AutismKB 2.0

Annotation Detail for LAMA5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LAMA5 ( KIAA1907 )
Gene Full Name: laminin, alpha 5
Band: 20q13.33
Quick LinksEntrez ID:3911; OMIM: 601033; Uniprot ID:LAMA5_HUMAN; ENSEMBL ID: ENSG00000130702; HGNC ID: 6485
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Integrin cell surface interactions
Pathway IDPathway Name
200134Syndecan-1-mediated signaling events
No data
Pathway IDPathway Name
500004Integrin cell surface interactions
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1831Prostate cancer
1832Congenital abnormality
1860Brain tumor
2022Liver cancer
2051Leukemia
2052Infection
2074Asthma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of LAMA5 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of LAMA5 mRNAaffects expression 17562736
D013196 Dihydrotestosterone Dihydrotestosterone results in increased expression of LAMA5 mRNAincreases expression 17023530
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of LAMA5 mRNAdecreases expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of LAMA5 mRNAdecreases expression 15336504
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LAMA5 mRNAaffects expression 17484886
D016047 Zalcitabine [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 18606552
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 18164116
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 17942748
D006072 Gossypol [zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNAaffects cotreatment|decreases expression 19825521
C514793 gp120 protein, Human immunodeficiency virus 1 [gp120 protein, Human immunodeficiency virus 1 co-treated with Zalcitabine] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 18606552
D009151 Mustard Gas Mustard Gas results in decreased expression of LAMA5 proteindecreases expression 12880345
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of LAMA5 mRNAaffects binding|decreases expression|increases activity 19710929
C009166 retinol acetate retinol acetate results in increased expression of LAMA5 mRNAincreases expression 16772331
D013629 Tamoxifen Tamoxifen affects the expression of LAMA5 mRNAaffects expression 14699072
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMA5 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in increased expression of LAMA5 mRNAincreases expression 17138961
C088658 zoledronic acid [zoledronic acid co-treated with Gossypol] results in decreased expression of LAMA5 mRNAaffects cotreatment|decreases expression 19825521
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4914745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.287525203
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.2814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.8917505938
MESH:D058186 Acute Kidney Injury zoledronic acid 4.4019715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.0518653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.4220200999
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1220464547 20127859
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1214692618
MESH:D000236 Adenoma Benzo(a)pyrene 10.996695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.9919389873
MESH:D000236 Adenoma Diethylnitrosamine 10.9910737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 16.9319061943 17620307 18056438 19052882 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.9316434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.9316835633
MESH:D000505 Alopecia Tretinoin 3.5615955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.8911748828
MESH:D000799 Angioedema Acetaminophen 3.7910982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0119183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4011256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.0715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.0716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2516292516
MESH:D001249 Asthma Mustard Gas 4.9110378619
MESH:D001249 Asthma Tretinoin 4.9116456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.3416935849
MESH:D001768 Blister Mustard Gas 5.1019167455
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.9119483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.9112125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.9116206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7215746008
MESH:D001859 Bone Neoplasms zoledronic acid 4.8916121404 17312309 19442620 16778634 11697798 15867366
MESH:D001862 Bone Resorption zoledronic acid 4.6418496637 15845617 8053405 18404659 16769263 11869084
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9320146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9317474063
MESH:D001943 Breast Neoplasms Tamoxifen 2.9319487384 19200415 19289846 19142967 17261762 18815881 19066611 19084267 18425577 18629630 17440819 19221464 18855134 17893378 20065188 20135344 16818667 15668708 19244106 16202921 20390343 19115204 18821012 19155303 18997820 18351453 19410462 19189210 19288272 20544844 21138602 21152245 19103187 19011961 16273361 15565566 18984771 11161223 19059307 19189212 20005174 20859285 17242785 16873071 17049068
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9320435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9316166294 16443354 16873071
MESH:D001943 Breast Neoplasms zoledronic acid 2.9318695136 16096432
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.1015286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 4.9217687719 10378619
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.5316813970
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.7216227642 16124888 3786805 16097048 15721981 10355542 15700767 16011737 15673190 18705752 16050911 16192424
