9211442880 3137016 4039156 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 5.366407741
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.321399818
MESH:D014581 Urticaria Acetaminophen 3.3810982225
MESH:D015430 Weight Gain Dietary Fats 4.0616723640
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA142670941
    • No data
    Releated disease ID Related disease Name
    PA447216Schizophrenia
    No data
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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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