AutismKB 2.0

Annotation Detail for LAMP1


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Basic Information Top
Gene Symbol:LAMP1 ( CD107a,LAMPA,LGP120 )
Gene Full Name: lysosomal-associated membrane protein 1
Band: 13q34
Quick LinksEntrez ID:3916; OMIM: 153330; Uniprot ID:LAMP1_HUMAN; ENSEMBL ID: ENSG00000185896; HGNC ID: 6499
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1770Melanoma
2051Leukemia
2239Lymphoma
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LAMP1 mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of LAMP1 mRNA]affects expression|affects reaction 19414516
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of LAMP1 mRNAincreases expression 18648102
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of LAMP1 mRNA]affects expression|affects reaction 19414516
C430898 AGN 194204 AGN 194204 results in increased expression of LAMP1 mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of LAMP1 mRNAaffects expression 16483693
D001710 Biotin Biotin results in decreased expression of LAMP1 mRNAdecreases expression 15219929
D003474 Curcumin Curcumin affects the expression of LAMP1 mRNAaffects expression 18539377
C056933 fumonisin B1 fumonisin B1 results in increased expression of LAMP1 mRNAincreases expression 16221962
D012643 Selenium Selenium results in increased expression of LAMP1 mRNAincreases expression 19244175
C025462 sulindac sulfide sulindac sulfide results in decreased expression of LAMP1 mRNAdecreases expression 16184548
D014810 Vitamin E Vitamin E results in increased expression of LAMP1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.833712494
MESH:D019973 Alcohol-Related Disorders Curcumin 5.3017887948
MESH:D000544 Alzheimer Disease Curcumin 4.7415590663
MESH:D000544 Alzheimer Disease sulindac sulfide 4.7418759972
MESH:D001172 Arthritis, Rheumatoid Curcumin 2.7616807698
MESH:D050197 Atherosclerosis Curcumin 3.4018704882
MESH:D001327 Autoimmune Diseases Curcumin 4.6719761891
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.241440618 11289319
MESH:D002545 Brain Ischemia Curcumin 4.5216770732
MESH:D001932 Brain Neoplasms Curcumin 4.0717596214
MESH:D001943 Breast Neoplasms Curcumin 2.7319250217 18462866 18593918 16243823
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1116050911
MESH:D002277 Carcinoma Curcumin 3.9518593918
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.763581430 7296757
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 6.0818414057
MESH:D002289 Carcinoma, Non-Small-Cell Lung sulindac sulfide 6.0812391285
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.737296757
MESH:D002294 Carcinoma, Squamous Cell Curcumin 2.7918462866
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.857505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.2519486331 9022650
MESH:D003092 Colitis Curcumin 10.2616804969 18200517 16782535
MESH:D003092 Colitis Selenium 10.2617936198
MESH:D003103 Coloboma Curcumin 4.6918809619
MESH:D003110 Colonic Neoplasms Curcumin 2.5219359593 16340194
MESH:D016510 Corneal Neovascularization Curcumin 5.0718497527
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9718759878 8970840 2524372 14531868 8156756 11298694 12868966 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.643621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 2.7318403477
MESH:D003928 Diabetic Nephropathies Curcumin 4.1318204486
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.6016192314 11289319 18289764 8291058 9653073 18648102 7440962 18692083 6679447 1440618 9022650 9328219 6482804
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 6.6016221962
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6015131321
MESH:D004381 Duodenal Ulcer Curcumin 4.2117351913
MESH:C538011 Eales disease Vitamin E 4.929068938
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005234 Fatty Liver Curcumin 3.8419297423
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.246705139
MESH:D005355 Fibrosis Curcumin 4.1618705752
MESH:D005770 Gastrointestinal Neoplasms Curcumin 4.8718462866
MESH:D005909 Glioblastoma Curcumin 3.5617596214
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.197505956
MESH:D006258 Head and Neck Neoplasms Curcumin 3.7518829502 18462866
MESH:D006330 Heart Defects, Congenital Vitamin E 3.0516080930