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7416835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4419066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1016168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.753084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 8.7518788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 8.7516807293 18210153 18056438 10672840 19418558 18393292 16698587 16288022 19383236 17173139 16779866 17761372 3581430 20514400 16830150 16502159 16540662 17138121 20007298 19171122 18665156 16328049 20524982 17978847 17162532 17055752 19107877 17428255 18971187 19539802 19822196 18788625 18978308 20727157 16681979 3084413 10737359 18506893 18785209 19052882 18691550 16878318 11831363 20935162 21159647 19701751 20101231 16569478 19208518 19919837 19394651 16935385 20432363 20214788 20084675 19335982 20512989 19519916 18494052
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 8.7516924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 8.751917145
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5219233551
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 3.8218507039
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5020419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5016096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5517572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3316120746 18670907 18850075
MESH:D009202 Cardiomyopathies Zalcitabine 4.6610591146
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 12.1514694615
MESH:D002386 Cataract Acetaminophen 12.1510977129
MESH:D002386 Cataract Tretinoin 12.1517460283
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.817505956 21159647 17174075 2727394
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.5316129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.1319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.1316835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.5817110522 16105132 15861022 17681005 17333356 16919318 11677210
MESH:D002779 Cholestasis pirinixic acid 7.5819176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1016461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.6715668235 15340226 12621046 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.679407595
MESH:D003092 Colitis Tretinoin 3.6417035595
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 8.9915095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 8.9914669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4310048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.4310589399 16925845 9224671 9211117 9125849 9142499 8800419 9664655 17551590 14991402
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3019031437
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.1720387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1717107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.4219279558
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 11.8121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 11.8118713872 12705907 11743745 11287661 19420014 16781746 16485898 19739265 10774834 17522070 11739529 10915739 12594235 18071297 17562736 16109766 19164858 11461765 16393943 19085960 12392966 14986274 14550746 16177239 15619225 15968718 19370779 11834606 2444490 19416960 19923254 12958197 11529661 10663392 12540782 16227642 12153990 16081117 14725611 17906064 11421492
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 11.816623471 19085960 15998439 9327722 10092053 16227642 7179309 17522070 3786805 15968718 15027814 7440962 11566570 10915739 19336974 2869522 7120509 16177239 3732212 21278145 6884620 4309450
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 11.8119107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 11.8120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0419426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.3811462148
MESH:D004362 Drug Toxicity Zalcitabine 8.387515130
MESH:D004487 Edema Mustard Gas 11.079260866 11402378 11428647 11428631
MESH:D004487 Edema pirinixic acid 11.0712083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 11.0711000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.7618230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.7618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.7312538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.7319031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2920544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 7.2916569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9610568697 9294722
MESH:D004890 Erythema Mustard Gas 5.109357497
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.0616302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 1.9916530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.6711564622
MESH:D005124 Eye Abnormalities Tretinoin 8.679664655 16938888
MESH:D005234 Fatty Liver Carbon Tetrachloride 29.9516045604 12631006 19224547 15959796 17595544 12795759 16239168 61145
MESH:D005234 Fatty Liver Diethylnitrosamine 29.9521071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.9515345470
MESH:D005234 Fatty Liver pirinixic acid 29.9520131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 29.9514986274 19224547
MESH:D005234 Fatty Liver Zalcitabine 29.9518299183
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1916709447
MESH:D005264 Femoral Fractures zoledronic acid 5.7716234978
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.3911858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1219069698
MESH:D005355 Fibrosis Carbon Tetrachloride 14.4018705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 14.4020067830
MESH:D005355 Fibrosis Tretinoin 14.4017994277
MESH:D005756 Gastritis Acetaminophen 3.6216983495
MESH:D005909 Glioblastoma Tretinoin 2.9617312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5410696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1016084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.8920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.8910048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.8914991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.5020558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2711000095
