AutismKB 2.0

Annotation Detail for LAMB2


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Basic Information Top
Gene Symbol:LAMB2 ( LAMS )
Gene Full Name: laminin, beta 2 (laminin S)
Band: 3p21.31
Quick LinksEntrez ID:3913; OMIM: 150325; Uniprot ID:LAMB2_HUMAN; ENSEMBL ID: ENSG00000172037; HGNC ID: 6487
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05146Amoebiasis
hsa05145Toxoplasmosis
hsa05222Small cell lung cancer
hsa04512ECM-receptor interaction
hsa04510Focal adhesion
hsa05200Pathways in cancer
Pathway IDPathway Name
Integrin cell surface interactions
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2001Mental retardation
2100Hepatitis C
2203Nephrosis
Desease Name
RENAL
nephrotic syndrome
No data
Desease Name
Pierson syndrome
Nephrosis, congenital, with or without ocular abnormalities
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of LAMB2 mRNAdecreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of LAMB2 mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LAMB2 mRNAaffects expression 16483693
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of LAMB2 mRNAaffects expression 17484886
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of LAMB2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMB2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of LAMB2 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LAMB2 mRNAaffects cotreatment|increases expression 17942748
C025643 vinclozolin vinclozolin affects the expression of LAMB2 mRNAaffects expression 19015723
D014810 Vitamin E Vitamin E results in increased expression of LAMB2 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1811752688 15322242 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.9018287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.883712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8015885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.401440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2912125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6820435547
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 10.9816050911 16227642 16124888 15673190 16192424 15700767 16097048 15721981 18705752 16011737 10355542 3786805
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 10.9816050911
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.693581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.693084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.6918788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.777296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.917505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.459022650 19486331
MESH:D002779 Cholestasis Ethinyl Estradiol 8.4511677210 17681005 17333356 16105132 17110522 16919318 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.198697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5410048152 15322242 20055451
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.5419769572
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.102524372 18759878 11298694 8156756 14531868 12868966 8970840 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.753621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.469653073 18692083 8291058 18289764 6679447 6482804 18648102 9022650 9328219 11289319 16192314 7440962 1440618
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.4616227642 10915739 16081117 15968718 16177239 19085960 11834606 17522070 14986274 11461765 16109766 17906064 10774834 19416960 11739529 11421492 12594235 16781746 12392966 14725611 19420014 11287661 19164858 12705907 19923254 19739265 17562736 18071297 12958197 10663392 15619225 16485898 12153990 18713872 16393943 11529661 14550746 12540782 2444490 19370779 11743745
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 9.4621278145 7120509 19085960 19336974 15968718 7179309 11566570 3786805 16177239 10092053 17522070 15027814 4309450 3732212 2869522 6623471 9327722 6884620 7440962 15998439 16227642 10915739
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.4620420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:C538011 Eales disease Vitamin E 5.089068938
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6112711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2815322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.2510568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.153581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1911564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.5112631006 61145 15959796 16239168 12795759 16045604 19224547 17595544
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.5115345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.406705139
MESH:D005355 Fibrosis Carbon Tetrachloride 9.6418705752
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6420067830
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.307505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.9511294989 10048152
MESH:D006330 Heart Defects, Congenital Vitamin E 6.9516080930
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.186705139
MESH:D006505 Hepatitis Carbon Tetrachloride 10.1819900420 19110552
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2015340226 12621046 16120746
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7716490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.3514716179
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4216354765 15340226 18606429 8697196 16959395
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.8716899240
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9818850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3915338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.1717937319
MESH:D007248 Infertility, Male vinclozolin 7.1716467254
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612200463 12878042
MESH:D007251 Influenza, Human Vitamin E 4.5916624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.409022650 8074119
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5816580747
MESH:D007674 Kidney Diseases Acetaminophen 6.3912587719 15629191
MESH:D007674 Kidney Diseases Vitamin E 6.3912488133
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.176582329
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9211408273 16239168 16221502 16943688 17174718 17157831 21278145 11903743 17334410
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3315034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5917557913 18210741 17721639 12649538 15996030 18251166 12958196 18054572 15876570 17761835 17640975 17714472 15959796 14748882 13678700 17698563 14724832 18277467 12445421 12666154 18263696 12445418 18279442 15673190 12741479 16248980 16027843 18395914 18429990 18412020 12586293 15370692 16011737 17805973 10355542 12632514 18156304 14512876 18418968 12898905 20821823 15338365 15052691 18472332 17976157 16097048 11481614 15931870 17766677 17922224 16116963 14716496 18317297 18376398 15123356 17823541 15362042 18472094 12667390 15925388 18339082 16638106 17565644 15730626 18187930 17481882 18205269 12546737 17525996 17869086 12632512 16015684 16192424 16136751 17631135 18006644 15650968 17900296 15893842 12389079 18420326 15818738 15057751 16033810 18166357 17708605 18395095 14620537 12609069 17944888 18705752 14716833 18481824
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5912878042
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 3.5916169303
MESH:D008107 Liver Diseases Acetaminophen 4.0712969438 16610002 19014921 12587719 19784758 11587558 19460945 16611625
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0715830285 16964402 16246199 15720792 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.4715123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.1816871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.1816899240 14706259
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.6519294768
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.6516984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 10.61598648 1399818 6587162 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.6112014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.6112151625
MESH:D008171 Lung Diseases Vitamin E 3.3316863852
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.3619555203 11884234
MESH:D008175 Lung Neoplasms Vitamin E 2.3611062179
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:C537346 Mesangial sclerosis, diffuse marker/mechanism 15367484
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2112213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.553581430
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.066679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.656482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.403988306
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.797296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.856228378
MESH:C537185 Pierson syndrome marker/mechanism 15367484
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.6411399792 11118676 11896295 11222880
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 10.6418042343 18220299 19015723
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms marker/mechanism 17013881
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D011537 Pruritus Ethinyl Estradiol 3.6516919318 15861022
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.553692021
MESH:D012871 Skin Diseases Vitamin E 2.4918709164
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1416192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D020521 Stroke Vitamin E 3.7116517955
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.066587162 7505956 1399818 6582329 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.358074119
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
Pathway ID Pathway Name
KEGG:05146 Amoebiasis
KEGG:04512 ECM-receptor interaction
KEGG:04510 Focal adhesion
REACT:13552 Integrin cell surface interactions
KEGG:05200 Pathways in cancer
KEGG:05222 Small cell lung cancer
KEGG:05145 Toxoplasmosis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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