MESH:D006333 Heart Failure Selenium 3.1517162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.676705139
MESH:D006529 Hepatomegaly fumonisin B1 4.4416221962
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 5.2217701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7416490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.1914716179
MESH:D006937 Hypercholesterolemia Curcumin 4.1918704882
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1115034207
MESH:D007249 Inflammation Curcumin 2.9518403477 16956363 17151092
MESH:D015212 Inflammatory Bowel Diseases Curcumin 3.2618200517 18596194
MESH:D007251 Influenza, Human Selenium 11.7016624496
MESH:D007251 Influenza, Human Vitamin E 11.7016624496
MESH:D007414 Intestinal Neoplasms Curcumin 4.3510783313
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.249022650 8074119
MESH:D007674 Kidney Diseases Vitamin E 2.8812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0216518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.086582329
MESH:D007889 Leiomyoma Curcumin 4.7218555241
MESH:D007938 Leukemia Curcumin 3.3018462866
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 4.3416106398
MESH:D015458 Leukemia, T-Cell Curcumin 4.9216106398
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2815034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 2.7618705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.7616169303
MESH:D008107 Liver Diseases Curcumin 2.6416956363
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.613712494 598648 1399818 6587162
MESH:D008171 Lung Diseases Vitamin E 3.2716863852
MESH:D008175 Lung Neoplasms Curcumin 2.7219359593 18462866 16243823
MESH:D008175 Lung Neoplasms Vitamin E 2.7211062179
MESH:D008223 Lymphoma Curcumin 3.6818462866
MESH:D016399 Lymphoma, T-Cell Curcumin 4.8716173963
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8515318939
MESH:D008545 Melanoma Curcumin 2.4317885582 18462866
MESH:D008569 Memory Disorders Curcumin 4.3117263510
MESH:D008654 Mesothelioma Selenium 2.8415107826
MESH:D020326 Migraine without Aura Cyclic AMP 5.3211304026
MESH:D009101 Multiple Myeloma Curcumin 3.6119372569
MESH:D009134 Muscular Atrophy, Spinal Curcumin 5.1117962980
MESH:D009361 Neoplasm Invasiveness Curcumin 4.5318495463
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.523581430
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 4.7512497104
MESH:D009423 Nervous System Neoplasms Curcumin 5.8518462866
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.006679447
MESH:D009765 Obesity Curcumin 2.7719297423
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.556482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.243988306
MESH:D010024 Osteoporosis Curcumin 3.5518719352
MESH:D010051 Ovarian Neoplasms Curcumin 2.8518462866 19020741
MESH:D010190 Pancreatic Neoplasms Curcumin 2.9817440100 19401701 19196508
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.667296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.696228378
MESH:D010954 Plasmacytoma Selenium 5.1115087411
MESH:D011471 Prostatic Neoplasms AGN 194204 2.7616000583
MESH:D011471 Prostatic Neoplasms Curcumin 2.7615129424 11398177 18226269 18156803 10851300 18769126 12497104
MESH:D011471 Prostatic Neoplasms Vitamin E 2.7615084515
MESH:D011656 Pulmonary Emphysema Curcumin 4.6619168576
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 4.1710666014 18379247
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.483692021
MESH:D012509 Sarcoma Curcumin 4.2518462866
MESH:D018805 Sepsis Curcumin 4.1918389075
MESH:D012871 Skin Diseases Vitamin E 2.4718709164
MESH:D013276 Stomach Ulcer Curcumin 3.6316631530 19188055
MESH:D020521 Stroke Vitamin E 3.6316517955
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.996587162 1399818 6582329 7505956 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.398074119
MESH:D001749 Urinary Bladder Neoplasms Curcumin 5.3918593936
MESH:D014565 Urogenital Neoplasms Curcumin 5.4618462866
MESH:D014594 Uterine Neoplasms sulindac sulfide 4.8118645019
Pathway ID Pathway Name
KEGG:04142 Lysosome
KEGG:04145 Phagosome
KEGG:05152 Tuberculosis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA30283
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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