MESH:D006505 Hepatitis Carbon Tetrachloride 3.5319900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 8.0519772884 16221962 18467677 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.0516120746 12621046 15340226
MESH:D015658 HIV Infections Zalcitabine 4.3017457083
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.9916354765 8697196 18606429 15340226 16959395
MESH:D006930 Hyperalgesia Acetaminophen 12.8316870215
MESH:D006930 Hyperalgesia Tretinoin 12.8316870215
MESH:D006930 Hyperalgesia zoledronic acid 12.8316769263
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.4716899240
MESH:D006934 Hypercalcemia zoledronic acid 4.9819622757 18089816
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5016778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1220558911
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8818670907 18850075
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.0215338365
MESH:D006996 Hypocalcemia zoledronic acid 6.1412669777
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7516945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4012013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1917937319
MESH:D007248 Infertility, Male Gossypol 7.1911202417 9639145
MESH:D007249 Inflammation Diethylnitrosamine 11.6818785209
MESH:D007249 Inflammation Mustard Gas 11.689260866 16001271 8975870 11428647 11428620 11428631 17524151 11402378 9357497
MESH:D007249 Inflammation Tamoxifen 11.6819457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 11.6812200463 12878042
MESH:D007333 Insulin Resistance pirinixic acid 2.5916306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7017994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.7316580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.7315992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 2.1612587719 15629191
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9918625569
MESH:D007938 Leukemia Tretinoin 2.7417143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.7118089816
MESH:D007951 Leukemia, Myeloid Tretinoin 3.6419285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0717596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1117506722 17294898 16140955 9834237 16331271 16891316 17301526 17361223 19029980 17712046 12679006 19035177 15748426 17339181 16766008 17107899 19225113 17649720 17217047 16823087 17368321 16788101 16935935 19075265 19642359
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.269224671
MESH:D008064 Lipidoses Tamoxifen 3.1117567588 15342952
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 6.4916943688 16221502 16239168 17157831 11408273 11903743 17334410 21278145 17174718
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.4918522880 19638242 18665156 18407596 20032147
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 6.6418376398 17761835 18006644 15052691 14620537 12632512 15730626 10355542 18251166 18166357 14716496 16192424 18472094 17766677 16015684 13678700 18277467 15996030 14512876 16027843 17714472 17640975 12649538 18418968 15673190 18279442 17481882 12586293 18472332 15650968 16136751 17565644 18412020 12445421 14748882 17976157 18054572 18429990 17698563 15123356 12898905 17525996 12632514 18395095 17557913 17631135 12389079 16033810 17823541 15959796 11481614 17900296 16638106 18481824 18395914 18187930 15925388 17708605 17922224 16011737 12666154 18263696 12546737 15893842 12445418 17721639 15370692 14724832 17869086 15876570 15818738 18156304 15931870 16097048 17805973 12609069 18210741 12667390 16248980 20821823 15338365 18420326 12741479 18339082 14716833 15057751 17944888 18705752 18205269 15362042 12958196 16116963 18317297
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6418564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.6412878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6416248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.3719784758 16610002 12969438 16611625 19460945 11587558 19014921 12587719
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.3715720792 17285989 16964402 15830285 16246199
MESH:D008107 Liver Diseases Diethylnitrosamine 6.3717034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.1015123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.2116871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.2114706259 16899240
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.5421137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.5419389873 21295105
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 21.5419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.5419850985 12771043 21047994 20137499 20434301 19294768 19642983 19833225 2422723 18754104 16942905 19690152 19427195 18644402 21071580 9163691 20492335 19426721 19551842 19812893 19256749 21278145 20118626 12112319 19073162 20452335 18648771 19499222 20583210 19638242 19996281 18977376 20101389 19254457 19255062 10737359 20405173 19090486 15175105 21167192 15885732 2862719 20501860 18978307
MESH:D008113 Liver Neoplasms pirinixic acid 21.5420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 21.5416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.5416984957
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 13.7918164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 13.7912014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 13.7919126423 18775883 16842330 18079962 18253720 18544905 3124819 19009564 17174075 16267830 19004024 19539802 18282651 19519916 2563599 17854601 21159647 17942915 18308698 18093689 9362446 18164116
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 13.7912151625
MESH:D008171 Lung Diseases Mustard Gas 3.4018702808 18161513
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5017053015 18816296 18520028 18569708 20464547 20064080 6695378 20869020 20135361
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.506695378 20970405 20512841 21163286
MESH:D008175 Lung Neoplasms Mustard Gas 6.503148597 8781369
MESH:D008175 Lung Neoplasms Tamoxifen 6.5018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5019555203 11884234
MESH:D008223 Lymphoma Zalcitabine 4.599205081 17941976 11980663 18798262 8840982 9488045 8764131
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7019428831
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.2514580682 19196723 11731420 19196722 16827153
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 6.2517312309
MESH:D020149 Manganese Poisoning Tamoxifen 4.4919453300
MESH:D008527 Medulloblastoma Tretinoin 2.7617453147
MESH:D008545 Melanoma Tamoxifen 3.2519393235 12393984
MESH:D008545 Melanoma Tretinoin 3.2516752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5019513568
MESH:D008591 Meningomyelocele Tretinoin 4.3616940565
MESH:D008654 Mesothelioma zoledronic acid 3.7216675582
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1416381670
MESH:D009101 Multiple Myeloma zoledronic acid 4.0316996129 18089719 19621390
MESH:D009135 Muscular Diseases pirinixic acid 3.4416239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0417596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1119151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9612213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8916411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.479029167 3581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.4719393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 9.4719139120 15867366 17312309
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4919410462
MESH:D009369 Neoplasms Benzo(a)pyrene 8.0011141357
MESH:D009369 Neoplasms pirinixic acid 8.0017405874
MESH:D009369 Neoplasms Tretinoin 8.0016594593 16946489
MESH:D009374 Neoplasms, Experimental Zalcitabine 5.049488045 8764131 9205081
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.9419200415 19189210 19196722
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.3014600291
MESH:D009421 Nervous System Malformations Tretinoin 9.309125849
MESH:D009437 Neuralgia Zalcitabine 6.2617292584
MESH:D009436 Neural Tube Defects Tretinoin 3.019142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.9918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.9920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.0620387270
MESH:D009503 Neutropenia Mustard Gas 3.9116761898 7688884
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 4.0414694615
MESH:D010014 Osteolysis zoledronic acid 5.3115867366
MESH:D010024 Osteoporosis zoledronic acid 3.9917882678
MESH:D010051 Ovarian Neoplasms Tretinoin 2.3316936753
MESH:D010146 Pain Acetaminophen 11.0116870215
MESH:D010146 Pain Tretinoin 11.0116870215
MESH:D010146 Pain zoledronic acid 11.0116475674
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.1716540662
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.1715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6211578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.1912520081
MESH:D010523 Peripheral Nervous System Diseases gp120 protein, Human immunodeficiency virus 1 10.7218606552
MESH:D010523 Peripheral Nervous System Diseases Zalcitabine 10.7218606552
MESH:D011041 Poisoning Mustard Gas 3.7315727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.4918163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.492563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6817292933
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6815067354
MESH:D011471 Prostatic Neoplasms zoledronic acid 2.6812438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.5416636307
MESH:D011537 Pruritus Ethinyl Estradiol 9.3215861022 16919318
MESH:D011537 Pruritus Mustard Gas 9.3218058305
MESH:D011625 Pterygium Tretinoin 4.7316723453
MESH:D011658 Pulmonary Fibrosis Mustard Gas 2.9017620002 17894541 17720292 17266442 10334151
MESH:D015427 Reperfusion Injury pirinixic acid 2.3519058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.7718990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.0416283617 16116481
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.8716121404
MESH:D012871 Skin Diseases Mustard Gas 2.7012880345 15451306 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.2919755658 10029692
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.298532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.2916192470
MESH:D012878 Skin Neoplasms Tretinoin 13.2916467112
MESH:D013088 Spermatocele Ethinyl Estradiol 11.3716709447
MESH:D013088 Spermatocele Tamoxifen 11.3716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.9819457130
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.292093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.2918456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.2917261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5611994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.0915669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8512697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.007505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.0016026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 3.7316051514
MESH:D014376 Tuberculosis Tretinoin 3.1916040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.9117053015
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 4.9116712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 2.9110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6216129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2314692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.5516752155
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.4815869587 14671159
MESH:D014820 Vitiligo Tretinoin 3.9916761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.1915886252
MESH:D009396 Wilms Tumor Tretinoin 3.9116287080
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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